{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:27Z","timestamp":1791925227367,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Background: Gut microbiota plays a key role in the aging process, with age-related microbial shifts contributing to chronic inflammation, metabolic dysfunction, frailty, and cognitive decline. Despite growing interest, an integrated synthesis of how diet and lifestyle modifications influence gut microbiota remains limited. This overview of reviews summarizes the current evidence on how dietary and lifestyle interventions shape microbial composition and affect aging outcomes. Methods: Following the PRISMA guidelines, we searched PubMed and Scopus for English-language reviews (January 2023\u2013October 2025) including human adults aged \u2265 18 years, evaluating dietary or lifestyle interventions, and reporting gut microbiota with healthy-aging outcomes. Quality of the reviews was appraised using the SANRA tool. Results: Mediterranean and plant-based diets, calorie restriction, and microbiota-targeted approaches such as probiotics, prebiotics, symbiotics, and fecal microbiota transplantation were associated with increases in short-chain fatty acid-producing bacteria, including Faecalibacterium, Bifidobacterium, Lactobacillus, and Akkermansia muciniphila, while reducing pro-inflammatory taxa. These changes were linked to improved metabolic and immune function, reduced inflammaging, lower frailty, and greater physical resilience. Cognitive benefits included decreased neuroinflammation and a lower risk of Alzheimer\u2019s and Parkinson\u2019s diseases. Conclusions: Maintaining microbial balance through targeted dietary strategies may support healthier, more resilient aging, offering practical insights for public health and clinical nutrition planning.<\/jats:p>","DOI":"10.3390\/geriatrics11040107","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:05:41Z","timestamp":1786953941000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How Gut Microbiota Influence Healthy Aging: Overview of Reviews"],"prefix":"10.3390","volume":"11","author":[{"given":"Tejas Ganesh","family":"Todmal","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, NO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-3911","authenticated-orcid":false,"given":"Rabia","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, NO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-6906","authenticated-orcid":false,"given":"Giovanni","family":"Cangelosi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Experimental Medicine and \u201cStefani Scuri\u201d Public Health Department, University of Camerino, 62032 Camerino, MC, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Panella","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, NO, Italy"},{"name":"Direzione Medica dei Presidi Ospedalieri, Azienda Ospedaliero-Universitaria di Alessandria, 15121 Alessandria, AL, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-3777","authenticated-orcid":false,"given":"Alice","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, NO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Petrut, S.-M., Bragaru, A.M., Munteanu, A.E., Moldovan, A.-D., Moldovan, C.-A., and Rusu, E. 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