{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:22:35Z","timestamp":1772119355111,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Background\/Objectives: Patient acceptability of oral anticancer drugs is a critical factor that influences treatment in older outpatients receiving cancer chemotherapy and plays a central role in enhancing adherence and treatment effectiveness. Identifying older outpatients receiving cancer chemotherapy who exhibit poor tablet acceptability before initiating oral anticancer therapy and offering alternative treatment options are beneficial. Therefore, we investigated the characteristics of patients with poor tablet acceptability by focusing on the tablet size, geriatric assessment, and polypharmacy. Methods: A questionnaire survey on experiences with tablet medication was conducted among patients who received chemotherapy at the Outpatient Treatment Center of Tokyo Metropolitan Bokutoh Hospital from September 2024 to September 2025. The median values of the long diameter (12 mm) and the combined length, width, and thickness (26 mm) of the tablets reported as acceptable in the questionnaire described in Method 1 were used as cutoff values. Patients whose reported acceptable tablet dimensions were below these median values were classified as \u201cpoor tablet acceptability,\u201d whereas those with values above the median were classified as \u201cgood tablet acceptability\u201d. Univariate and multivariate logistic regression analysis was performed to identify characteristic factors associated with poor tablet acceptability in older outpatients receiving cancer chemotherapy, with poor tablet acceptability as the dependent variable and patient sex, body mass index, Geriatric 8 score, each item of the Oral Frailty 5-item Checklist, and polypharmacy as explanatory variables. Results: 90 patients completed the questionnaire survey. Female sex and polypharmacy were independent factors associated with poor tablet acceptability in older outpatients receiving cancer chemotherapy. In addition, subjective difficulty in chewing tended to be associated with poor tablet acceptability. Conclusions: This study suggests that assessing polypharmacy and oral function, along with early multidisciplinary intervention before and during oral anticancer therapy, particularly in females, patients taking multiple medications, and those reporting difficulty in chewing, may help maintain tablet acceptability and improve adherence.<\/jats:p>","DOI":"10.3390\/geriatrics11020025","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:58:03Z","timestamp":1772114283000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tablet Acceptability in Older Outpatients Undergoing Cancer Chemotherapy"],"prefix":"10.3390","volume":"11","author":[{"given":"Eri","family":"Hikita","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"},{"name":"Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, Tokyo 204-8588, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Oosaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanako","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Terayama","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"},{"name":"Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-0091","authenticated-orcid":false,"given":"Takeo","family":"Yasu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, Tokyo 204-8588, Japan"},{"name":"Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, Tokyo 130-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12943-024-02069-w","article-title":"Cancer, metastasis, and the epigenome","volume":"23","author":"Kiri","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/jjco\/hyaa057","article-title":"Age-specific cancer incidence rate in the world","volume":"50","author":"Matsuda","year":"2020","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_3","unstructured":"(2025, October 21). Available online: https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/index.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1200\/JCO.2007.14.9898","article-title":"Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil\/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer","volume":"26","author":"Cassidy","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_5","unstructured":"(2025, November 11). Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/reflection-paper-pharmaceutical-development-medicines-use-older-population-first-version_en.pdf."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shariff, Z., Kirby, D., Missaghi, S., Rajabi-Siahboomi, A., and Maidment, I. (2020). Patient-centric medicine design: Key characteristics of oral solid dosage forms that improve adherence and acceptance in older people. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12100905"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/sj.bjc.6604758","article-title":"Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer","volume":"99","author":"McCowan","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1016\/S1470-2045(15)00080-7","article-title":"Polypharmacy in patients with advanced cancer and the role of medication discontinuation","volume":"16","author":"LeBlanc","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.canep.2014.07.005","article-title":"Estimated life expectancy and risk of death from cancer by quartiles in the older Japanese population: 2010 vital statistics","volume":"38","author":"Iwamoto","year":"2014","journal-title":"Cancer Epidemiol."},{"key":"ref_10","unstructured":"ICH (2025, November 11). E7 Guideline for Industry: Studies in Support of Special Populations: Geriatrics, Available online: https:\/\/www.fda.gov\/media\/71317\/download."},{"key":"ref_11","unstructured":"NCCN (2025, November 11). Guidelines for Specific Populations: Older Adult Oncology. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/older_adult.pdf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1200\/JCO.2014.60.3548","article-title":"Polypharmacy: Geriatric oncology evaluation should become mainstream","volume":"33","author":"Lichtman","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1200\/JCO.2018.78.8687","article-title":"Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology","volume":"36","author":"Mohile","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.7326\/0003-4819-130-11-199906010-00022","article-title":"Toward an understanding of frailty","volume":"130","author":"Hamerman","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hummler, H., Stillhart, C., Meilicke, L., Grimm, M., Krause, E., Mannaa, M., Gollasch, M., Weitschies, W., and Page, S. (2023). Impact of tablet size and shape on the swallowability in older adults. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041042"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Vallet, T., Michelon, H., Orlu, M., Jani, Y., Leglise, P., Laribe-Caget, S., Piccoli, M., Le Fur, A., Liu, F., and Ruiz, F. (2020). Acceptability in the older population: The importance of an appropriate tablet size. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080746"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2147\/PPA.S253663","article-title":"Threshold size of medical tablets and capsules: Based on information collected by Japanese medical wholesaler","volume":"14","author":"Kabeya","year":"2020","journal-title":"Patient Prefer. Adherence"},{"key":"ref_18","first-page":"1221","article-title":"Survey on the size of oral anticancer drugs","volume":"51","author":"Hikita","year":"2024","journal-title":"Gan Kagaku Ryoho"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","article-title":"International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer","volume":"32","author":"Wildiers","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/annonc\/mdr587","article-title":"Screening older cancer patients: First evaluation of the G-8 geriatric screening tool","volume":"23","author":"Bellera","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/jjco\/hyz093","article-title":"Geriatric Research Policy: Japan Clinical Oncology Group (JCOG) policy","volume":"49","author":"Mizutani","year":"2019","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/annonc\/mdu210","article-title":"Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: An update on SIOG recommendations","volume":"26","author":"Decoster","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/ggi.14634","article-title":"Oral frailty five-item checklist to predict adverse health outcomes in community-dwelling older adults: A Kashiwa cohort study","volume":"23","author":"Tanaka","year":"2023","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s40266-025-01249-7","article-title":"Medication non-adherence in older adults: Underlying factors, potential interventions and outcomes","volume":"42","author":"Stanly","year":"2025","journal-title":"Drugs Aging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/jech-2020-214238","article-title":"Medication adherence in community-dwelling older people exposed to chronic polypharmacy","volume":"75","author":"Franchi","year":"2021","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1248\/bpb.b21-00184","article-title":"The combined use of 5 or more drugs is a factor related to lower adherence to S-1 in S-1 and oxaliplatin treatment for advanced gastric cancer","volume":"44","author":"Kawakami","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1248\/bpb.b19-00043","article-title":"A nationwide survey of community pharmacist contributions to polypharmacy in opioid-using and non-using cancer patients in Japan","volume":"42","author":"Suzuki","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Alqahtani, B. (2023). Number of medications and polypharmacy are associated with frailty in older adults: Results from the Midlife in the United States study. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1148671"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/jphp.12547","article-title":"Standardized method to assess medicines\u2019 acceptability: Focus on paediatric population","volume":"69","author":"Ruiz","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Klingmann, V., Vallet, T., M\u00fcnch, J., Wolters, L., Stegemann, R., Bosse, H.M., and Ruiz, F. (2023). Dosage forms suitability in pediatrics: Acceptability of antibiotics in a German Hospital. Antibiotics, 12.","DOI":"10.3390\/antibiotics12121709"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104630","DOI":"10.1016\/j.archger.2022.104630","article-title":"Association between polypharmacy and mortality in the older adults: A systematic review and meta-analysis","volume":"100","author":"Li","year":"2022","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d (Easy R) for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transpl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10384-011-0026-2","article-title":"Age-related changes in functional visual acuity in healthy individuals","volume":"55","author":"Kaido","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1007\/s00429-021-02338-0","article-title":"Simultaneous changes in visual acuity, cortical population receptive field size, visual field map size, and retinal thickness in healthy human aging","volume":"226","author":"Silva","year":"2021","journal-title":"Brain Struct. Funct."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00221-024-06940-6","article-title":"Subclinical variability in visual function modulates visual dependence\u2014Independent of age","volume":"242","author":"Fathi","year":"2024","journal-title":"Exp. Brain Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00455-021-10280-w","article-title":"A safe way to administer drugs through a nutrition tube-The simple suspension method","volume":"37","author":"Kunieda","year":"2022","journal-title":"Dysphagia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s00277-022-04871-2","article-title":"Increased blood levels of venetoclax due to intake of crushed venetoclax tablets","volume":"101","author":"Anzai","year":"2022","journal-title":"Ann. Hematol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s10637-011-9725-2","article-title":"A phase I pharmacokinetic and safety evaluation of oral pazopanib dosing administered as crushed tablet or oral suspension in patients with advanced solid tumors","volume":"30","author":"Heath","year":"2012","journal-title":"Investig. New Drugs"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1078155212455446","article-title":"Disintegration of chemotherapy tablets for oral administration in patients with swallowing difficulties","volume":"19","author":"Siden","year":"2013","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1248\/yakushi.23-00194","article-title":"Evaluation of the simple suspension method for oral anticancer drugs","volume":"144","author":"Abe","year":"2024","journal-title":"Yakugaku Zasshi"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.3747\/co.21.2151","article-title":"Safe handling of cytotoxics: Guideline recommendations","volume":"22","author":"Easty","year":"2015","journal-title":"Curr. Oncol."},{"key":"ref_42","unstructured":"Connor, T.H., MacKenzie, B.A., DeBord, D.G., Trout, D.B., O\u2019Callaghan, J.P., and Cincinnati, O.H. (2016). NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, NIOSH."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1248\/bpb.b19-00343","article-title":"Evaluation of measures against exposure during administration of hazardous drugs through a feeding tube","volume":"42","author":"Aoki","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_44","unstructured":"(2025, November 11). Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/020896s043lbl.pdf."},{"key":"ref_45","unstructured":"(2025, November 11). Available online: https:\/\/www.nccn.org\/guidelines\/."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1245\/s10434-018-7063-8","article-title":"Survival outcomes of two Phase 2 studies of adjuvant chemotherapy with S-1 plus oxaliplatin or capecitabine plus oxaliplatin for patients with gastric cancer after D2 gastrectomy","volume":"26","author":"Nakamura","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e7326","DOI":"10.1002\/cam4.7326","article-title":"Comparison of SOX and CAPOX in patients with advanced gastric cancer after laparoscopic D2 gastrectomy: A randomized controlled trial","volume":"13","author":"Liu","year":"2024","journal-title":"Cancer Med."},{"key":"ref_48","first-page":"172","article-title":"CAPOX associated with toxicities of higher grade but improved disease-free survival when compared with FOLFOX in the adjuvant treatment of stage III colon cancer","volume":"13","author":"Loree","year":"2014","journal-title":"Clin. Color. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ijc.30423","article-title":"Recurrence-free and overall survival among elderly stage III colon cancer patients treated with CAPOX or capecitabine monotherapy","volume":"140","author":"Creemers","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2300080","DOI":"10.1200\/CCI.23.00080","article-title":"Estimating treatment effect of adjuvant chemotherapy in elderly patients with Stage III colon cancer using bayesian networks","volume":"7","author":"Sieswerda","year":"2023","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMoa2027071","article-title":"Osimertinib in resected EGFR-mutated non-small-cell lung cancer","volume":"383","author":"Wu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Li, F., Xiao, T., Qiu, X., Liu, C., Ma, Q., Yu, D., Zhou, L., Xiao, R., He, B., and Tang, A. (2025). Oral frailty and its influencing factors in patients with cancer undergoing chemotherapy: A cross-sectional study. BMC Oral. Health, 25.","DOI":"10.1186\/s12903-025-05789-7"},{"key":"ref_53","first-page":"93","article-title":"Masticatory efficiency: The effect of age, the loss of teeth and prosthetic rehabilitation","volume":"34","author":"Carlsson","year":"1984","journal-title":"Int. Dent. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s40520-020-01707-9","article-title":"Association between anticholinergic burden and oropharyngeal dysphagia among hospitalized older adults","volume":"33","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s40520-020-01606-z","article-title":"Simple oral exercise with chewing gum for improving oral function in older adults","volume":"33","author":"Kim","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/ggi.12399","article-title":"Relationship between chewing ability and sarcopenia in Japanese community-dwelling older adults","volume":"15","author":"Murakami","year":"2015","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10266-021-00622-3","article-title":"Gender differences in masticatory function in elderly adults with natural dentition","volume":"109","author":"Sano","year":"2021","journal-title":"Odontology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Nagao-Sato, S., Kushida, O., Kurita, Y., Ozaki, E., Kuriyama, N., Kato, M., Akamatsu, R., Goda, T., and Tabara, Y. (2025). Sex differences in the association between masticatory function and sarcopenia components: The Shizuoka study. Nutrients, 17.","DOI":"10.3390\/nu17060968"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kim, H.E., Wallace, J., and Sohn, W. (2022). Factors affecting masticatory performance of older adults are sex-dependent: A cross-sectional study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192315742"},{"key":"ref_60","unstructured":"(2025, November 11). Available online: https:\/\/www.mhlw.go.jp\/content\/11120000\/000343469.pdf."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Oliveira, R.F., Oliveira, A.I., Cruz, A.S., Ribeiro, O., Afreixo, V., and Pimentel, F. (2024). Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: Associated factors. BMC Geriatr., 24.","DOI":"10.1186\/s12877-024-05135-6"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jtxs.12573","article-title":"Relationship between polypharmacy, xerostomia, gustatory sensitivity, and swallowing complaints in the elderly: A multidisciplinary approach","volume":"52","author":"Fernandes","year":"2021","journal-title":"J. Texture Stud."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/ger.12635","article-title":"Anticholinergic burden and poor oral health are associated with frailty in geriatric patients undergoing inpatient rehabilitation: A cross-sectional study","volume":"40","author":"Shwe","year":"2023","journal-title":"Gerodontology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/nau.24536","article-title":"Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis","volume":"40","author":"Dmochowski","year":"2021","journal-title":"Neurourol. Urodyn."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"112766","DOI":"10.1016\/j.physbeh.2019.112766","article-title":"Relating oral physiology and anatomy of consumers varying in age, gender and ethnicity to food oral processing behavior","volume":"215","author":"Ketel","year":"2020","journal-title":"Physiol. Behav."}],"container-title":["Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/2\/25\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:32:04Z","timestamp":1772116324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/2\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["geriatrics11020025"],"URL":"https:\/\/doi.org\/10.3390\/geriatrics11020025","relation":{},"ISSN":["2308-3417"],"issn-type":[{"value":"2308-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}