{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:11:18Z","timestamp":1760447478434,"version":"build-2065373602"},"reference-count":133,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","award":["AARF-22-967198"],"award-info":[{"award-number":["AARF-22-967198"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a growing public health issue disproportionately affecting adults 65 years and older. This growing trend is accompanied by rising economic, social, emotional, and physical costs, both for patients and their caregivers. As the U.S. population ages, understanding disparities in AD prevalence particularly by gender and age has become increasingly important, particularly in high-burden states like Illinois. This review focuses on gender and age disparities in AD, with a specific emphasis on Illinois. This review integrates national and global trends with state-specific projections and explores modifiable and non-modifiable risk factors that may contribute to these disparities. We analyzed projections from the Illinois Department of Public Health and the Alzheimer\u2019s Association to assess AD prevalence by gender and age across Illinois\u2019 102 counties from 2020 to 2030, disaggregated by gender and age. Rates were compared with U.S. and global trends. Risk factors such as diabetes, education, access to care, and socioeconomic status were reviewed in the context of these disparities. Women consistently show higher AD prevalence across age groups and regions, with the greatest increase in cases is projected among adults aged 75 to 84 years, particularly in regions with higher women populations and social vulnerability. If unaddressed, risk factors like lower education, rural residency, and limited healthcare access may worsen these disparities. Addressing them requires focused public health efforts that combine early screening, caregiver support, and regional resource allocation. Illinois serves as a case study for targeted interventions applicable to broader national strategies.<\/jats:p>","DOI":"10.3390\/geriatrics10050132","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T10:37:14Z","timestamp":1760438234000},"page":"132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alzheimer\u2019s Disease in Illinois: Analyzing Disparities and Projected Trends"],"prefix":"10.3390","volume":"10","author":[{"given":"Temitope","family":"Adeleke","sequence":"first","affiliation":[{"name":"Department of Neurology, Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aston","family":"Knelsen-Dobson","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Manitoba, Winnipeg, MB R3T2N2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"McGinity","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle M.","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict C.","family":"Albensi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Barry & Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"},{"name":"Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada"},{"name":"Department of Pharmacology & Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0T6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banibrata","family":"Roy","sequence":"additional","affiliation":[{"name":"Dwyer School of Nursing, Widener University School of Nursing, One University Place, Chester, PA 19013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-5286","authenticated-orcid":false,"given":"Aida","family":"Adlimoghaddam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dale and Deborah Smith Center for Alzheimer\u2019s Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"},{"name":"Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"},{"name":"Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jns.2004.11.022","article-title":"Survival following dementia onset: Alzheimer\u2019s disease and vascular dementia","volume":"229","author":"Fitzpatrick","year":"2005","journal-title":"J. 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