{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:21:36Z","timestamp":1780467696953,"version":"3.54.1"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Infertility as a consequence of therapy presents a high psychosocial burden for HL patients. In the cohort of our analyzed patients, within the post-ABVD surviving patients, alterations of the spermogram were documented in a total of 6.1% of the male patients and 5.4% of the female patients developed amenorrhea. On the other hand, within the subgroup of surviving patients following BEACOPP chemotherapy, 60% of the male patients manifested defects in their spermogram, and as high as 28.6% of the female survivors reported loss of their monthly cycle. It has been reported on several occasions that even prior to treatment, the sperm of HL patients manifests poorer quality characteristics when analyzed against control specimens from healthy male donors. The analyzed results in ABVD-treated male HL patients confirm ABVD to be a safe regimen for males of all age categories, as well as for female patients under the age of thirty. In women above the age of 30, the infertility risk rate is relatively low (14%), which leaves the decision of preserving fertility to themselves. For all BEACOPP-treated female, as well as male patients, a consult with a reproductive medicine specialist is warranted prior to therapy, due to the high infertility risk, and the final decision should be made on an individual basis.<\/jats:p>","DOI":"10.3390\/hematolrep14020013","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:45:51Z","timestamp":1648590351000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reproductive Issues in Long-Term Surviving Patients following Therapy for Hodgkin\u2019s Disease in the Republic of North Macedonia: Risks of Infertility According to First-Line Treatment Regimens"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-9976","authenticated-orcid":false,"given":"Gazmend","family":"Amzai","sequence":"first","affiliation":[{"name":"University Clinic for Hematology, Medical Faculty, University \u201cSts. Cyril and Methodius\u201d, 1000 Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Karanfilski","sequence":"additional","affiliation":[{"name":"University Clinic for Hematology, Medical Faculty, University \u201cSts. Cyril and Methodius\u201d, 1000 Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-9984","authenticated-orcid":false,"given":"Sonja Genadieva","family":"Stavrikj","sequence":"additional","affiliation":[{"name":"University Clinic for Hematology, Medical Faculty, University \u201cSts. Cyril and Methodius\u201d, 1000 Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Stojanovikj","sequence":"additional","affiliation":[{"name":"University Clinic for Hematology, Medical Faculty, University \u201cSts. Cyril and Methodius\u201d, 1000 Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"ref_1","unstructured":"Howlader, N., Noone, A.M., Krapcho, M., Garshell, J., Miller, D., Altekruse, S.F., Kosary, C.L., Yu, M., Ruhl, J., and Tatalovich, Z. (2017). SEER Cancer Statistics Review, 1975\u20132014, Based on November 2016 SEER data submission, posted to the SEER web site, April 2017."},{"key":"ref_2","unstructured":"National Cancer Institute (2019, November 23). 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