{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:25:25Z","timestamp":1787851525197,"version":"build-2784847793"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR27199517"],"award-info":[{"award-number":["BR27199517"]}]},{"award":["BR27199517"],"award-info":[{"award-number":["BR27199517"]}],"id":[{"id":"https:\/\/ror.org\/05tyne317","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: Occupational exposure to coal mine dust is a major risk factor for respiratory impairment; however, the genetic determinants of individual variation in lung function remain poorly understood, particularly in occupational cohorts that have been largely absent from genome-wide association studies. This study aimed to identify genetic variants associated with quantitative lung function traits in underground coal miners from Kazakhstan. Methods: A total of 186 underground coal miners from the Karaganda coal basin were genotyped using the Illumina Global Screening Array. Genome-wide association analyses were performed for six spirometric parameters (FVC, FEV1, FEV1\/FVC, MEF25, MEF50, and MEF75), adjusting for age, mining exposure, body mass index, smoking status, and population structure. Genotype imputation was performed to increase genomic coverage and evaluate the consistency of association signals. Results: No variants reached the conventional genome-wide significance threshold. However, recurrent suggestive associations identified PRKCB, FANCE, and UBTD1 as the principal candidate loci across correlated spirometric parameters, with independent support from genotype imputation. Conclusions: Recurrent associations across complementary spirometric parameters identified biologically plausible candidate loci involved in inflammatory signalling, DNA repair, and epithelial homeostasis. These findings provide one of the first genomic insights into lung function in underground coal miners and provide a foundation for future validation and functional studies.<\/jats:p>","DOI":"10.3390\/genes17091021","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:47:13Z","timestamp":1787849233000},"page":"1021","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Susceptibility to Impaired Lung Function in Underground Coal Miners from Kazakhstan"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-0042","authenticated-orcid":false,"given":"Anastassiya","family":"Perfilyeva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayagul","family":"Kairgeldina","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Gulyayev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"},{"name":"National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan"},{"name":"Department of Clinical Pharmacology and Evidence-Based Medicine, NC JSC \u201cKaraganda Medical University\u201d, Karaganda 100030, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanat","family":"Tekebayev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-2418","authenticated-orcid":false,"given":"Kanagat","family":"Yergali","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-4512","authenticated-orcid":false,"given":"Ozada","family":"Khamdiyeva","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Mutagenesis, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sholpan","family":"Koigel\u2019dinova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, NC JSC \u201cKaraganda Medical University\u201d, Karaganda 100030, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-3604","authenticated-orcid":false,"given":"Zhanbol","family":"Sabirov","sequence":"additional","affiliation":[{"name":"NC JSC National Centre for Occupational Health and Diseases, Karaganda 100008, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-8101","authenticated-orcid":false,"given":"Nazym","family":"Sagandykova","sequence":"additional","affiliation":[{"name":"Corporate Fund \u201cUniversity Medical Center\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-8673","authenticated-orcid":false,"given":"Madina","family":"Baurzhan","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of Kazakhstan, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-9577","authenticated-orcid":false,"given":"Gulnur","family":"Zhunussova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1183\/09031936.00021707","article-title":"Forced Expiratory Volume in One Second: Not Just a Lung Function Test but a Marker of Premature Death from All Causes","volume":"30","author":"Young","year":"2007","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"00093-2024","DOI":"10.1183\/23120541.00093-2024","article-title":"Air Pollution, Lung Function and Mortality: Survival and Mediation Analyses in UK Biobank","volume":"10","author":"Guyatt","year":"2024","journal-title":"ERJ Open Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1016\/S2214-109X(19)30070-1","article-title":"Mortality and Cardiovascular and Respiratory Morbidity in Individuals with Impaired FEV1 (PURE): An International, Community-Based Cohort Study","volume":"7","author":"Duong","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2101499","DOI":"10.1183\/13993003.01499-2021","article-title":"ERS\/ATS Technical Standard on Interpretive Strategies for Routine Lung Function Tests","volume":"60","author":"Stanojevic","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of Spirometry 2019 Update an Official American Thoracic Society and European Respiratory Society Technical Statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.12688\/f1000research.11185.1","article-title":"Recent Advances in Understanding Lung Function Development","volume":"6","author":"Guerra","year":"2017","journal-title":"F1000Research"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.chest.2021.04.009","article-title":"Impaired Respiratory Health and Life Course Transitions From Health to Chronic Lung Disease","volume":"160","author":"Liu","year":"2021","journal-title":"Chest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S2213-2600(18)30529-0","article-title":"Lung Function Trajectories in Health and Disease","volume":"7","author":"Agusti","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40789-025-00841-x","article-title":"Toxicity of Respirable Coal Dust: An Overview of Origin, Chemistry, Mechanisms, and Possible Remedies","volume":"13","author":"Eskanlou","year":"2026","journal-title":"Int. J. Coal Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/resp.13034","article-title":"Coal Mine Dust Lung Disease in the Modern Era","volume":"22","author":"Perret","year":"2017","journal-title":"Respirology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40572-019-00237-5","article-title":"Current Review of Pneumoconiosis Among US Coal Miners","volume":"6","author":"Hall","year":"2019","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_12","unstructured":"Department of Health and Human Services (2011). Coal Mine Dust Exposures and Associated Health Outcomes: A Review of Information Published Since 1995, National Institute for Occupational Safety and Health."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ajim.23324","article-title":"Respiratory Health of American Indian and Alaska Native Coal Miners Participating in the Coal Workers\u2019 Health Surveillance Program, 2014\u20132019","volume":"65","author":"Hall","year":"2022","journal-title":"Am. J. Ind. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.31612\/2616-4868.7.2024.13","article-title":"Prevalence of Respiratory Symptoms of Toxic and Dust Etiology in Underground Coal Miners and Factors Affecting It","volume":"7","author":"Basanets","year":"2024","journal-title":"Clin. Prev. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/JOM.0000000000003004","article-title":"Assessment of the Respiratory Health of Working US Coal Miners Since 2014\u2014Radiography, Spirometry, and Symptom Assessments","volume":"66","author":"Hall","year":"2024","journal-title":"J. Occup. Environ. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1080\/10803548.2020.1742463","article-title":"Association between Duration of Coal Dust Exposure and Respiratory Impairment in Coal Miners of West Bengal, India","volume":"27","author":"Prasad","year":"2021","journal-title":"Int. J. Occup. Saf. Ergon."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajim.22727","article-title":"Respiratory Morbidity among U.S. Coal Miners in States Outside of Central Appalachia","volume":"60","author":"Reynolds","year":"2017","journal-title":"Am. J. Ind. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.med.58.071105.111738","article-title":"Toward a Comprehensive Set of Asthma Susceptibility Genes","volume":"58","author":"Hudson","year":"2007","journal-title":"Annu. Rev. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1183\/09031936.01.17406960","article-title":"Familial Aggregation and Heritability of Adult Lung Function: Results from the Busselton Health Study","volume":"17","author":"Palmer","year":"2001","journal-title":"Eur. Respir. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8","article-title":"Evidence for Major Genes Influencing Pulmonary Function in the NHLBI Family Heart Study","volume":"19","author":"Wilk","year":"2000","journal-title":"Genet. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zainab, A., Anzawa, H., and Kinoshita, K. (2024). Identifying Key Genes in COPD Risk via Multiple Population Data Integration and Gene Prioritization. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0305803"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8658","DOI":"10.1038\/ncomms9658","article-title":"Sixteen New Lung Function Signals Identified through 1000 Genomes Project Reference Panel Imputation","volume":"6","author":"Artigas","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Patchen, B.K., Zhang, J., Gaddis, N., Bartz, T.M., Chen, J., Debban, C., Leonard, H., Nguyen, N.Q., Seo, J., and Tern, C. (2024). Multi-Ancestry Genome-Wide Association Study Reveals Novel Genetic Signals for Lung Function Decline. medRxiv.","DOI":"10.1101\/2024.11.25.24317794"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41588-023-01314-0","article-title":"Multi-Ancestry Genome-Wide Association Analyses Improve Resolution of Genes and Pathways Influencing Lung Function and Chronic Obstructive Pulmonary Disease Risk","volume":"55","author":"Shrine","year":"2023","journal-title":"Nat. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/resp.12212","article-title":"Association of Five Genetic Variants with Chronic Obstructive Pulmonary Disease Susceptibility and Spirometric Phenotypes in a Chinese Han Population","volume":"19","author":"Yang","year":"2014","journal-title":"Respirology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107923","DOI":"10.1016\/j.rmed.2024.107923","article-title":"Impact of IL13 Genetic Polymorphisms on COPD Susceptibility in the Chinese Han Population","volume":"237","author":"Yang","year":"2025","journal-title":"Respir. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1080\/15384101.2020.1831246","article-title":"TRPV1 Genetic Polymorphisms and Risk of COPD or COPD Combined with PH in the Han Chinese Population","volume":"19","author":"Xiong","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.2147\/COPD.S321150","article-title":"The Rs74794265 SNP of the SREK1 Gene Is Associated with COPD in Kashi, China","volume":"16","author":"Abudureheman","year":"2021","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pulmoe.2021.07.004","article-title":"Genetic Polymorphisms in MIR1208 and MIR5708 Are Associated with Susceptibility to COPD in the Chinese Population","volume":"29","author":"Zhou","year":"2023","journal-title":"Pulmonology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.2147\/COPD.S478095","article-title":"Genetic Variants in the Adhesive G Protein-Coupled Receptor ADGRG6 Are Associated with Increased Susceptibility to COPD in the Elderly Han Chinese Population of Southern China","volume":"19","author":"Chen","year":"2024","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfy017","article-title":"Association Analysis Identifies New Risk Loci for Coal Workers\u2019 Pneumoconiosis in Han Chinese Men","volume":"163","author":"Wang","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/tox.23554","article-title":"Transcriptome-Wide Association Study Identifies PSMB9 as a Susceptibility Gene for Coal Workers\u2019 Pneumoconiosis","volume":"37","author":"Yuan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Sun, D., Song, Y., and Ye, Q. (2024). Candidate Gene Polymorphisms Associated with Silicosis and Coal Workers\u2019 Pneumoconiosis: A Systematic Review and Meta-Analysis. BMC Pulm. Med., 24.","DOI":"10.1186\/s12890-024-03392-0"},{"key":"ref_34","unstructured":"Illumina (2026, June 10). Infinium Global Screening Array-24 v3.0 BeadChip. Available online: https:\/\/www.illumina.com\/products\/by-type\/microarray-kits\/infinium-global-screening.html."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-Generation PLINK: Rising to the Challenge of Larger and Richer Datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-Generation Genotype Imputation Service and Methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_37","unstructured":"Wei, T., and Simko, V. (2026, June 10). R Package \u201ccorrplot\u201d: Visualization of a Correlation Matrix, Version 0.95, 2024. Available online: https:\/\/github.com\/taiyun\/corrplot."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"731","DOI":"10.21105\/joss.00731","article-title":"qqman: An R Package for Visualizing GWAS Results Using Q-Q and Manhattan Plots","volume":"3","author":"Turner","year":"2018","journal-title":"J. Open Source Softw."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl Variant Effect Predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D998","DOI":"10.1093\/nar\/gkae1070","article-title":"The NHGRI-EBI GWAS Catalog: Standards for Reusability, Sustainability and Diversity","volume":"53","author":"Cerezo","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kim, H., Zamel, R., Bai, X.H., and Liu, M. (2013). PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064182"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5837123","DOI":"10.1155\/2018\/5837123","article-title":"P66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101923","DOI":"10.1016\/j.xcrm.2024.101923","article-title":"A Genome-Wide Association Study Identified PRKCB as a Causal Gene and Therapeutic Target for Mycobacterium Avium Complex Disease","volume":"6","author":"Zheng","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/CEJ.0000000000000832","article-title":"Comprehensive Analysis of the Clinical and Prognostic Significance of SFRP1 and PRKCB Expression in Non-Small Cell Lung Cancer: A Retrospective Analysis","volume":"33","author":"Hu","year":"2024","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/sj.bjc.6604362","article-title":"Cigarette Smoke Induces Genetic Instability in Airway Epithelial Cells by Suppressing FANCD2 Expression","volume":"98","author":"Hays","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12929-016-0240-9","article-title":"Fanconi Anemia Genes in Lung Adenocarcinoma\u2014A Pathway-Wide Study on Cancer Susceptibility","volume":"23","author":"Yang","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e68348","DOI":"10.7554\/eLife.68348","article-title":"UBTD1 Regulates Ceramide Balance and Endolysosomal Positioning to Coordinate EGFR Signaling","volume":"10","author":"Torrino","year":"2021","journal-title":"eLife"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41419-024-06890-5","article-title":"The Ubiquitin-like Protein UBTD1 Promotes Colorectal Cancer Progression by Stabilizing c-Myc to Upregulate Glycolysis","volume":"15","author":"Zhao","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"L421","DOI":"10.1152\/ajplung.00273.2017","article-title":"Docosahexaenoic Acid Enhances Amphiregulin-Mediated Bronchial Epithelial Cell Repair Processes Following Organic Dust Exposure","volume":"314","author":"Nordgren","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1165\/rcmb.2010-0419OC","article-title":"Airway Epithelial Epidermal Growth Factor Receptor Mediates Hogbarn Dust-Induced Cytokine Release but Not Ca 2+ Response","volume":"45","author":"Dodmane","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"L127","DOI":"10.1152\/ajplung.00448.2018","article-title":"Organic Dust Induces Inflammatory Gene Expression in Lung Epithelial Cells via ROS-Dependent STAT-3 Activation","volume":"317","author":"Natarajan","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_52","first-page":"307","article-title":"Relation between Dust Exposure and Lung Function in Miners and Ex-Miners","volume":"43","author":"Soutar","year":"1986","journal-title":"Br. J. Ind. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/thx.37.3.193","article-title":"Longitudinal Study of Lung Function in Coal-Miners","volume":"37","author":"Love","year":"1982","journal-title":"Thorax"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1136\/thx.40.2.132","article-title":"Longitudinal Decline in FEV1 in United States Coalminers","volume":"40","author":"Attfield","year":"1985","journal-title":"Thorax"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1164\/ajrccm\/145.3.605","article-title":"Pulmonary Function of U.S. Coal Miners Related to Dust Exposure Estimates","volume":"145","author":"Attfield","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ajim.22211","article-title":"Rapid Decline in Lung Function in Coal Miners: Evidence of Disease in Small Airways","volume":"56","author":"Stansbury","year":"2013","journal-title":"Am. J. Ind. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1093\/hmg\/ddu333","article-title":"A Genome-Wide Association Study Identifies Susceptibility Loci of Silica-Related Pneumoconiosis in Han Chinese","volume":"23","author":"Chu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/oemed-2018-105545","article-title":"Functional Variant of the Carboxypeptidase M (CPM) Gene May Affect Silica-Related Pneumoconiosis Susceptibility by Its Expression: A Multistage Case-Control Study","volume":"76","author":"Chu","year":"2019","journal-title":"Occup. Environ. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/oemed-2020-106610","article-title":"Respiratory Traits and Coal Workers\u2019 Pneumoconiosis: Mendelian Randomisation and Association Analysis","volume":"78","author":"Wang","year":"2021","journal-title":"Occup. Environ. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"108232","DOI":"10.1016\/j.pharmthera.2022.108232","article-title":"Progressive Massive Fibrosis: An Overview of the Recent Literature","volume":"240","author":"Weissman","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S2213-2600(13)70045-6","article-title":"Genetic Variants Associated with Idiopathic Pulmonary Fibrosis Susceptibility and Mortality: A Genome-Wide Association Study","volume":"1","author":"Noth","year":"2013","journal-title":"Lancet Respir. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ng.2609","article-title":"Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Pulmonary Fibrosis","volume":"45","author":"Fingerlin","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1165\/rcmb.2018-0293OC","article-title":"Long Noncoding RNA FENDRR Exhibits Antifibrotic Activity in Pulmonary Fibrosis","volume":"62","author":"Huang","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Senavirathna, L.K., Liang, Y., Huang, C., Yang, X., Bamunuarachchi, G., Xu, D., Dang, Q., Sivasami, P., Vaddadi, K., and Munteanu, M.C. (2021). Long Noncoding RNA FENDRR Inhibits Lung Fibroblast Proliferation via a Reduction of \u03b2-Catenin. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168536"},{"key":"ref_65","first-page":"OA2909","article-title":"Decreased Expression of FENDRR, a Lung Mesenchymal Long Non-Coding RNA, Regulates Fibroblast Phenotypes in IPF through NOX4","volume":"50","author":"Sakamoto","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of Idiopathic Pulmonary Fibrosis An Official ATS\/ERS\/JRS\/ALAT Clinical Practice Guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1021\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:53:15Z","timestamp":1787849595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["genes17091021"],"URL":"https:\/\/doi.org\/10.3390\/genes17091021","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}