{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:39:23Z","timestamp":1767922763890,"version":"3.49.0"},"reference-count":76,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva","doi-asserted-by":"publisher","award":["PICT2013-1122, PICT2013-1118"],"award-info":[{"award-number":["PICT2013-1122, PICT2013-1118"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other proteins or enzymes. Understanding these properties may help to define the function of a protein and also the role of an organelle. In the case of microorganisms like protozoa parasites, it may help to understand singular features that will eventually lead to the design of parasite-specific drugs. The protozoa parasite Giardia lamblia is an example of a widespread parasite that has been infecting humans and animals from ancestral times, adjusting itself to the changes of the environment inside and outside the host. Several membrane-associated proteins have been posted in the genome database GiardiaDB, although only a few of them have been characterized. This review discusses the data regarding membrane-associated proteins in relationship with lipids and specific organelles and their implication in the discovery of anti-giardial therapies.<\/jats:p>","DOI":"10.3390\/genes9080404","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T10:52:01Z","timestamp":1533898321000},"page":"404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Membrane-Associated Proteins in Giardia lamblia"],"prefix":"10.3390","volume":"9","author":[{"given":"Mar\u00eda C.","family":"Touz","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra\u2014INIMEC-CONICET\u2014Universidad Nacional de C\u00f3rdoba, Friuli 2434, C\u00f3rdoba 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Feliziani","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra\u2014INIMEC-CONICET\u2014Universidad Nacional de C\u00f3rdoba, Friuli 2434, C\u00f3rdoba 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea S.","family":"R\u00f3polo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra\u2014INIMEC-CONICET\u2014Universidad Nacional de C\u00f3rdoba, Friuli 2434, C\u00f3rdoba 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1550-7408.2005.00053.x","article-title":"The new higher level classification of eukaryotes with emphasis on the taxonomy of protists","volume":"52","author":"Adl","year":"2005","journal-title":"J. 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