{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:04:47Z","timestamp":1784880287424,"version":"3.55.0"},"reference-count":170,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Cellular plasticity allows organisms to adapt dynamically to both physiological and pathological contexts. Epithelial\u2013mesenchymal transition (EMT) is a well-known example of this plasticity and is now widely recognized as a reversible and highly dynamic spectrum of cellular states rather than a simple binary switch. In this review, we summarize current knowledge on the Hippo pathway transcriptional co-activators YAP and TAZ, focusing on their role as a central hub that integrates mechanical, biochemical and metabolic signals from the microenvironment to control cell fate reprogramming. We discuss how YAP\/TAZ interact with EMT-related signaling pathways and transcriptional networks to regulate the acquisition, maintenance and dynamic remodeling of mesenchymal states, as well as hybrid epithelial\/mesenchymal (E\/M) phenotypes. We also highlight the presence of interconnected feed-forward and feedback regulatory loops within the YAP\/TAZ\u2013EMT axis, which contribute to the stabilization of cellular plasticity and support context-dependent transcriptional programs. These mechanisms are involved in key physiological processes, including embryonic development and tissue repair, and in pathological conditions such as organ fibrosis and cancer progression. Therefore, we propose a model where YAP\/TAZ act as the central molecular hub within the networks governing cellular plasticity and EMT dynamics. Finally, we discuss how a better understanding of the mechanistic basis of YAP\/TAZ-driven EMT may provide a useful framework for the development of therapeutic strategies aimed at modulating cellular plasticity in cancer, fibrotic diseases and regenerative medicine.<\/jats:p>","DOI":"10.3390\/genes17080851","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:36:13Z","timestamp":1784878573000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linking EMT Dynamics to Cellular Plasticity: YAP\/TAZ as Central Regulators Across Physiological and Pathological States"],"prefix":"10.3390","volume":"17","author":[{"given":"Laura","family":"Amicone","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-5674","authenticated-orcid":false,"given":"Carla","family":"Cicchini","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Petti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-848X","authenticated-orcid":false,"given":"Alessandra","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41556-018-0144-x","article-title":"Deconstructing and Reconstructing the Mouse and Human Early Embryo","volume":"20","author":"Shahbazi","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrm.2016.24","article-title":"Adult Cell Plasticity in Vivo: De-Differentiation and Transdifferentiation Are Back in Style","volume":"17","author":"Merrell","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: From Mechanisms to Medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10555-024-10172-z","article-title":"Cancer Cell Plasticity: From Cellular, Molecular, and Genetic Mechanisms to Tumor Heterogeneity and Drug Resistance","volume":"43","author":"Bhat","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo Signalling Pathway and Its Implications in Human Health and Diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.devcel.2019.06.003","article-title":"The Hippo Signaling Pathway in Development and Disease","volume":"50","author":"Zheng","year":"2019","journal-title":"Dev. Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The Biology of YAP\/TAZ: Hippo Signaling and Beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-Mesenchymal Transitions in Development and Disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"EMT: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10555-016-9648-7","article-title":"EMT, Cell Plasticity and Metastasis","volume":"35","author":"Chaffer","year":"2016","journal-title":"Cancer Metastasis Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","article-title":"Identification of the Tumour Transition States Occurring during EMT","volume":"556","author":"Pastushenko","year":"2018","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41576-023-00601-0","article-title":"The Epithelial\u2013Mesenchymal Plasticity Landscape: Principles of Design and Mechanisms of Regulation","volume":"24","author":"Haerinck","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11665","DOI":"10.1021\/acsomega.2c07989","article-title":"Dynamics of Epithelial\u2013Mesenchymal Plasticity: What Have Single-Cell Investigations Elucidated So Far?","volume":"8","author":"Subhadarshini","year":"2023","journal-title":"ACS Omega"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD Mediates YAP-Dependent Gene Induction and Growth Control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1242\/dev.010223","article-title":"Transcription Factor TEAD4 Specifies the Trophectoderm Lineage at the Beginning of Mammalian Development","volume":"134","author":"Yagi","year":"2007","journal-title":"Development"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature15382","article-title":"Yap-Dependent Reprogramming of Lgr5+ Stem Cells Drives Intestinal Regeneration and Cancer","volume":"526","author":"Gregorieff","year":"2015","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo Pathway Activity Influences Liver Cell Fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.stem.2016.08.009","article-title":"Induction of Expandable Tissue-Specific Stem\/Progenitor Cells through Transient Expression of YAP\/TAZ","volume":"19","author":"Panciera","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-018-0658-1","article-title":"The SWI\/SNF Complex Is a Mechanoregulated Inhibitor of YAP and TAZ","volume":"563","author":"Chang","year":"2018","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hillmer, R.E., and Link, B.A. (2019). The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. Cells, 8.","DOI":"10.3390\/cells8050502"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3892\/etm.2017.4512","article-title":"Induction of Reprogramming of Human Amniotic Epithelial Cells into iPS Cells by Overexpression of Yap, Oct4, and Sox2 through the Activation of the Hippo-Yap Pathway","volume":"14","author":"Zhao","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pharmthera.2018.09.007","article-title":"Hybrid Epithelial\/Mesenchymal Phenotypes Promote Metastasis and Therapy Resistance across Carcinomas","volume":"194","author":"Jolly","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.ccell.2021.05.005","article-title":"Single-Cell Lineage Tracing of Metastatic Cancer Reveals Selection of Hybrid EMT States","volume":"39","author":"Simeonov","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New Insights into the Mechanisms of Epithelial\u2013Mesenchymal Transition and Implications for Cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17379","DOI":"10.1038\/srep17379","article-title":"Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis","volume":"5","author":"Huang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41568-021-00332-6","article-title":"Linking EMT Programmes to Normal and Neoplastic Epithelial Stem Cells","volume":"21","author":"Lambert","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Canciello, A., Cerver\u00f3-Varona, A., Peserico, A., Mauro, A., Russo, V., Morrione, A., Giordano, A., and Barboni, B. (2022). \u201cIn Medio Stat Virtus\u201d: Insights into Hybrid E\/M Phenotype Attitudes. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1038841"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bastos, V.A.F., Souza, A.G.D., Guedes, V.C.S., and Cunha, T.M. (2025). Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199476"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.tig.2017.08.004","article-title":"Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity","volume":"33","author":"Skrypek","year":"2017","journal-title":"Trends Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41556-018-0196-y","article-title":"Non-Redundant Functions of EMT Transcription Factors","volume":"21","author":"Stemmler","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1158\/0008-5472.CAN-19-3147","article-title":"Hybrid Epithelial\u2013Mesenchymal Phenotypes Are Controlled by Microenvironmental Factors","volume":"80","author":"Selvaggio","year":"2020","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-016-0502-x","article-title":"Regulation of Epithelial-Mesenchymal Transition through Epigenetic and Post-Translational Modifications","volume":"15","author":"Maziveyi","year":"2016","journal-title":"Mol. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2210844119","DOI":"10.1073\/pnas.2210844119","article-title":"Epigenetic Factor Competition Reshapes the EMT Landscape","volume":"119","author":"Tripathi","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/cdd.2011.175","article-title":"An Epistatic Mini-Circuitry between the Transcription Factors Snail and HNF4\u03b1 Controls Liver Stem Cell and Hepatocyte Features Exhorting Opposite Regulation on Stemness-Inhibiting microRNAs","volume":"19","author":"Garibaldi","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"20200693","DOI":"10.1098\/rsif.2020.0693","article-title":"Systems Biology Approach Suggests New miRNAs as Phenotypic Stability Factors in the Epithelial\u2013Mesenchymal Transition","volume":"17","author":"Silveira","year":"2020","journal-title":"J. R. Soc. Interface"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/onc.2016.260","article-title":"The Snail Repressor Recruits EZH2 to Specific Genomic Sites through the Enrollment of the lncRNA HOTAIR in Epithelial-to-Mesenchymal Transition","volume":"36","author":"Battistelli","year":"2017","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41418-018-0170-z","article-title":"The lncRNA HOTAIR Transcription Is Controlled by HNF4\u03b1-Induced Chromatin Topology Modulation","volume":"26","author":"Battistelli","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/s41588-018-0252-3","article-title":"Long Noncoding RNA MALAT1 Suppresses Breast Cancer Metastasis","volume":"50","author":"Kim","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhuo, M., Yuan, C., Han, T., Cui, J., Jiao, F., and Wang, L. (2018). A Novel Feedback Loop between High MALAT-1 and Low miR-200c-3p Promotes Cell Migration and Invasion in Pancreatic Ductal Adenocarcinoma and Is Predictive of Poor Prognosis. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4954-9"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s43018-024-00839-5","article-title":"Two Distinct Epithelial-to-Mesenchymal Transition Programs Control Invasion and Inflammation in Segregated Tumor Cell Populations","volume":"5","author":"Youssef","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1038\/s41467-019-13091-8","article-title":"A Gene Regulatory Network to Control EMT Programs in Development and Disease","volume":"10","author":"Fazilaty","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2013.06.005","article-title":"Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity","volume":"154","author":"Chaffer","year":"2013","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"123586","DOI":"10.1016\/j.envpol.2024.123586","article-title":"A Dynamic Model of Inorganic Arsenic-Induced Carcinogenesis Reveals an Epigenetic Mechanism for Epithelial\u2013Mesenchymal Plasticity","volume":"347","author":"Rea","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41556-022-00877-0","article-title":"Genome-Wide CRISPR Screen Identifies PRC2 and KMT2D-COMPASS as Regulators of Distinct EMT Trajectories That Contribute Differentially to Metastasis","volume":"24","author":"Zhang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Bornes, L., Belthier, G., and Van Rheenen, J. (2021). Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E\/M States. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112403"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1158\/0008-5472.CAN-08-1942","article-title":"A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition","volume":"68","author":"Bracken","year":"2008","journal-title":"Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s42003-019-0506-3","article-title":"The Role of GRHL2 and Epigenetic Remodeling in Epithelial\u2013Mesenchymal Plasticity in Ovarian Cancer Cells","volume":"2","author":"Chung","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18144","DOI":"10.1073\/pnas.1318192110","article-title":"MicroRNA-Based Regulation of Epithelial\u2013Hybrid\u2013Mesenchymal Fate Determination","volume":"110","author":"Lu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27067","DOI":"10.18632\/oncotarget.8166","article-title":"Stability of the Hybrid Epithelial\/Mesenchymal Phenotype","volume":"7","author":"Jolly","year":"2016","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/intbio\/zyz021","article-title":"NRF2 Activates a Partial Epithelial-Mesenchymal Transition and Is Maximally Present in a Hybrid Epithelial\/Mesenchymal Phenotype","volume":"11","author":"Bocci","year":"2019","journal-title":"Integr. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular Mechanisms of Epithelial\u2013Mesenchymal Transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev-cellbio-111315-125150","article-title":"Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer","volume":"32","author":"Przybyla","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jcb.22545","article-title":"Tissue Geometry Patterns Epithelial\u2013Mesenchymal Transition via Intercellular Mechanotransduction","volume":"110","author":"Gomez","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrm3416","article-title":"Transduction of Mechanical and Cytoskeletal Cues by YAP and TAZ","volume":"13","author":"Halder","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in Mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A Mechanical Checkpoint Controls Multicellular Growth through YAP\/TAZ Regulation by Actin-Processing Factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in Physiology and Disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.070987","article-title":"Hippo Pathway Regulation by Cell Morphology and Stress Fibers","volume":"138","author":"Wada","year":"2011","journal-title":"Development"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Katoh, K. (2025). Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction. Biomolecules, 15.","DOI":"10.3390\/biom15020166"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.celrep.2019.01.090","article-title":"Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP","volume":"26","author":"Strippoli","year":"2019","journal-title":"Cell Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41419-020-02822-1","article-title":"Caveolin1 and YAP Drive Mechanically Induced Mesothelial to Mesenchymal Transition and Fibrosis","volume":"11","author":"Strippoli","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"14122","DOI":"10.1038\/ncomms14122","article-title":"Fluid Shear Stress Activates YAP1 to Promote Cancer Cell Motility","volume":"8","author":"Lee","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1002\/1878-0261.13061","article-title":"Fluid Shear Stress Activates YAP to Promote Epithelial\u2013Mesenchymal Transition in Hepatocellular Carcinoma","volume":"15","author":"Yu","year":"2021","journal-title":"Mol. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5481493","DOI":"10.1155\/2016\/5481493","article-title":"Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes","volume":"2016","author":"Cozzolino","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41419-019-2000-8","article-title":"YAP Integrates the Regulatory Snail\/HNF4\u03b1 Circuitry Controlling Epithelial\/Hepatocyte Differentiation","volume":"10","author":"Noce","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGF\u03b2 Signalling in Context","volume":"13","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-\u03b2-Induced Epithelial to Mesenchymal Transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.jmb.2015.04.015","article-title":"Crosstalk between Hippo and TGF\u03b2: Subcellular Localization of YAP\/TAZ\/Smad Complexes","volume":"427","author":"Grannas","year":"2015","journal-title":"J. Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ncb1748","article-title":"TAZ Controls Smad Nucleocytoplasmic Shuttling and Regulates Human Embryonic Stem-Cell Self-Renewal","volume":"10","author":"Varelas","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.celrep.2013.11.021","article-title":"Switch Enhancers Interpret TGF-\u03b2 and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells","volume":"5","author":"Beyer","year":"2013","journal-title":"Cell Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1074\/jbc.M113.529115","article-title":"The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor \u03b2-Induced Tumorigenic Phenotypes in Breast Cancer Cells","volume":"289","author":"Hiemer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1091\/mbc.12.1.27","article-title":"Transforming Growth Factor-B1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-Dependent Mechanism","volume":"12","author":"Bhowmick","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/21541248.2018.1435986","article-title":"Reciprocal Regulation of YAP\/TAZ by the Hippo Pathway and the Small GTPase Pathway","volume":"11","author":"Jang","year":"2020","journal-title":"Small GTPases"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.cellsig.2008.08.002","article-title":"ERK5\/MAPK Is Activated by TGF\u03b2 in Hepatocytes and Required for the GSK-3\u03b2-Mediated Snail Protein Stabilization","volume":"20","author":"Marchetti","year":"2008","journal-title":"Cell. Signal."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41419-023-05569-7","article-title":"Extracellular Signal-Regulated Kinase 5 (ERK5) Is Required for the Yes-Associated Protein (YAP) Co-Transcriptional Activity","volume":"14","author":"Ippolito","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.cell.2012.11.027","article-title":"Role of TAZ as Mediator of Wnt Signaling","volume":"151","author":"Azzolin","year":"2012","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","article-title":"YAP\/TAZ Incorporation in the \u03b2-Catenin Destruction Complex Orchestrates the Wnt Response","volume":"158","author":"Azzolin","year":"2014","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","article-title":"\u03b2-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis","volume":"151","author":"Rosenbluh","year":"2012","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41419-017-0244-8","article-title":"YAP Triggers the Wnt\/\u03b2-Catenin Signalling Pathway and Promotes Enterocyte Self-Renewal, Regeneration and Tumorigenesis after DSS-Induced Injury","volume":"9","author":"Deng","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11730","DOI":"10.1074\/jbc.M111.327767","article-title":"Wnt\/\u03b2-Catenin Signaling Regulates Yes-Associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells","volume":"287","author":"Konsavage","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/emboj.2011.487","article-title":"A Molecular Mechanism That Links Hippo Signalling to the Inhibition of Wnt\/B-catenin Signalling","volume":"31","author":"Imajo","year":"2012","journal-title":"EMBO J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex Networks Orchestrate Epithelial\u2013Mesenchymal Transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yexcr.2018.07.041","article-title":"Paracrine HGF\/c-MET Enhances the Stem Cell-like Potential and Glycolysis of Pancreatic Cancer Cells via Activation of YAP\/HIF-1\u03b1","volume":"371","author":"Yan","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s42003-021-02744-4","article-title":"EGFR Regulates the Hippo Pathway by Promoting the Tyrosine Phosphorylation of MOB1","volume":"4","author":"Ando","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e11484","DOI":"10.1002\/advs.202511484","article-title":"ERK-Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells","volume":"13","author":"Zhao","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Tam, S.Y., Wu, V.W.C., and Law, H.K.W. (2020). Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1\u03b1 and Beyond. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00486"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb3073","article-title":"Hypoxia Regulates Hippo Signalling through the SIAH2 Ubiquitin E3 Ligase","volume":"17","author":"Ma","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Choi, S.H., and Kim, D.Y. (2024). Regulation of Tumor Microenvironment through YAP\/TAZ under Tumor Hypoxia. Cancers, 16.","DOI":"10.3390\/cancers16173030"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41420-023-01687-5","article-title":"YAP Nuclear Translocation Induced by HIF-1\u03b1 Prevents DNA Damage under Hypoxic Conditions","volume":"9","author":"Chang","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9918379","DOI":"10.1155\/2021\/9918379","article-title":"Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer","volume":"2021","author":"Chattopadhyay","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chen, L., Jin, X., Ma, J., Xiang, B., and Li, X. (2023). YAP at the Progression of Inflammation. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1204033"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ncb3290","article-title":"Chronic Inflammation Imposes Aberrant Cell Fate in Regenerating Epithelia through Mechanotransduction","volume":"18","author":"Nowell","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14228","article-title":"A Gp130\u2013Src\u2013YAP Module Links Inflammation to Epithelial Regeneration","volume":"519","author":"Taniguchi","year":"2015","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1053\/j.gastro.2016.05.006","article-title":"YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-Regulation of JAK\u2013STAT3 Signaling","volume":"151","author":"Gruber","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e67312","DOI":"10.7554\/eLife.67312","article-title":"YAP and TAZ Are Transcriptional Co-Activators of AP-1 Proteins and STAT3 during Breast Cellular Transformation","volume":"10","author":"He","year":"2021","journal-title":"eLife"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.emboj.7600069","article-title":"Integration of TGF-\u03b2\/Smad and Jagged1\/Notch Signalling in Epithelial-to-mesenchymal Transition","volume":"23","author":"Zavadil","year":"2004","journal-title":"EMBO J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/stem.1030","article-title":"Genome-Wide Analysis of N1ICD\/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1","volume":"30","author":"Li","year":"2012","journal-title":"Stem Cells"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1053\/j.gastro.2013.02.009","article-title":"Yes-Associated Protein Up-Regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma","volume":"144","author":"Tschaharganeh","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"46135","DOI":"10.1038\/srep46135","article-title":"Notch and Hippo Signaling Converge on Strawberry Notch 1 (Sbno1) to Synergistically Activate Cdx2 during Specification of the Trophectoderm","volume":"7","author":"Watanabe","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Engel-Pizcueta, C., and Pujades, C. (2021). Interplay Between Notch and YAP\/TAZ Pathways in the Regulation of Cell Fate During Embryo Development. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.711531"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1038\/ncomms10498","article-title":"ZEB1 Turns into a Transcriptional Activator by Interacting with YAP1 in Aggressive Cancer Types","volume":"7","author":"Lehmann","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"EMBJ2019103209","DOI":"10.15252\/embj.2019103209","article-title":"Genome-wide Cooperation of EMT Transcription Factor ZEB1 with YAP and AP-1 in Breast Cancer","volume":"39","author":"Feldker","year":"2020","journal-title":"EMBO J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/j.gastro.2020.12.077","article-title":"Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/onc.2012.196","article-title":"KIBRA Exhibits MST-Independent Functional Regulation of the Hippo Signaling Pathway in Mammals","volume":"32","author":"Moleirinho","year":"2013","journal-title":"Oncogene"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Huang, X., Zhang, M., Pearce, A.D., Gibbons, M.D., Jin, D., Li, L., Hu, D., Liu, R., Yu, M., and Tan, M. (2025). Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion. Cancers, 17.","DOI":"10.20944\/preprints202507.1544.v1"},{"key":"ref_108","first-page":"701","article-title":"YAP Promotes Epithelial Mesenchymal Transition by Upregulating Slug Expression in Human Colorectal Cancer Cells","volume":"13","author":"Cheng","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/hep.24280","article-title":"The Stable Repression of Mesenchymal Program Is Required for Hepatocyte Identity: A Novel Role for Hepatocyte Nuclear Factor 4\u03b1","volume":"53","author":"Santangelo","year":"2011","journal-title":"Hepatology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/liv.12577","article-title":"Molecular Mechanisms Controlling the Phenotype and the EMT \/ MET Dynamics of Hepatocyte","volume":"35","author":"Cicchini","year":"2015","journal-title":"Liver Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jhep.2012.08.023","article-title":"TGF\u03b2 Overrides HNF4\u03b1 Tumor Suppressing Activity through GSK3\u03b2 Inactivation: Implication for Hepatocellular Carcinoma Gene Therapy","volume":"58","author":"Cozzolino","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Bisceglia, F., Battistelli, C., Noce, V., Montaldo, C., Zammataro, A., Strippoli, R., Tripodi, M., Amicone, L., and Marchetti, A. (2019). TGF\u03b2 Impairs HNF1\u03b1 Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP\/P300 Acetyltransferases. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00942"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1038\/s41467-019-10729-5","article-title":"Switch-like Enhancement of Epithelial-Mesenchymal Transition by YAP through Feedback Regulation of WT1 and Rho-Family GTPases","volume":"10","author":"Park","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s41419-022-05398-0","article-title":"Restoration of WT1\/miR-769-5p Axis by HDAC1 Inhibition Promotes MMT Reversal in Mesenchymal-like Mesothelial Cells","volume":"13","author":"Bontempi","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng.494","article-title":"Wt1 Is Required for Cardiovascular Progenitor Cell Formation through Transcriptional Control of Snail and E-Cadherin","volume":"42","author":"Lettice","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00395-011-0181-0","article-title":"In Vitro Epithelial-to-Mesenchymal Transformation in Human Adult Epicardial Cells Is Regulated by TGF\u03b2-Signaling and WT1","volume":"106","author":"Bax","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1073\/pnas.1103345108","article-title":"E-Cadherin Mediates Contact Inhibition of Proliferation through Hippo Signaling-Pathway Components","volume":"108","author":"Kim","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.neo.2017.10.003","article-title":"YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC","volume":"19","author":"Ghiso","year":"2017","journal-title":"Neoplasia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1158\/0008-5472.CAN-17-0392","article-title":"AXL-Driven EMT State as a Targetable Conduit in Cancer","volume":"77","author":"Antony","year":"2017","journal-title":"Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12943-024-02210-9","article-title":"AXL: Shapers of Tumor Progression and Immunosuppressive Microenvironments","volume":"24","author":"Liu","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1038\/s41388-023-02810-7","article-title":"AXL Activates YAP through the EGFR-LATS1\/2 Axis and Confers Resistance to EGFR-Targeted Drugs in Head and Neck Squamous Cell Carcinoma","volume":"42","author":"Okamoto","year":"2023","journal-title":"Oncogene"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ Upstream Signals and Downstream Responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.stemcr.2021.12.012","article-title":"YAP1 Regulates the Self-Organized Fate Patterning of hESC-Derived Gastruloids","volume":"17","author":"Stronati","year":"2022","journal-title":"Stem Cell Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature14215","article-title":"YAP Is Essential for Tissue Tension to Ensure Vertebrate 3D Body Shape","volume":"521","author":"Porazinski","year":"2015","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1038\/s41467-023-38482-w","article-title":"A Yap-Dependent Mechanoregulatory Program Sustains Cell Migration for Embryo Axis Assembly","volume":"14","author":"Corbacho","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature25742","article-title":"Tissue Stiffening Coordinates Morphogenesis by Triggering Collective Cell Migration in Vivo","volume":"554","author":"Barriga","year":"2018","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"23208","DOI":"10.1038\/srep23208","article-title":"The Hippo Pathway Member YAP Enhances Human Neural Crest Cell Fate and Migration","volume":"6","author":"Hindley","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2009.04.070","article-title":"Yap Is Required for the Development of Brain, Eyes, and Neural Crest in Zebrafish","volume":"384","author":"Jiang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.devcel.2020.03.005","article-title":"Metabolic Reprogramming Promotes Neural Crest Migration via Yap\/Tead Signaling","volume":"53","author":"Bhattacharya","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Zhao, X., Le, T.P., Erhardt, S., Findley, T.O., and Wang, J. (2021). Hippo-Yap Pathway Orchestrates Neural Crest Ontogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.706623"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP Oncoprotein by the Hippo Pathway Is Involved in Cell Contact Inhibition and Tissue Growth Control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13238-017-0371-0","article-title":"The Hippo Pathway in Tissue Homeostasis and Regeneration","volume":"8","author":"Wang","year":"2017","journal-title":"Protein Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1038\/s41467-024-49230-z","article-title":"A YAP-Centered Mechanotransduction Loop Drives Collective Breast Cancer Cell Invasion","volume":"15","author":"Khalil","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Piersma, B., Bank, R.A., and Boersema, M. (2015). Signaling in Fibrosis: TGF-\u03b2, WNT, and YAP\/TAZ Converge. Front. Med., 2.","DOI":"10.3389\/fmed.2015.00059"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Li, W., Xie, Y., Chen, Z., Cao, D., and Wang, Y. (2025). Epithelial\u2013Mesenchymal Transition in Pulmonary Fibrosis: Molecular Mechanisms and Emerging Therapeutic Strategies. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1658001"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molcel.2016.05.012","article-title":"TGF-\u03b2 Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP\/SMAD2 Nuclear Translocation","volume":"63","author":"Pefani","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/hep.30668","article-title":"P300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2\/3 and TAZ Nuclear Transport in Transforming Growth Factor \u03b2\u2013Stimulated Hepatic Stellate Cells","volume":"70","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1681\/ASN.2015050499","article-title":"YAP\/TAZ Are Mechanoregulators of TGF-\u03b2-Smad Signaling and Renal Fibrogenesis","volume":"27","author":"Szeto","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo\u2013YAP\/TAZ Signalling in Organ Regeneration and Regenerative Medicine","volume":"20","author":"Moya","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/B978-0-12-394305-7.00004-5","article-title":"New Insights into the Regulation of Epithelial\u2013Mesenchymal Transition and Tissue Fibrosis","volume":"Volume 294","author":"Lee","year":"2012","journal-title":"International Review of Cell and Molecular Biology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"42595","DOI":"10.1038\/srep42595","article-title":"TAZ Contributes to Pulmonary Fibrosis by Activating Profibrotic Functions of Lung Fibroblasts","volume":"7","author":"Noguchi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ Drives Fibroblast Activation and Fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3399357","DOI":"10.1155\/2021\/3399357","article-title":"Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway","volume":"2021","author":"Li","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo Pathway Effector YAP Controls Mouse Hepatic Stellate Cell Activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molimm.2019.01.004","article-title":"Blockade of YAP Alleviates Hepatic Fibrosis through Accelerating Apoptosis and Reversion of Activated Hepatic Stellate Cells","volume":"107","author":"Yu","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2016.09.016","article-title":"Hepatocyte TAZ\/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis","volume":"24","author":"Wang","year":"2016","journal-title":"Cell Metab."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"16364","DOI":"10.1074\/jbc.RA118.004073","article-title":"Yap\/Taz Mediates mTORC2-Stimulated Fibroblast Activation and Kidney Fibrosis","volume":"293","author":"Gui","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","article-title":"Yap1 Acts Downstream of \u03b1-Catenin to Control Epidermal Proliferation","volume":"144","author":"Schlegelmilch","year":"2011","journal-title":"Cell"},{"key":"ref_150","first-page":"1674","article-title":"Integrin Signalling Regulates YAP\/TAZ to Control Skin Homeostasis","volume":"143","author":"Elbediwy","year":"2016","journal-title":"Development"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/jid.2013.339","article-title":"YAP and TAZ Regulate Skin Wound Healing","volume":"134","author":"Lee","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1016\/j.ajpath.2015.08.011","article-title":"YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts","volume":"185","author":"Piersma","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jid.2017.08.024","article-title":"Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis","volume":"138","author":"Toyama","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the Roots of Cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1228522","article-title":"Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition","volume":"339","author":"Yu","year":"2013","journal-title":"Science"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1186\/bcr2896","article-title":"Epithelial to Mesenchymal Transition Markers Expressed in Circulating Tumour Cells of Early and Metastatic Breast Cancer Patients","volume":"13","author":"Kallergi","year":"2011","journal-title":"Breast Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo\u2013YAP Pathway in Organ Size Control and Tumorigenesis: An Updated Version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Thrash, H.L., and Pendergast, A.M. (2023). Multi-Functional Regulation by YAP\/TAZ Signaling Networks in Tumor Progression and Metastasis. Cancers, 15.","DOI":"10.3390\/cancers15194701"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s43018-020-00150-z","article-title":"Single-Cell Analyses Reveal YAP\/TAZ as Regulators of Stemness and Cell Plasticity in Glioblastoma","volume":"2","author":"Castellan","year":"2020","journal-title":"Nat. Cancer"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"114003","DOI":"10.1016\/j.celrep.2024.114003","article-title":"Hippo-Signaling-Controlled MHC Class I Antigen Processing and Presentation Pathway Potentiates Antitumor Immunity","volume":"43","author":"Peng","year":"2024","journal-title":"Cell Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1158\/0008-5472.CAN-17-3139","article-title":"The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1","volume":"78","author":"Azad","year":"2018","journal-title":"Cancer Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/2159-8290.CD-15-0224","article-title":"Targeting YAP-Dependent MDSC Impairs Tumor Progression","volume":"6","author":"Wang","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Yang, D., Zhang, N., Li, M., Hong, T., Meng, W., and Ouyang, T. (2021). The Hippo Signaling Pathway: The Trader of Tumor Microenvironment. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.772134"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-Dependent Matrix Remodelling Is Required for the Generation and Maintenance of Cancer-Associated Fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gad.262816.115","article-title":"A YAP\/TAZ-Induced Feedback Mechanism Regulates Hippo Pathway Homeostasis","volume":"29","author":"Moroishi","year":"2015","journal-title":"Genes Dev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/ATVBAHA.123.320300","article-title":"Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction","volume":"44","author":"Mannion","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1038\/s12276-025-01551-9","article-title":"The Multifaceted Role of YAP in the Tumor Microenvironment and Its Therapeutic Implications in Cancer","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and Pharmacological Disruption of the TEAD\u2013YAP Complex Suppresses the Oncogenic Activity of YAP","volume":"26","author":"Huang","year":"2012","journal-title":"Genes Dev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.7150\/jca.34145","article-title":"Verteporfin Suppresses the Proliferation, Epithelial-Mesenchymal Transition and Stemness of Head and Neck Squamous Carcinoma Cells via Inhibiting YAP1","volume":"10","author":"Liu","year":"2019","journal-title":"J. Cancer"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Jin, J., Wang, T., Park, W., Li, W., Kim, W., Park, S.K., and Kang, K.P. (2020). Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218184"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/8\/851\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:47:19Z","timestamp":1784879239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/8\/851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":170,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["genes17080851"],"URL":"https:\/\/doi.org\/10.3390\/genes17080851","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}