{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:43:16Z","timestamp":1792507396210,"version":"4.5.0"},"reference-count":101,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics"],"abstract":"<jats:p>Alzheimer\u2019s disease was described more than 100 years ago and despite the fact that several molecules are being tested for its treatment, which are in phase III trials, the disease continues to progress. The main problem is that these molecules function properly in healthy neurons, while neuronal pathology includes plasma membrane disruption, malfunction of various organelles, and hyperphosphorylation of Tau and amyloid plaques. The main objective of this article is the discussion of a neuronal restoration therapy, where molecules designed for the treatment of Alzheimer\u2019s disease would probably be more effective, and the quality of life of people would be better.<\/jats:p>","DOI":"10.3390\/geriatrics9040086","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:41:12Z","timestamp":1719225672000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alzheimer\u2019s Disease: Cellular and Pharmacological Aspects"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-5473","authenticated-orcid":false,"given":"Gonzalo Emiliano","family":"Aranda-Abreu","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Rojas-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-5636","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Hern\u00e1ndez-Aguilar","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deissy","family":"Herrera-Covarrubias","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-5787","authenticated-orcid":false,"given":"Lizbeth Donaj\u00ed","family":"Ch\u00ed-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-4944","authenticated-orcid":false,"given":"Mar\u00eda Rebeca","family":"Toledo-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-5143","authenticated-orcid":false,"given":"Jorge Manuel","family":"Su\u00e1rez-Medell\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91192, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/0004-282X20140207","article-title":"Alzheimer\u2019s 100th anniversary of death and his contribution to a better understanding of Senile dementia","volume":"73","author":"Engelhardt","year":"2015","journal-title":"Arq. 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