{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:39:44Z","timestamp":1792787984727,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Objectives: The objective of this study was to separately examine the effects of exercise addiction and the Collagen Type I Alpha 1 Chain (COL1A1) gene rs1800012 G\/T polymorphism on injury susceptibility in elite female volleyball players, and to test the hypothesis that the T allele, previously identified as a risk allele, is underrepresented in volleyball players compared to the general population. Methods: The study included 50 professional Turkish female volleyball players with documented injury data, along with 557 Turkish controls, 53 professional Russian volleyball players, and 810 Russian controls. The Turkish participants were enrolled in a case\u2013control study, an injury study, and an exercise addiction study, whereas the Russian participants were enrolled solely in a case\u2013control study. Results: Injured players had significantly higher scores in the Delay of Individual Social Needs and Conflict subscale of the Exercise Addiction Scale compared to their uninjured counterparts (p = 0.036). The random-effects meta-analysis revealed a significantly lower frequency of the COL1A1 T allele in volleyball players compared to controls (pooled OR = 0.63, 95% CI: 0.41\u20130.96, p = 0.031). Athletes who had not undergone surgery had a significantly higher frequency of the G allele compared to controls (89.2% vs. 78.7%, p = 0.037; OR = 2.23, 95% CI: 1.1\u20134.7). Among injured athletes, those carrying the GT genotype were significantly more likely to experience prolonged recovery (\u22653 months) (57.1%) compared to those with the GG genotype (28.0%, p = 0.017). Conclusions: Exercise addiction and the COL1A1 rs1800012 T allele were associated with a higher incidence of injury in female volleyball players. The T allele was also associated with a longer recovery time following injury.<\/jats:p>","DOI":"10.3390\/genes16111300","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:22:36Z","timestamp":1762176156000},"page":"1300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Exercise Addiction and the COL1A1 Gene rs1800012 Polymorphism on Injury Susceptibility in Elite Female Volleyball Players"],"prefix":"10.3390","volume":"16","author":[{"given":"Muhammed Mustafa","family":"Piri","sequence":"first","affiliation":[{"name":"Department of Exercise and Sports Science, Lokman Hekim University, 06510 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Cerit","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sports Science, Lokman Hekim University, 06510 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"An\u0131l\u0131r","sequence":"additional","affiliation":[{"name":"Department of Sports Management, Lokman Hekim University, 06510 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Polat","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Basic Medical Sciences, Department of Basic Health Sciences, Marmara University, 34722 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur Ay\u015fe","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Physiotherapy, Lokman Hekim University, 06510 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-4304","authenticated-orcid":false,"given":"Attila","family":"Szabo","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sport Sciences, Sz\u00e9chenyi Istv\u00e1n University, 9026 Gy\u0151r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany Georges Abi","family":"Antoun","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon"},{"name":"Transform Specialist Medical Centre, Dubai 119190, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"John","sequence":"additional","affiliation":[{"name":"Transform Specialist Medical Centre, Dubai 119190, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-2855","authenticated-orcid":false,"given":"Ekaterina A.","family":"Semenova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"},{"name":"Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, 420138 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-792X","authenticated-orcid":false,"given":"Andrey K.","family":"Larin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay A.","family":"Kulemin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-4883","authenticated-orcid":false,"given":"Edward V.","family":"Generozov","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-4020","authenticated-orcid":false,"given":"Ildus I.","family":"Ahmetov","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"},{"name":"Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, 420111 Kazan, Russia"},{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 5AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1177\/0363546506286866","article-title":"Understanding and Preventing Noncontact Anterior Cruciate Ligament Injuries: A Review of the Hunt Valley II Meeting, January 2005","volume":"34","author":"Griffin","year":"2006","journal-title":"Am. 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