{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:12:12Z","timestamp":1790190732552,"version":"4.1.0"},"reference-count":135,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ram\u00f3n y Cajal Researchers","award":["RyC2014-15242"],"award-info":[{"award-number":["RyC2014-15242"]}]},{"name":"Chinese Scholarship Council"},{"name":"German Research Foundation","award":["DFG NE 2128\/2-1"],"award-info":[{"award-number":["DFG NE 2128\/2-1"]}]},{"name":"German Research Foundation","award":["SFB\/TRR57\/P04"],"award-info":[{"award-number":["SFB\/TRR57\/P04"]}]},{"name":"Ram\u00f3n y Cajal Research","award":["RYC2015-17438"],"award-info":[{"award-number":["RYC2015-17438"]}]},{"name":"Spanish Ministerio de Econom\u00eda y Competitividad","award":["SAF2016-78711"],"award-info":[{"award-number":["SAF2016-78711"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.<\/jats:p>","DOI":"10.3390\/genes8040123","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T10:22:01Z","timestamp":1492597321000},"page":"123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["c-MYC\u2014Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease"],"prefix":"10.3390","volume":"8","author":[{"given":"Kang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Immunology, Complutense University School of Medicine, Plaza Ram\u00f3n y Cajal s\/n, Madrid 28040, Spain"},{"name":"12 de Octubre Health Research Institute (imas12), Madrid 28041, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-650X","authenticated-orcid":false,"given":"Francisco","family":"Cubero","sequence":"additional","affiliation":[{"name":"Department of Immunology, Complutense University School of Medicine, Plaza Ram\u00f3n y Cajal s\/n, Madrid 28040, Spain"},{"name":"12 de Octubre Health Research Institute (imas12), Madrid 28041, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1390-8002","authenticated-orcid":false,"given":"Yulia","family":"Nevzorova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital RWTH, Aachen 52074, Germany"},{"name":"Department of Animal Physiology II, Faculty of Biology, Complutense University of Madrid (UCM), Jos\u00e9 Antonio Novais 12, Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00018-011-0860-x","article-title":"Tumor microenvironment: Becoming sick of myc","volume":"69","author":"Whitfield","year":"2012","journal-title":"Cell. 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