{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:41:48Z","timestamp":1792226508739,"version":"4.4.0"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>An imbalance of regeneration and destruction of the extracellular matrix due to a plethora of chemo- and cytokines, elevated matrix metalloproteinases, bacterial contamination and repetitive painless tissue damage can lead the chronicity of a wound, especially in diabetic foot ulcers (DFU). Along general lines, wound healing and cancer development are similar. Therefore chronic wounds prepare a breeding ground for cancer development. Several characteristics such as increase in size, verrucous everted margins and contact bleeding are suspicious for malignant growth in a chronic wound. While previously the term Marjolin\u2019s ulcer was attributed to a malignant tumor in (burn) scars, it is nowadays used for every malignant tumor in chronic wounds. Furthermore, chronic ulcers in diabetic feet are susceptible for malignant transformation. We describe two cases of squamous cell carcinoma in patients with DFU\u2014a 71 year-old woman and a 67 year old man. Both received total tumor excision and split-skin grafts with good short-time results.<\/jats:p>","DOI":"10.3390\/geriatrics4040062","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T11:17:25Z","timestamp":1573125445000},"page":"62","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Malignant Transformation in Diabetic Foot Ulcers\u2014Case Reports and Review of the Literature"],"prefix":"10.3390","volume":"4","author":[{"given":"Stefan","family":"D\u00f6rr","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Geriatrics, Stuttgart General Hospital, 70374 Bad Cannstatt, 24 Prie\u00dfnitzweg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Lucke-Paulig","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Geriatrics, Stuttgart General Hospital, 70374 Bad Cannstatt, 24 Prie\u00dfnitzweg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Stuttgart General Hospital, 70374 Bad Cannstatt, 24 Prie\u00dfnitzweg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Lobmann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Geriatrics, Stuttgart General Hospital, 70374 Bad Cannstatt, 24 Prie\u00dfnitzweg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2337\/dc08-0763","article-title":"Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers","volume":"32","author":"Liu","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1046\/j.1523-1747.1998.00381.x","article-title":"Differences in cellular infiltrate and extracellular Matrix of chronic diabetic and venous ulcers versus acute wounds","volume":"111","author":"Loots","year":"1998","journal-title":"J. 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