{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:11:30Z","timestamp":1785161490726,"version":"3.55.0"},"reference-count":83,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Precision medicine is facing a critical transition driven by the growing complexity of biological data and the insufficient ability of current models to translate such data into clinically meaningful information. Linear, single-gene approaches are no longer adequate to explain the multifactorial nature of most modern diseases, whose phenotypes emerge from combinations of genetic, molecular, and environmental factors. Network-based precision medicine addresses this by providing a systemic framework capable of integrating heterogeneous omics data, interactomes, and clinical information to identify disease modules and novel therapeutic opportunities. The distinct novelty of this review is its focus on the potential of \u201cnetwork language\u201d as the primary driver for realizing precision medicine through professional collaboration. We argue that networks are not merely tools that achieve precision \u201cper se\u201d; rather, their transformative power lies in their ability to serve as a shared and interpretable interface grounded in network theory. By offering this common conceptual ground, the paradigm bridges the deep cultural and methodological gaps between clinicians and data analysts, enabling effective cooperation between figures with fundamentally different, and often divergent, backgrounds. Practical tools\u2014such as biological network analysis and Molecular Tumor Boards\u2014demonstrate how computational modeling and clinical expertise can be successfully combined to generate actionable insights. Ultimately, network-based precision medicine represents a decisive step toward reconstructing the patient\u2019s complexity and promoting a genuinely personalized clinical approach in which quantitative analysis and medical reasoning act synergistically through multidisciplinary integration.<\/jats:p>","DOI":"10.3390\/genes17040467","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:14:46Z","timestamp":1776334486000},"page":"467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Precision Medicine Through Network Language: Integrating Clinical Insight and Data Expertise"],"prefix":"10.3390","volume":"17","author":[{"given":"Maria Concetta","family":"Palumbo","sequence":"first","affiliation":[{"name":"Institute for Applied Computing (IAC) \u201cMauro Picone\u201d, National Research Council of Italy, Via dei Taurini 19, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-6029","authenticated-orcid":false,"given":"Lorenzo","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Computer, Control and Information Engineering \u201cA. Ruberti\u201d, Sapienza University of Rome, Via Ariosto 25, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-161X","authenticated-orcid":false,"given":"Manuela","family":"Petti","sequence":"additional","affiliation":[{"name":"Department of Computer, Control and Information Engineering \u201cA. Ruberti\u201d, Sapienza University of Rome, Via Ariosto 25, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref_1","unstructured":"Obama, B. (2005). Remarks by the President in State of the Union Address, The White House."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMp1500523","article-title":"A new initiative on precision medicine","volume":"372","author":"Collins","year":"2015","journal-title":"N. Engl. J. 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