{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:06:25Z","timestamp":1788199585598,"version":"build-2803163510"},"reference-count":106,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Healthcare"],"abstract":"<jats:p>(1) Background: Molar-incisor hypomineralization (MIH) is a clinical condition affecting permanent teeth in children, with a documented rising trend in the last two decades. The aim of the present study was to analyze and synthesize the available evidence on caries experience (dmft\/DMFT) and MIH in children. (2) Methods: A systematic review and meta-analysis were conducted according to the PRISMA statement. (3) Results: 59 papers published between 2007 and 2022 were included in the qualitative synthesis and 18 in the meta-analysis. The total sample of subjects was 17,717 (mean: 896), of which 2378 (13.4%) had MIH (mean: 119), with a girl\/boy ratio of 1:1. The mean age of the enrolled participants was 8.6 (age range 7\u201310 years). Meta-analysis showed that MIH has a positive correlation with both dmft (effect size of 0.67, 95% CI [0.15, 1.19]) and DMFT (effect size of 0.56, 95% CI [0.41, 0.72]); (4) Conclusions: Children with MIH should be diagnosed correctly and on time. Treatment and management options for moderate and severe forms of MIH should consider prognosis based on known risk factors, and secondary and tertiary prevention policies should also consider the multifactorial nature of caries etiology.<\/jats:p>","DOI":"10.3390\/healthcare11121795","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:59:51Z","timestamp":1687139991000},"page":"1795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-681X","authenticated-orcid":false,"given":"Marta","family":"Mazur","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-4106","authenticated-orcid":false,"given":"Denise","family":"Corridore","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-8607","authenticated-orcid":false,"given":"Artnora","family":"Ndokaj","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-4863","authenticated-orcid":false,"given":"Roman","family":"Ardan","sequence":"additional","affiliation":[{"name":"Department of Economic Sciences, Koszalin University of Technology, 75-343 Koszalin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-9889","authenticated-orcid":false,"given":"Iole","family":"Vozza","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-3490","authenticated-orcid":false,"given":"Sylvie","family":"Babajko","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research in Odontology, Unit\u00e9 Propre de Recherche 2496, Universit\u00e9 Paris Cit\u00e9, 1 rue Maurice Arnoux, 92120 Montrouge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Jedeon","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Research in Odontology, Unit\u00e9 Propre de Recherche 2496, Universit\u00e9 Paris Cit\u00e9, 1 rue Maurice Arnoux, 92120 Montrouge, France"},{"name":"Department of Restorative Dentistry and Endodontics, Rothschild Hospital, 5 rue Santerre, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"key":"ref_1","first-page":"114","article-title":"Molar incisor hypomineralisation (MIH)","volume":"4","author":"Weerheijm","year":"2003","journal-title":"Eur. 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