{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:05:18Z","timestamp":1784264718307,"version":"3.55.0"},"reference-count":121,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) constitute an important group of regulatory RNA molecules involved in the control of gene expression at the epigenetic, transcriptional, and post-transcriptional levels. In recent years, their crucial role in the pathophysiology of cardiovascular diseases, particularly coronary heart disease, has become increasingly evident. The aim of this review is to present current knowledge regarding the mechanisms of lncRNA action in the cardiovascular system, their involvement in the molecular processes associated with myocardial ischaemia, and their potential diagnostic and therapeutic applications. We discuss the molecular mechanisms responsible for the regulation of cardiomyocyte apoptosis, oxidative stress, mitochondrial dysfunction, angiogenesis, coronary vessel remodelling, and cardiac fibrosis. Particular attention is paid to selected lncRNAs involved in coronary heart disease, including MIAT, MALAT1, ANRIL, and H19, which influence inflammatory processes, vascular smooth muscle cell proliferation, responses to hypoxia, and cardiac fibrosis. The potential of lncRNAs as diagnostic and prognostic biomarkers in coronary artery disease is also discussed. Current evidence suggests that molecules such as MALAT1, MIAT, LIPCAR, and HCG11 may have considerable diagnostic and prognostic value, including for predicting major adverse cardiovascular events and the no-reflow phenomenon following percutaneous coronary intervention. Furthermore, contemporary therapeutic strategies targeting lncRNAs are presented, including antisense oligonucleotides, siRNAs, and CRISPR\/Cas9 genome-editing technologies. Despite promising preclinical findings, the clinical application of lncRNA-based therapies remains limited by challenges related to safety, delivery of therapeutic molecules, and translation of experimental findings into clinical practice. Nevertheless, lncRNAs represent a promising avenue for the development of precision medicine and may play an important role in the future diagnosis and treatment of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/genes17070807","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:08:34Z","timestamp":1784189314000},"page":"807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Long Non-Coding RNAs in the Pathogenesis of Coronary Heart Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6821-0086","authenticated-orcid":false,"given":"Paulina","family":"Plewa","sequence":"first","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7057-6282","authenticated-orcid":false,"given":"Joanna","family":"Kulpa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9694-1944","authenticated-orcid":false,"given":"Jacek","family":"Szulc","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0475-6187","authenticated-orcid":false,"given":"Marcin","family":"Szczepanik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Doma\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-1208","authenticated-orcid":false,"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","unstructured":"(2025). Global Burden of Cardiovascular Diseases and Risks. Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990\u20132023. J. Am. Coll. Cardiol., 86, 2167\u20132243."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yang, L., Zheng, B., and Gong, Y. (2025). Global, regional and national burden of ischemic heart disease and its attributable risk factors from 1990 to 2021: A systematic analysis of the Global Burden of Disease study 2021. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-05022-x"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/CM9.0000000000004006","article-title":"Global burden of ischemic heart disease from 1990 to 2021: Findings from the Global Burden of Disease Study 2021 and predictions to 2030","volume":"139","author":"Jing","year":"2026","journal-title":"Chin. Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-1924-7_1","article-title":"Atherosclerosis: Pathogenesis and Key Cellular Processes, Current and Emerging Therapies, Key Challenges, and Future Research Directions","volume":"2419","author":"Chan","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jacc.2021.10.035","article-title":"Coronary Atherosclerotic Plaque Regression: JACC State-of-the-Art Review","volume":"79","author":"Dawson","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41569-021-00542-3","article-title":"Plaque erosion and acute coronary syndromes: Phenotype, molecular characteristics and future directions","volume":"18","author":"Fahed","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"H603","DOI":"10.1152\/ajpheart.00681.2024","article-title":"Emerging roles of noncoding RNAs in cardiovascular pathophysiology","volume":"328","author":"Abbas","year":"2025","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jacc.2017.05.067","article-title":"Translational Perspective on Epigenetics in Cardiovascular Disease","volume":"70","author":"Chambers","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.ygeno.2020.10.024","article-title":"Non-coding RNAs: The key detectors and regulators in cardiovascular disease","volume":"113","author":"Zhu","year":"2021","journal-title":"Genomics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2024.10.046","article-title":"snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.120.16752","article-title":"Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases","volume":"78","author":"Zhang","year":"2021","journal-title":"Hypertension"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/cvr\/cvaa195","article-title":"Non-coding RNAs: Update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart","volume":"116","author":"Chatterjee","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fumarulo, I., De Prisco, A., Salerno, E.N.M., Ravenna, S.E., Vaccarella, M., Garramone, B., Burzotta, F., and Aspromonte, N. (2025). New Frontiers of microRNA in Heart Failure: From Clinical Risk to Therapeutic Applications. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186361"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00018-025-05915-2","article-title":"A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling","volume":"82","author":"Pan","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11033-026-11443-4","article-title":"Circular RNAs in human biology: From splicing noise to master regulators","volume":"53","author":"Kargar","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.semcdb.2021.07.007","article-title":"Non-coding RNAs in cardiac regeneration: Mechanism of action and therapeutic potential","volume":"118","author":"Wang","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12900","DOI":"10.1111\/jcmm.15968","article-title":"The biological function and potential mechanism of long non-coding RNAs in cardiovascular disease","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Klapproth, C., Sen, R., Stadler, P.F., Findei\u00df, S., and Fallmann, J. (2021). Common Features in lncRNA Annotation and Classification: A Survey. Noncoding RNA, 7.","DOI":"10.3390\/ncrna7040077"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1016\/j.cell.2024.10.024","article-title":"Small and long non-coding RNAs: Past, present, and future","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000062","DOI":"10.1161\/HCG.0000000000000062","article-title":"Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association","volume":"13","author":"Das","year":"2020","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.tibs.2020.07.001","article-title":"Mechanisms of Long Noncoding RNA Nuclear Retention","volume":"45","author":"Guo","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1657","DOI":"10.1002\/wrna.1657","article-title":"The control of polycomb repressive complexes by long noncoding RNAs","volume":"12","author":"Trotman","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00439-017-1807-6","article-title":"Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions","volume":"136","author":"Morriss","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-0716-1503-4_10","article-title":"An Overview of the Computational Models Dealing with the Regulatory ceRNA Mechanism and ceRNA Deregulation in Cancer","volume":"2324","author":"Conte","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12943-025-02415-6","article-title":"MALAT1 as a molecular driver of tumor progression, immune evasion, and resistance to therapy","volume":"24","author":"Bitaraf","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107281","DOI":"10.1016\/j.phrs.2024.107281","article-title":"Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches","volume":"206","author":"Cai","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Marinescu, M.-C., Lazar, A.-L., Marta, M.M., Cozma, A., and Catana, C.-S. (2022). Non-Coding RNAs: Prevention, Diagnosis, and Treatment in Myocardial Ischemia\u2013Reperfusion Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052728"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sun, Y., Su, Q., Li, L., Wang, X., Lu, Y., and Liang, J. (2017). MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathway. BMC Cardiovasc. Disord., 17.","DOI":"10.1186\/s12872-017-0549-7"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Leivaditis, V., Dahm, M., Baikoussis, N.G., Papatriantafyllou, A., Grapatsas, K., Mulita, F., Charokopos, N., and Koletsis, E. (2025). From Injury to Heart Failure: Molecular and Cellular Mechanisms of Ischemia-Reperfusion Injury. Med. Res. Arch., 13.","DOI":"10.18103\/mra.v13i1.6143"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s00018-020-03694-6","article-title":"The regulatory roles of p53 in cardiovascular health and disease","volume":"78","author":"Men","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e40812","DOI":"10.1016\/j.heliyon.2024.e40812","article-title":"Investigating the NF-\u03baB signaling pathway in heart failure: Exploring potential therapeutic approaches","volume":"10","author":"Ghiasi","year":"2024","journal-title":"Heliyon"},{"key":"ref_36","first-page":"6955","article-title":"MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-\u03b21 signaling pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xie, L., Zhang, Q., Mao, J., Zhang, J., and Li, L. (2021). The Roles of lncRNA in Myocardial Infarction: Molecular Mechanisms, Diagnosis Biomarkers, and Therapeutic Perspectives. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.680713"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101529","DOI":"10.1016\/j.ijcha.2024.101529","article-title":"Importance of long non-coding RNAs in the pathogenesis, diagnosis, and treatment of myocardial infarction","volume":"55","author":"Dehkharghani","year":"2024","journal-title":"IJC Heart Vasc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"816","DOI":"10.5603\/fm.105003","article-title":"Inflammatory signalling pathways and non-coding RNAs in myocardial infarction: Insights into pathogenesis and therapeutic opportunities","volume":"84","author":"Bi","year":"2025","journal-title":"Folia Morphol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.15420\/ecr.2023.10","article-title":"Nuclear Factor-\u03baB is a Prime Candidate for the Diagnosis and Control of Inflammatory Cardiovascular Disease","volume":"18","author":"Matsumori","year":"2023","journal-title":"Eur. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.37871\/jbres2120","article-title":"Modulation of Inflammation in Cardiac Function after Myocardial Infarction","volume":"6","author":"Sharifi","year":"2025","journal-title":"J. Biomed. Res. Environ. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fonseca, F.A.H., Fran\u00e7a, C.N., Fonseca, H.A.R., Serra, A.J., and Izar, M.C. (2025). Key inflammatory players for infarcted mass and cardiac remodeling after acute myocardial infarction. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1609705"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.37349\/edd.2024.00062","article-title":"Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseases","volume":"3","author":"Jaara","year":"2024","journal-title":"Explor. Dig. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117084","DOI":"10.1016\/j.biopha.2024.117084","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5603\/mrj.101643","article-title":"Impact of angiogenesis inhibitors on inflammatory activation in human vascular endothelial cells","volume":"9","author":"Piekarska","year":"2024","journal-title":"Med. Res. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Florek, K., Mendyka, D., and Gomu\u0142ka, K. (2024). Vascular Endothelial Growth Factor (VEGF) and Its Role in the Cardiovascular System. Biomedicines, 12.","DOI":"10.3390\/biomedicines12051055"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e0059420","DOI":"10.1128\/MCB.00594-20","article-title":"Genomic Landscapes of Noncoding RNAs Regulating","volume":"41","author":"Mushimiyimana","year":"2021","journal-title":"Mol. Cell. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zhu, X., Cui, H., Shi, J., Yuan, G., Shi, S., and Hu, Y. (2021). The Role of the VEGF Family in Coronary Heart Disease. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.738325"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Carmichael, E., Reme, A.S., Bosco, P.J., Ortiz, Y.Y., Ramos, D.A., Gomez, K., Nguyen, B.N., Bornak, A., Liu, Z.J., and Velazquez, O.C. (2025). Biological Regulation of HIF-1\u03b1 and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202510.0665.v1"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"117753","DOI":"10.1016\/j.bcp.2026.117753","article-title":"Hypoxia-inducible factor-1\u03b1 in cardiovascular disease, mechanistic insights, pathophysiological roles, and therapeutic targeting strategies","volume":"246","author":"Rahman","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"103029","DOI":"10.1016\/j.jbc.2023.103029","article-title":"Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-\u03b1 induction and regulates hypoxic signaling","volume":"299","author":"Man","year":"2023","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"110919","DOI":"10.1016\/j.cellsig.2023.110919","article-title":"The interplay between H19 and HIF-1\u03b1 in mitochondrial dysfunction in myocardial infarction","volume":"112","author":"Xie","year":"2023","journal-title":"Cell Signal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105291","DOI":"10.1016\/j.jbc.2023.105291","article-title":"Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription","volume":"299","author":"Downes","year":"2023","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bertaud, A., Joshkon, A., Heim, X., Bachelier, R., Bardin, N., Leroyer, A.S., and Blot-Chabaud, M. (2023). Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021756"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"C1893","DOI":"10.1152\/ajpcell.01043.2024","article-title":"The theatrics of collagens in the myocardium: The supreme architect of the fibrotic heart","volume":"328","author":"Chakraborty","year":"2025","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109824","DOI":"10.1016\/j.cellsig.2020.109824","article-title":"Fibroblast contributions to ischemic cardiac remodeling","volume":"77","author":"Burke","year":"2021","journal-title":"Cell Signal."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"H563","DOI":"10.1152\/ajpheart.00603.2017","article-title":"A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure","volume":"315","author":"Bradley","year":"2018","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10038-006-0070-9","article-title":"Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction","volume":"51","author":"Ishii","year":"2006","journal-title":"J. Hum. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/kjm2.12444","article-title":"Upregulation of long non-coding RNA myocardial infarction-associated transcription is correlated with coronary artery stenosis and elevated inflammation in patients with coronary atherosclerotic heart disease","volume":"37","author":"Yan","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","article-title":"Apoptosis in ischemic heart disease","volume":"15","author":"Teringova","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41420-025-02352-9","article-title":"Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction","volume":"11","author":"Hayasaka","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cbin.11945","article-title":"Knockdown of long noncoding RNA MIAT attenuates hypoxia-induced cardiomyocyte injury by regulating the miR-488-3p\/Wnt\/\u03b2-catenin pathway","volume":"47","author":"Zhang","year":"2023","journal-title":"Cell Biol. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1124\/pr.117.013896","article-title":"WNT Signaling in Cardiac and Vascular Disease","volume":"70","author":"Foulquier","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e32455","DOI":"10.1016\/j.heliyon.2024.e32455","article-title":"Hypoxia triggers cardiomyocyte apoptosis via regulating the m 6A methylation-mediated LncMIAT\/miR-708-5p\/p53 axis","volume":"10","author":"Shen","year":"2024","journal-title":"Heliyon"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jjcc.2021.08.018","article-title":"LncRNA MIAT knockdown alleviates oxygen-glucose deprivation-induced cardiomyocyte injury by regulating JAK2\/STAT3 pathway via miR-181a-5p","volume":"78","author":"Tan","year":"2021","journal-title":"J. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"116313","DOI":"10.1016\/j.biopha.2024.116313","article-title":"Targeting the JAK2\/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases","volume":"172","author":"Guo","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/1440-1681.13538","article-title":"LncRNA Miat knockdown alleviates endothelial cell injury through regulation of miR-214-3p\/Caspase-1 signalling during atherogenesis","volume":"48","author":"Li","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1161\/CIRCRESAHA.116.308501","article-title":"Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells","volume":"118","author":"Xi","year":"2016","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11010-020-03684-z","article-title":"MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p\/HIF-1\u03b1 axis","volume":"466","author":"Liu","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000327951","article-title":"Involvement of HIF-1\u03b1 in MLCK-dependent endothelial barrier dysfunction in hypoxia","volume":"27","author":"Qi","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1002\/jcp.27117","article-title":"Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110695","DOI":"10.1016\/j.intimp.2023.110695","article-title":"Malat1 promotes macrophage-associated inflammation by increasing PPAR-\u03b3 methylation through binding to EZH2 in acute myocardial infarction","volume":"123","author":"Chang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9959746","DOI":"10.1155\/2021\/9959746","article-title":"M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1\/MicroRNA-25-3p\/CDC42 Axis","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101910","DOI":"10.1016\/j.redox.2021.101910","article-title":"The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p\/Mfn1 axis-mediated mitochondrial dynamics","volume":"41","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.yjmcc.2011.07.023","article-title":"Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells","volume":"51","author":"Lugus","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.cell.2018.11.014","article-title":"Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing","volume":"175","author":"Chubukov","year":"2018","journal-title":"Cell"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e031121","DOI":"10.1161\/JAHA.123.031121","article-title":"Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis","volume":"12","author":"Chen","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/ATVBAHA.114.304936","article-title":"MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells","volume":"35","author":"Ranayhossaini","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41419-020-2645-3","article-title":"LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lu, K., Tao, H., Si, X., and Chen, Q. (2018). The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00502"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/j.1349-7006.2008.00840.x","article-title":"Regulation of growth factor signaling by FRS2 family docking\/scaffold adaptor proteins","volume":"99","author":"Gotoh","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_87","first-page":"1956","article-title":"LncRNA ANRIL regulates cell proliferation and migration via sponging miR-339-5p and regulating FRS2 expression in atherosclerosis","volume":"24","author":"Huang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1093\/eurheartj\/ehaa519","article-title":"Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy","volume":"41","author":"Viereck","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/jcmm.14846","article-title":"LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","article-title":"Mechanisms of hypoxia signalling: New implications for nephrology","volume":"15","author":"Ratcliffe","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41569-022-00806-6","article-title":"Regression of cardiac hypertrophy in health and disease: Mechanisms and therapeutic potential","volume":"20","author":"Martin","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s11886-022-01766-6","article-title":"Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction","volume":"24","author":"Moroni","year":"2022","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.canlet.2013.01.033","article-title":"Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression","volume":"333","author":"Luo","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.atherosclerosis.2016.12.007","article-title":"Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats","volume":"257","author":"Chen","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCULATIONAHA.120.049715","article-title":"Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation","volume":"143","author":"Zeng","year":"2021","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","article-title":"Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4070\/kcj.2021.0252","article-title":"CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p\/PTGS2 Axis","volume":"52","author":"Tang","year":"2022","journal-title":"Korean Circ. J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"118251","DOI":"10.1016\/j.lfs.2020.118251","article-title":"Hsa_circ_0029589 knockdown inhibits the proliferation, migration and invasion of vascular smooth muscle cells via regulating miR-214-3p and STIM1","volume":"259","author":"Huang","year":"2020","journal-title":"Life Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.24976\/Discov.Med.202436187.154","article-title":"Targeting STIM1 Contributes to Alleviating Remodeling of Vascular Smooth Muscle Cells in Atherosclerosis","volume":"36","author":"Cui","year":"2024","journal-title":"Discov. Med."},{"key":"ref_100","first-page":"3282","article-title":"Circ_CHFR expedites cell growth, migration and inflammation in ox-LDL-treated human vascular smooth muscle cells via the miR-214-3p\/Wnt3\/\u03b2-catenin pathway","volume":"24","author":"Zhuang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Roozbehi, K., Semirani-Nezhad, D., Alipour, B., Javadian, P., Sadeghi, M., Mashayekh, M., Javdani, F., Attar, A., Hosseinpour, A., and Askari, M.K. (2025). Diagnostic value of long noncoding RNAs MIAT and MALAT1 in coronary artery disease: A systematic review and diagnostic accuracy test meta-analysis. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-05285-4"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21501","DOI":"10.1038\/s41598-025-08777-7","article-title":"Integrative in Silico and in vitro validation suggest LINC00963 and SNHG15 as candidate biomarkers for coronary artery disease","volume":"15","author":"Saberiyan","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"118042","DOI":"10.1016\/j.atherosclerosis.2024.118042","article-title":"Circulating circular and linear long noncoding RNA ANRIL in patients with coronary artery disease with and without type 2 diabetes mellitus","volume":"395","author":"Serik","year":"2024","journal-title":"Atherosclerosis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1007\/s10528-025-11091-6","article-title":"The Mechanism and Diagnostic Value of the LINC01220\/hsa-miR- 6727 -\u20095p\/FBLN5 Axis in Coronary Atherosclerosis","volume":"64","author":"Li","year":"2026","journal-title":"Biochem. Genet."},{"key":"ref_105","first-page":"46","article-title":"Circulating exosomal lncRNAs in patients with chronic coronary syndromes","volume":"19","author":"Zheng","year":"2023","journal-title":"Arch. Med. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Barbalata, T., Niculescu, L.S., Stancu, C.S., Pinet, F., and Sima, A.V. (2023). Elevated Levels of Circulating lncRNAs LIPCAR and MALAT1 Predict an Unfavorable Outcome in Acute Coronary Syndrome Patients. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512076"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41598-022-06923-z","article-title":"LncRNA MALAT1 functions as a biomarker of no-reflow phenomenon in ST-segment elevation myocardial infarction patients receiving primary percutaneous coronary intervention","volume":"12","author":"Yang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1186\/s13019-024-03110-1","article-title":"The clinical value of serum long non-coding RNA human leukocyte antigen complex group 11\/microRNA-532-3p in the diagnosis and prognosis of patients with acute myocardial infarction undergoing percutaneous coronary intervention","volume":"19","author":"Cao","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/s41598-022-05731-9","article-title":"Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease","volume":"12","author":"Zibaeenezhad","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12265-020-10053-0","article-title":"Multiple Non-coding ANRIL Transcripts Are Associated with Risk of Coronary Artery Disease: A Promising Circulating Biomarker","volume":"14","author":"Fang","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41573-020-0075-7","article-title":"Advances in oligonucleotide drug delivery","volume":"19","author":"Roberts","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"eaai9118","DOI":"10.1126\/scitranslmed.aai9118","article-title":"The long noncoding RNA","volume":"9","author":"Micheletti","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e008686","DOI":"10.1161\/CIRCHEARTFAILURE.121.008686","article-title":"MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic","volume":"15","author":"Aonuma","year":"2022","journal-title":"Circ. Heart Fail."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1111\/bph.15972","article-title":"Small interfering RNA: Discovery, pharmacology and clinical development-An introductory review","volume":"180","author":"Ranasinghe","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCRESAHA.114.302476","article-title":"The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"18446","DOI":"10.1002\/jcb.29162","article-title":"Interfering with long chain noncoding RNA ANRIL expression reduces heart failure in rats with diabetes by inhibiting myocardial oxidative stress","volume":"120","author":"Dai","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e148555","DOI":"10.1172\/JCI148555","article-title":"Moving toward genome-editing therapies for cardiovascular diseases","volume":"132","author":"Musunuru","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.addr.2020.02.003","article-title":"Therapeutic genome editing in cardiovascular diseases","volume":"168","author":"Nishiga","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Ambardekar, A.V., Bhatt, A., Hoekstra, M., Kelly, M.A., Musunuru, K., and Natarajan, P. (2026). Gene Editing Therapy in Cardiovascular Disease: 2026 ACC Scientific Statement: A Report of the American College of Cardiology. JACC, Accepted.","DOI":"10.1016\/j.jacc.2026.02.5092"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nm.4179","article-title":"The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbrc.2020.01.062","article-title":"Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b\/SMAD3 axis","volume":"524","author":"Gong","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/7\/807\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:21:53Z","timestamp":1784262113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/7\/807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":121,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["genes17070807"],"URL":"https:\/\/doi.org\/10.3390\/genes17070807","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}