{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:35:16Z","timestamp":1790642116746,"version":"4.1.0"},"reference-count":218,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Duchenne muscular dystrophy (DMD) is caused by defects in the DMD gene and results in progressive wasting of skeletal and cardiac muscle due to an absence of functional dystrophin. Cardiomyopathy is prominent in DMD patients, and contributes significantly to mortality. This is particularly true following respiratory interventions that reduce death rate and increase ambulation and consequently cardiac load. Cardiomyopathy shows an increasing prevalence with age and disease progression, and over 95% of patients exhibit dilated cardiomyopathy by the time they reach adulthood. Development of the myopathy is complex, and elevations in intracellular calcium, functional muscle ischemia, and mitochondrial dysfunction characterise the pathophysiology. Current therapies are limited to treating symptoms of the disease and there is therefore an urgent need to treat the underlying genetic defect. Several novel therapies are outlined here, and the unprecedented success of phosphorodiamidate morpholino oligomers (PMOs) in preclinical and clinical studies is overviewed.<\/jats:p>","DOI":"10.3390\/genes8040108","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:38:27Z","timestamp":1490355507000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dystrophic Cardiomyopathy\u2014Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-3607","authenticated-orcid":false,"given":"Victoria P. A.","family":"Johnstone","sequence":"first","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Viola","sequence":"additional","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia C.","family":"Hool","sequence":"additional","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, Crawley, WA 6009, Australia"},{"name":"Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (CDC) (2009). Prevalence of duchenne\/becker muscular dystrophy among males aged 5\u201324 years\u2014Four states, 2007. Morb. Mortal. Wkly. Rep., 58, 1119\u20131122."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/cphy.c140048","article-title":"The dystrophin complex: Structure, function, and implications for therapy","volume":"5","author":"Gao","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nrm2024","article-title":"Molecular mechanisms of muscular dystrophies: Old and new players","volume":"7","author":"Davies","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.jacc.2016.02.081","article-title":"Dystrophin-deficient cardiomyopathy","volume":"67","author":"Kamdar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0167-5273(90)90082-G","article-title":"The incidence and evolution of cardiomyopathy in duchenne muscular dystrophy","volume":"26","author":"Nigro","year":"1990","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.yjmcc.2012.12.009","article-title":"Cardiac phenotype of duchenne muscular dystrophy: Insights from cellular studies","volume":"58","author":"Shirokova","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ppul.23215","article-title":"Cardiac phenotype determines survival in duchenne muscular dystrophy","volume":"51","author":"Birnkrant","year":"2016","journal-title":"Pediatr. Pulmonol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1532-429X-15-107","article-title":"Prevalence and distribution of late gadolinium enhancement in a large population of patients with duchenne muscular dystrophy: Effect of age and left ventricular systolic function","volume":"15","author":"Hor","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10554-010-9781-2","article-title":"Patterns of left ventricular remodeling in patients with duchenne muscular dystrophy: A cardiac mri study of ventricular geometry, global function, and strain","volume":"28","author":"Mazur","year":"2012","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nmd.2010.04.008","article-title":"Hereditary muscular dystrophies and the heart","volume":"20","author":"Hermans","year":"2010","journal-title":"Neuromusc. Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/0002-8703(92)90407-M","article-title":"The prevalence and prognostic significance of arrhythmias in duchenne type muscular dystrophy","volume":"124","author":"Yanagisawa","year":"1992","journal-title":"Am. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0960-8966(93)90060-W","article-title":"Ventricular arrhythmia in duchenne muscular dystrophy: Prevalence, significance and prognosis","volume":"3","author":"Chenard","year":"1993","journal-title":"Neuromusc. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.3390\/molecules20058823","article-title":"Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy","volume":"20","author":"Betts","year":"2015","journal-title":"Molecules"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"35375","DOI":"10.1074\/jbc.274.50.35375","article-title":"Utrophin lacks the rod domain actin binding activity of dystrophin","volume":"274","author":"Amann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00028.2001","article-title":"Function and genetics of dystrophin and dystrophin-related proteins in muscle","volume":"82","author":"Blake","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"28419","DOI":"10.1074\/jbc.273.43.28419","article-title":"A cluster of basic repeats in the dystrophin rod domain binds f-actin through an electrostatic interaction","volume":"273","author":"Amann","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1083\/jcb.142.6.1461","article-title":"Progressive muscular dystrophy in \u03b1-sarcoglycan-deficient mice","volume":"142","author":"Duclos","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.139.2.375","article-title":"Animal models for muscular dystrophy show different patterns of sarcolemmal disruption","volume":"139","author":"Straub","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pediatrneurol.2006.09.016","article-title":"Pathophysiology of duchenne muscular dystrophy: Current hypotheses","volume":"36","author":"Deconinck","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"H767","DOI":"10.1152\/ajpheart.00700.2012","article-title":"L-type Ca(2+) channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte","volume":"304","author":"Viola","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/mus.880050306","article-title":"Membrane myopathy: Morphological similarities to duchenne muscular dystrophy","volume":"5","author":"Pestronk","year":"1982","journal-title":"Muscle Nerve"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1212\/WNL.25.12.1111","article-title":"Duchenne dystrophy: Electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber","volume":"25","author":"Mokri","year":"1975","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1083\/jcb.119.5.1183","article-title":"Direct visualization of the dystrophin network on skeletal muscle fiber membrane","volume":"119","author":"Straub","year":"1992","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.nmd.2004.08.004","article-title":"Albumin targeting of damaged muscle fibres in the mdx mouse can be monitored by mri","volume":"14","author":"Amthor","year":"2004","journal-title":"Neuromusc. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mus.21716","article-title":"Timeline of cardiac dystrophy in 3\u201318-month-old mdx mice","volume":"42","author":"Loch","year":"2010","journal-title":"Muscle Nerve"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nature03844","article-title":"Dystrophic heart failure blocked by membrane sealant poloxamer","volume":"436","author":"Yasuda","year":"2005","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ceca.2009.06.002","article-title":"Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes","volume":"46","author":"Fanchaouy","year":"2009","journal-title":"Cell Calcium"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.biocel.2010.11.005","article-title":"Duchenne muscular dystrophy\u2014What causes the increased membrane permeability in skeletal muscle?","volume":"43","author":"Allen","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1113\/jphysiol.2004.075275","article-title":"Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse","volume":"562","author":"Yeung","year":"2005","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pbiomolbio.2008.02.009","article-title":"Stretch-activated channels in the heart: Contributions to length-dependence and to cardiomyopathy","volume":"97","author":"Ward","year":"2008","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1113\/jphysiol.1994.sp020440","article-title":"Mechanosensitive ion channels in skeletal muscle from normal and dystrophic mice","volume":"481","author":"Lansman","year":"1994","journal-title":"J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0960-8966(00)00153-X","article-title":"Cationic channels in normal and dystrophic human myotubes","volume":"11","author":"Vandebrouck","year":"2001","journal-title":"Neuromusc. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"H846","DOI":"10.1152\/ajpheart.00688.2006","article-title":"Intracellular calcium handling in ventricular myocytes from mdx mice","volume":"292","author":"Williams","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0906591106","article-title":"Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism","volume":"106","author":"Millay","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1161\/CIRCRESAHA.114.302614","article-title":"Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation","volume":"114","author":"Seo","year":"2014","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/cvr\/cvv021","article-title":"Dystrophic cardiomyopathy: Role of TRPV2 channels in stretch-induced cell damage","volume":"106","author":"Lorin","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.yjmcc.2012.11.017","article-title":"Calcium flux balance in the heart","volume":"58","author":"Eisner","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1172\/JCI43844","article-title":"Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle","volume":"121","author":"Goonasekera","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1089\/hum.2010.077","article-title":"Overexpression of serca1a in the mdx diaphragm reduces susceptibility to contraction-induced damage","volume":"21","author":"Morine","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvu119","article-title":"Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in duchenne muscular dystrophy","volume":"103","author":"Li","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2003.09.005","article-title":"Decreased makap, ryanodine receptor, and SERCA2A gene expression in mdx hearts","volume":"310","author":"Rohman","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.bbamcr.2012.08.016","article-title":"Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and ec-coupling","volume":"1833","author":"Niggli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1161\/01.RES.0000125626.33738.E2","article-title":"Ca2+\/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor","volume":"94","author":"Wehrens","year":"2004","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1161\/CIRCRESAHA.112.268094","article-title":"Role of RYR2 phosphorylation at S2814 during heart failure progression","volume":"110","author":"Respress","year":"2012","journal-title":"Circ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1172\/JCI37649","article-title":"Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice","volume":"120","author":"Shan","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1073\/pnas.0908540107","article-title":"Leaky RYR2 trigger ventricular arrhythmias in duchenne muscular dystrophy","volume":"107","author":"Fauconnier","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/(SICI)1097-4598(199807)21:7<902::AID-MUS8>3.0.CO;2-A","article-title":"Differences in both inositol 1,4,5-trisphosphate mass and inositol 1,4,5-trisphosphate receptors between normal and dystrophic skeletal muscle cell lines","volume":"21","author":"Liberona","year":"1998","journal-title":"Muscle Nerve"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.bbrc.2014.09.045","article-title":"Age-dependent changes in diastolic Ca2+ and Na+ concentrations in dystrophic cardiomyopathy: Role of Ca2+ entry and IP3","volume":"452","author":"Mijares","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1074\/jbc.M006337200","article-title":"Alteration in calcium handling at the subcellular level in mdx myotubes","volume":"276","author":"Robert","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.physiol.010908.163216","article-title":"Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies","volume":"71","author":"Wallace","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0031-3955(16)32067-3","article-title":"Muscle biopsies in neuromuscular diseases","volume":"14","author":"Engel","year":"1967","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/archneur.1970.00480220079011","article-title":"Experimental myopathy after microarterial embolization: Comparison with childhood X-linked pseudohypertrophic muscular dystrophy","volume":"22","author":"Hathaway","year":"1970","journal-title":"Arch. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.172.3988.1143","article-title":"Duchenne muscular dystrophy: Functional ischemia reproduces its characteristic lesions","volume":"172","author":"Mendell","year":"1971","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/239522a0","article-title":"Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of duchenne muscular dystrophy","volume":"239","author":"Mendell","year":"1972","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20120787","article-title":"Nitric oxide signalling pathway in duchenne muscular dystrophy mice: Up-regulation of L-arginine transporters","volume":"449","author":"Ramachandran","year":"2013","journal-title":"Biochem. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1006\/jmcc.1999.1018","article-title":"Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of duchenne muscular dystrophy","volume":"31","author":"Bia","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13663","DOI":"10.1073\/pnas.1512991112","article-title":"Dystrophin-glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of ampk signaling","volume":"112","author":"Garbincius","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0092-8674(95)90471-9","article-title":"Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in duchenne muscular dystrophy","volume":"82","author":"Brenman","year":"1995","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1073\/pnas.93.17.9142","article-title":"Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy","volume":"93","author":"Chang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI36612","article-title":"Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy","volume":"119","author":"Lai","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1073\/pnas.1211431109","article-title":"Alpha2 and alpha3 helices of dystrophin R16 and R17 frame a microdomain in the alpha1 helix of dystrophin R17 for neuronal NOS binding","volume":"110","author":"Lai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1469-7793.1998.817bv.x","article-title":"Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle","volume":"506","author":"Thomas","year":"1998","journal-title":"J. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15090","DOI":"10.1073\/pnas.95.25.15090","article-title":"Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle","volume":"95","author":"Thomas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.RES.0000061570.83105.52","article-title":"Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal nitric oxide synthase","volume":"92","author":"Thomas","year":"2003","journal-title":"Circ. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"13818","DOI":"10.1073\/pnas.250379497","article-title":"Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with duchenne muscular dystrophy","volume":"97","author":"Sander","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/jphysiol.2001.013153","article-title":"Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle","volume":"540","author":"Chavoshan","year":"2002","journal-title":"J. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"162ra155","DOI":"10.1126\/scitranslmed.3004327","article-title":"Tadalafil alleviates muscle ischemia in patients with becker muscular dystrophy","volume":"4","author":"Martin","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1093\/hmg\/ddu029","article-title":"Partial restoration of cardiac function with deltapdz nNOS in aged mdx model of duchenne cardiomyopathy","volume":"23","author":"Lai","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fphys.2013.00381","article-title":"Functional muscle ischemia in duchenne and becker muscular dystrophy","volume":"4","author":"Thomas","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0092-8674(00)81728-6","article-title":"Apoptotic pathways: The roads to ruin","volume":"94","author":"Green","year":"1998","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S1471-4914(03)00046-7","article-title":"Mitochondria in cell death: Novel targets for neuroprotection and cardioprotection","volume":"9","author":"Mattson","year":"2003","journal-title":"Trends Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.yjmcc.2009.09.004","article-title":"Alterations in mitochondrial function as a harbinger of cardiomyopathy: Lessons from the dystrophic heart","volume":"48","author":"Burelle","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yjmcc.2007.05.015","article-title":"Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy","volume":"43","author":"Khairallah","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"H144","DOI":"10.1152\/ajpheart.00522.2010","article-title":"Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil","volume":"300","author":"Ascah","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm1736","article-title":"Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy","volume":"14","author":"Millay","year":"2008","journal-title":"Nat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E2905","DOI":"10.1073\/pnas.1402544111","article-title":"Impaired functional communication between the L-type calcium channel and mitochondria contributes to metabolic inhibition in the mdx heart","volume":"111","author":"Viola","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.yjmcc.2008.12.015","article-title":"Evidence for regulation of mitochondrial function by the L-type Ca2+ channel in ventricular myocytes","volume":"46","author":"Viola","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1440-1681.2009.05277.x","article-title":"Cross-talk between L-type Ca2+ channels and mitochondria","volume":"37","author":"Viola","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/1440-1681.12072","article-title":"Role of the cytoskeleton in communication between L-type Ca2+ channels and mitochondria","volume":"40","author":"Viola","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1096\/fj.01-0855com","article-title":"The carboxyl-terminal region of ahnak provides a link between cardiac l-type Ca2+ channels and the actin-based cytoskeleton","volume":"16","author":"Hohaus","year":"2002","journal-title":"FASEB J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0960-8966(02)00140-2","article-title":"Survival in duchenne muscular dystrophy: Improvements in life expectancy since 1967 and the impact of home nocturnal ventilation","volume":"12","author":"Eagle","year":"2002","journal-title":"Neuromusc. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.rehab.2013.06.002","article-title":"Evolution of life expectancy of patients with duchenne muscular dystrophy at afm yolaine de kepper centre between 1981 and 2011","volume":"56","author":"Kieny","year":"2013","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/mus.23807","article-title":"The cooperative international neuromuscular research group duchenne natural history study\u2014A longitudinal investigation in the era of glucocorticoid therapy: Design of protocol and the methods used","volume":"48","author":"McDonald","year":"2013","journal-title":"Muscle Nerve"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/mus.22097","article-title":"Cardiomyopathy of duchenne muscular dystrophy: Current understanding and future directions","volume":"44","author":"Spurney","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1161\/CIRCULATIONAHA.114.015151","article-title":"Contemporary cardiac issues in duchenne muscular dystrophy. Working group of the national heart, lung, and blood institute in collaboration with parent project muscular dystrophy","volume":"131","author":"McNally","year":"2015","journal-title":"Circulation"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.nmd.2004.05.006","article-title":"Report on the 124th enmc international workshop. Treatment of duchenne muscular dystrophy; defining the gold standards of management in the use of corticosteroids. 2\u20134 April 2004, Naarden, The Netherlands","volume":"14","author":"Bushby","year":"2004","journal-title":"Neuromusc. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nmd.2006.01.010","article-title":"Long-term benefits of deflazacort treatment for boys with duchenne muscular dystrophy in their second decade","volume":"16","author":"Biggar","year":"2006","journal-title":"Neuromusc. Disord."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/archneur.1991.00530160047012","article-title":"Prednisone in duchenne dystrophy. A randomized, controlled trial defining the time course and dose response. Clinical investigation of duchenne dystrophy group","volume":"48","author":"Griggs","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/bmj.282.6261.351","article-title":"Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown","volume":"282","author":"Elia","year":"1981","journal-title":"Br. Med. J."},{"key":"ref_92","first-page":"E67","article-title":"Effect of prednisone on protein metabolism in duchenne dystrophy","volume":"268","author":"Rifai","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcp.1041020105","article-title":"A synergistic effect of glucocorticoids and insulin on the differentiation of myoblasts","volume":"102","author":"Ball","year":"1980","journal-title":"J. Cell. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/BF00869001","article-title":"Prednisone can protect against exercise-induced muscle damage","volume":"243","author":"Jacobs","year":"1996","journal-title":"J. Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/096368970000900411","article-title":"Deflazacort increases laminin expression and myogenic repair, and induces early persistent functional gain in mdx mouse muscular dystrophy","volume":"9","author":"Anderson","year":"2000","journal-title":"Cell Transplant."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1111\/j.1476-5381.1995.tb15930.x","article-title":"Modulation by prednisolone of calcium handling in skeletal muscle cells","volume":"116","author":"Metzinger","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjp.0702036","article-title":"Calcium influx inhibition by steroids and analogs in c2c12 skeletal muscle cells","volume":"124","author":"Passaquin","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0960-8966(94)00042-8","article-title":"The effect of glucocorticoids on the accumulation of utrophin by cultured normal and dystrophic human skeletal muscle satellite cells","volume":"5","author":"Pasquini","year":"1995","journal-title":"Neuromusc. Disord."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jpeds.2013.05.060","article-title":"Oral corticosteroids and onset of cardiomyopathy in duchenne muscular dystrophy","volume":"163","author":"Barber","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1517\/14728214.2012.691965","article-title":"Emerging drugs for duchenne muscular dystrophy","volume":"17","author":"Malik","year":"2012","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/01.CIR.100.10.1032","article-title":"Role of angiotensin receptor blockers in heart failure: Not yet resolvd","volume":"100","author":"Greenberg","year":"1999","journal-title":"Circulation"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1161\/CIRCULATIONAHA.104.528281","article-title":"Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy","volume":"112","author":"Jefferies","year":"2005","journal-title":"Circulation"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1006\/jmcc.2002.2088","article-title":"Molecular mechanisms of myocardial remodeling. The role of aldosterone","volume":"34","author":"Delcayre","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.amjcard.2012.02.064","article-title":"Effects of angiotensin-converting enzyme inhibitors and\/or beta blockers on the cardiomyopathy in duchenne muscular dystrophy","volume":"110","author":"Viollet","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jjcc.2008.08.013","article-title":"Beneficial effects of beta-blockers and angiotensin-converting enzyme inhibitors in duchenne muscular dystrophy","volume":"53","author":"Ogata","year":"2009","journal-title":"J. Cardiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/heartjnl-2011-300254","article-title":"Cardiac involvement in muscular dystrophy: Advances in diagnosis and therapy","volume":"98","author":"Yilmaz","year":"2012","journal-title":"Heart"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.89.10.4524","article-title":"Surfactant-induced sealing of electropermeabilized skeletal muscle membranes in vivo","volume":"89","author":"Lee","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1172\/JCI41329","article-title":"Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs","volume":"120","author":"Townsend","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"139ra85","DOI":"10.1126\/scitranslmed.3003921","article-title":"Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy","volume":"4","author":"Weisleder","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/360591a0","article-title":"Primary structure of dystrophin-related protein","volume":"360","author":"Tinsley","year":"1992","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1113\/expphysiol.2010.053025","article-title":"Progress in therapy for duchenne muscular dystrophy","volume":"96","author":"Fairclough","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Moorwood, C., Lozynska, O., Suri, N., Napper, A.D., Diamond, S.L., and Khurana, T.S. (2011). Drug discovery for duchenne muscular dystrophy via utrophin promoter activation screening. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026169"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"13856","DOI":"10.1073\/pnas.0405972101","article-title":"Heregulin ameliorates the dystrophic phenotype in mdx mice","volume":"101","author":"Krag","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1051\/jbio:2005003","article-title":"Pharmacological treatments for duchenne and becker dystrophies","volume":"199","author":"Voisin","year":"2005","journal-title":"J. Soc. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1093\/hmg\/ddp431","article-title":"Pharmacological activation of pparbeta\/delta stimulates utrophin a expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice","volume":"18","author":"Miura","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Sonnemann, K.J., Heun-Johnson, H., Turner, A.J., Baltgalvis, K.A., Lowe, D.A., and Ervasti, J.M. (2009). Functional substitution by tat-utrophin in dystrophin-deficient mice. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000083"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbrc.2009.04.127","article-title":"Rhoa leads to up-regulation and relocalization of utrophin in muscle fibers","volume":"384","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1073\/pnas.1013067108","article-title":"Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice","volume":"108","author":"Amenta","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1177\/0883073810371129","article-title":"Read-through strategies for suppression of nonsense mutations in duchenne\/becker muscular dystrophy: Aminoglycosides and ataluren (ptc124)","volume":"25","author":"Finkel","year":"2010","journal-title":"J. Child Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/mus.23738","article-title":"Gene and cell-mediated therapies for muscular dystrophy","volume":"47","author":"Konieczny","year":"2013","journal-title":"Muscle Nerve"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ana.22024","article-title":"Gentamicin-induced readthrough of stop codons in duchenne muscular dystrophy","volume":"67","author":"Malik","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature05756","article-title":"Ptc124 targets genetic disorders caused by nonsense mutations","volume":"447","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/0091270006297140","article-title":"Safety, tolerability, and pharmacokinetics of ptc124, a nonaminoglycoside nonsense mutation suppressor, following single- and multiple-dose administration to healthy male and female adult volunteers","volume":"47","author":"Hirawat","year":"2007","journal-title":"J. Clin. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Finkel, R.S., Flanigan, K.M., Wong, B., Bonnemann, C., Sampson, J., Sweeney, H.L., Reha, A., Northcutt, V.J., Elfring, G., and Barth, J. (2013). Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation duchenne muscular dystrophy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081302"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/mus.24332","article-title":"Ataluren treatment of patients with nonsense mutation dystrophinopathy","volume":"50","author":"Bushby","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S0960-8966(02)00078-0","article-title":"Viral vectors for gene transfer of micro-, mini-, or full-length dystrophin","volume":"12","author":"Scott","year":"2002","journal-title":"Neuromusc. Disord."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1161\/01.CIR.0000089371.11664.27","article-title":"Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart","volume":"108","author":"Yue","year":"2003","journal-title":"Circulation"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1089\/hum.2008.058","article-title":"Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice","volume":"19","author":"Bostick","year":"2008","journal-title":"Hum. Gene Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1089\/hum.2011.017","article-title":"Long-term preservation of cardiac structure and function after adeno-associated virus serotype 9-mediated microdystrophin gene transfer in mdx mice","volume":"23","author":"Schinkel","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/gt.2011.36","article-title":"Improvement of cardiac fibrosis in dystrophic mice by raav9-mediated microdystrophin transduction","volume":"18","author":"Shin","year":"2011","journal-title":"Gene Ther."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/sj.mt.6300144","article-title":"Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure","volume":"15","author":"Townsend","year":"2007","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.yjmcc.2012.05.002","article-title":"Aav micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of duchenne muscular dystrophy cardiomyopathy","volume":"53","author":"Bostick","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/mt.2011.154","article-title":"Aav-microdystrophin therapy improves cardiac performance in aged female mdx mice","volume":"19","author":"Bostick","year":"2011","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrg3460","article-title":"Therapy for duchenne muscular dystrophy: Renewed optimism from genetic approaches","volume":"14","author":"Fairclough","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2012.04.078","article-title":"Gene therapy for muscular dystrophy: Lessons learned and path forward","volume":"527","author":"Mendell","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJMoa1000228","article-title":"Dystrophin immunity in Duchenne\u2032s muscular dystrophy","volume":"363","author":"Mendell","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1089\/hum.2012.099","article-title":"Genetic therapeutic approaches for duchenne muscular dystrophy","volume":"23","author":"Foster","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/sj.gt.3301259","article-title":"Immune responses to dystropin: Implications for gene therapy of duchenne muscular dystrophy","volume":"7","author":"Ferrer","year":"2000","journal-title":"Gene Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.mt.6300377","article-title":"Transient immunomodulation allows repeated injections of aav1 and correction of muscular dystrophy in multiple muscles","volume":"16","author":"Lorain","year":"2008","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/337176a0","article-title":"Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts","volume":"337","author":"Partridge","year":"1989","journal-title":"Nature"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJM199509283331303","article-title":"Myoblast transfer in the treatment of duchenne\u2019s muscular dystrophy","volume":"333","author":"Mendell","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/43919","article-title":"Dystrophin expression in the mdx mouse restored by stem cell transplantation","volume":"401","author":"Gussoni","year":"1999","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1182\/blood-2004-06-2247","article-title":"Hematopoietic stem cell transplantation does not restore dystrophin expression in duchenne muscular dystrophy dogs","volume":"104","author":"Wang","year":"2004","journal-title":"Blood"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.stem.2007.09.016","article-title":"Restoration of human dystrophin following transplantation of exon-skipping-engineered dmd patient stem cells into dystrophic mice","volume":"1","author":"Benchaouir","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3727\/000000007783465064","article-title":"Autologous transplantation of muscle-derived CD133+ stem cells in Duchenne muscle patients","volume":"16","author":"Torrente","year":"2007","journal-title":"Cell Transplant."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nature05282","article-title":"Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs","volume":"444","author":"Sampaolesi","year":"2006","journal-title":"Nature"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1006\/bbrc.1998.8995","article-title":"Transplantation of dermal fibroblasts expressing myod1 in mouse muscles","volume":"248","author":"Huard","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/jcp.21895","article-title":"Cell based therapy for duchenne muscular dystrophy","volume":"221","author":"Farini","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/mus.880150504","article-title":"Human myoblast transplantation: Preliminary results of 4 cases","volume":"15","author":"Huard","year":"1992","journal-title":"Muscle Nerve"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jgm.1611","article-title":"Endonucleases: Tools to correct the dystrophin gene","volume":"13","author":"Rousseau","year":"2011","journal-title":"J. Gene Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.stemcr.2014.10.013","article-title":"Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by talen and crispr-cas9","volume":"4","author":"Li","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/hum.2013.081","article-title":"Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in","volume":"24","author":"Popplewell","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/cr.2016.28","article-title":"Duchenne muscular dystrophy: Crispr\/cas9 treatment","volume":"26","author":"Mendell","year":"2016","journal-title":"Cell Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"128","DOI":"10.12659\/AJCR.890078","article-title":"Autologous bone marrow mononuclear cell transplantation in duchenne muscular dystrophy\u2014A case report","volume":"15","author":"Sharma","year":"2014","journal-title":"Am. J. Case Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nmd.2006.10.003","article-title":"First test of a \u201chigh-density injection\u201d protocol for myogenic cell transplantation throughout large volumes of muscles in a duchenne muscular dystrophy patient: Eighteen months follow-up","volume":"17","author":"Skuk","year":"2007","journal-title":"Neuromusc. Disord."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.15252\/emmm.201505636","article-title":"Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy","volume":"7","author":"Cossu","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ajpath.2011.10.038","article-title":"Urocortins improve dystrophic skeletal muscle structure and function through both pka- and epac-dependent pathways","volume":"180","author":"Boittin","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/156652312800840577","article-title":"Interference with myostatin\/actriib signaling as a therapeutic strategy for duchenne muscular dystrophy","volume":"12","author":"Amthor","year":"2012","journal-title":"Curr. Gene Ther."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ncb2790","article-title":"Role of telomere dysfunction in cardiac failure in duchenne muscular dystrophy","volume":"15","author":"Mourkioti","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1113\/jphysiol.2007.148338","article-title":"N-acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice","volume":"586","author":"Whitehead","year":"2008","journal-title":"J. Physiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1479-5876-9-68","article-title":"Improvement of cardiac contractile function by peptide-based inhibition of NF-kB in the utrophin\/dystrophin-deficient murine model of muscular dystrophy","volume":"9","author":"Xu","year":"2011","journal-title":"J. Transl. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1113\/expphysiol.2014.083360","article-title":"Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment","volume":"100","author":"Ballmann","year":"2015","journal-title":"Exp. Physiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jprot.2016.03.011","article-title":"Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy","volume":"145","author":"Murphy","year":"2016","journal-title":"J. Proteom."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.ajpath.2016.08.008","article-title":"Bgp-15 improves aspects of the dystrophic pathology in mdx and dko mice with differing efficacies in heart and skeletal muscle","volume":"186","author":"Kennedy","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.molmed.2015.04.006","article-title":"The emperor\u2019s new dystrophin: Finding sense in the noise","volume":"21","author":"Wilton","year":"2015","journal-title":"Trends Mol. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mcn.2013.04.005","article-title":"Splicing therapy for neuromuscular disease","volume":"56","author":"Douglas","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.20918","article-title":"Theoretic applicability of antisense-mediated exon skipping for duchenne muscular dystrophy mutations","volume":"30","author":"Fokkema","year":"2009","journal-title":"Hum. Mutat."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1474-4422(03)00585-4","article-title":"Dystrophin and mutations: One gene, several proteins, multiple phenotypes","volume":"2","author":"Muntoni","year":"2003","journal-title":"Lancet Neurol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/sj.mt.6300095","article-title":"Antisense oligonucleotide-induced exon skipping across the human dystrophin gene transcript","volume":"15","author":"Wilton","year":"2007","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1517\/14712598.2012.693469","article-title":"Exon skipping for nonsense mutations in duchenne muscular dystrophy: Too many mutations, too few patients?","volume":"12","author":"Yokota","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.addr.2015.03.008","article-title":"Antisense oligonucleotides in therapy for neurodegenerative disorders","volume":"87","author":"Evers","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.pharmtox.010909.105654","article-title":"Rna targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform","volume":"50","author":"Bennett","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1073\/pnas.98.1.42","article-title":"Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse","volume":"98","author":"Mann","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jgm.295","article-title":"Improved antisense oligonucleotide induced exon skipping in the mdx mouse model of muscular dystrophy","volume":"4","author":"Mann","year":"2002","journal-title":"J. Gene Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1073\/pnas.0406700102","article-title":"Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles","volume":"102","author":"Lu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1011367","article-title":"Systemic administration of pro051 in duchenne\u2019s muscular dystrophy","volume":"364","author":"Goemans","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(14)70195-4","article-title":"Safety and efficacy of drisapersen for the treatment of duchenne muscular dystrophy (demand ii): An exploratory, randomised, placebo-controlled phase 2 study","volume":"13","author":"Voit","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_178","unstructured":"GlaxoSmithKline (2013). A Clinical Study to Assess the Efficacy and Safety of GSK2402968 in Subjects with Duchenne Muscular Dystrophy."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nmd.2013.09.004","article-title":"Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with duchenne muscular dystrophy: Results of a double-blind randomized clinical trial","volume":"24","author":"Flanigan","year":"2014","journal-title":"Neuromusc. Disord."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.molimm.2004.06.022","article-title":"CG sequence- and phosphorothioate backbone modification-dependent activation of the nf-kappab-responsive gene expression by cpg-oligodeoxynucleotides in human rpmi 8226 b cells","volume":"41","author":"Lee","year":"2004","journal-title":"Mol. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.4049\/jimmunol.174.10.6113","article-title":"Cpg-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate oligodeoxynucleotides and granulocyte-macrophage colony-stimulating factor in elutriated human primary monocytes","volume":"174","author":"Wang","year":"2005","journal-title":"J. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0192623313505781","article-title":"Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide","volume":"42","author":"Frazier","year":"2014","journal-title":"Toxicol. Pathol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.addr.2015.05.008","article-title":"Exon skipping therapy for duchenne muscular dystrophy","volume":"87","author":"Kole","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.coph.2005.07.001","article-title":"Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers","volume":"5","author":"Amantana","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/hmg\/ddg196","article-title":"Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle","volume":"12","author":"Gebski","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm1345","article-title":"Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology","volume":"12","author":"Alter","year":"2006","journal-title":"Nat. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/gt.2009.120","article-title":"Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino","volume":"17","author":"Wu","year":"2010","journal-title":"Gene Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/mt.2010.261","article-title":"Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice","volume":"19","author":"Malerba","year":"2011","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1474-4422(09)70211-X","article-title":"Local restoration of dystrophin expression with the morpholino oligomer avi-4658 in duchenne muscular dystrophy: A single-blind, placebo-controlled, dose-escalation, proof-of-concept study","volume":"8","author":"Kinali","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0140-6736(11)60756-3","article-title":"Exon skipping and dystrophin restoration in patients with duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, phase 2, dose-escalation study","volume":"378","author":"Cirak","year":"2011","journal-title":"Lancet"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ana.24555","article-title":"Longitudinal effect of eteplirsen versus historical control on ambulation in duchenne muscular dystrophy","volume":"79","author":"Mendell","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Pane, M., Mazzone, E.S., Sormani, M.P., Messina, S., Vita, G.L., Fanelli, L., Berardinelli, A., Torrente, Y., D\u2019Amico, A., and Lanzillotta, V. (2014). 6 minute walk test in duchenne md patients with different mutations: 12 month changes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0083400"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10741-009-9156-8","article-title":"Cardiomyopathy in duchenne muscular dystrophy: Pathogenesis and therapeutics","volume":"15","author":"Fayssoil","year":"2010","journal-title":"Heart Fail. Rev."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/mt.2011.284","article-title":"Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery","volume":"20","author":"Margus","year":"2012","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"8986","DOI":"10.1038\/srep08986","article-title":"Prevention of exercised induced cardiomyopathy following pip-pmo treatment in dystrophic mdx mice","volume":"5","author":"Betts","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yjmcc.2016.11.011","article-title":"Uniform low-level dystrophin expression in the heart partially preserved cardiac function in an aged mouse model of duchenne cardiomyopathy","volume":"102","author":"Wasala","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cardiores.2005.04.003","article-title":"Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes","volume":"67","author":"Meadows","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"e000961","DOI":"10.1161\/JAHA.114.000961","article-title":"Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel","volume":"3","author":"Viola","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.hlc.2014.02.009","article-title":"How does calcium regulate mitochondrial energetics in the heart?\u2014New insights","volume":"23","author":"Viola","year":"2014","journal-title":"Heart Lung Circ."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1113\/JP271681","article-title":"The L-type Ca2+ channel facilitates abnormal metabolic activity in the cTni-G203S mouse model of hypertrophic cardiomyopathy","volume":"594","author":"Viola","year":"2016","journal-title":"J. Physiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1161\/01.RES.0000263010.19273.48","article-title":"Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes","volume":"100","author":"Viola","year":"2007","journal-title":"Circ. Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"C1277","DOI":"10.1152\/ajpcell.1999.277.6.C1277","article-title":"Role of gelsolin in the actin filament regulation of cardiac L-type calcium channels","volume":"277","author":"Lader","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1469-7793.2001.00363.x","article-title":"Cytochalasin d reduces Ca2+ currents via cofilin-activated depolymerization of F-actin in guinea-pig cardiomyocytes","volume":"537","author":"Rueckschloss","year":"2001","journal-title":"J. Physiol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1006843113166","article-title":"Cytoskeleton and mitochondrial morphology and function","volume":"184","author":"Rappaport","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1050-1738(02)00184-6","article-title":"Desmin cytoskeleton: A potential regulator of muscle mitochondrial behavior and function","volume":"12","author":"Capetanaki","year":"2002","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1161\/CIRCULATIONAHA.105.572552","article-title":"Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-b-crystallin desmin-related cardiomyopathy","volume":"112","author":"Maloyan","year":"2005","journal-title":"Circulation"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/nn5061404","article-title":"Nanoparticle-mediated dual delivery of an antioxidant and a peptide against the L-type Ca2+ channel enables simultaneous reduction of cardiac ischemia-reperfusion injury","volume":"9","author":"Hardy","year":"2015","journal-title":"ACS Nano"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.yjmcc.2006.07.016","article-title":"Molecular insights from a novel cardiac troponin i mouse model of familial hypertrophic cardiomyopathy","volume":"41","author":"Tsoutsman","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jacbts.2015.12.001","article-title":"The role of the L-type Ca2+ channel in altered metabolic activity in a murine model of hypertrophic cardiomyopathy","volume":"1","author":"Viola","year":"2016","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Phillips, M.F., and Quinlivan, R. (2008). Calcium antagonists for duchenne muscular dystrophy. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD004571.pub2"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Koenig, X., Dysek, S., Kimbacher, S., Mike, A.K., Cervenka, R., Lukacs, P., Nagl, K., Dang, X.B., Todt, H., and Bittner, R.E. (2011). Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020300"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"H564","DOI":"10.1152\/ajpheart.00441.2013","article-title":"Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart","volume":"306","author":"Koenig","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/(SICI)1097-4598(199711)20:11<1422::AID-MUS10>3.0.CO;2-3","article-title":"Skeletal muscle fiber degeneration in mdx mice induced by electrical stimulation","volume":"20","author":"Yoshida","year":"1997","journal-title":"Muscle Nerve"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"C1502","DOI":"10.1152\/ajpcell.00435.2001","article-title":"Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin","volume":"282","author":"Sadeghi","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.ne.04.030181.000441","article-title":"Calcium channel","volume":"4","author":"Hagiwara","year":"1981","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"H2439","DOI":"10.1152\/ajpheart.00844.2005","article-title":"Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle","volume":"290","author":"Woolf","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"C697","DOI":"10.1152\/ajpcell.00056.2015","article-title":"Can\u2019t live with or without it: Calcium and its role in duchenne muscular dystrophy-induced muscle weakness. Focus on \u201cserca1 overexpression minimizes skeletal muscle damage in dystrophic mouse models\u201d","volume":"308","author":"Cheng","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1016\/j.biocel.2013.05.001","article-title":"Wasting mechanisms in muscular dystrophy","volume":"45","author":"Shin","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/8\/4\/108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:31:10Z","timestamp":1760207470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/8\/4\/108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":218,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4]]}},"alternative-id":["genes8040108"],"URL":"https:\/\/doi.org\/10.3390\/genes8040108","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,24]]}}}