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In response to the limitations of traditional, one-size-fits-all dietary recommendations, the concept of precision nutrition is emerging, which involves tailoring nutrition to a patient\u2019s clinical, biological, and genetic characteristics. Of particular importance in this context is nutrigenomics, the science that studies the impact of dietary components on gene expression and the modulation of immune processes. Dietary components, such as polyphenols and certain vitamins, may influence gene expression and immune pathways. However, direct evidence that specific nutrients directly regulate genes associated with inflammatory bowel disease in humans remains limited. Nutrigenomic mechanisms reveal complex relationships between diet, gut microbiota, and genetic predispositions in IBD, encompassing transcriptome regulation, metabolomic changes, and epigenetic processes. A personalized nutritional approach, based on regular assessment of clinical and biological parameters and the close integration of dietary therapy with comprehensive treatment, appears to be a promising direction for the further development of IBD therapy.<\/jats:p>","DOI":"10.3390\/genes17070806","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:08:34Z","timestamp":1784189314000},"page":"806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutrigenomics and Precision Nutrition in Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-4744","authenticated-orcid":false,"given":"Sara","family":"Jarmakiewicz-Czaja","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-8766","authenticated-orcid":false,"given":"Aneta","family":"Sokal-Dembowska","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-9621","authenticated-orcid":false,"given":"Kacper","family":"Helma","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6399-6719","authenticated-orcid":false,"given":"Krystian","family":"Krysa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-151X","authenticated-orcid":false,"given":"Rafa\u0142","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology with IBD Unit, Clinical Hospital, 35-301 Rzeszow, Poland"},{"name":"Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s Disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative Colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. 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