{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:54:14Z","timestamp":1790175254261,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Without physical contact with plants, certain plant growth-promoting rhizobacteria (PGPR) can release volatile organic compounds (VOCs) to regulate nutrient acquisition and induce systemic immunity in plants. However, whether the PGPR-emitted VOCs can induce cadmium (Cd) tolerance of plants and the underlying mechanisms remain elusive. In this study, we probed the effects of Bacillus amyloliquefaciens (strain SAY09)-emitted VOCs on the growth of Arabidopsis plants under Cd stress. SAY09 exposure alleviates Cd toxicity in plants with increased auxin biosynthesis. RNA-Seq analyses revealed that SAY09 exposure provoked iron (Fe) uptake- and cell wall-associated pathways in the Cd-treated plants. However, SAY09 exposure failed to increase Cd resistance of plants after treatment with 1-naphthylphthalamic acid (NPA) or 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO). Under Cd stress, SAY09 exposure markedly promoted Fe absorption in plants with the increased hemicellulose 1 (HC1) content and Cd deposition in root cell wall, whereas these effects were almost abrogated by treatment with NPA or c-PTIO. Moreover, exogenous NPA remarkably repressed the accumulation of nitric oxide (NO) in the SAY09-exposed roots under Cd stress. Taken together, the findings indicated that NO acted as downstream signals of SAY09-induced auxin to regulate Fe acquisition and augment Cd fixation in roots, thereby ameliorating Cd toxicity.<\/jats:p>","DOI":"10.3390\/genes8070173","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T10:25:56Z","timestamp":1498645556000},"page":"173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Bacillus amyloliquefaciens SAY09 Increases Cadmium Resistance in Plants by Activation of Auxin-Mediated Signaling Pathways"],"prefix":"10.3390","volume":"8","author":[{"given":"Cheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Organic Fertilizer Creation, Ministry of Agriculture, Anhui Science and Technology University, Bengbu 233100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyou","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Organic Fertilizer Creation, Ministry of Agriculture, Anhui Science and Technology University, Bengbu 233100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Organic Fertilizer Creation, Ministry of Agriculture, Anhui Science and Technology University, Bengbu 233100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1104\/pp.111.183897","article-title":"A comparison of sulfate and selenium accumulation in relation to the expression of sulfate transporter genes in Astragalus species","volume":"157","author":"Cabannes","year":"2011","journal-title":"Plant Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0269-7491(97)00110-3","article-title":"Studies on cadmium toxicity in plants: A review","volume":"98","author":"Das","year":"1997","journal-title":"Environ. Pollut."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.biochi.2006.07.003","article-title":"Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants","volume":"88","author":"Clemens","year":"2006","journal-title":"Biochimie"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1081\/ESE-120018594","article-title":"Soil contamination and plant uptake of heavy metals at polluted sites in China","volume":"38","author":"Wang","year":"2003","journal-title":"J. Environ. Sci. Health Part A"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0098-8472(93)90059-O","article-title":"Response of roots of trees to heavy metals","volume":"33","author":"Kahle","year":"1993","journal-title":"Environ. Exp. Bot."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/ppl.12207","article-title":"Cadmium exposure affects iron acquisition in barley (Hordeum vulgare) seedlings","volume":"152","author":"Astolfi","year":"2014","journal-title":"Physiol. Plant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1104\/pp.111.190983","article-title":"Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Arabidopsis enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots","volume":"158","author":"Wu","year":"2012","journal-title":"Plant Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00299-005-0092-3","article-title":"Cadmium inducible Fe deficiency responses observed from macro and molecular views in tobacco plants","volume":"25","author":"Yoshihara","year":"2006","journal-title":"Plant Cell Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1104\/pp.116.3.1063","article-title":"The role of iron deficiency stress responses in stimulating heavy-metal transport in plants","volume":"116","author":"Cohen","year":"1998","journal-title":"Plant Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1104\/pp.010731","article-title":"Influence of iron status on cadmium and zinc uptake by different ecotypes of the hyperaccumulator Thlaspi caerulescens","volume":"128","author":"Lombi","year":"2002","journal-title":"Plant Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1105\/tpc.001388","article-title":"IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth","volume":"14","author":"Vert","year":"2002","journal-title":"Plant Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jhazmat.2012.08.077","article-title":"Gibberellic acid alleviates cadmium toxicity by reducing nitric oxide accumulation and expression of IRT1 in Arabidopsis thaliana","volume":"239\u2013240","author":"Zhu","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fpls.2014.00721","article-title":"Exogenous abscisic acid application decreases cadmium accumulation in Arabidopsis plants, which is associated with the inhibition of IRT1-mediated cadmium uptake","volume":"5","author":"Fan","year":"2014","journal-title":"Front. Plant Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1001-0742(11)60978-9","article-title":"Endogenous nitric oxide mediates alleviation of cadmium toxicity induced by calcium in rice seedlings","volume":"24","author":"Zhang","year":"2012","journal-title":"J. Environ. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.plaphy.2012.12.001","article-title":"Importance of nitric oxide in cadmium stress tolerance in crop plants","volume":"63","author":"Gill","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10534-013-9608-4","article-title":"Nitric oxide (NO) counteracts cadmium induced cytotoxic processes mediated by reactive oxygen species (ROS) in Brassica juncea: Cross-talk between ROS, NO and antioxidant responses","volume":"26","author":"Verma","year":"2013","journal-title":"Biometals"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00425-009-0984-5","article-title":"Exogenous nitric oxide enhances cadmium tolerance of rice by increasing pectin and hemicellulose contents in root cell wall","volume":"230","author":"Xiong","year":"2009","journal-title":"Planta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhazmat.2013.09.018","article-title":"Exogenous auxin alleviates cadmium toxicity in Arabidopsis thaliana by stimulating synthesis of hemicellulose 1 and increasing the cadmium fixation capacity of root cell walls","volume":"2","author":"Zhu","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.arplant.52.1.527","article-title":"Function and mechanism of organic anion exudation from plant roots","volume":"52","author":"Ryan","year":"2001","journal-title":"Annu. Rev. Plant Physiol. Plant Mol. Boil."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/286885a0","article-title":"Enhanced plant growth by siderophores produced by plant growth promoting rhizobacteria","volume":"286","author":"Kloepper","year":"1980","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1073\/pnas.0730845100","article-title":"Bacterial volatiles promote growth in Arabidopsis","volume":"100","author":"Ryu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.micres.2013.09.009","article-title":"Bacteria with ACC deaminase can promote plant growth and help to feed the world","volume":"169","author":"Glick","year":"2014","journal-title":"Microbiol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1094\/MPMI-21-6-0737","article-title":"Soil bacteria confer plant salt tolerance by tissue-specific regulation of the sodium transporter HKT1","volume":"21","author":"Zhang","year":"2008","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.plaphy.2016.04.025","article-title":"Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms","volume":"105","author":"Zhou","year":"2016","journal-title":"Plant Physiol. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhou, C., Ma, Z.Y., Zhu, L., Xiao, X., Xie, Y., Zhu, J., and Wang, J.F. (2016). Rhizobacterial strain Bacillus megaterium BOFC15 induces cellular polyamine changes that improve plant growth and drought resistance. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060976"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.plaphy.2014.12.014","article-title":"Plant-microorganism-soil interactions influence the Fe availability in the rhizosphere of cucumber plants","volume":"87","author":"Pii","year":"2015","journal-title":"Plant Physiol. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envexpbot.2016.06.011","article-title":"Modulation of Fe acquisition process by Azospirillum brasilense in cucumber plants","volume":"130","author":"Pii","year":"2016","journal-title":"Environ. Exp. Bot."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00284-007-9038-z","article-title":"Cadmium-induced siderophore production by a high Cd-resistant bacterial strain relieved Cd toxicity in plants through root colonization","volume":"56","author":"Sinha","year":"2008","journal-title":"Curr. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ecoenv.2013.05.002","article-title":"Cadmium-tolerant bacteria reduce the uptake of cadmium in rice: Potential for microbial bioremediation","volume":"94","author":"Siripornadulsil","year":"2013","journal-title":"Ecotoxcol. Environ. Saf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.scitotenv.2016.06.121","article-title":"Characterization of cadmium-resistant bacteria and their potential for reducing accumulation of cadmium in rice grains","volume":"569\u2013570","author":"Lin","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1104\/pp.103.026583","article-title":"Bacterial volatiles induce systemic resistance in Arabidopsis","volume":"134","author":"Ryu","year":"2014","journal-title":"Plant Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fpls.2016.00458","article-title":"Augmenting sulfur metabolism and herbivore defense in Arabidopsis by bacterial volatile signaling","volume":"7","author":"Aziz","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ecoenv.2016.09.013","article-title":"Cadmium stress tolerance in wheat seedlings induced by ascorbic acid was mediated by NO signaling pathways","volume":"135","author":"Wang","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, J.F., Zhou, C., Xiao, X., Xie, Y., Zhu, L., and Ma, Z.Y. (2017). Enhanced iron and selenium uptake in plants by volatile emissions of Bacillus amyloliquefaciens (BF06). Appl. Sci., 7.","DOI":"10.3390\/app7010085"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00425-009-1076-2","article-title":"Belowground volatiles facilitate interactions between plant roots and soil organisms","volume":"231","author":"Wenke","year":"2010","journal-title":"Planta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00425-007-0530-2","article-title":"Rhizobacterial volatile emissions regulate auxin homeostasis and cell expansion in Arabidopsis","volume":"226","author":"Zhang","year":"2007","journal-title":"Planta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1365-313X.2009.03803.x","article-title":"A soil bacteria regulates plant acquisition of iron via deficiency-inducible mechanisms","volume":"58","author":"Zhang","year":"2009","journal-title":"Plant J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, B., Farag, M.A., Park, H.B., Kloepper, J.W., Lee, S.H., and Ryu, C.M. (2012). Induced resistance by a long-chain bacterial volatile: Elicitation of plant systemic defense by a C13 volatile produced by Paenibacillus polymyxa. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048744"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2015.04.039","article-title":"Promotion of plant growth by Pseudomonas fluorescens strain SS101 via novel volatile organic compounds","volume":"461","author":"Park","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"fiw070","DOI":"10.1093\/femsec\/fiw070","article-title":"Multiple effects of Bacillus amyloliquefaciens volatile compounds: Plant growth promotion and growth inhibition of phytopathogens","volume":"92","author":"Asari","year":"2016","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/pce.12203","article-title":"Abscisic acid alleviates iron deficiency by promoting root iron reutilization and transport from root to shoot in Arabidopsis","volume":"37","author":"Lei","year":"2014","journal-title":"Plant Cell Environ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.gene.2015.10.042","article-title":"GhNAC12, a neutral candidate gene, leads to early aging in cotton (Gossypium hirsutum L)","volume":"576","author":"Zhao","year":"2016","journal-title":"Gene"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16837","DOI":"10.3390\/molecules191016837","article-title":"Effect of tea polyphenols on lipid peroxidation and antioxidant activity of litchi (Litchichinensis Sonn.) fruit during cold storage","volume":"19","author":"Chen","year":"2014","journal-title":"Molecules"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fpls.2015.01223","article-title":"Overexpression of the maize psbA gene enhances drought tolerance through regulating antioxidant system, photosynthetic capability, and stress defense gene expression in tobacco","volume":"6","author":"Huo","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0891-5849(93)90035-S","article-title":"A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials","volume":"15","author":"Draper","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10725-011-9610-1","article-title":"Trichoderma harzianum strain T-22 induces changes in phytohormone levels in cherry rootstocks (Prunus cerasus \u00d7 P. canescens)","volume":"65","author":"Sofo","year":"2011","journal-title":"Plant Growth Regul."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00425-012-1652-8","article-title":"Cell wall polysaccharides are involved in P-deficiency-induced Cd exclusion in Arabidopsis thaliana","volume":"236","author":"Zhu","year":"2012","journal-title":"Planta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10535-005-7245-7","article-title":"Cadmium uptake, localization and detoxification in Zea mays","volume":"49","author":"Tukiendorf","year":"2005","journal-title":"Biol. Plant."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1104\/pp.110.161109","article-title":"Nitric oxide acts downstream of auxin to trigger root ferric-chelate reductase activity in response to iron deficiency in Arabidopsis","volume":"154","author":"Chen","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.plantsci.2011.08.006","article-title":"Exposure to nitric oxide increases the nitrosyl-iron complexes content in sorghum embryonic axes","volume":"183","author":"Simontacchi","year":"2012","journal-title":"Plant Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00299-015-1843-4","article-title":"Overexpression of the iron transporter NtPIC1 in tobacco mediates tolerance to cadmium","volume":"34","author":"Gong","year":"2015","journal-title":"Plant Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/plb.12484","article-title":"Iron plaque decreases cadmium accumulation in Oryza sativa L. and serves as a source of iron","volume":"18","author":"Sebastian","year":"2016","journal-title":"Plant Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jplph.2013.09.024","article-title":"Selenium alleviates cadmium toxicity by preventing oxidative stress in sunflower (Helianthus annuus) seedlings","volume":"171","author":"Saidi","year":"2014","journal-title":"J. Plant Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16843","DOI":"10.1007\/s11356-015-4888-6","article-title":"Exogenous NO depletes Cd-induced toxicity by eliminating oxidative damage, re-establishing ATPase activity, and maintaining stress-related hormone equilibrium in white clover plants","volume":"22","author":"Liu","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/jxb\/err384","article-title":"Cadmium interferes with auxin physiology and lignification in poplar","volume":"63","author":"Elobeid","year":"2012","journal-title":"J. Exp. Bot."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jplph.2013.02.008","article-title":"Cadmium interferes with maintenance of auxin homeostasis in Arabidopsis seedlings","volume":"170","author":"Hu","year":"2013","journal-title":"J. Plant Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ecoenv.2013.04.013","article-title":"Exogenous treatment with indole-3-acetic acid and salicylic acid alleviates cadmium toxicity in wheat seedlings","volume":"94","author":"Agami","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ecoenv.2016.06.015","article-title":"Exogenous IAA differentially affects growth, oxidative stress and antioxidants system in Cd stressed Trigonella foenum-graecum L. seedlings: Toxicity alleviation by up-regulation of ascorbate-glutathione cycle","volume":"132","author":"Bashri","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1365-3040.2003.01018.x","article-title":"Role of abscisic acid in cadmium tolerance of rice (Oryza sativa L.) seedlings","volume":"26","author":"Hsu","year":"2003","journal-title":"Plant Cell Environ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/jxb\/erp119","article-title":"Root-to-shoot Cd translocation via the xylem is the major process determining shoot and grain cadmium accumulation in rice","volume":"60","author":"Uraguchi","year":"2009","journal-title":"J. Exp. Bot."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1104\/pp.15.01617","article-title":"Putrescine alleviates iron deficiency via NO-dependent reutilization of root cell-wall Fe in Arabidopsis","volume":"170","author":"Zhu","year":"2016","journal-title":"Plant Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1104\/pp.009076","article-title":"Nitric oxide improves internal iron availability in plants","volume":"30","author":"Graziano","year":"2002","journal-title":"Plant Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1365-313X.2007.03283.x","article-title":"Nitric oxide accumulation is required for molecular and physiological responses to iron deficiency in tomato roots","volume":"52","author":"Graziano","year":"2007","journal-title":"Plant J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.plaphy.2016.11.005","article-title":"Nitric oxide signaling is involved in the response to iron deficiency in the woody plant Malus xiaojinensis","volume":"109","author":"Zhai","year":"2016","journal-title":"Plant Physiol. Biochem."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/8\/7\/173\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:40:38Z","timestamp":1760208038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/8\/7\/173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":65,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["genes8070173"],"URL":"https:\/\/doi.org\/10.3390\/genes8070173","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]}}}