{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:25Z","timestamp":1786978525618,"version":"build-2736575974"},"reference-count":167,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Skeletal muscle retains adaptive information from previous mechanical loading, enabling faster responses to subsequent training and regenerative challenges. This review synthesizes current evidence on the cellular and epigenetic mechanisms underlying skeletal muscle memory and examines how these mechanisms are modified by aging and post-injury regeneration. Muscle memory emerges from complementary structural and molecular components, including myonuclear retention, persistent DNA methylation changes, chromatin remodeling, transcriptional priming, non-coding RNA regulation, and mitochondrial epigenetic adaptations. These mechanisms interact with muscle satellite cells (MuSCs), fibro-adipogenic progenitors (FAPs), immune cells, and extracellular matrix remodeling to maintain regenerative competence. During aging, epigenetic drift, chronic low-grade inflammation, altered macrophage states, MuSC dysfunction, persistent FAP activity, fibrosis, mitochondrial impairment, and anabolic resistance progressively reduce this plasticity, thereby contributing to sarcopenia. Training\u2013detraining\u2013retraining studies indicate that parts of the exercise-induced epigenetic landscape remain detectable after training cessation and can be reactivated during renewed loading, although the persistence and functional importance of individual molecular signatures remain incompletely defined. Physical exercise remains the most established intervention for preserving muscle function and epigenetic responsiveness, whereas caloric restriction, modulation of nutrient-sensing pathways, senolytic strategies, and direct targeting of epigenetic regulators remain promising but translationally less mature approaches. Overall, the preservation of epigenetic plasticity may be a key determinant of healthy skeletal muscle aging and effective regeneration.<\/jats:p>","DOI":"10.3390\/genes17080964","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:42:17Z","timestamp":1786974137000},"page":"964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Skeletal Muscle Memory: The Impact of Physical Activity on Aging and Post-Injury Regeneration"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0406-8421","authenticated-orcid":false,"given":"Antoni","family":"Godlewski","sequence":"first","affiliation":[{"name":"Student Scientific Club of Biochemistry and Bioorganic Chemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-132X","authenticated-orcid":false,"given":"Marcin","family":"Wr\u00f3blewski","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kuk","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Biochemistry and Bioorganic Chemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Moritz","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Biochemistry and Bioorganic Chemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Dobrak","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Biochemistry and Bioorganic Chemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-721X","authenticated-orcid":false,"given":"Renata","family":"Ko\u0142odziejska","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4492-4796","authenticated-orcid":false,"given":"Alina","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 24 Kar\u0142owicza St., 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.stem.2012.04.002","article-title":"Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function","volume":"10","author":"Cerletti","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2009.11.010","article-title":"Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster","volume":"11","author":"Bjedov","year":"2010","journal-title":"Cell Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small Molecule Activators of Sirtuins Extend Saccharomyces Cerevisiae Lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ncomms3192","article-title":"Metformin Improves Healthspan and Lifespan in Mice","volume":"4","author":"Mercken","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41598-018-20287-3","article-title":"Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy","volume":"8","author":"Seaborne","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1389202920666190116094736","article-title":"An Overview About the Biology of Skeletal Muscle Satellite Cells","volume":"20","author":"Forcina","year":"2019","journal-title":"Curr. Genom."},{"key":"ref_9","unstructured":"Terjung, R. (2015). Satellite Cells and Skeletal Muscle Regeneration. Comprehensive Physiology, Wiley."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Biferali, B., Proietti, D., Mozzetta, C., and Madaro, L. (2019). Fibro\u2013Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01074"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"858606","DOI":"10.1155\/2010\/858606","article-title":"Assembly and Dynamics of Myofibrils","volume":"2010","author":"Sanger","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00043.2011","article-title":"Satellite Cells and the Muscle Stem Cell Niche","volume":"93","author":"Yin","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1242\/dev.068858","article-title":"Effective Fiber Hypertrophy in Satellite Cell-Depleted Skeletal Muscle","volume":"138","author":"McCarthy","year":"2011","journal-title":"Development"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.067595","article-title":"An Absolute Requirement for Pax7-Positive Satellite Cells in Acute Injury-Induced Skeletal Muscle Regeneration","volume":"138","author":"Lepper","year":"2011","journal-title":"Development"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cell.2013.02.053","article-title":"Type 2 Innate Signals Stimulate Fibro\/Adipogenic Progenitors to Facilitate Muscle Regeneration","volume":"153","author":"Heredia","year":"2013","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle Injury Activates Resident Fibro\/Adipogenic Progenitors That Facilitate Myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13395-021-00265-6","article-title":"Origins, Potency, and Heterogeneity of Skeletal Muscle Fibro-Adipogenic Progenitors-Time for New Definitions","volume":"11","author":"Contreras","year":"2021","journal-title":"Skelet. Muscle"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s00018-016-2445-1","article-title":"Retinoic Acid Maintains Human Skeletal Muscle Progenitor Cells in an Immature State","volume":"74","author":"Notarnicola","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.scr.2016.06.007","article-title":"Pharmacological Blockage of Fibro\/Adipogenic Progenitor Expansion and Suppression of Regenerative Fibrogenesis Is Associated with Impaired Skeletal Muscle Regeneration","volume":"17","author":"Fiore","year":"2016","journal-title":"Stem Cell Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nm.3869","article-title":"Nilotinib Reduces Muscle Fibrosis in Chronic Muscle Injury by Promoting TNF-Mediated Apoptosis of Fibro\/Adipogenic Progenitors","volume":"21","author":"Lemos","year":"2015","journal-title":"Nat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103020","DOI":"10.1016\/j.ebiom.2020.103020","article-title":"Retinoic Acid Signalling in Fibro\/Adipogenic Progenitors Robustly Enhances Muscle Regeneration","volume":"60","author":"Zhao","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100993","DOI":"10.1016\/j.isci.2020.100993","article-title":"Temporal Dynamics and Heterogeneity of Cell Populations during Skeletal Muscle Regeneration","volume":"23","author":"Oprescu","year":"2020","journal-title":"iScience"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C895","DOI":"10.1152\/ajpcell.00245.2023","article-title":"Thrown for a Loop: Fibro-Adipogenic Progenitors in Skeletal Muscle Fibrosis","volume":"325","author":"Loomis","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.tcb.2012.07.008","article-title":"Wnt Signaling in Myogenesis","volume":"22","author":"Chang","year":"2012","journal-title":"Trends Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.stem.2009.03.013","article-title":"Wnt7a Activates the Planar Cell Polarity Pathway to Drive the Symmetric Expansion of Satellite Stem Cells","volume":"4","author":"Jones","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1242\/jcs.086629","article-title":"Fibrosis and Adipogenesis Originate from a Common Mesenchymal Progenitor in Skeletal Muscle","volume":"124","author":"Uezumi","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrm3265","article-title":"Satellite Cells, the Engines of Muscle Repair","volume":"13","author":"Wang","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1242\/dev.114223","article-title":"Intrinsic and Extrinsic Mechanisms Regulating Satellite Cell Function","volume":"142","author":"Dumont","year":"2015","journal-title":"Development"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-021-00421-2","article-title":"Control of Satellite Cell Function in Muscle Regeneration and Its Disruption in Ageing","volume":"23","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R1173","DOI":"10.1152\/ajpregu.00735.2009","article-title":"Regulatory Interactions between Muscle and the Immune System during Muscle Regeneration","volume":"298","author":"Tidball","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Prakash, Y.S. (2011). Mechanisms of Muscle Injury, Repair, and Regeneration. Comprehensive Physiology, Wiley.","DOI":"10.1002\/cphy"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wang, X., and Zhou, L. (2022). The Many Roles of Macrophages in Skeletal Muscle Injury and Repair. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.952249"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage Biology in Development, Homeostasis and Disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.smim.2016.03.017","article-title":"Development and Function of Tissue Resident Macrophages in Mice","volume":"27","author":"Kierdorf","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev-physiol-022516-034356","article-title":"Mechanisms of Organ Injury and Repair by Macrophages","volume":"79","author":"Vannella","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, X., and Zhou, L. (2023). The Multifaceted Role of Macrophages in Homeostatic and Injured Skeletal Muscle. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1274816"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in Tissue Repair, Regeneration, and Fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/jphysiol.2002.031450","article-title":"Interactions between Neutrophils and Macrophages Promote Macrophage Killing of Rat Muscle Cells in Vitro","volume":"547","author":"Nguyen","year":"2003","journal-title":"J. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/mus.880140605","article-title":"Analysis of Inflammatory Cells and Complement C3 in Bupivacaine-Induced Myonecrosis","volume":"14","author":"Orimo","year":"1991","journal-title":"Muscle Nerve"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1249\/00005768-199507000-00011","article-title":"Inflammatory Cell Response to Acute Muscle Injury","volume":"27","author":"Tidball","year":"1995","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.it.2020.04.006","article-title":"Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!","volume":"41","author":"Chazaud","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature03260","article-title":"Rejuvenation of Aged Progenitor Cells by Exposure to a Young Systemic Environment","volume":"433","author":"Conboy","year":"2005","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-022-05535-x","article-title":"Senescence Atlas Reveals an Aged-like Inflamed Niche That Blunts Muscle Regeneration","volume":"613","author":"Moiseeva","year":"2023","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ncb3397","article-title":"NOTCH1 Mediates a Switch between Two Distinct Secretomes during Senescence","volume":"18","author":"Hoare","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tcb.2017.07.004","article-title":"Spatial and Temporal Control of Senescence","volume":"27","author":"Ito","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/mus.20995","article-title":"Muscle Satellite Cell and Atypical Myogenic Progenitor Response Following Exercise","volume":"37","author":"Parise","year":"2008","journal-title":"Muscle Nerve"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1242\/dev.067587","article-title":"Pax7-Expressing Satellite Cells Are Indispensable for Adult Skeletal Muscle Regeneration","volume":"138","author":"Sambasivan","year":"2011","journal-title":"Development"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0960-8966(99)00093-0","article-title":"Shorter Telomeres in Dystrophic Muscle Consistent with Extensive Regeneration in Young Children","volume":"10","author":"Decary","year":"2000","journal-title":"Neuromuscul. Disord."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41467-018-03244-6","article-title":"Somatic Mutagenesis in Satellite Cells Associates with Human Skeletal Muscle Aging","volume":"9","author":"Franco","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-021-03307-7","article-title":"The Central Role of DNA Damage in the Ageing Process","volume":"592","author":"Schumacher","year":"2021","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0092-8674(02)01078-4","article-title":"Biological Progression from Adult Bone Marrow to Mononucleate Muscle Stem Cell to Multinucleate Muscle Fiber in Response to Injury","volume":"111","author":"LaBarge","year":"2002","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1101\/gad.173922.111","article-title":"Rejuvenating Senescent and Centenarian Human Cells by Reprogramming through the Pluripotent State","volume":"25","author":"Lapasset","year":"2011","journal-title":"Genes Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1034\/j.1600-0625.2001.100503.x","article-title":"Human Skin Mast Cells Rapidly Release Preformed and Newly Generated TNF-Alpha and IL-8 Following Stimulation with Anti-IgE and Other Secretagogues","volume":"10","author":"Gibbs","year":"2001","journal-title":"Exp. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"C1660","DOI":"10.1152\/ajpcell.00486.2006","article-title":"TNF-\u03b1 Regulates Myogenesis and Muscle Regeneration by Activating P38 MAPK","volume":"292","author":"Chen","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2007.11.011","article-title":"Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy","volume":"7","author":"Serrano","year":"2008","journal-title":"Cell Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cophys.2019.03.009","article-title":"Exercise and Health\u2014Emerging Roles of IL-6","volume":"10","author":"Ellingsgaard","year":"2019","journal-title":"Curr. Opin. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/japplphysiol.01026.2004","article-title":"IL-6-Induced Skeletal Muscle Atrophy","volume":"98","author":"Haddad","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/nm.3655","article-title":"Inhibition of JAK-STAT Signaling Stimulates Adult Satellite Cell Function","volume":"20","author":"Price","year":"2014","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nm.3656","article-title":"STAT3 Signaling Controls Satellite Cell Expansion and Skeletal Muscle Repair","volume":"20","author":"Tierney","year":"2014","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2016.01.009","article-title":"Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells","volume":"44","author":"Kuswanto","year":"2016","journal-title":"Immunity"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1050-1738(00)00075-X","article-title":"How Calcium Influx through Calcium Leak Channels Is Responsible for the Elevated Levels of Calcium-Dependent Proteolysis in Dystrophic Myotubes","volume":"10","author":"Alderton","year":"2000","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1006\/excr.1998.4325","article-title":"Potential M-Calpain Substrates during Myoblast Fusion","volume":"246","author":"Dourdin","year":"1999","journal-title":"Exp. Cell Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1440-1681.2009.05310.x","article-title":"Calpains, Skeletal Muscle Function and Exercise","volume":"37","author":"Murphy","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/stem.759","article-title":"CD34 Promotes Satellite Cell Motility and Entry into Proliferation to Facilitate Efficient Skeletal Muscle Regeneration","volume":"29","author":"Alfaro","year":"2011","journal-title":"Stem Cells"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1242\/dev.068411","article-title":"Eph\/Ephrin Interactions Modulate Muscle Satellite Cell Motility and Patterning","volume":"138","author":"Stark","year":"2011","journal-title":"Development"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/jcs.112.17.2895","article-title":"In Vivo Satellite Cell Activation via Myf5 and MyoD in Regenerating Mouse Skeletal Muscle","volume":"112","author":"Cooper","year":"1999","journal-title":"J. Cell Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/emboj\/18.4.926","article-title":"Coupling of the Cell Cycle and Myogenesis through the Cyclin D1-Dependent Interaction of MyoD with Cdk4","volume":"18","author":"Zhang","year":"1999","journal-title":"EMBO J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13072-019-0281-x","article-title":"Phosphorylation of TET2 by AMPK Is Indispensable in Myogenic Differentiation","volume":"12","author":"Zhang","year":"2019","journal-title":"Epigenet. Chromatin"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"43539","DOI":"10.1038\/srep43539","article-title":"Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro","volume":"7","author":"Zhong","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.200911123","article-title":"The P38 MAPK Family, a Pushmi-Pullyu of Skeletal Muscle Differentiation","volume":"187","author":"Lassar","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.stem.2012.05.025","article-title":"Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of P38\u03b1\/\u03b2 MAPK","volume":"11","author":"Troy","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2007.03.044","article-title":"Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in Muscle","volume":"129","author":"Kuang","year":"2007","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.200608122","article-title":"Reciprocal Inhibition between Pax7 and Muscle Regulatory Factors Modulates Myogenic Cell Fate Determination","volume":"177","author":"Olguin","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.stem.2009.12.015","article-title":"Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration","volume":"6","author":"Shea","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ydbio.2010.01.006","article-title":"The Depletion of Skeletal Muscle Satellite Cells with Age Is Concomitant with Reduced Capacity of Single Progenitors to Produce Reserve Progeny","volume":"340","author":"Day","year":"2010","journal-title":"Dev. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"553","DOI":"10.18632\/aging.100477","article-title":"Age Dependent Increase in the Levels of Osteopontin Inhibits Skeletal Muscle Regeneration","volume":"4","author":"Paliwal","year":"2012","journal-title":"Aging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.trsl.2020.03.001","article-title":"Emerging Molecular Mediators and Targets for Age-Related Skeletal Muscle Atrophy","volume":"221","author":"Brown","year":"2020","journal-title":"Transl. Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Cau, S.B.A., Carneiro, F.S., and Tostes, R.C. (2012). Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities. Front. Physiol., 3.","DOI":"10.3389\/fphys.2012.00218"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1084\/jem.184.2.609","article-title":"Selective Loss of Sarcolemmal Nitric Oxide Synthase in Becker Muscular Dystrophy","volume":"184","author":"Chao","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_84","first-page":"3276","article-title":"Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men","volume":"85","author":"Grobbee","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.stem.2018.09.017","article-title":"Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence","volume":"23","author":"Baghdadi","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/gerona\/62.1.9","article-title":"Impaired Expression of Notch Signaling Genes in Aged Human Skeletal Muscle","volume":"62","author":"Carey","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/stem.775","article-title":"A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State","volume":"30","author":"Mourikis","year":"2012","journal-title":"Stem Cells"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1073\/pnas.0610647104","article-title":"RBP-J (Rbpsuh) Is Essential to Maintain Muscle Progenitor Cells and to Generate Satellite Cells","volume":"104","author":"Vasyutina","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2007.10.006","article-title":"A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis","volume":"2","author":"Brack","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1144090","article-title":"Increased Wnt Signaling during Aging Alters Muscle Stem Cell Fate and Increases Fibrosis","volume":"317","author":"Brack","year":"2007","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1474-9726.2009.00517.x","article-title":"Relative Roles of TGF-Beta1 and Wnt in the Systemic Regulation and Aging of Satellite Cell Responses","volume":"8","author":"Carlson","year":"2009","journal-title":"Aging Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/jcmm.13085","article-title":"Activation of Wnt\/\u03b2-Catenin Signalling Is Required for TGF-\u03b2\/Smad2\/3 Signalling during Myofibroblast Proliferation","volume":"21","author":"Xu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7026","DOI":"10.1074\/jbc.M111.276311","article-title":"Interactions between \u03b2-Catenin and Transforming Growth Factor-\u03b2 Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-Activator cAMP-Response Element-Binding Protein (CREB)-Binding Protein (CBP)","volume":"287","author":"Zhou","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1096\/fj.14-254011","article-title":"Glucocorticoids Increase Adipocytes in Muscle by Affecting IL-4 Regulated FAP Activity","volume":"28","author":"Dong","year":"2014","journal-title":"FASEB J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1242\/dev.064162","article-title":"Satellite Cells, Connective Tissue Fibroblasts and Their Interactions Are Crucial for Muscle Regeneration","volume":"138","author":"Murphy","year":"2011","journal-title":"Development"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e139617","DOI":"10.1172\/JCI139617","article-title":"Mesenchymal Bmp3b Expression Maintains Skeletal Muscle Integrity and Decreases in Age-Related Sarcopenia","volume":"131","author":"Uezumi","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.celrep.2019.04.074","article-title":"Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle","volume":"27","author":"Wosczyna","year":"2019","journal-title":"Cell Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ncb2014","article-title":"Mesenchymal Progenitors Distinct from Satellite Cells Contribute to Ectopic Fat Cell Formation in Skeletal Muscle","volume":"12","author":"Uezumi","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/jbmr.1562","article-title":"Multipotent Progenitors Resident in the Skeletal Muscle Interstitium Exhibit Robust BMP-Dependent Osteogenic Activity and Mediate Heterotopic Ossification","volume":"27","author":"Wosczyna","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1096\/fj.202000506R","article-title":"Mir-22-3p\/KLF6\/MMP14 Axis in Fibro-Adipogenic Progenitors Regulates Fatty Infiltration in Muscle Degeneration","volume":"34","author":"Lin","year":"2020","journal-title":"FASEB J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","article-title":"Ror2 Signaling Regulates Golgi Structure and Transport through IFT20 for Tumor Invasiveness","volume":"7","author":"Nishita","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41418-020-0551-y","article-title":"Adipogenesis of Skeletal Muscle Fibro\/Adipogenic Progenitors Is Affected by the WNT5a\/GSK3\/\u03b2-Catenin Axis","volume":"27","author":"Reggio","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e201900437","DOI":"10.26508\/lsa.201900437","article-title":"Fibro-Adipogenic Progenitors of Dystrophic Mice Are Insensitive to NOTCH Regulation of Adipogenesis","volume":"2","author":"Marinkovic","year":"2019","journal-title":"Life Sci. Alliance"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of Adipogenesis by Wnt Signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Acharyya, S., Sharma, S.M., Cheng, A.S., Ladner, K.J., He, W., Kline, W., Wang, H., Ostrowski, M.C., Huang, T.H., and Guttridge, D.C. (2010). TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012479"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12964-018-0251-0","article-title":"Interleukin-15 Facilitates Muscle Regeneration through Modulation of Fibro\/Adipogenic Progenitors","volume":"16","author":"Kang","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2018.12.014","article-title":"Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors","volume":"24","author":"Lukjanenko","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of Skeletal Muscle Mass in Mice by a New TGF-Beta Superfamily Member","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.kint.2016.07.029","article-title":"The Pathway to Muscle Fibrosis Depends on Myostatin Stimulating the Differentiation of Fibro\/Adipogenic Progenitor Cells in Chronic Kidney Disease","volume":"91","author":"Dong","year":"2017","journal-title":"Kidney Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13395-015-0038-6","article-title":"Wnt\/\u03b2-Catenin Controls Follistatin Signalling to Regulate Satellite Cell Myogenic Potential","volume":"5","author":"Jones","year":"2015","journal-title":"Skelet. Muscle"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e103924","DOI":"10.15252\/embj.2019103924","article-title":"A Destabilised Metabolic Niche Provokes Loss of a Subpopulation of Aged Muscle Stem Cells","volume":"38","author":"Evano","year":"2019","journal-title":"EMBO J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature13013","article-title":"Geriatric Muscle Stem Cells Switch Reversible Quiescence into Senescence","volume":"506","author":"Gutarra","year":"2014","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10522-012-9372-9","article-title":"Cultured Senescent Myoblasts Derived from Human Vastus Lateralis Exhibit Normal Mitochondrial ATP Synthesis Capacities with Correlating Concomitant ROS Production While Whole Cell ATP Production Is Decreased","volume":"13","author":"Minet","year":"2012","journal-title":"Biogerontology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nm.3464","article-title":"Rejuvenation of the Muscle Stem Cell Population Restores Strength to Injured Aged Muscles","volume":"20","author":"Cosgrove","year":"2014","journal-title":"Nat. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1038\/s41467-019-10479-4","article-title":"The Transcription Factor Slug Represses p16Ink4a and Regulates Murine Muscle Stem Cell Aging","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"C649","DOI":"10.1152\/ajpcell.00050.2019","article-title":"Elevated Myonuclear Density during Skeletal Muscle Hypertrophy in Response to Training Is Reversed during Detraining","volume":"316","author":"Dungan","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","article-title":"Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle","volume":"15","author":"Yan","year":"2012","journal-title":"Cell Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"15360","DOI":"10.1038\/s41598-020-72730-z","article-title":"DNA Methylation across the Genome in Aged Human Skeletal Muscle Tissue and Muscle-Derived Cells: The Role of HOX Genes and Physical Activity","volume":"10","author":"Turner","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"GEG.S3992","DOI":"10.4137\/GEG.S3992","article-title":"UHRF1 Links the Histone Code and DNA Methylation to Ensure Faithful Epigenetic Memory Inheritance","volume":"2","author":"Bronner","year":"2009","journal-title":"Genet. Epigenet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1947601910373794","article-title":"Dnmt1\/Transcription Factor Interactions: An Alternative Mechanism of DNA Methylation Inheritance","volume":"1","author":"Hervouet","year":"2010","journal-title":"Genes Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Xu, J., Li, C., and Kang, X. (2023). The Epigenetic Regulatory Effect of Histone Acetylation and Deacetylation on Skeletal Muscle Metabolism-a Review. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1267456"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/org.6.1.11293","article-title":"Epigenetic Regulation of Skeletal Myogenesis","volume":"6","author":"Saccone","year":"2010","journal-title":"Organogenesis"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Huang, Z., Hu, L., Liu, Z., and Wang, S. (2025). The Functions and Regulatory Mechanisms of Histone Modifications in Skeletal Muscle Development and Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083644"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"C258","DOI":"10.1152\/ajpcell.00423.2024","article-title":"Human Skeletal Muscle Possesses an Epigenetic Memory of High-Intensity Interval Training","volume":"328","author":"Pilotto","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1113\/JP285675","article-title":"Muscle Memory in Humans: Evidence for Myonuclear Permanence and Long-term Transcriptional Regulation after Strength Training","volume":"602","author":"Cumming","year":"2024","journal-title":"J. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"C1274","DOI":"10.1152\/ajpcell.00099.2023","article-title":"Skeletal Muscle Memory","volume":"324","author":"Sharples","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Castillo, \u00cd.M., Ruiz-Caride, S.R., Rueda, R., L\u00f3pez-Chicharro, J., Segura-Ortiz, F., and Bouzamondo, H. (2025). Skeletal Muscle Memory: Implications for Sports, Aging and Nutrition. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1701520"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"15111","DOI":"10.1073\/pnas.0913935107","article-title":"Myonuclei Acquired by Overload Exercise Precede Hypertrophy and Are Not Lost on Detraining","volume":"107","author":"Bruusgaard","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1152\/japplphysiol.00050.2019","article-title":"Mechanisms of Inspiration That Modulate Cardiovascular Control: The Other Side of Breathing","volume":"127","author":"Convertino","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"zqab038","DOI":"10.1093\/function\/zqab038","article-title":"Nucleus Type-Specific DNA Methylomics Reveals Epigenetic \u201cMemory\u201d of Prior Adaptation in Skeletal Muscle","volume":"2","author":"Wen","year":"2021","journal-title":"Function"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e21864","DOI":"10.1096\/fj.202100873RR","article-title":"Resistance Training Rejuvenates the Mitochondrial Methylome in Aged Human Skeletal Muscle","volume":"35","author":"Ruple","year":"2021","journal-title":"FASEB J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI69735","article-title":"Aging and Epigenetic Drift: A Vicious Cycle","volume":"124","author":"Issa","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Gensous, N., Bacalini, M.G., Franceschi, C., Meskers, C.G.M., Maier, A.B., and Garagnani, P. (2019). Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00996"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/acel.12180","article-title":"Genome-wide DNA Methylation Changes with Age in Disease-free Human Skeletal Muscle","volume":"13","author":"Zykovich","year":"2014","journal-title":"Aging Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"180213","DOI":"10.1038\/sdata.2018.213","article-title":"Methylome of Human Skeletal Muscle after Acute & Chronic Resistance Exercise Training, Detraining & Retraining","volume":"5","author":"Seaborne","year":"2018","journal-title":"Sci. Data"},{"key":"ref_136","first-page":"139","article-title":"Epigenetic Regulation of Skeletal Muscle Development and Differentiation","volume":"Volume 61","author":"Kundu","year":"2013","journal-title":"Epigenetics: Development and Disease"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tcb.2009.03.002","article-title":"Chromatin: The Interface between Extrinsic Cues and the Epigenetic Regulation of Muscle Regeneration","volume":"19","author":"Guasconi","year":"2009","journal-title":"Trends Cell Biol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Yoshida, T., and Delafontaine, P. (2020). Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy. Cells, 9.","DOI":"10.3390\/cells9091970"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2044-5040-1-4","article-title":"Regulation of Skeletal Muscle Growth by the IGF1-Akt\/PKB Pathway: Insights from Genetic Models","volume":"1","author":"Schiaffino","year":"2011","journal-title":"Skelet. Muscle"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR Pathway Is a Crucial Regulator of Skeletal Muscle Hypertrophy and Can Prevent Muscle Atrophy in Vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1210\/jc.2004-0084","article-title":"Androgen Receptor in Human Skeletal Muscle and Cultured Muscle Satellite Cells: Up-Regulation by Androgen Treatment","volume":"89","author":"Taylor","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5966\/sctm.2015-0266","article-title":"Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease","volume":"5","author":"Sincennes","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.cell.2016.07.050","article-title":"Epigenetic Mechanisms of Longevity and Aging","volume":"166","author":"Sen","year":"2016","journal-title":"Cell"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s40279-014-0152-3","article-title":"A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy","volume":"44","author":"Phillips","year":"2014","journal-title":"Sports Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e22726","DOI":"10.1002\/advs.202522726","article-title":"Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle","volume":"13","author":"Turner","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1172\/JCI34022","article-title":"In Vivo Time-Lapse Microscopy Reveals No Loss of Murine Myonuclei during Weeks of Muscle Atrophy","volume":"118","author":"Bruusgaard","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1249\/MSS.0000000000001593","article-title":"Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-Analysis","volume":"50","author":"Vechin","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1113\/jphysiol.2013.264457","article-title":"A Cellular Memory Mechanism Aids Overload Hypertrophy in Muscle Long after an Episodic Exposure to Anabolic Steroids","volume":"591","author":"Egner","year":"2013","journal-title":"J. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1210\/clinem\/dgad432","article-title":"Higher Myonuclei Density in Muscle Fibers Persists Among Former Users of Anabolic Androgenic Steroids","volume":"109","author":"Nielsen","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"110860","DOI":"10.1016\/j.exger.2020.110860","article-title":"The Effect of Resistance Training, Detraining and Retraining on Muscle Strength and Power, Myofibre Size, Satellite Cells and Myonuclei in Older Men","volume":"133","author":"Blocquiaux","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1152\/japplphysiol.00436.2012","article-title":"No Change in Myonuclear Number during Muscle Unloading and Reloading","volume":"113","author":"Bruusgaard","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/gerona\/gln050","article-title":"Skeletal Muscle Hypertrophy Following Resistance Training Is Accompanied by a Fiber Type-Specific Increase in Satellite Cell Content in Elderly Men","volume":"64","author":"Verdijk","year":"2009","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"zqab047","DOI":"10.1093\/function\/zqab047","article-title":"Skeletal Muscle Possesses an Epigenetic Memory of Exercise: Role of Nucleus Type-Specific DNA Methylation","volume":"2","author":"Sharples","year":"2021","journal-title":"Function"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"C338","DOI":"10.1152\/ajpcell.00239.2004","article-title":"Aging Influences Cellular and Molecular Responses of Apoptosis to Skeletal Muscle Unloading","volume":"288","author":"Siu","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/jcsm.13043","article-title":"Myonuclear Permanence in Skeletal Muscle Memory: A Systematic Review and Meta-Analysis of Human and Animal Studies","volume":"13","author":"Rahmati","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cmet.2009.07.011","article-title":"Non-CpG Methylation of the PGC-1alpha Promoter through DNMT3B Controls Mitochondrial Density","volume":"10","author":"Osler","year":"2009","journal-title":"Cell Metab."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK Regulates Energy Expenditure by Modulating NAD+ Metabolism and SIRT1 Activity","volume":"458","author":"Feige","year":"2009","journal-title":"Nature"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.celrep.2016.08.005","article-title":"Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation","volume":"16","author":"Gaur","year":"2016","journal-title":"Cell Rep."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Lochmann, T.L., Thomas, R.R., Bennett, J.P., and Taylor, S.M. (2015). Epigenetic Modifications of the PGC-1\u03b1 Promoter during Exercise Induced Expression in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129647"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1113\/jphysiol.2009.181065","article-title":"Exercise-Induced Histone Modifications in Human Skeletal Muscle","volume":"587","author":"McGee","year":"2009","journal-title":"J. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2337\/db07-0843","article-title":"AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5","volume":"57","author":"McGee","year":"2008","journal-title":"Diabetes"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2337\/db11-1653","article-title":"Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle from First-Degree Relatives of Patients with Type 2 Diabetes","volume":"61","author":"Nitert","year":"2012","journal-title":"Diabetes"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s13059-014-0513-0","article-title":"TET1 Regulates Hypoxia-Induced Epithelial-Mesenchymal Transition by Acting as a Co-Activator","volume":"15","author":"Tsai","year":"2014","journal-title":"Genome Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"E447","DOI":"10.1152\/ajpendo.00149.2020","article-title":"No Effect of the Endurance Training Status on Senescence despite Reduced Inflammation in Skeletal Muscle of Older Individuals","volume":"319","author":"Balan","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1038\/s41467-019-12293-4","article-title":"Ageing Affects DNA Methylation Drift and Transcriptional Cell-to-Cell Variability in Mouse Muscle Stem Cells","volume":"10","author":"Evano","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13395-020-00259-w","article-title":"Epigenetic Regulation of Satellite Cell Fate during Skeletal Muscle Regeneration","volume":"11","author":"Massenet","year":"2021","journal-title":"Skelet. Muscle"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/8\/964\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:56:14Z","timestamp":1786974974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/8\/964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":167,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["genes17080964"],"URL":"https:\/\/doi.org\/10.3390\/genes17080964","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}