{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:10Z","timestamp":1789571110199,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Longevity science has shifted from the pursuit of lifespan extension toward preservation of healthspan, resilience, and functional independence. The hallmarks of aging provide a powerful descriptive structure, but they do not by themselves specify how diverse molecular defects translate into loss of adaptive function. We propose a complementary conceptual framework in which aging is viewed as progressive impairment of biological self-correction: the distributed capacity to sense consequential perturbations, scale an appropriate response, repair or remove damage, terminate the response, and recover or adaptively re-equilibrate while preserving future functional reserve. This framework is not intended to replace homeostasis, homeodynamics, allostasis, physiological reserve, or resilience; rather, it links these established concepts to the molecular machinery that generates dynamic recovery. Correction fidelity is proposed to be measured independently of the hallmarks using stress-response trajectories, including response latency, magnitude of deviation, recovery slope or half-time, integrated deviation, residual deficit, overshoot, biological cost, final functional state, and preservation of subsequent reserve. Importantly, successful recovery need not mean return to a fixed youthful baseline because aging may also shift the physiological setpoint toward a less favorable but actively defended equilibrium. We integrate evolutionary and biodemographic principles with inflammaging, nutrient sensing, NAD+ biology, senescence, autophagy, partial reprogramming, and resilience research, and propose falsifiable predictions for testing whether dynamic recovery adds information beyond chronological age, frailty, and static aging biomarkers.<\/jats:p>","DOI":"10.3390\/geriatrics11050134","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:50:27Z","timestamp":1789566627000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aging as Loss of Biological Self-Correction: A Geroscience Framework for Longevity, Inflammaging, and Restored Resilience"],"prefix":"10.3390","volume":"11","author":[{"given":"David","family":"Bar-Or","sequence":"first","affiliation":[{"name":"Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-2607","authenticated-orcid":false,"given":"Jason","family":"Williams","sequence":"additional","affiliation":[{"name":"Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-8001","authenticated-orcid":false,"given":"Daniel","family":"Paredes","sequence":"additional","affiliation":[{"name":"Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking Aging to Chronic Disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"a025163","DOI":"10.1101\/cshperspect.a025163","article-title":"The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span","volume":"6","author":"Sierra","year":"2016","journal-title":"Cold Spring Harb. 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