{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:04:44Z","timestamp":1790053484678,"version":"4.0.1"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2023YFD1300100"],"award-info":[{"award-number":["2023YFD1300100"]}]},{"name":"National Key R&D Program of China","award":["2023YFD1300102"],"award-info":[{"award-number":["2023YFD1300102"]}]},{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunnan Province","award":["202449CE340020"],"award-info":[{"award-number":["202449CE340020"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["CARS-37"],"award-info":[{"award-number":["CARS-37"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Wuling cattle are a native breed in southern China and primarily inhabit mountainous regions. They are distributed across three geographically distinct mountainous regions and were historically classified into three local populations: Enshi cattle (western Hubei), Sinan cattle (eastern Guizhou) and Xiangxi cattle (western Hunan). Here, we aim to elucidate the genetic relationships and describe the genetic characteristics of Wuling cattle across these regions. Methods: We performed whole-genome resequencing of 20 Sinan cattle, together with public data of 10 Enshi cattle, 20 Xiangxi cattle and 65 cattle from four reference continental groups. Reads were aligned to the ARS-UCD1.2 reference genome. Genetic differences between different cattle breeds were assessed through analyses of population structure and genetic diversity. Selective signals in Wuling cattle were identified using single-population selective analysis and local ancestry inference, whilst potential differences between different Wuling cattle subpopulations were pinpointed using cross-population selective analysis. Results: On the basis of whole-genome resequencing data, Enshi, Sinan and Xiangxi cattle share highly similar genetic backgrounds (with similar ancestral lineages comprising East Asian taurine and East Asian indicine) and negligible genetic differentiation (the pairwise FST among Enshi cattle, Sinan cattle and Xiangxi cattle was approximately 0.01), supporting their classification as a single breed\u2014Wuling cattle. Selective sweep analysis in Wuling cattle revealed multiple genomic regions under selection associated with key biological processes, including reproduction, fat deposition, feed efficiency, skeletal and muscle development, and immune response. Part of these regions is derived from East Asian indicine, related with SYTL1, TMEM222, WDTC1 and SLC9A1. Furthermore, Wuling cattle are found in various regions, where geographical conditions vary. Distinct selective signals were also observed among regional groups of Wuling cattle, likely reflecting adaptation to their diverse local environments. Conclusions: This study provides a comprehensive genomic characterization of Wuling cattle, outlines the selection signals for Wuling cattle, whilst demonstrating that different geographical environments have generated unique selection pressures within the Wuling cattle population. Providing a genetic guidelines for the conservation and sustainable utilization of their genetic resources.<\/jats:p>","DOI":"10.3390\/genes17091141","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:47Z","timestamp":1789977827000},"page":"1141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-Genome Resequencing Reveals Genetic Diversity and Selective Sweep Signatures in Wuling Cattle"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2442-8326","authenticated-orcid":false,"given":"Kunyou","family":"Xian","sequence":"first","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"},{"name":"College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Yuee","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Zhiyi","family":"Su","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Yating","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Zexuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Xiaoqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Jicai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Halima","family":"Jafari","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Chuzhao","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ankui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beef Cattle Genetics, Breeding and Reproduction Technology of Yunan Province, Yunan Academy of Grassland and Animal Science, Kunming 650000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, H., Xia, X., Zeng, L., Yang, J., Han, J., MacHugh, D.E., Lenstra, J.A., Song, Y., Fan, A., and Zhu, Y. (2025). The Indicine X-linked CYBBL237M Mutation Can Suppress Intracellular Infection with Tubercle Bacilli. Genom. Proteom. Bioinform., qzaf131.","DOI":"10.1093\/gpbjnl\/qzaf131"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1073\/pnas.91.7.2757","article-title":"Evidence for two independent domestications of cattle","volume":"91","author":"Loftus","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e70108","DOI":"10.1002\/imt2.70108","article-title":"Climate factors drive the local adaptation of Old World cattle","volume":"5","author":"Sun","year":"2026","journal-title":"iMeta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/age.12836","article-title":"Genomic clues of the evolutionary history of Bos indicus cattle","volume":"50","author":"Utsunomiya","year":"2019","journal-title":"Anim. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1038\/s41467-018-04737-0","article-title":"Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, Y., Cheng, H., Wang, S., Luo, X., Ma, X., and Sun, L. (2022). Genomic Diversity and Selection Signatures for Weining Cattle on the Border of Yunnan-Guizhou. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.848951"},{"key":"ref_7","first-page":"e03258","article-title":"Structural Variations Associated with Adaptation and Coat Color in Qinghai-Tibetan Plateau Cattle","volume":"12","author":"Xia","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, C., Han, J., Chang, T., Jafari, H., Yang, Q., Guo, J., Lei, C., and Dang, R. (2025). Whole-genome analysis reveals genetic diversity and selection pressure in Sichuan donkey. BMC Genom., 26.","DOI":"10.1186\/s12864-025-12254-w"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1080\/10495398.2021.2009846","article-title":"Muscle transcriptome analysis reveal candidate genes and pathways related to fat and lipid metabolism in Yunling cattle","volume":"34","author":"Zhang","year":"2021","journal-title":"Anim. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Cheng, H., Lyu, Y., Liu, Z., Li, C., Qu, K., Li, S., Ahmed, Z., Ma, W., Qi, X., and Chen, N. (2024). A Whole-Genome Scan Revealed Genomic Features and Selection Footprints of Mengshan Cattle. Genes, 15.","DOI":"10.3390\/genes15091113"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Li, S., Liu, L., Ahmed, Z., Wang, F., Lei, C., and Sun, F. (2024). Identification of Heilongjiang crossbred beef cattle pedigrees and reveals functional genes related to economic traits based on whole-genome SNP data. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1435793"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2402924121","DOI":"10.1073\/pnas.2402924121","article-title":"Unraveling the genomic diversity and admixture history of captive tigers in the United States","volume":"121","author":"Armstrong","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/molbev\/msy126","article-title":"Loter: A Software Package to Infer Local Ancestry for a Wide Range of Species","volume":"35","author":"Mairal","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s44154-023-00101-5","article-title":"Local ancestry and selection in admixed Sanjiang cattle","volume":"3","author":"Lyu","year":"2023","journal-title":"Stress Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"btae006","DOI":"10.1093\/bioinformatics\/btae006","article-title":"selscan 2.0: Scanning for sweeps in unphased data","volume":"40","author":"Szpiech","year":"2024","journal-title":"Bioinformatics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/bioinformatics\/btw051","article-title":"SweepFinder2: Increased sensitivity, robustness and flexibility","volume":"32","author":"DeGiorgio","year":"2016","journal-title":"Bioinformatics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/age.13363","article-title":"A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province","volume":"54","author":"Lyu","year":"2023","journal-title":"Anim. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/mrd.22323","article-title":"Regulation of the polyamine metabolic pathway in the endometrium of cows during early diestrus","volume":"81","author":"Mesquita","year":"2014","journal-title":"Mol. Reprod. Dev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kiser, J.N., Keuter, E.M., Seabury, C.M., Neupane, M., Moraes, J.G.N., and Dalton, J. (2019). Validation of 46 loci associated with female fertility traits in cattle. BMC Genom., 20.","DOI":"10.1186\/s12864-019-5935-3"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40104-018-0283-8","article-title":"Residual feed intake in beef cattle and its association with carcass traits, ruminal solid-fraction bacteria, and epithelium gene expression","volume":"9","author":"Elolimy","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19227","DOI":"10.1074\/jbc.M110.105338","article-title":"Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects","volume":"285","author":"Matsumoto","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/jbg.12326","article-title":"Multimarker and rare variants genomewide association studies for bone weight in Simmental cattle","volume":"135","author":"Miao","year":"2018","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40104-025-01164-2","article-title":"Comprehensive characterization of lncRNA N(6)-methyladenosine modification dynamics throughout bovine skeletal muscle development","volume":"16","author":"Mao","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.15252\/embr.201540500","article-title":"The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase","volume":"17","author":"Groh","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/age.13242","article-title":"Integration analyses of structural variations and differential gene expression associated with beef fatty acid profile in Nellore cattle","volume":"53","author":"Berton","year":"2022","journal-title":"Anim. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110725","DOI":"10.1016\/j.vetmic.2025.110725","article-title":"Identification of bovine genotypes conferring diminished susceptibility to salmonellosis and colonization by Salmonella and E. coli O157:H7","volume":"310","author":"Anderson","year":"2025","journal-title":"Vet. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huang, Y., Guo, S., Lin, Y., Huo, L., Yan, H., and Lin, Z. (2023). LincRNA01703 Facilitates CD81+ Exosome Secretion to Inhibit Lung Adenocarcinoma Metastasis via the Rab27a\/SYTL1\/CD81 Complex. Cancers, 15.","DOI":"10.3390\/cancers15245781"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"475-e180","DOI":"10.1111\/j.1365-2982.2011.01685.x","article-title":"Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn\u2019s disease and diverticular disease: A role for hemokinin-1?","volume":"23","author":"Liu","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1016\/j.scib.2024.05.030","article-title":"Recent selection and introgression facilitated high-altitude adaptation in cattle","volume":"69","author":"Lyu","year":"2024","journal-title":"Sci. Bull."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Li, Y., Yang, H., Zhang, X., He, X., Liuli, A., Li, R., Han, X., Li, Y., and Gao, P. (2025). Integrated proteomic and metabolomic profiling identifies distinct molecular signatures and metabolic pathways associated with obesity and potential targets for anti-obesity therapies. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1625501"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1017\/S1751731114002754","article-title":"Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle","volume":"9","author":"Hudson","year":"2015","journal-title":"Animal"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/asj.13030","article-title":"Genome-wide association studies identified variants for taurine concentration in Japanese Black beef","volume":"89","author":"Sasago","year":"2018","journal-title":"Anim. Sci. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1530\/REP-15-0586","article-title":"Roles of EDNs in regulating oviductal NO synthesis and smooth muscle motility in cows","volume":"151","author":"Kobayashi","year":"2016","journal-title":"Reproduction"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Verardo, L.L., e Silva, F.F., Machado, M.A., do Carmo Panetto, J.C., de Lima Reis Faza, D.R., Otto, P.I., de Almeida Regitano, L.C., da Silva, L.O.C., do Egito, A.A., and do Socorro Mau\u00e9s Albuquerque, M. (2021). Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.702822"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/10495398.2020.1772802","article-title":"A molecular marker of milk composition traits in NCAM2 gene of Chinese Holstein","volume":"33","author":"Ding","year":"2022","journal-title":"Anim. Biotechnol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15685","DOI":"10.1038\/s41598-025-93021-5","article-title":"DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits","volume":"15","author":"Muansangi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kostyunina, O.V., Mityashova, O.S., Bardukov, N.V., Aleynikova, O.V., and Lebedeva, I.Y. (2023). DIO1 Gene Polymorphism Is Associated with Thyroid Profiles and Reproductive Performance in Dairy Cows. Agriculture, 13.","DOI":"10.3390\/agriculture13020398"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7827-11-3","article-title":"Changes in the transcriptome of morula-stage bovine embryos caused by heat shock: Relationship to developmental acquisition of thermotolerance","volume":"11","author":"Sakatani","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuron.2019.12.028","article-title":"LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells","volume":"105","author":"Sinha","year":"2020","journal-title":"Neuron"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, W., Gao, X., Zhang, Y., Zhao, Y., Zhang, J., Jia, Y., Zhu, B., Xu, L., Zhang, L., and Gao, H. (2018). Genome-wide assessment of genetic diversity and population structure insights into admixture and introgression in Chinese indigenous cattle. BMC Genet., 19.","DOI":"10.1186\/s12863-018-0705-9"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"32168","DOI":"10.1038\/s41598-025-09103-x","article-title":"Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study","volume":"15","author":"Maddahi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Pan, C., Lei, Z., Wang, S., Wang, X., Wei, D., and Cai, X. (2021). Genome-wide identification of cyclin-dependent kinase (CDK) genes affecting adipocyte differentiation in cattle. BMC Genom., 22.","DOI":"10.1186\/s12864-021-07653-8"},{"key":"ref_46","first-page":"e569","article-title":"Increases in the expression of Na+\/H+ exchanger 1 and 3 are associated with insulin signalling in the ruminal epithelium","volume":"102","author":"Yan","year":"2017","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s10815-018-1320-4","article-title":"Variants in the CYP19A1 gene can affect in vitro embryo production traits in cattle","volume":"35","author":"Vega","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lu, X., Duan, A., Ma, X., Liang, S., and Deng, T. (2020). Knockdown of CYP19A1 in Buffalo Follicular Granulosa Cells Results in Increased Progesterone Secretion and Promotes Cell Proliferation. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.539496"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1141\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:30:21Z","timestamp":1790051421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/17\/9\/1141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["genes17091141"],"URL":"https:\/\/doi.org\/10.3390\/genes17091141","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}