{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:57:51Z","timestamp":1772467071366,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretariat of Science, Humanities, Technology and Innovation","award":["1560315"],"award-info":[{"award-number":["1560315"]}]},{"name":"SECIHTI","award":["CVU 829255"],"award-info":[{"award-number":["CVU 829255"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Obesity is associated with hypothalamic dysfunction characterized by neuroinflammation and altered transcriptional programs. While resveratrol (RSV) has shown beneficial metabolic effects in peripheral tissues, its central effects on hypothalamic gene expression in obesity remain poorly understood. This study provides the first predictive transcriptomic analysis of the hypothalamic response to RSV in a mouse model of diet-induced obesity. C57BL\/6 male mice were fed a high-fat diet (HFD) to induce obesity and then subsequently treated with RSV. Methods: Hypothalamic RNA was extracted and analyzed using RNA sequencing. Differentially expressed genes (DEGs) were identified and functionally analyzed through KEGG pathway analysis. Results: Although RSV did not significantly alter body weight, it reversed the expression of several HFD-induced DEGs. Key genes modulated by RSV included Aqp7, Ccl27a, Lta, Rilp, M6pr-ps, C1ra, Snail1, Gbgt1, and Ppargc1b, which are involved in inflammation, lipid metabolism, mitochondrial function, and immune signaling. Pathway enrichment analysis revealed significant modulation of TNF and NF-\u03baB signaling, cytokine\u2013cytokine receptor interactions, glycosphingolipid biosynthesis, and phagosome-related activity. Remarkably, 45% of RSV-responsive transcripts were non-coding RNAs, suggesting epigenetic regulation. Conclusions: RSV reprograms the hypothalamic transcriptome in obesity, targeting both coding and non-coding RNAs associated with inflammation and metabolic regulation, independently of weight loss. These findings identify RSV as a potential central modulator of metabolic dysfunction and highlight the hypothalamus as a promising therapeutic target in obesity-related disease.<\/jats:p>","DOI":"10.3390\/genes17030297","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:55:01Z","timestamp":1772463301000},"page":"297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Predictive Transcriptomic Approach to the Resveratrol-Mediated Reversal of Hypothalamic Alterations in a Mouse Model of Obesity"],"prefix":"10.3390","volume":"17","author":[{"given":"Brenda","family":"De la Cruz-Concepci\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular y Gen\u00f3mica, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-1804","authenticated-orcid":false,"given":"Juan Miguel","family":"Mendoza-Bello","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular y Gen\u00f3mica, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-7879","authenticated-orcid":false,"given":"Fredy Omar","family":"Beltr\u00e1n-Anaya","sequence":"additional","affiliation":[{"name":"Laboratorio de Diagn\u00f3stico e Investigaci\u00f3n en Salud, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-8530","authenticated-orcid":false,"given":"M\u00f3nica","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Laboratorio de Prote\u00f3mica y Gen\u00f3mica Funcional, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaccil Adilene","family":"Flores-Cortez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular y Gen\u00f3mica, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Damian-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular y Gen\u00f3mica, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-8874","authenticated-orcid":false,"given":"Eugenia","family":"Flores-Alfaro","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isela","family":"Parra-Rojas","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Obesidad y Diabetes, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Del Moral-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Diagn\u00f3stico e Investigaci\u00f3n en Salud, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-6172","authenticated-orcid":false,"given":"Miguel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauht\u00e9moc 330, Colonia Doctores, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Espinoza-Rojo","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular y Gen\u00f3mica, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas S\/N, Ciudad Universitaria, Chilpancingo 39086, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"ref_1","unstructured":"World Heald Organization (WHO) (2026, January 27). Obesity and Overweight. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbi.2024.01.216","article-title":"Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity","volume":"117","author":"Sanchez","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"167528","DOI":"10.1016\/j.bbadis.2024.167528","article-title":"Myeloid PGC1\u03b2 attenuates high-fat-diet induced inflammation via mitochondrial fission\/mtDNA\/Nlrp3 pathway","volume":"1871","author":"Li","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e23770","DOI":"10.1096\/fj.202400289R","article-title":"High-intensity interval training improves hypothalamic inflammation by suppressing HIF-1\u03b1 signaling in microglia of male C57BL\/6J mice","volume":"38","author":"Chen","year":"2024","journal-title":"FASEB J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ubaldo-Reyes, L.M., Espitia-Bautista, E., Barajas-Mart\u00ednez, A., Mart\u00ednez-Tapia, R., Rodr\u00edguez-Mata, V., Noriega-Navarro, R., Escalona, R., Castillo-Hern\u00e1ndez, J., P\u00e9rez-Torres, A., and Navarro, L. (2024). High-fat diet-induced blood-brain barrier dysfunction: Impact on allodynia and motor coordination in rats. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202409.1979.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2013.06.007","article-title":"Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system","volume":"35","author":"Buckman","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lee, Y.H., Hsu, H.C., Kao, P.C., Shiao, Y.J., Yeh, S.H., Shie, F.S., Hsu, S.M., Yeh, C.W., Liu, H.K., and Yang, S.B. (2018). Augmented insulin and leptin resistance of high fat diet-fed APPswe\/PS1dE9 transgenic mice exacerbate obesity and glycemic dysregulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082333"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e70111","DOI":"10.1096\/fj.202401931R","article-title":"KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus","volume":"38","author":"Jo","year":"2024","journal-title":"FASEB J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/09645284251327205","article-title":"Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1\/PI3K\/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes","volume":"43","author":"Zhuang","year":"2025","journal-title":"Acupunct. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111574","DOI":"10.1016\/j.cbpa.2024.111574","article-title":"Identification of C1q\/TNF-related protein 4 as a novel appetite-regulating peptide that reduces food intake in Siberian sturgeon (Acipenser baerii)","volume":"289","author":"Zhang","year":"2024","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s41366-025-01754-0","article-title":"Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation","volume":"49","author":"Manceau","year":"2025","journal-title":"Int. J. Obes."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1007\/s11064-024-04243-4","article-title":"High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice","volume":"49","author":"Duarte","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111448","DOI":"10.1016\/j.cellsig.2024.111448","article-title":"Resveratrol inhibits white adipose deposition by the ESR1-mediated PI3K\/AKT signaling pathway","volume":"124","author":"Yang","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102128","DOI":"10.1016\/j.molmet.2025.102128","article-title":"Microglial ER stress response via IRE1\u03b1 regulates diet-induced metabolic imbalance and obesity in mice","volume":"95","author":"Stilgenbauer","year":"2025","journal-title":"Mol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/s41366-021-00945-9","article-title":"Hypothalamic long noncoding RNA AK044061 is involved in the development of dietary obesity in mice","volume":"45","author":"Li","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrm2738","article-title":"Regulatory roles of natural antisense transcripts","volume":"10","author":"Faghihi","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Barman, P., Reddy, D., and Bhaumik, S. (2019). Mechanisms of Antisense Transcription Initiation with Implications in Gene Expression, Genomic Integrity and Disease Pathogenesis. Non-Coding RNA, 5.","DOI":"10.3390\/ncrna5010011"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s40618-021-01559-8","article-title":"Long non-coding RNAs in metabolic disorders: Pathogenetic relevance and potential biomarkers and therapeutic targets","volume":"44","author":"Alipoo","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e22969","DOI":"10.1002\/dneu.22969","article-title":"Cannabis oil protects against valproic acid-induced autism spectrum disorder by reducing oxidative stress","volume":"85","author":"Ali","year":"2025","journal-title":"Dev. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12017-025-08859-9","article-title":"Hydro-alcoholic extract of cynodon dactylon ameliorates malathion-induced neurocognitive behavior and neurotoxicity","volume":"27","author":"Sharma","year":"2025","journal-title":"Neuromol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nutres.2024.12.009","article-title":"Cashew nut consumption reduces waist circumference and oxidative stress in adolescents with obesity: A randomized clinical trial","volume":"134","author":"Maia","year":"2025","journal-title":"Nutr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.32725\/jab.2024.008","article-title":"Resveratrol alleviates endoplasmic reticulum stress-induced cell death and improves functional prognosis after traumatic brain injury in mice","volume":"22","author":"Cao","year":"2024","journal-title":"J. Appl. Biomed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/08982104.2025.2476529","article-title":"Effect of oral resveratrol-loaded nanoliposomes on hyperlipidemia via toll-like receptor 3 and TIR domain-containing adaptor inducing interferon-\u03b2 protein expression in an animal model","volume":"35","author":"Beheshtkhoo","year":"2025","journal-title":"J. Liposome Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.1038\/s41598-025-91027-7","article-title":"Role of trans-resveratrol in ameliorating biochemical and molecular alterations in obese rats induced by a high fructose\/fat diet","volume":"15","author":"Khamis","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ispiryan, A., Kraujutiene, I., and Viskelis, J. (2024). Retaining resveratrol content in berries and berry products with agricultural and processing techniques: Review. Processes, 12.","DOI":"10.3390\/pr12061216"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108569","DOI":"10.1016\/j.jnutbio.2020.108569","article-title":"Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer\u2019s disease via modulation of proteolytic mechanisms","volume":"89","author":"Sarroca","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"114899","DOI":"10.1016\/j.expneurol.2024.114899","article-title":"Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1\/PGC-1\u03b1","volume":"380","author":"Su","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref_29","first-page":"366","article-title":"Glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (IFN\u03b1\/\u03b2R-\/-) mice","volume":"59","author":"Sovrani","year":"2023","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00394-018-1715-0","article-title":"Switching from high-fat diet to foods containing resveratrol as a calorie restriction mimetic changes the architecture of arcuate nucleus to produce more newborn anorexigenic neurons","volume":"58","author":"Safahani","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bissacotti, B.F., da Silveira, M.V., Assmann, C.E., Copetti, P.M., Santos, A.F.D., Fagan, S.B., da Rocha, J.A., Schetinger, M.R., Morsch, V.M., and Bottari, N.B. (2025). Resveratrol alleviates inflammatory response through P2X7\/NLRP3 signaling pathway: In silico and in vitro evidence from activated microglia. Pharmaceuticals, 18.","DOI":"10.3390\/ph18070950"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00795-019-00216-7","article-title":"The therapeutic effects of resveratrol on hepatic steatosis in high-fat diet-induced obese mice by improving oxidative stress, inflammation and lipid-related gene transcriptional expression","volume":"52","author":"Cheng","year":"2019","journal-title":"Med. Mol. Morphol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.nut.2013.11.016","article-title":"Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation","volume":"30","author":"Andrade","year":"2014","journal-title":"Nutrition"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e5173","DOI":"10.7717\/peerj.5173","article-title":"Resveratrol reduces the inflammatory response in adipose tissue and improves adipose insulin signaling in high-fat diet-fed mice","volume":"6","author":"Ding","year":"2018","journal-title":"PeerJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.nutres.2015.05.006","article-title":"Resveratrol prevents hepatic steatosis and endoplasmic reticulum stress and regulates the expression of genes involved in lipid metabolism, insulin resistance, and inflammation in rats","volume":"35","author":"Pan","year":"2015","journal-title":"Nutr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"114871","DOI":"10.1016\/j.taap.2019.114871","article-title":"Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2\/STAT3 signaling pathway is independent of SOCS3","volume":"388","author":"Jiang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: A revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1126\/science.1087447","article-title":"A gene-coexpression network for global discovery of conserved genetic modules","volume":"302","author":"Stuart","year":"2003","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/msb.2011.99","article-title":"Differential network biology","volume":"8","author":"Ideker","year":"2012","journal-title":"Mol. Syst. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/mnfr.201400933","article-title":"Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner","volume":"59","author":"Rada","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dubitzky, W., Wolkenhauer, O., Cho, K.H., and Yokota, H. (2013). Benjamini\u2013Hochberg Method. Encyclopedia of Systems Biology, Springer.","DOI":"10.1007\/978-1-4419-9863-7"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1507\/endocrj.EJ15-0545","article-title":"Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells","volume":"63","author":"Chang","year":"2016","journal-title":"Endocr. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e70075","DOI":"10.1002\/mnfr.70075","article-title":"Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet-Induced Obese Rats","volume":"69","author":"Cirasino","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","first-page":"e70075","article-title":"Involvements of long noncoding RNAs in obesity-associated inflammatory diseases","volume":"69","author":"Wijesinghe","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2539519","DOI":"10.1155\/2022\/2539519","article-title":"Resveratrol Alleviates Skeletal Muscle Insulin Resistance by Downregulating Long Noncoding RNA","volume":"2022","author":"Liu","year":"2022","journal-title":"Int. J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2524638","DOI":"10.1080\/21623945.2025.2524638","article-title":"Electroacupuncture stimulation induced M1\/M2 polarization in white adipose tissues by activating the Y1 receptor in obese mice to reduce chronic inflammation","volume":"14","author":"Lu","year":"2025","journal-title":"Adipocyte"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E961","DOI":"10.1152\/ajpendo.00447.2011","article-title":"Deficiency of lymphotoxin-\u03b1 does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice","volume":"302","author":"Pamir","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1093\/brain\/awac232","article-title":"Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration","volume":"145","author":"Browne","year":"2022","journal-title":"Brain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2010.04.019","article-title":"Expression and regulation in the brain of the chemokine CCL27 gene locus","volume":"225","author":"Gunsolly","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/21623945.2022.2060059","article-title":"Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery","volume":"11","author":"Yan","year":"2022","journal-title":"Adipocyte"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s10020-024-00793-z","article-title":"Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity","volume":"30","author":"Okekawa","year":"2024","journal-title":"Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sindhu, S., Kochumon, S., Shenouda, S., Wilson, A., Al-Mulla, F., and Ahmad, R. (2019). The cooperative induction of CCL4 in human monocytic cells by TNF-\u03b1 and palmitate requires MyD88 and involves MAPK\/NF-\u03baB signaling pathways. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184658"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mir, M.M., Alfaifi, J., Sohail, S.K., Rizvi, S.F., Akhtar, M.T., Alghamdi, M.A.A., Mir, R., Wani, J.I., Sabah, Z.U., and Alhumaydhi, F.A. (2024). The role of pro-inflammatory chemokines CCL-1, 2, 4, and 5 in the etiopathogenesis of type 2 diabetes mellitus in subjects from the asir region of Saudi Arabia: Correlation with different degrees of obesity. J. Pers. Med., 14.","DOI":"10.3390\/jpm14070743"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/trf.14813","article-title":"Gbgt1 is allelically diverse but dispensable in humans and naturally occurring anti-fors1 shows an abo-restricted pattern","volume":"58","author":"Hult","year":"2018","journal-title":"Transfusion"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Li, J., Huang, Q., Yang, C., Yu, C., Zhang, Z., Chen, M., Ren, P., and Qiu, M. (2023). Molecular regulation of differential lipid molecule accumulation in the intramuscular fat and abdominal fat of chickens. Genes, 14.","DOI":"10.3390\/genes14071457"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"108481","DOI":"10.1016\/j.abb.2020.108481","article-title":"Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells","volume":"691","author":"Cardoso","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.bbalip.2018.05.007","article-title":"High-fat diet-induced lipidome perturbations in the cortex, hippocampus, hypothalamus, and olfactory bulb of mice","volume":"1863","author":"Lee","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_59","first-page":"51","article-title":"Genistein, daidzein, and resveratrols stimulate PGC-1\u03b2-mediated gene expression","volume":"17","author":"Uchitomi","year":"2018","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12264-017-0153-y","article-title":"MiR-30a positively regulates the inflammatory response of microglia in experimental autoimmune encephalomyelitis","volume":"33","author":"Fang","year":"2017","journal-title":"Neurosci. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12378","DOI":"10.1073\/pnas.2135217100","article-title":"PPARgamma coactivator 1beta\/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity","volume":"100","author":"Kamei","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"31693","DOI":"10.1074\/jbc.272.50.31693","article-title":"A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation","volume":"272","author":"Vega","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.celrep.2016.10.070","article-title":"Adipose Snail1 regulates lipolysis and lipid partitioning by suppressing adipose triacylglycerol lipase expression","volume":"17","author":"Sun","year":"2016","journal-title":"Cell Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1080\/15548627.2020.1778294","article-title":"A RILP-regulated pathway coordinating autophagosome biogenesis with transport","volume":"16","author":"Khobrekar","year":"2020","journal-title":"Autophagy"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.15252\/embj.201591881","article-title":"Complement activation, regulation, and molecular basis for complement related diseases","volume":"34","author":"Bajic","year":"2015","journal-title":"EMBO J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1093\/brain\/awaf018","article-title":"Mendelian randomization identifies proteins involved in neurodegenerative diseases","volume":"148","author":"Belbasis","year":"2025","journal-title":"Brain"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1038\/s41380-021-01169-z","article-title":"Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity","volume":"26","author":"Wang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"419092","DOI":"10.1155\/2013\/419092","article-title":"Resveratrol Protects the Brain of Obese Mice from Oxidative Damage","volume":"2013","author":"Rege","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ma, X., Sun, Z., Han, X., Li, S., Jiang, X., Chen, S., Zhang, J., and Lu, H. (2020). Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer\u2019s Disease. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01400"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/3\/297\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:08:54Z","timestamp":1772464134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/3\/297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["genes17030297"],"URL":"https:\/\/doi.org\/10.3390\/genes17030297","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}