{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:05:15Z","timestamp":1789646715522,"version":"4.0.0"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2021C02070-9"],"award-info":[{"award-number":["2021C02070-9"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2021C02070-9"],"award-info":[{"award-number":["2021C02070-9"]}],"id":[{"id":"https:\/\/ror.org\/05yj3y977","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: We compared juvenile whole-stem transcriptomes of Quercus glauca, Quercus acutissima, Quercus fabri, and Castanopsis sclerophylla to examine carbon metabolism and transport. Methods: Three seedlings per species were sampled in one session. RNA sequencing (RNA-seq) data were analyzed using differential-expression analysis, direction-specific Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, gene set enrichment analysis (GSEA), and leading-edge analysis. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed on aliquots from the same RNA extractions. Results: Reference-based analyses identified 8596\u201311,823 differentially expressed genes across six contrasts. GSEA detected 25 significant pathway-by-contrast associations across 13 pathways at a false discovery rate below 0.05. Q. glauca showed photosynthesis, starch turnover, and flavonoid pathway signals. Q. acutissima showed sugar-metabolism and ATP-binding cassette (ABC) transport signals, with XTH23 providing an annotation-based wall-remodeling candidate. Q. fabri showed enrichment of sulfur amino acid metabolism, nucleotide sugar metabolism, and mitogen-activated protein kinase signaling. C. sclerophylla showed ABC transport and galactose metabolism enrichment, with candidates annotated for raffinose synthesis and extracellular sucrose cleavage. Eleven of 12 candidates were present in at least one significant GSEA leading edge; XTH23 was selected using differential expression and annotation. Both assays identified the same species as having the highest expression for every candidate; eight genes also showed the same rank order across all four species. Conclusions: The sampled stems differed in the expression of genes associated with carbon metabolism, transport, and regulation. These whole-stem patterns provide candidates for tissue-resolved and physiological studies.<\/jats:p>","DOI":"10.3390\/genes17091139","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:41:35Z","timestamp":1789645295000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Transcriptomics Reveals Divergent Expression Patterns Related to Carbon Metabolism, Transport, and Regulation in Juvenile Stems of Four Fagaceae Species"],"prefix":"10.3390","volume":"17","author":[{"given":"Xiyuan","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, No. 1 Dongxiaofu, Xiangshan Road, Haidian District, Beijing 100091, China"},{"name":"Research Institute of Subtropical Forestry, Chinese Academy of Forestry, No. 73 Daqiao Road, Fuyang District, Hangzhou 311400, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Liwen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, No. 1 Dongxiaofu, Xiangshan Road, Haidian District, Beijing 100091, China"},{"name":"Research Institute of Subtropical Forestry, Chinese Academy of Forestry, No. 73 Daqiao Road, Fuyang District, Hangzhou 311400, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Yangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, No. 1 Dongxiaofu, Xiangshan Road, Haidian District, Beijing 100091, China"},{"name":"Research Institute of Subtropical Forestry, Chinese Academy of Forestry, No. 73 Daqiao Road, Fuyang District, Hangzhou 311400, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1093\/jxb\/erx200","article-title":"Spatially Resolved Metabolic Analysis Reveals a Central Role for Transcriptional Control in Carbon Allocation to Wood","volume":"68","author":"Roach","year":"2017","journal-title":"J. Exp. Bot."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1105\/tpc.104.024190","article-title":"A High-Resolution Transcript Profile across the Wood-Forming Meristem of Poplar Identifies Potential Regulators of Cambial Stem Cell Identity","volume":"16","author":"Schrader","year":"2004","journal-title":"Plant Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1105\/tpc.17.00153","article-title":"AspWood: High-Spatial-Resolution Transcriptome Profiles Reveal Uncharacterized Modularity of Wood Formation in Populus tremula","volume":"29","author":"Sundell","year":"2017","journal-title":"Plant Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1111\/j.1365-3040.2010.02197.x","article-title":"Woody Tissue Photosynthesis and Its Contribution to Trunk Growth and Bud Development in Young Plants","volume":"33","author":"Saveyn","year":"2010","journal-title":"Plant Cell Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1104\/pp.125.4.2029","article-title":"Function and Dynamics of Auxin and Carbohydrates during Earlywood\/Latewood Transition in Scots Pine","volume":"125","author":"Uggla","year":"2001","journal-title":"Plant Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/nph.16162","article-title":"Genomic Landscape of the Global Oak Phylogeny","volume":"226","author":"Hipp","year":"2020","journal-title":"New Phytol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: A Revolutionary Tool for Transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Qin, S., Fu, S., Yang, Y., Sun, Q., Wang, J., Dong, Y., Gu, X., Wang, T., Xie, X., and Mo, X. (2023). Comparative Microscopic, Transcriptome and IAA Content Analyses Reveal the Stem Growth Variations in Two Cultivars Ilex verticillata. Plants, 12.","DOI":"10.3390\/plants12101941"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T.T., Kim, M.-H., Park, E.-J., Lee, H., and Ko, J.-H. (2023). Seasonal Developing Xylem Transcriptome Analysis of Pinus densiflora Unveils Novel Insights for Compression Wood Formation. Genes, 14.","DOI":"10.3390\/genes14091698"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wu, X., Xiao, Y., Liu, P., Pang, Q., Deng, C., Fu, C., Fang, H., and Chen, C. (2025). Identification and Functional Analysis of Candidate Genes Influencing Citrus Leaf Size Through Transcriptome and Coexpression Network Approaches. Genes, 16.","DOI":"10.3390\/genes16010097"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lin, Y., Zheng, J., Wan, Q., Chen, Z., Chen, Q., Wan, S., and Chen, J. (2025). Identification of Key Pathways and Candidate Genes Controlling Organ Size Through Transcriptome and Weighted Gene Co-Expression Network Analyses in Navel Orange Plants (Citrus sinensis). Genes, 16.","DOI":"10.3390\/genes16030259"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/plphys\/kiac420","article-title":"Gene Expression and Genetic Divergence in Oak Species Highlight Adaptive Genes to Soil Water Constraints","volume":"190","author":"Brachi","year":"2022","journal-title":"Plant Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xiong, S., Wang, Y., Chen, Y., Gao, M., Zhao, Y., and Wu, L. (2022). Effects of Drought Stress and Rehydration on Physiological and Biochemical Properties of Four Oak Species in China. Plants, 11.","DOI":"10.21203\/rs.3.rs-605400\/v2"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116284","DOI":"10.1016\/j.indcrop.2023.116284","article-title":"Transcriptome and Proteome Analyses Reveal a Critical Role of the Sucrose Anabolic Pathway in Regulating Quercus fabri Hance Axillary Bud Outgrowth","volume":"194","author":"Xiong","year":"2023","journal-title":"Ind. Crop. Prod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105373","DOI":"10.1016\/j.jprot.2024.105373","article-title":"Multi-Omics Analysis Reveals the Regulatory Mechanism of Branching Development in Quercus fabri","volume":"313","author":"Xiong","year":"2025","journal-title":"J. Proteom."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kim, T.-L., Oh, C., Denison, M.I.J., Natarajan, S., Lee, K., and Lim, H. (2024). Transcriptomic and Physiological Responses of Quercus acutissima and Quercus palustris to Drought Stress and Rewatering. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1430485"},{"key":"ref_17","first-page":"632","article-title":"Whole-Transcriptome Response to Water Stress in a California Endemic Oak, Quercus lobata","volume":"37","author":"Gugger","year":"2017","journal-title":"Tree Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev-arplant-042809-112301","article-title":"Starch: Its Metabolism, Evolution, and Biotechnological Modification in Plants","volume":"61","author":"Zeeman","year":"2010","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-arplant-050213-040251","article-title":"Sucrose Metabolism: Gateway to Diverse Carbon Use and Sugar Signaling","volume":"65","author":"Ruan","year":"2014","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/pcp\/pcf171","article-title":"The XTH Family of Enzymes Involved in Xyloglucan Endotransglucosylation and Endohydrolysis: Current Perspectives and a New Unifying Nomenclature","volume":"43","author":"Rose","year":"2002","journal-title":"Plant Cell Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrm1746","article-title":"Growth of the Plant Cell Wall","volume":"6","author":"Cosgrove","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/nph.17265","article-title":"Brassinosteroid\u2013BZR1\/2\u2013WAT1 Module Determines the High Level of Auxin Signalling in Vascular Cambium during Wood Formation","volume":"230","author":"Lee","year":"2021","journal-title":"New Phytol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"uhab048","DOI":"10.1093\/hr\/uhab048","article-title":"Integrated Transcriptome and Proteome Analysis Reveals Brassinosteroid-Mediated Regulation of Cambium Initiation and Patterning in Woody Stem","volume":"9","author":"Wang","year":"2022","journal-title":"Hortic. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100665","DOI":"10.1016\/j.xplc.2023.100665","article-title":"Combining Single-Cell RNA Sequencing with Spatial Transcriptome Analysis Reveals Dynamic Molecular Maps of Cambium Differentiation in the Primary and Secondary Growth of Trees","volume":"4","author":"Li","year":"2023","journal-title":"Plant Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.cub.2016.05.053","article-title":"Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity","volume":"26","author":"Immanen","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-018-03256-2","article-title":"Spatial Specificity of Auxin Responses Coordinates Wood Formation","volume":"9","author":"Brackmann","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/nph.16799","article-title":"A Metabolite Roadmap of the Wood-Forming Tissue in Populus tremula","volume":"228","author":"Abreu","year":"2020","journal-title":"New Phytol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1105\/tpc.19.00335","article-title":"Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses","volume":"32","author":"Nolan","year":"2020","journal-title":"Plant Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-phyto-082712-102314","article-title":"MAPK Cascades in Plant Disease Resistance Signaling","volume":"51","author":"Meng","year":"2013","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tplants.2010.02.006","article-title":"WRKY Transcription Factors","volume":"15","author":"Rushton","year":"2010","journal-title":"Trends Plant Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbagrm.2011.10.005","article-title":"NAC Transcription Factors in Plant Abiotic Stress Responses","volume":"1819","author":"Nakashima","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbagrm.2011.08.004","article-title":"AP2\/ERF Family Transcription Factors in Plant Abiotic Stress Responses","volume":"1819","author":"Mizoi","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/nph.15488","article-title":"Hydrogen Peroxide Metabolism and Functions in Plants","volume":"221","author":"Smirnoff","year":"2019","journal-title":"New Phytol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.molp.2023.05.010","article-title":"The LBD11\u2013ROS Feedback Regulatory Loop Modulates Vascular Cambium Proliferation and Secondary Growth in Arabidopsis","volume":"16","author":"Dang","year":"2023","journal-title":"Mol. Plant"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1111\/1755-0998.13616","article-title":"A Chromosome-Scale Genome Assembly of the Mongolian Oak (Quercus mongolica)","volume":"22","author":"Ai","year":"2022","journal-title":"Mol. Ecol. Resour."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R Package for Comparing Biological Themes among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/j.1742-4658.2005.04636.x","article-title":"Functional Dissection of Two Arabidopsis PsbO Proteins","volume":"272","author":"Murakami","year":"2005","journal-title":"FEBS J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/plphys\/kiab603","article-title":"A Dominant Mutation in \u03b2-AMYLASE1 Disrupts Nighttime Control of Starch Degradation in Arabidopsis Leaves","volume":"188","author":"Feike","year":"2022","journal-title":"Plant Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1105\/tpc.16.00855","article-title":"A Proteolytic Regulator Controlling Chalcone Synthase Stability and Flavonoid Biosynthesis in Arabidopsis","volume":"29","author":"Zhang","year":"2017","journal-title":"Plant Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1073\/pnas.0912516107","article-title":"ABC Transporter AtABCG25 Is Involved in Abscisic Acid Transport and Responses","volume":"107","author":"Kuromori","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1104\/pp.108.125237","article-title":"Mitochondrial Serine Acetyltransferase Functions as a Pacemaker of Cysteine Synthesis in Plant Cells","volume":"148","author":"Haas","year":"2008","journal-title":"Plant Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17276","DOI":"10.1074\/jbc.M512727200","article-title":"Distinct Properties of the Five UDP-D-Glucose\/UDP-D-Galactose 4-Epimerase Isoforms of Arabidopsis thaliana","volume":"281","author":"Barber","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1104\/pp.105.070128","article-title":"ABA-Hypersensitive Germination3 Encodes a Protein Phosphatase 2C (AtPP2CA) That Strongly Regulates Abscisic Acid Signaling during Germination among Arabidopsis Protein Phosphatase 2Cs","volume":"140","author":"Yoshida","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Egert, A., Keller, F., and Peters, S. (2013). Abiotic Stress-Induced Accumulation of Raffinose in Arabidopsis Leaves Is Mediated by a Single Raffinose Synthase. BMC Plant Biol., 13.","DOI":"10.1186\/1471-2229-13-218"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yan, W., Wu, X., Li, Y., Liu, G., Cui, Z., Jiang, T., Ma, Q., Luo, L., and Zhang, P. (2019). Cell Wall Invertase 3 Affects Cassava Productivity via Regulating Sugar Allocation from Source to Sink. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00541"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Jenness, M.K., Tayengwa, R., Bate, G.A., Tapken, W., Zhang, Y., Pang, C., and Murphy, A.S. (2022). Loss of Multiple ABCB Auxin Transporters Recapitulates the Major twisted dwarf 1 Phenotypes in Arabidopsis thaliana. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.840260"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hornett, E.A., and Wheat, C.W. (2012). Quantitative RNA-Seq Analysis in Non-Model Species: Assessing Transcriptome Assemblies as a Scaffold and the Utility of Evolutionary Divergent Genomic Reference Species. BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-361"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Torres-Oliva, M., Almudi, I., McGregor, A.P., and Posnien, N. (2016). A Robust (Re-)Annotation Approach to Generate Unbiased Mapping References for RNA-seq-Based Analyses of Differential Expression across Closely Related Species. BMC Genom., 17.","DOI":"10.1186\/s12864-016-2646-x"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btp579","article-title":"Effect of Read-Mapping Biases on Detecting Allele-Specific Expression from RNA-Sequencing Data","volume":"25","author":"Degner","year":"2009","journal-title":"Bioinformatics"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:53:48Z","timestamp":1789646028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["genes17091139"],"URL":"https:\/\/doi.org\/10.3390\/genes17091139","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}