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Unlike previous reviews that focus primarily on individual IncRNA catalogues, this review systematically integrates recent advances across five dimensions: (1) molecular characteristics and multidimensional classification of muscle related lncRNAs; (2) stage-specific expression patterns spanning embryonic myogenesis, postnatal growth, adult maintenance, and regeneration; (3) underlying molecular mechanisms including chromatin remodeling, ceRNA networks, IncRNA protein interactions, and nucleocytoplasmic trafficking; (4) pathological implications in muscular dystrophy, atrophy, and neuromuscular diseases; (5) translational applications in precision animal breeding. We critically evaluate the controversial ceRNA hypothesis and highlight quantitative limitations in current evidence. By integrating existing knowledge into a multi-layer regulatory network model and addressing current technical challenges and controversies (e.g., the ceRNA stoichiometry debate), this review provides a comprehensive roadmap for future basic research and translational applications in muscle biology.<\/jats:p>","DOI":"10.3390\/genes17050592","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:02:27Z","timestamp":1779375747000},"page":"592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Mechanisms and Research Progress of Long Non-Coding RNAs in Regulating Mammalian Skeletal Muscle Development"],"prefix":"10.3390","volume":"17","author":[{"given":"Xiaojiao","family":"Cui","sequence":"first","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Mu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-4731","authenticated-orcid":false,"given":"Xingdong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China"},{"name":"Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot 010022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116563","DOI":"10.1016\/j.biopha.2024.116563","article-title":"Regulation of Myogenic Cell Proliferation and Differentiation during Mammalian Skeletal Myogenesis","volume":"174","author":"Wu","year":"2024","journal-title":"Biomed. 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