{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:57:36Z","timestamp":1785412656508,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["111-2314-B-002-195-MY2"],"award-info":[{"award-number":["111-2314-B-002-195-MY2"]}]},{"award":["111-2314-B-002-195-MY2"],"award-info":[{"award-number":["111-2314-B-002-195-MY2"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: Diabetes mellitus is associated with sensorineural hearing loss, but the cochlear molecular alterations related to this complication remain unclear. This pilot study aimed to characterize auditory function and region-specific transcriptomic changes in the diabetic cochlea. Methods: A streptozotocin-induced type 1 diabetic mouse model was established. Auditory function was assessed by auditory brainstem response (ABR) testing. Next-generation RNA sequencing was performed on micro-dissected cochlear regions, including the modiolus, lateral wall, and organ of Corti, followed by differential expression and gene ontology analyses. Results: STZ-induced diabetic mice showed elevated ABR thresholds compared with control mice. RNA sequencing revealed region-specific transcriptomic alterations across cochlear regions, with the lateral wall showing the greatest changes. Cross-region analysis identified a shared transcriptional signature consisting of 32 upregulated and 2 downregulated genes across the modiolus, lateral wall, and organ of Corti. Gene Ontology analysis showed enrichment of immune-related, inflammatory, metabolic stress-associated, and membrane-associated signaling. Conclusions: STZ-induced diabetes was associated with ABR threshold elevation and shared as well as region-specific cochlear transcriptomic alterations in this mouse model. These findings provide a region-specific cochlear transcriptomic resource for diabetes-associated auditory dysfunction and support future studies using larger cohorts, independent molecular validation, histological assessment, and cell-type-resolved approaches.<\/jats:p>","DOI":"10.3390\/genes17070836","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:16:39Z","timestamp":1784650599000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetic Hyperglycemia Induces Region-Specific Transcriptomic Remodeling in the Cochlea"],"prefix":"10.3390","volume":"17","author":[{"given":"Ting-Yu","family":"Chang","sequence":"first","affiliation":[{"name":"Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-8465","authenticated-orcid":false,"given":"Cheng-Tien","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 406040, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fong-Ling","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-1197","authenticated-orcid":false,"given":"Shing-Hwa","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-7065","authenticated-orcid":false,"given":"Ting-Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, June 11). 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