{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:06:54Z","timestamp":1763748414670,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160"],"award-info":[{"award-number":["U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000046","name":"Abbott","doi-asserted-by":"publisher","award":["(none)"],"award-info":[{"award-number":["(none)"]}],"id":[{"id":"10.13039\/100000046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>How different measures of adiposity are similarly or differentially related to mobility limitation and mortality is not clear. In total, 5849 community-dwelling men aged \u226565 years (mean age: 72 years) were followed mortality over 10 years and self-reported mobility limitations (any difficulty walking 2\u20133 blocks or with climbing 10 steps) at six contacts over 14 years. Baseline measures of adiposity included weight, BMI and percent fat by DXA. Appendicular lean mass (ALM, by DXA) was analyzed as ALM\/ht2. Proportional hazards models estimated the risk of mortality, and repeated measures generalized estimating equations estimated the likelihood of mobility limitation. Over 10 years, 27.9% of men died; over 14 years, 48.0% of men reported at least one mobility limitation. We observed U-shaped relationships between weight, BMI, percent fat and ALM\/ht2 with mortality. There was a clear log-linear relationship between weight, BMI and percent fat with incident mobility limitation, with higher values associated with a greater likelihood of mobility limitation. In contrast, there was a U-shaped relationship between ALM\/ht2 and incident mobility limitation. These observational data suggest that no single measure of adiposity or body composition reflects both the lowest risk of mortality and the lowest likelihood for developing mobility limitation in older men.<\/jats:p>","DOI":"10.3390\/geriatrics6020053","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T23:34:46Z","timestamp":1621380886000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body Weight, BMI, Percent Fat and Associations with Mortality and Incident Mobility Limitation in Older Men"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9478","authenticated-orcid":false,"given":"Peggy M.","family":"Cawthon","sequence":"first","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco, CA 94143, USA"},{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Rogers-Soeder","sequence":"additional","affiliation":[{"name":"Sacramento VA Medical Center, Mather, CA 95655, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-394X","authenticated-orcid":false,"given":"Katey","family":"Webber","sequence":"additional","affiliation":[{"name":"Research Institute, California Pacific Medical Center, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satya","family":"Jonnalagadda","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Inc., Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-7266","authenticated-orcid":false,"given":"Suzette L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Inc., Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California at Davis Medical Center, Sacramento, CA 95871, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Shikany","sequence":"additional","affiliation":[{"name":"Division of Preventative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samaneh","family":"Farsijani","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Langsetmo","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","unstructured":"Ogden, C.L., Carroll, M.D., Fryar, C.D., and Flegal, K.M. 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