{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:34:18Z","timestamp":1760150058134,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Background: Orthostatic hypotension (OH) is a common blood pressure abnormality in older adults that makes them prone to balance disorders and falls. The maintenance of balance relies on a complex regulatory system. The use of computerized dynamic posturography (CDP) can provide a quantitative evaluation of balance function. The objective of this study was to utilize CDP to measure balance indicators in older individuals with OH. Methods: A total of 303 older adults were divided into an OH group of 91 and a non-OH group of 212. Various factors, including chronic diseases, medication history, laboratory tests, and balance indicators, were compared between the two groups. Results: \u2460 Participants with OH had more chronic diseases, including coronary heart disease (p = 0.049) and a history of falls (p &lt; 0.001), than those without OH. A history of multiple medications in the OH group was significantly more likely than in the non-OH group (p = 0.006). \u2461 There was a significant reduction in the composite equilibrium score (SOT-COM) (p &lt; 0.001), vision ratio score (VIS) (p &lt; 0.001), vestibular ratio score (VEST) (p &lt; 0.001), and directional control (DCL) (p = 0.028) in the OH group. \u2462 A logistic regression analysis revealed that SOT-COM was a significant independent factor associated with OH. The area under the curve (AUC) of SOT-COM was 0.833 (95% confidence interval: 0.778\u20130.887, p &lt; 0.001), with a sensitivity of 0.826 and a specificity of 0.759. Conclusions: This study demonstrates that older individuals with OH are more prone to falls, due to decreased sensory integration for balance.<\/jats:p>","DOI":"10.3390\/geriatrics8050103","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:55:06Z","timestamp":1697622906000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Assessment of Balance Function Characteristics in Older Patients with Orthostatic Hypotension"],"prefix":"10.3390","volume":"8","author":[{"given":"Yao","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(22)00169-7","article-title":"Diagnosis and treatment of orthostatic hypotension","volume":"21","author":"Wieling","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"afac295","DOI":"10.1093\/ageing\/afac295","article-title":"Asymptomatic orthostatic hypotension and risk of falls in community-dwelling older people","volume":"51","author":"Claffey","year":"2022","journal-title":"Age Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.arr.2018.10.007","article-title":"Orthostatic hypotension and physical functioning in older adults: A systematic review and meta-analysis","volume":"48","author":"Mol","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autneu.2011.02.004","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"161","author":"Freeman","year":"2011","journal-title":"Auton. Neurosci. Basic"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2147\/CIA.S81283","article-title":"Uncontrolled hypertension and orthostatic hypotension in relation to standing balance in older hypertensive patients","volume":"10","author":"Shen","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"ii7","DOI":"10.1093\/ageing\/afl077","article-title":"Postural orientation and equilibrium: What do we need to know about neural control of balance to prevent falls?","volume":"35","author":"Horak","year":"2006","journal-title":"Age Ageing"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0002-9343(99)00425-8","article-title":"The association between orthostatic hypotension and recurrent falls in nursing home residents","volume":"108","author":"Ooi","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1519\/JPT.0000000000000186","article-title":"Diminished Dynamic Physical Performance is Associated with orthostatic hypotension in Geriatric Outpatients","volume":"42","author":"Reijnierse","year":"2019","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_9","first-page":"439","article-title":"A prospective study of the association between orthostatic hypotension and falls: Definition matters","volume":"46","author":"McDonald","year":"2017","journal-title":"Age Ageing"},{"key":"ref_10","first-page":"940","article-title":"The clinical use of dynamic posturography in the older","volume":"68","author":"Shepard","year":"1989","journal-title":"Ear Nose Throat J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fiedorov\u00e1, I., Mr\u00e1zkov\u00e1, E., Z\u00e1drapov\u00e1, M., and Tom\u00e1\u0161kov\u00e1, H. (2022). Receiver Operating Characteristic Curve Analysis of the Somatosensory Organization Test, Berg Balance Scale, and Fall Efficacy Scale-International for Predicting Falls in Discharged Stroke Patients. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19159181"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s40520-018-1003-0","article-title":"Vestibular rehabilitation in older patients with postural instability: Reducing the number of falls-a randomized clinical trial","volume":"30","year":"2018","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jacc.2015.06.1084","article-title":"Orthostatic hypotension: Epidemiology, Prognosis, and Treatment","volume":"66","author":"Ricci","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e010573","DOI":"10.1161\/CIRCEP.121.010573","article-title":"Orthostatic hypotension: Management of a Complex, but Common, Medical Problem","volume":"15","author":"Fedorowski","year":"2022","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/HJH.0000000000000781","article-title":"Orthostatic hypotension and drug therapy in patients at an outpatient comprehensive geriatric assessment unit","volume":"34","author":"Press","year":"2016","journal-title":"J. Hypertens."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainresrev.2010.12.002","article-title":"The thalamocortical vestibular system in animals and humans","volume":"67","author":"Lopez","year":"2011","journal-title":"Brain Res. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/hipo.20588","article-title":"Move it or lose it--is stimulation of the vestibular system necessary for normal spatial memory?","volume":"20","author":"Smith","year":"2010","journal-title":"Hippocampus"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Onofrei, R.R., and Amaricai, E. (2022). Postural Balance in Relation with Vision and Physical Activity in Healthy Young Adults. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19095021"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104078","DOI":"10.1016\/j.archger.2020.104078","article-title":"Executive function as a mediating factor between visual acuity and postural stability in cognitively healthy adults and adults with Alzheimer\u2019s dementia","volume":"89","author":"Hunter","year":"2020","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3109\/00016489.2010.498024","article-title":"Effect of vision, proprioception, and the position of the vestibular organ on postural sway","volume":"130","author":"Hansson","year":"2010","journal-title":"Acta Oto-Laryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.apmr.2013.08.012","article-title":"Age-related hip proprioception declines: Effects on postural sway and dynamic balance","volume":"95","author":"Wingert","year":"2014","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s41999-021-00505-4","article-title":"Subjective vision and hearing impairment and falls among community-dwelling adults: A prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE)","volume":"12","author":"Ogliari","year":"2021","journal-title":"Eur. Geriatr. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/archinternmed.2009.66","article-title":"Disorders of balance and vestibular function in US adults: Data from the National Health and Nutrition Examination Survey, 2001\u20132004","volume":"169","author":"Agrawal","year":"2009","journal-title":"Arch. Int. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2692155231162423","DOI":"10.1177\/02692155231162423","article-title":"Vestibular dysfunction in people who fall: A systematic review and meta-analysis of prevalence and associated factors","volume":"37","author":"Donovan","year":"2023","journal-title":"Clin. Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000351204","article-title":"Benign paroxysmal positional vertigo in the older","volume":"59","author":"Zschaeck","year":"2013","journal-title":"Gerontology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4239\/wjd.v1.i2.57","article-title":"Neurodegeneration: An early event of diabetic retinopath","volume":"1","author":"Villarroel","year":"2010","journal-title":"World J. Diabetes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/ajh\/hpu301","article-title":"Orthostatic blood pressure changes and subclinical markers of atherosclerosis","volume":"28","author":"Takahashi","year":"2015","journal-title":"Am. J. Hypertens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jns.2016.11.027","article-title":"Lower body mass index is associated with orthostatic hypotension in Parkinson\u2019s disease","volume":"372","author":"Nakamura","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jash.2016.06.038","article-title":"Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults","volume":"10","author":"Veronese","year":"2016","journal-title":"J. Am. Soc. Hypertens."}],"container-title":["Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3417\/8\/5\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:08:48Z","timestamp":1760130528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3417\/8\/5\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["geriatrics8050103"],"URL":"https:\/\/doi.org\/10.3390\/geriatrics8050103","relation":{},"ISSN":["2308-3417"],"issn-type":[{"type":"electronic","value":"2308-3417"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}