{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:34:13Z","timestamp":1785429253482,"version":"3.56.0"},"reference-count":73,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32371463"],"award-info":[{"award-number":["32371463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32371463"],"award-info":[{"award-number":["32371463"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Major Science and Technology Program of Yunnan","award":["202502AU100002"],"award-info":[{"award-number":["202502AU100002"]}]},{"name":"Team of Graduate Supervisors, and Cardiovascular Ultrasound Innovation Team of Yunnan Province","award":["202305AS350021"],"award-info":[{"award-number":["202305AS350021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: The androgen receptor (AR)-driven transcriptional program plays a pivotal role in the development and progression of prostate cancer. The binding of androgen dihydrotestosterone (DHT) to AR initiates transcriptional activation, thereby altering the transcriptional landscape. DHT-induced long non-coding RNAs (lncRNAs) have been recognized as crucial players in prostate cancer pathogenesis. This study aims to identify and explore the important role of such lncRNAs in prostate cancer. Methods: This study first analyzed transcriptome data from an androgen-dependent cell line, LNCaP, treated with different DHT concentrations and found a batch of lncRNAs exhibiting DHT concentration dependence. TCGA data suggested a correlation between the DHT-induced lncRNA and prostate cancer. Finally, a series of in vivo and in vitro experiments confirmed the effect and mechanism of lncRNA in prostate cancer. Results: AC092718.4 was highly expressed in AR-positive prostate cancer cell lines and tissues, and its expression in patients with Gleason scores 6\u20139 was significantly higher than in a normal control group. Notably, the expression level of AC092718.4 was upregulated in a concentration-dependent manner with DHT. In vitro experiments revealed that overexpression of AC092718.4 promoted cell proliferation and inhibited cell apoptosis. Conversely, knockdown of AC092718.4 suppressed tumorigenesis in vivo. Furthermore, our investigation into the pathogenetic mechanism demonstrated that AC092718.4 could act as an miRNA sponge for miR-138-5p, attenuating its inhibitory effect on downstream oncogenes, such as FERMT2, RHOC, and HIF1A. These AC092718.4\/miR-138-5p\/mRNA axes, in turn, facilitated the progression of prostate cancer. Conclusions: For the first time, we demonstrate that AC092718.4 may function as an oncogenic factor in prostate cancer. The AC0927.8.4\/miR-138-5p\/mRNA axes potentially offer promising diagnostic and therapeutic targets for prostate cancer.<\/jats:p>","DOI":"10.3390\/genes17050538","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:15:27Z","timestamp":1777630527000},"page":"538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DHT-Induced lncRNA AC092718.4 Promotes Prostate Cancer Cell Proliferation via ceRNA Mechanism"],"prefix":"10.3390","volume":"17","author":[{"given":"Lian","family":"Jin","sequence":"first","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-1114","authenticated-orcid":false,"given":"Ya-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"},{"name":"State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"},{"name":"Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"},{"name":"Bio-X Center for Interdisciplinary Innovation, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/iju.12146","article-title":"Transcriptional network of androgen receptor in prostate cancer progression","volume":"20","author":"Takayama","year":"2013","journal-title":"Int. J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/er.2002-0032","article-title":"Androgen receptor in prostate cancer","volume":"25","author":"Heinlein","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1200\/JCO.23.00433","article-title":"Targeting the androgen signaling axis in prostate cancer","volume":"41","author":"Dai","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.5534\/wjmh.180040","article-title":"Role of androgen receptor in prostate cancer: A review","volume":"37","author":"Fujita","year":"2019","journal-title":"World J. Men\u2019s Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-020-00243-0","article-title":"Prostate cancer","volume":"7","author":"Rebello","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jcb.20794","article-title":"Molecular regulation of androgen action in prostate cancer","volume":"99","author":"Dehm","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1007\/s11427-024-2740-7","article-title":"Androgen induces 3\u2032 UTR shortening of de novo lipogenesis genes by alternative polyadenylation in prostate cancer cells","volume":"68","author":"Sun","year":"2025","journal-title":"Sci. China Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13046-022-02406-1","article-title":"Molecular landscape of lncRNAs in prostate cancer: A focus on pathways and therapeutic targets for intervention","volume":"41","author":"Mirzaei","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41420-021-00407-1","article-title":"Progress in understanding the role of lncRNA in programmed cell death","volume":"7","author":"Jiang","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/ijc.30546","article-title":"Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets","volume":"140","author":"Gupta","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/pros.24494","article-title":"Identification of androgen response-related lncRNAs in prostate cancer","volume":"83","author":"Karthikeyan","year":"2023","journal-title":"Prostate"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/cas.13151","article-title":"Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells","volume":"108","author":"Misawa","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liu, B., Qian, D.C., Zhou, W.D., Jiang, H.Y., Xiang, Z.D., and Wu, D.L. (2021). A novel androgen-induced lncRNA FAM83H-AS1 promotes prostate cancer progression via the miR-15a\/CCNE2 axis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.620306"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/emboj.2013.99","article-title":"Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer","volume":"32","author":"Takayama","year":"2013","journal-title":"EMBO J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, L.Y., Cho, K.B., Li, Y., Tao, G., Xie, Z.X., and Guo, B. (2019). Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225758"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.canlet.2021.04.002","article-title":"LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack","volume":"509","author":"Venkatesh","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2018.02.036","article-title":"Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer","volume":"654","author":"Chang","year":"2018","journal-title":"Gene"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Taheri, M., Safarzadeh, A., Hussen, B.M., Ghafouri-Fard, S., and Baniahmad, A. (2022). LncRNA\/miRNA\/mRNA network introduces novel biomarkers in prostate cancer. Cells, 11.","DOI":"10.3390\/cells11233776"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"19809","DOI":"10.1038\/s41598-024-70202-2","article-title":"Role of Kindlin 2 in prostate cancer","volume":"14","author":"Bialkowska","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/s41598-018-19458-z","article-title":"Identification of valid reference genes for mRNA and microRNA normalisation in prostate cancer cell lines","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"FeatureCounts: An efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13059-016-0873-8","article-title":"Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans","volume":"17","author":"Kornienko","year":"2016","journal-title":"Genome Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"D1184","DOI":"10.1093\/nar\/gkaf1192","article-title":"Charting the expression landscape of human long non-coding RNAs across diverse biological contexts with LncExpDB 2.0","volume":"54","author":"Qi","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/s41380-024-02736-w","article-title":"Transcriptomic profiles in major depressive disorder: The role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation","volume":"30","author":"Sforzini","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: An update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1080\/15476286.2020.1833529","article-title":"LncRBase V.2: An updated resource for multispecies lncRNAs and ClinicLSNP hosting genetic variants in lncRNAs for cancer patients","volume":"18","author":"Das","year":"2021","journal-title":"RNA Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"D183","DOI":"10.1093\/nar\/gkab1092","article-title":"LncACTdb 3.0: An updated database of experimentally supported ceRNA interactions and personalized networks contributing to precision medicine","volume":"50","author":"Wang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"MiRDB: An online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13059-019-1629-z","article-title":"Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data","volume":"20","author":"Liu","year":"2019","journal-title":"Genome Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"D276","DOI":"10.1093\/nar\/gkx1004","article-title":"LncRNASNP2: An updated database of functional SNPs and mutations in human and mouse lncRNAs","volume":"46","author":"Miao","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"D186","DOI":"10.1093\/nar\/gkac999","article-title":"LncBook 2.0: Integrating human long non-coding RNAs with multi-omics annotations","volume":"51","author":"Li","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"D232","DOI":"10.1093\/nar\/gkac1002","article-title":"NPInter v5.0: ncRNA interaction database in a new era","volume":"51","author":"Zheng","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"StarBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"MiRTarBase 2025: Updates to the collection of experimentally validated microRNA-target interactions","volume":"53","author":"Cui","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neo.2016.07.001","article-title":"Identification and validation of PCAT14 as prognostic biomarker in prostate cancer","volume":"18","author":"Shukla","year":"2016","journal-title":"Neoplasia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1515\/hsz-2017-0255","article-title":"LncRNA PART1 modulates toll-like receptor pathways to influence cell proliferation and apoptosis in prostate cancer cells","volume":"399","author":"Sun","year":"2018","journal-title":"Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17861","DOI":"10.1074\/jbc.M116.718536","article-title":"Androgen-induced long noncoding RNA (lncRNA) SOCS2-AS1 promotes cell growth and inhibits apoptosis in prostate cancer cells","volume":"291","author":"Misawa","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41588-018-0120-1","article-title":"Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.18632\/aging.204426","article-title":"A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression","volume":"14","author":"Chen","year":"2022","journal-title":"Aging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1168175","article-title":"Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer","volume":"324","author":"Tran","year":"2009","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.14440\/jbm.2015.63","article-title":"In vitro and in vivo model systems used in prostate cancer research","volume":"2","author":"Cunningham","year":"2015","journal-title":"J. Biol. Methods"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/01.ju.0000141580.30910.57","article-title":"Cell lines used in prostate cancer research: A compendium of old and new lines\u2014Part 1","volume":"173","author":"Sobel","year":"2005","journal-title":"J. Urol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"114672","DOI":"10.1016\/j.biopha.2023.114672","article-title":"Mechanisms of circRNA\/lncRNA-miRNA interactions and applications in disease and drug research","volume":"162","author":"Ma","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_52","first-page":"96","article-title":"Effect of lncRNA AC092718.4 on drug resistance of breast cancer in HER2 positive and its possible mechanism","volume":"46","author":"Shi","year":"2024","journal-title":"Guangxi Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"114113","DOI":"10.1016\/j.addr.2022.114113","article-title":"RNAi-based therapeutics and tumor targeted delivery in cancer","volume":"182","author":"Kara","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12935-021-02234-x","article-title":"Role of RhoC in cancer cell migration","volume":"21","author":"Lou","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e001157","DOI":"10.1136\/jitc-2020-001157","article-title":"Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: Results from a phase I\/II clinical trial","volume":"8","author":"Schuhmacher","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tran, M.G.B., Bibby, B.A.S., Yang, L.J., Lo, F., Warren, A.Y., Shukla, D., Osborne, M., Hadfield, J., Carroll, T., and Stark, R. (2020). Independence of HIF1a and androgen signaling pathways in prostate cancer. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-06890-6"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1158\/1541-7786.MCR-15-0299","article-title":"MiR-138-mediated regulation of KINDLIN-2 expression modulates sensitivity to chemotherapeutics","volume":"14","author":"Plow","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e70337","DOI":"10.1002\/cam4.70337","article-title":"Unlocking the potential of disulfidptosis-related lncRNAs in lung adenocarcinoma: A promising prognostic lncRNA model for survival and immunotherapy prediction","volume":"13","author":"Nie","year":"2024","journal-title":"Cancer Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Chen, Z.L., Feng, R.F., Kahlert, U.D., Chen, Z.T., Roche, L., Soliman, A., Miao, C., De Wilde, R.L., and Shi, W.J. (2022). Construction of ceRNA networks associated with CD8 T cells in breast cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.883197"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Grandt, C.L., Brackmann, L.K., Poplawski, A., Schwarz, H., Marini, F., Hankeln, T., Galetzka, D., Zahnreich, S., Mirsch, J., and Spix, C. (2023). Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1158176"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/nar\/gkt839","article-title":"MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12935-020-01386-6","article-title":"MiR-138-5p inhibits the malignant progression of prostate cancer by targeting FOXC1","volume":"20","author":"Zhang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45370","DOI":"10.18632\/oncotarget.9659","article-title":"The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1010428317697575","DOI":"10.1177\/1010428317697575","article-title":"MiR-138: A promising therapeutic target for cancer","volume":"39","author":"Sha","year":"2017","journal-title":"Tumor Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e1193","DOI":"10.1002\/mgg3.1193","article-title":"MiR-138-5p inhibits the progression of prostate cancer by targeting FOXC1","volume":"8","author":"Huang","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Guo, S.Q., Ma, B.J., Jiang, X.K., Li, X.J., and Jia, Y.J. (2020). Astragalus Polysaccharides inhibits tumorigenesis and lipid metabolism through miR-138-5p\/SIRT1\/SREBP1 pathway in prostate cancer. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00598"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101723","DOI":"10.1016\/j.tranon.2023.101723","article-title":"MiR-138-5p inhibits prostate cancer cell proliferation and chemoresistance by targeting APOBEC3B","volume":"35","author":"Liu","year":"2023","journal-title":"Transl. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/ijc.28086","article-title":"MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1\u03b1","volume":"133","author":"Yeh","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1073\/pnas.1703064114","article-title":"Structural basis of kindlin-mediated integrin recognition and activation","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/35020106","article-title":"Genomic analysis of metastasis reveals an essential role for RhoC","volume":"406","author":"Clark","year":"2000","journal-title":"Nature"},{"key":"ref_71","first-page":"5832","article-title":"RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype","volume":"60","author":"Wu","year":"2000","journal-title":"Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13046-019-1327-4","article-title":"RhoC: A fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target","volume":"38","author":"Thomas","year":"2019","journal-title":"J. Exp. Clin. 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