{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:04:31Z","timestamp":1774627471711,"version":"3.50.1"},"reference-count":86,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Cardiovascular disease (CVD) and cancer frequently coexist in older patients, posing significant challenges in clinical management due to overlapping risk factors and treatment-related complications. This narrative review summarizes current knowledge on the epidemiology, shared pathophysiological mechanisms and clinical impact of neoplastic comorbidities in older adults with cardiovascular diseases. It highlights the increased mortality, morbidity and diminished quality of life resulting from the coexistence of these conditions. The review also discusses personalized management strategies, emphasizing comprehensive geriatric and cardiac assessments, and tailoring oncologic treatments to minimize cardiotoxicity, as well as the role of prevention and rehabilitation programs. As the population ages and cancer survival improves, integrated cardio-oncology care adapted to older adults becomes increasingly essential to optimize outcomes and preserve functional status.<\/jats:p>","DOI":"10.3390\/geriatrics11020035","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:33:33Z","timestamp":1774622013000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoplastic Disorders and Cardiovascular Comorbidities in Geriatric Patients: A Simple Association?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-5706","authenticated-orcid":false,"given":"Andreea Taisia","family":"Tiron","sequence":"first","affiliation":[{"name":"Clinical Department 1-Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Cardiology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian-Vlad","family":"L\u0103p\u0103dat","sequence":"additional","affiliation":[{"name":"Clinical Department 1-Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M\u0103d\u0103lina","family":"Georgic\u0103","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinical and Emergency Hospital \u201cSf. 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Pract."},{"key":"ref_2","first-page":"75","article-title":"Results of prevalence study regarding comorbidities for various patients","volume":"61","author":"Capisizu","year":"2013","journal-title":"Rom. Stat. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Topa, E., De Rosa, E., Cuomo, A., Curcio, F., Rizza, M., Elia, F., Flocco, V., Attanasio, U., Iengo, M., and Fiore, F. (2025). Cardio-Oncology Challenges in Elderly Patients. J. Clin. Med., 14.","DOI":"10.3390\/jcm14093257"},{"key":"ref_4","unstructured":"World Health Organization (2025). Ageing and Health (Fact Sheet), WHO. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7326\/0003-4819-120-2-199401150-00002","article-title":"The effect of comorbidity on 3-year survival of women with primary breast cancer","volume":"120","author":"Satariano","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","article-title":"International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer","volume":"32","author":"Wildiers","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12944-020-01277-9","article-title":"Hyperlipidemias in elderly patients: Results from the Berlin Aging Study II (BASEII), a cross-sectional study","volume":"19","author":"Rosada","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S2213-8587(25)00299-2","article-title":"11th edition of the IDF Diabetes Atlas: Global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050","volume":"14","author":"Genitsaridi","year":"2026","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1093\/eurheartj\/ehz766","article-title":"A population-based study of cardiovascular disease mortality risk in US cancer patients","volume":"40","author":"Sturgeon","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_11","first-page":"7","article-title":"CARDIAC-STAR: Prevalence of cardiovascular comorbidities in patients with HR+\/HER2- metastatic breast cancer","volume":"11","author":"Dent","year":"2025","journal-title":"Cardiooncology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.lungcan.2015.01.006","article-title":"Cardiovascular comorbidities and survival of lung cancer patients: Medicare data based analysis","volume":"88","author":"Kravchenko","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Islam, M.T., Saif, M.S.I., Alam, N., Pepper, S., Ratnayake, I., and Mudaranthakam, D.P. (2025). Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-21784-7"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s11912-025-01638-6","article-title":"Epidemiology of cancer in older adults: A systematic review of age-related differences in solid malignancies treatment","volume":"27","author":"Bastiaannet","year":"2025","journal-title":"Curr. Oncol. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tylutka, A., Walas, \u0141., and Zembron-Lacny, A. (2024). Level of IL-6, TNF, and IL-1\u03b2 and age-related diseases: A systematic review and meta-analysis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1330386"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1038\/s12276-025-01527-9","article-title":"Targeting immunosenescence and inflammaging: Advancing longevity research","volume":"57","author":"Nguyen","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"B\u0103l\u0103ceanu, L.A., Grigore, C., Dina, I., Gur\u0103u, C.-D., Mihai, M.M., and B\u0103l\u0103ceanu-Gur\u0103u, B. (2025). CA125 as a Potential Biomarker in Non-Malignant Serous Effusions: Diagnostic and Prognostic Considerations. J. Clin. Med., 14.","DOI":"10.3390\/jcm14124152"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Katkenov, N., Mukhatayev, Z., Kozhakhmetov, S., Sailybayeva, A., Bekbossynova, M., and Kushugulova, A. (2024). Systematic Review on the Role of IL-6 and IL-1\u03b2 in Cardiovascular Diseases. J. Cardiovasc. Dev. Dis., 11.","DOI":"10.3390\/jcdd11070206"},{"key":"ref_20","first-page":"327","article-title":"Clinical factors and biomarkers in ovarian tumors development","volume":"49","author":"Vrabie","year":"2008","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"188891","DOI":"10.1016\/j.bbcan.2023.188891","article-title":"S100A8 and S100A9 in Cancer","volume":"1878","author":"Chen","year":"2023","journal-title":"Biochim. Biophys. Acta\u2014Rev. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mitranovici, M.-I., Caravia, L., Oal\u0103, I.E., Tiron, A.-T., Buicu, C.-F., Dumitrascu-Biris, D., Munteanu, M., Ivan, V., Apostol, A., and Petre, I. (2025). Exploring the Relevance of S100A8 and S100A9 Proteins in Preeclampsia: A Narrative Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262010118"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cozac, D.-A., Hala\u021biu, V.-B., and Scridon, A. (2025). The alarmin tandem: Unraveling the complex effect of S100A8\/A9\u2014From atherosclerosis to cardiac arrhythmias. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1630410"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaccao.2024.10.010","article-title":"Shared Mechanisms in Cancer and Cardiovascular Disease: S100A8\/9 and the NLRP3 Inflammasome: JACC: CardioOncology State-of-the-Art Review","volume":"7","year":"2025","journal-title":"JACC CardioOncology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Przytu\u0142a, N., Podolec, J., Przew\u0142ocki, T., Podolec, P., and Kab\u0142ak-Ziembicka, A. (2025). Inflammasomes as Potential Therapeutic Targets to Prevent Chronic Active Viral Myocarditis\u2014Translating Basic Science into Clinical Practice. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202509.1796.v1"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhu, L., Tang, Z., Hu, R., Gu, M., and Yang, Y. (2023). Ageing and Inflammation: What Happens in Periodontium?. Bioengineering, 10.","DOI":"10.3390\/bioengineering10111274"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3748\/wjg.v28.i4.402","article-title":"Helicobacter pylori infection: How does age influence the inflammatory pattern?","volume":"28","author":"Marques","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_28","first-page":"e220271","article-title":"Immunology of chronic low-grade inflammation: Relationship with metabolic function","volume":"257","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nishida, A., and Andoh, A. (2025). The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis. Cells, 14.","DOI":"10.3390\/cells14070488"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liu, W., Wang, L., Ou, J., Peng, D., Zhang, Y., Chen, W., and Wang, Y. (2025). Gut Microbiota Metabolites and Chronic Diseases: Interactions, Mechanisms, and Therapeutic Strategies. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083752"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Asgharzadeh, S., Pourhajibagher, M., and Bahador, A. (2025). The microbial landscape of tumors: A deep dive into intratumoral microbiota. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1542142"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3907147","DOI":"10.1155\/2016\/3907147","article-title":"The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression","volume":"2016","author":"Tafani","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Myszko, M., Bychowski, J., Skrzydlewska, E., and \u0141uczaj, W. (2025). The Dual Role of Oxidative Stress in Atherosclerosis and Coronary Artery Disease: Pathological Mechanisms and Diagnostic Potential. Antioxidants, 14.","DOI":"10.3390\/antiox14030275"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Aldosari, S., Awad, M., Harrington, E.O., Sellke, F.W., and Abid, M.R. (2018). Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology. Antioxidants, 7.","DOI":"10.3390\/antiox7010014"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/ijms16010193","article-title":"Oxidative stress and its significant roles in neurodegenerative diseases and cancer","volume":"16","author":"Thanan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e62852","DOI":"10.7554\/eLife.62852","article-title":"DNA damage-how and why we age?","volume":"10","author":"Yousefzadeh","year":"2021","journal-title":"eLife"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.31557\/apjcb.2023.8.1.75-89","article-title":"Epigenetics and Cancer: A Comprehensive Review","volume":"8","author":"Pathak","year":"2023","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"ref_38","first-page":"108","article-title":"Advance and challenge of DNA methylation as cancer biomarkers for risk stratification, screening and early detection","volume":"5","author":"Li","year":"2025","journal-title":"J. Natl. Cancer Cent."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Moln\u00e1r, A.\u00c1., Birg\u00e9s, K., Surman, A., and Merkely, B. (2024). The Complex Connection Between Myocardial Dysfunction and Cancer Beyond Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313185"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"108116","DOI":"10.1016\/j.pharmthera.2022.108116","article-title":"Endothelial dysfunction as a complication of anti-cancer therapy","volume":"237","author":"Terwoord","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_41","first-page":"101300","article-title":"Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction","volume":"49","author":"Hammond","year":"2023","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"da Silva, D.V.T., Bai\u00e3o, D.d.S., Almeida, C.C., and Paschoalin, V.M.F. (2023). A Critical Review on Vasoactive Nutrients for the Management of Endothelial Dysfunction and Arterial Stiffness in Individuals under Cardiovascular Risk. Nutrients, 15.","DOI":"10.3390\/nu15112618"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.amjms.2024.05.017","article-title":"D-dimers in advanced cirrhosis: Useful biomarker or not?","volume":"368","author":"Balaceanu","year":"2024","journal-title":"Am. J. Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12170-016-0485-6","article-title":"Sedentary Behavior and Cardiovascular Risk in Older Adults: A Scoping Review","volume":"10","author":"Hajduk","year":"2016","journal-title":"Curr. Cardiovasc. Risk Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4082\/kjfm.20.0165","article-title":"Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks","volume":"41","author":"Park","year":"2020","journal-title":"Korean J. Fam. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bekendam, R.H., and Ravid, K. (2023). Mechanisms of platelet activation in cancer-associated thrombosis: A focus on myeloproliferative neoplasms. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1207395"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Contursi, A., Tacconelli, S., Di Berardino, S., De Michele, A., and Patrignani, P. (2024). Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: Unveiling new strategies for cancer prevention. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1520488"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Strukel, S., Teshome, B., and Rai, V. (2025). The Multifaceted Role of Platelets in Atherosclerosis and Ischemic Disease: Pathogenesis, Inflammation, and Therapeutic Opportunities. Life, 15.","DOI":"10.3390\/life15111656"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12935-023-03080-9","article-title":"The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: Foes versus allies","volume":"23","author":"Hassani","year":"2023","journal-title":"Cancer Cell Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jaccao.2024.02.001","article-title":"Cardiovascular Concerns, Cancer Treatment, and Biological and Chronological Aging in Cancer: JACC Family Series","volume":"6","author":"Ioffe","year":"2024","journal-title":"JACC CardioOncology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"ehaf784.4086","DOI":"10.1093\/eurheartj\/ehaf784.4086","article-title":"Cardiovascular disease is a significant contributor to the incidence of cancer, second-primary cancer, and cancer-related hospitalization","volume":"46","author":"Caller","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jaccao.2023.01.010","article-title":"Risk of cancer after diagnosis of cardiovascular disease","volume":"5","author":"Bell","year":"2023","journal-title":"JACC CardioOncology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/ehjopen\/oead073","article-title":"Association between heart failure and the incidence of cancer: A systematic review and meta-analysis","volume":"3","author":"Jaiswal","year":"2023","journal-title":"Eur. Heart J. Open"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mauriello, A., Correra, A., Quagliariello, V., Iovine, M., Di Micco, P., Imbalzano, E., Giallauria, F., Giordano, A., Russo, V., and D\u2019Andrea, A. (2025). Atrial Fibrillation and Cancer: Pathophysiological Mechanism and Clinical Implications. J. Clin. Med., 14.","DOI":"10.3390\/jcm14155600"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jaccao.2021.08.011","article-title":"Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis: JACC: CardioOncology State-of-the-Art Review","volume":"3","author":"Leiva","year":"2021","journal-title":"JACC CardioOncology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11795549231220297","DOI":"10.1177\/11795549231220297","article-title":"Cancer-Associated Thrombosis: Epidemiology, Pathophysiological Mechanisms, Treatment, and Risk Assessment","volume":"17","author":"Pavlovic","year":"2023","journal-title":"Clin. Med. Insights Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1002\/cam4.1572","article-title":"Long-term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta-analysis","volume":"7","author":"Boyne","year":"2018","journal-title":"Cancer Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41416-024-02888-0","article-title":"Cardiotoxicity following thoracic radiotherapy for lung cancer","volume":"132","author":"Walls","year":"2025","journal-title":"Br. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1093\/eurheartj\/ehaf260","article-title":"Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy","volume":"46","author":"Kotanidis","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/jamainternmed.2015.1180","article-title":"Cardiovascular disease after Hodgkin lymphoma treatment 40-year disease risk","volume":"175","author":"Schaapveld","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kundnani, N.R., Passini, V., Carlogea, I.S., Dumitrescu, P., Meche, V., Buzas, R., and Duda-Seiman, D.M. (2025). Overview of Oncology: Drug-Induced Cardiac Toxicity. Medicina, 61.","DOI":"10.3390\/medicina61040709"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jjcc.2022.01.001","article-title":"The effects of doxorubicin on cardiac calcium homeostasis and contractile function","volume":"80","author":"Shinlapawittayatorn","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.7150\/jca.78004","article-title":"What Causes Death in Esophageal Cancer Patients Other Than the Cancer Itself: A Large Population-Based Analysis","volume":"13","author":"Zheng","year":"2022","journal-title":"J. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"113426","DOI":"10.1016\/j.ejca.2023.113426","article-title":"Major cardiovascular adverse events in older adults with early-stage triple-negative breast cancer treated with adjuvant taxane + anthracycline versus taxane-based chemotherapy regimens: A SEER-medicare study","volume":"196","author":"Roy","year":"2024","journal-title":"Eur. J. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Guan, T., Su, M., Luo, Z., Peng, W., Zhou, R., Lu, Z., Feng, M., Li, W., Teng, Y., and Jiang, Y. (2022). Long-Term Cardiovascular Mortality among 80,042 Older Patients with Bladder Cancer. Cancers, 14.","DOI":"10.3390\/cancers14194572"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41467-024-45307-x","article-title":"Causes of death among people living with metastatic cancer","volume":"15","author":"Mani","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jaccao.2024.02.003","article-title":"Impact of Preexisting Heart Failure on Treatment and Outcomes in Older Patients With Hodgkin Lymphoma","volume":"6","author":"Upshaw","year":"2024","journal-title":"JACC CardioOncology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/ejhf.1920","article-title":"Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: A position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society","volume":"22","author":"Lyon","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/ejhf.1985","article-title":"The cancer patient and cardiology","volume":"22","author":"Zamorano","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1093\/annonc\/12.suppl_3.S49","article-title":"Quality of life in elderly cancer patients","volume":"12","author":"Repetto","year":"2001","journal-title":"Ann. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2340\/1651-226X.2025.42602","article-title":"Quality of life in older patients with cancer and related unmet needs: A scoping review","volume":"64","author":"Springer","year":"2025","journal-title":"Acta Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"102773","DOI":"10.1016\/j.jgo.2025.102773","article-title":"Treatment decision-making and quality of life versus length of life preferences of older patients with early stage cancer: A systematic review","volume":"16","author":"Martin","year":"2025","journal-title":"J. Geriatr. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"100960","DOI":"10.1016\/j.arr.2019.100960","article-title":"Frailty as a predictor of adverse outcomes in hospitalized older adults: A systematic review and meta-analysis","volume":"56","author":"Veronese","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1634\/theoncologist.2019-0406","article-title":"Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis","volume":"25","author":"Mohamed","year":"2020","journal-title":"Oncologist"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1046\/j.1532-5415.2003.51174.x","article-title":"What Is A Geriatric Syndrome Anyway?","volume":"51","author":"Flacker","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Bergo, E., De Rui, M., Ceolin, C., Iannizzi, P., Curreri, C., Devita, M., Ruffini, C., Chiusole, B., Feltrin, A., and Sergi, G. (2025). Beyond Treatment Decisions: The Predictive Value of Comprehensive Geriatric Assessment in Older Cancer Patients. Cancers, 17.","DOI":"10.3390\/cancers17152489"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12029-025-01337-2","article-title":"Impact of Age and Comorbidities On Therapeutic Decision-making Among Older Patients With Gastrointestinal Cancer","volume":"56","author":"Galli","year":"2025","journal-title":"J. Gastrointest. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e46929","DOI":"10.1097\/MD.0000000000046929","article-title":"Comparative analysis of adverse events associated with epirubicin and doxorubicin: An observational study based on FDA Adverse Event Reporting System (FAERS) following STROBE guidelines","volume":"105","author":"Yang","year":"2026","journal-title":"Medicine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"120000","DOI":"10.1016\/j.cca.2024.120000","article-title":"Early detection of anthracycline-induced cardiotoxicity","volume":"565","author":"Feng","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s10741-025-10531-0","article-title":"Cancer therapy-induced cardiotoxicity: Mechanisms and mitigations","volume":"30","author":"Shil","year":"2025","journal-title":"Heart Fail. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaccao.2019.08.003","article-title":"Efficacy of dexrazoxane in preventing anthracycline cardiotoxicity in breast cancer","volume":"1","author":"Macedo","year":"2019","journal-title":"JACC CardioOncology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.jacc.2019.03.495","article-title":"Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer","volume":"73","author":"Guglin","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e23813","DOI":"10.1096\/fj.202400725RR","article-title":"The multifaceted role of beta-blockers in overcoming cancer progression and drug resistance: Extending beyond cardiovascular disorders","volume":"38","author":"Cavalu","year":"2024","journal-title":"FASEB J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11739-020-02508-8","article-title":"Prevention of anthracycline-induced cardiotoxicity: A systematic review and meta-analysis","volume":"16","author":"Caspani","year":"2021","journal-title":"Intern. Emerg. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejim.2024.04.007","article-title":"Cardio-protective effects of statins in patients undergoing anthracycline-based chemotherapy: An updated meta-analysis of randomized controlled trials","volume":"126","author":"Felix","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Lin, X., Wu, Z., Liu, Y., and Liao, X. (2026). Cancer therapy-related cardiovascular aging: Mechanisms, monitoring, and intervention strategies. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1668623"}],"container-title":["Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/2\/35\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:08:45Z","timestamp":1774624125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/2\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":86,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["geriatrics11020035"],"URL":"https:\/\/doi.org\/10.3390\/geriatrics11020035","relation":{},"ISSN":["2308-3417"],"issn-type":[{"value":"2308-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}