{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:24:26Z","timestamp":1787117066508,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bayes Center Health Sciences","award":["XXII Bayes Center Health Sciences Grant"],"award-info":[{"award-number":["XXII Bayes Center Health Sciences Grant"]}]},{"DOI":"10.13039\/501100019945","name":"Departament de Recerca i Universitats","doi-asserted-by":"publisher","award":["grant number 2024 DI 00157"],"award-info":[{"award-number":["grant number 2024 DI 00157"]}],"id":[{"id":"10.13039\/501100019945","id-type":"DOI","asserted-by":"publisher"}]},{"award":["grant number 2024 DI 00157"],"award-info":[{"award-number":["grant number 2024 DI 00157"]}],"id":[{"id":"https:\/\/ror.org\/01gbnem66","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Objectives: To examine the association between premorbid personality in people with Alzheimer\u2019s disease and caregiver well-being, while accounting for caregiver personality, sociodemographic characteristics, and behavioural and psychological symptoms of dementia. Methods: This cross-sectional observational study included 56 dyads consisting of people with mild-to-moderate Alzheimer\u2019s disease and their informal caregiver. Caregiver well-being was operationalised using a continuous index derived from a principal component analysis integrating depressive and anxiety symptoms, burden, loneliness, perceived social support, quality of life and happiness. Caregiver personality and the premorbid personality of people with Alzheimer\u2019s disease (assessed retrospectively by an informant) were assessed according to the Big Five model. Behavioural and psychological symptoms of dementia were assessed using the Neuropsychiatric Inventory. Associations were examined using correlation analyses and hierarchical multiple linear regression models. Results: Caregivers had a mean age of 55.2 years (SD = 11.0), and 82.1% were women. Higher premorbid extraversion of people with Alzheimer\u2019s disease was significantly associated with better caregiver well-being (\u03b2 = 0.123; p &lt; 0.05), and this association remained significant after adjustment for caregiver personality and other covariates. The final model explained 57.3% of the variance in caregiver well-being (R2 = 0.573; p &lt; 0.001). Conclusions: Premorbid extraversion of people with Alzheimer\u2019s disease was independently associated with caregiver well-being. These findings suggest that personality characteristics of both may be relevant for understanding caregiver well-being within a relational perspective of caregiving.<\/jats:p>","DOI":"10.3390\/geriatrics11040108","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:35:08Z","timestamp":1786984508000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Premorbid Personality in Alzheimer\u2019s Disease and Caregiver Well-Being: The Role of Extraversion"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-4862","authenticated-orcid":false,"given":"Jordina","family":"Mu\u00f1oz-Padros","sequence":"first","affiliation":[{"name":"Vic Hospital Consortium, Carrer de Francesc Pla el Vigat\u00e0, 1, 08500 Vic, Spain"},{"name":"Comprehensive Care and Health Services Doctoral Programme, Doctoral School, University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6069-5305","authenticated-orcid":false,"given":"Quint\u00ed","family":"Foguet-Boreu","sequence":"additional","affiliation":[{"name":"Vic Hospital Consortium, Carrer de Francesc Pla el Vigat\u00e0, 1, 08500 Vic, Spain"},{"name":"Multidisciplinary Inflammation Research Group (MIRG), Institut de Recerca i Innovaci\u00f3 en Ci\u00e8ncies de La Vida i de La Salut a La Catalunya Central (IRIS-CC), 08500 Vic, Spain"},{"name":"Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Puigoriol-Juvanteny","sequence":"additional","affiliation":[{"name":"Vic Hospital Consortium, Carrer de Francesc Pla el Vigat\u00e0, 1, 08500 Vic, Spain"},{"name":"Multidisciplinary Inflammation Research Group (MIRG), Institut de Recerca i Innovaci\u00f3 en Ci\u00e8ncies de La Vida i de La Salut a La Catalunya Central (IRIS-CC), 08500 Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-8249","authenticated-orcid":false,"given":"Maite","family":"Garolera","sequence":"additional","affiliation":[{"name":"Neuropsychology Unit, Terrassa Sanitary Consortium, 08227 Terrassa, Spain"},{"name":"Brain, Cognition and Behaviour of Clinical Research, Terrassa Sanitary Consortium, 08227 Terrassa, Spain"},{"name":"Department of Psychology, Catalunya International University, 08195 Sant Cugat del Vall\u00e8s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Safiri, S., Ghaffari Jolfayi, A., Fazlollahi, A., Morsali, S., Sarkesh, A., Daei Sorkhabi, A., Golabi, B., Aletaha, R., Asghari, K.M., and Hamidi, S. 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