{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:15:51Z","timestamp":1785413751169,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG052493-01A1"],"award-info":[{"award-number":["R01AG052493-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R01AG052493-01A1"],"award-info":[{"award-number":["R01AG052493-01A1"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Introduction: The Trauma Medical Home (TMH) randomized clinical trial tested the efficacy of a collaborative care intervention on the biopsychosocial recovery of older injured adults compared to usual care. Study enrollment occurred between 11 October 2017 and 13 October 2021 and study operations were impacted by the COVID-19 pandemic. It is important to measure the potential effects of COVID-19 on research study participants to ensure accurate reporting of results. The purpose of this secondary analysis was to compare depression and anxiety symptoms and health-related quality of life in older adults at TMH study enrollment pre-COVID-19 and during COVID-19. We hypothesized that those enrolled during COVID-19 would have worse symptoms and quality of life. Methods: This study was a secondary analysis of data from a multicenter randomized clinical trial (R01AG052493-01A1) TMH, that examined the ability of a collaborative care model to enhance the recovery of older injured adults compared to usual care. It was hypothesized that the TMH intervention would improve biopsychosocial recovery for injured older adults compared to usual care. The enrollment periods pre-COVID-19 and during COVID-19 were compared. Chi-square tests and Wilcoxon Rank Sum tests, then multivariable linear and logistic regressions were completed with SF-36 component scores and depression (PHQ-9) and anxiety (GAD-7) scores as the dependent variables, respectively. Results: A total of 429 participants were analyzed. There was no significant difference in anxiety and depression symptoms between the pre-COVID-19 and during-COVID-19 enrollment periods. Perceived limitations due to physical health problems were worse for those enrolled during COVID-19 (adjusted \u03b2 = \u22129.8, 95% CI \u221218.3 to \u22121.4), but other health-related quality of life measures were similar between the two groups. Conclusions: These findings support the conclusion that the negative psychological impacts of the pandemic are likely due to individual factors other than age or COVID-19. These results suggest a high degree of psychological resiliency in older adults under stress. Future research should focus on the potential effects of socioeconomic status, demographic background, and level of physical functioning on psychological outcomes.<\/jats:p>","DOI":"10.3390\/geriatrics11040090","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:00:17Z","timestamp":1784548817000},"page":"90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Pandemic- and During-COVID-19 Anxiety and Depression Symptoms and Health-Related Quality of Life Were Similar in Injured Older Adults Enrolled in a Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-7778","authenticated-orcid":false,"given":"Damaris","family":"Ortiz","sequence":"first","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"},{"name":"Surgical Outcomes and Quality Improvement Center, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7784-6723","authenticated-orcid":false,"given":"Nicholas Adam","family":"Sergiwa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Holler","sequence":"additional","affiliation":[{"name":"Surgical Outcomes and Quality Improvement Center, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-2274","authenticated-orcid":false,"given":"Ashley D.","family":"Meagher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"},{"name":"Indiana University Health, Methodist Hospital Level One Trauma Center, 1701 Senate Ave., Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-3457","authenticated-orcid":false,"given":"Sanjay","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"},{"name":"Surgical Outcomes and Quality Improvement Center, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin D.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-2557","authenticated-orcid":false,"given":"Sue","family":"Lasiter","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Studies, Health Sciences District, University of Missouri, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babar","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, 1120 W. Michigan St., CL 260, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-677X","authenticated-orcid":false,"given":"Malaz","family":"Boustani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, 1120 W. Michigan St., CL 260, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Zarzaur","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin School of Medicine, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/geront\/gnaa138","article-title":"Challenges Experienced by Older People During the Initial Months of the COVID-19 Pandemic","volume":"61","author":"Heid","year":"2021","journal-title":"Gerontologist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/0898264321991314","article-title":"Impact of COVID-19 \u2018Stay Home, Stay Healthy\u2019 Orders on Function among Older Adults Participating in a Community-Based, Behavioral Intervention Study","volume":"33","author":"Adams","year":"2021","journal-title":"J. Aging Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12992-021-00698-0","article-title":"Exploring fear of COVID-19 and its correlates among older adults in Bangladesh","volume":"17","author":"Mistry","year":"2021","journal-title":"Glob. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.jamda.2021.09.003","article-title":"Depressive Symptoms Among Older Adults Pre- and Post-COVID-19 Pandemic","volume":"22","author":"Briggs","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/geronb\/gbaa120","article-title":"Age Differences in Risk and Resilience Factors in COVID-19-Related Stress","volume":"76","author":"Pearman","year":"2021","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/jgs.18146","article-title":"Rationale, Design, and Characteristics of the VALIANT (COVID-19 in Older Adults: A Longitudinal Assessment) Cohort","volume":"71","author":"Cohen","year":"2023","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6909413","DOI":"10.1155\/2022\/6909413","article-title":"The Impact of the COVID-19 Pandemic on the Mental Health of Older Primary Care Patients and Their Family Members","volume":"2022","author":"Seibert","year":"2022","journal-title":"J. Aging Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e817","DOI":"10.3399\/bjgp20X713021","article-title":"Impact of COVID-19 on loneliness, mental health, and health service utilisation: A prospective cohort study of older adults with multimorbidity in primary care","volume":"70","author":"Wong","year":"2020","journal-title":"Br. J. Gen. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101124","DOI":"10.1016\/j.conctc.2023.101124","article-title":"COVID-19 and the Physio4FMD trial: Impact, mitigating strategies and analysis plans","volume":"33","author":"Marston","year":"2023","journal-title":"Contemp. Clin. Trials Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/jgs.17170","article-title":"Research on the front lines of COVID-19 in hospitalized older adults with dementia","volume":"69","author":"Sinvani","year":"2021","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/jamasurg.2024.1043","article-title":"Collaborative Care for Injured Older Adults: The Trauma Medical Home Randomized Clinical Trial","volume":"159","author":"Zarzaur","year":"2024","journal-title":"JAMA Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e074787","DOI":"10.1136\/bmj-2023-074787","article-title":"Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): Randomised controlled trial","volume":"382","author":"Harwood","year":"2023","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.amepre.2012.01.019","article-title":"Collaborative care to improve the management of depressive disorders: A community guide systematic review and meta-analysis","volume":"42","author":"Thota","year":"2012","journal-title":"Am. J. Prev. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1056\/NEJMoa1003955","article-title":"Collaborative care for patients with depression and chronic illnesses","volume":"363","author":"Katon","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/fampra\/cmr108","article-title":"Variations in depression care and outcomes among high-risk mothers from different racial\/ethnic groups","volume":"29","author":"Huang","year":"2012","journal-title":"Fam. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jamasurg.2021.0131","article-title":"Stepped Collaborative Care Targeting Posttraumatic Stress Disorder Symptoms and Comorbidity for US Trauma Care Systems: A Randomized Clinical Trial","volume":"156","author":"Zatzick","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1001\/jama.288.22.2836","article-title":"Collaborative Care Management of Late-Life Depression in the Primary Care Setting: A Randomized Controlled Trial","volume":"288","author":"Katon","year":"2002","journal-title":"JAMA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1186\/s13063-020-04582-x","article-title":"A trauma medical home, evaluating collaborative care for the older injured patient: Study protocol for a randomized controlled trial","volume":"21","author":"Ortiz","year":"2020","journal-title":"Trials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J. Trauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1097\/AS9.0000000000000217","article-title":"Pre-Existing Anxiety and Depression in Injured Older Adults: An Under-Recognized Comorbidity with Major Health Implications","volume":"3","author":"Ortiz","year":"2022","journal-title":"Ann. Surg. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7326\/0003-4819-146-5-200703060-00004","article-title":"Anxiety disorders in primary care: Prevalence, impairment, comorbidity, and detection","volume":"146","author":"Kroenke","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: Validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/00005650-200412000-00006","article-title":"Monitoring depression treatment outcomes with the patient health questionnaire-9","volume":"42","author":"Lowe","year":"2004","journal-title":"Med. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/ip.2.2.135","article-title":"The SF-36 health survey: A valid measure of changes in health status after injury","volume":"2","author":"Kopjar","year":"1996","journal-title":"Inj. Prev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/00005373-200005000-00007","article-title":"Outcome from injury: General health, work status, and satisfaction 12 months after trauma","volume":"48","author":"Michaels","year":"2000","journal-title":"J. Trauma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s40520-021-01873-4","article-title":"A review on the COVID-19-related psychological impact on older adults: Vulnerable or not?","volume":"33","author":"Parlapani","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jpsychires.2022.05.022","article-title":"The effect of pre-pandemic PTSD and depression symptoms on mental distress among older adults during COVID-19","volume":"151","author":"Hoffman","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/aid.2021.0024","article-title":"Facors Influencing Psychological Distress During the COVID-19 Pandemic in People Aging with HIV","volume":"38","author":"Brouillette","year":"2022","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1093\/geronb\/gbab173","article-title":"Financial Hardship and Psychological Resilience During COVID-19: Differences by Race\/Ethnicity","volume":"77","author":"Taylor","year":"2022","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/07317115.2021.1928355","article-title":"Emotional Resilience of Older Adults during COVID-19: A Systematic Review of Studies of Stress and Well-Being","volume":"45","author":"Sterina","year":"2022","journal-title":"Clin. Gerontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1044\/2022_AJA-21-00234","article-title":"Adults With Hearing Loss Demonstrate Resilience During COVID-19 Pandemic: Applications for Postpandemic Services","volume":"31","author":"Teece","year":"2022","journal-title":"Am. J. Audiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hoel, V., Wolf-Ostermann, K., and Ambugo, E.A. (2022). Social Isolation and the Use of Technology in Caregiving Dyads Living With Dementia During COVID-19 Restrictions. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.697496"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e1983","DOI":"10.1002\/pri.1983","article-title":"Functional impact on adults and older people after hospitalization by COVID-19","volume":"28","author":"Ochiai","year":"2023","journal-title":"Physiother. Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101896","DOI":"10.1016\/j.eclinm.2023.101896","article-title":"Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: A multicentre, longitudinal cohort study","volume":"57","author":"McAuley","year":"2023","journal-title":"EClinicalMedicine"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wister, A., Li, L., Cosco, T.D., McMillan, J., Griffith, L.E., and Canadian Longitudinal Study on Aging, T. (2022). Multimorbidity resilience and COVID-19 pandemic self-reported impact and worry among older adults: A study based on the Canadian Longitudinal Study on Aging (CLSA). BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-02769-2"}],"container-title":["Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/4\/90\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:34:03Z","timestamp":1784651643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3417\/11\/4\/90"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["geriatrics11040090"],"URL":"https:\/\/doi.org\/10.3390\/geriatrics11040090","relation":{},"ISSN":["2308-3417"],"issn-type":[{"value":"2308-3417","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}