{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:37:53Z","timestamp":1760243873940,"version":"build-2065373602"},"reference-count":5,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Sinus tumors are arduous to diagnose due to often prolonging asymptomatic course until the infiltration of the adjacent structures occurs. Therefore, patients are diagnosed with advanced-stage disease, which negatively affects the treatment outcomes. A 60-year-old male was referred to our ward from an outpatient clinic. The patient presented with double vision, right-side lacrimation, and exophthalmos. He also reported significant weight loss: 15 kg in 2 months. Physical examination revealed achiness and edema of the right temporal area, and subconjunctival hemorrhage of the right eye, and surprisingly no anosmia, no nasal obstruction, and no head\/neck lymphadenopathy were present. The histopathology examination identified diffuse large B-cell lymphoma (CD20+ CD3- p63- bcl-2+ CD23-\/+ bcl-6+ CD 10- MUM1+ Tdt- CD38- cyclin D1- CD30- c-myc+). The patient was qualified for R-CHOP immunochemotherapy (rituximab, cyclophosphamide, and hydroxydaunorubicin hydrochloride), which was well tolerated. After 3 months of treatment, all of the symptoms reversed and a whole-body PET scan showed no abnormal metabolic activity.<\/jats:p>","DOI":"10.3390\/hematolrep14040044","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:31:18Z","timestamp":1665552678000},"page":"305-309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immense Tumor of Maxillary Sinus with Exophthalmos\u2014A Rare Underlying Cause"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-026X","authenticated-orcid":false,"given":"Olga","family":"Lesniewska-Skowerska","sequence":"first","affiliation":[{"name":"Department of Laryngology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Symela-Kaspera","sequence":"additional","affiliation":[{"name":"Department of Laryngology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucyna","family":"Klimczak-Go\u0142\u0105b","sequence":"additional","affiliation":[{"name":"Department of Laryngology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Smolka","sequence":"additional","affiliation":[{"name":"Department of Laryngology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Markowski","sequence":"additional","affiliation":[{"name":"Department of Laryngology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","first-page":"e14118","article-title":"Sinonasal Tract Malignancies: Prognostic Factors and Surgery Outcomes","volume":"15","author":"Cengiz","year":"2013","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e048876","DOI":"10.1136\/bmjopen-2021-048876","article-title":"Survival analysis of 8785 malignant lymphoma cases in the oral and nasal cavities in the USA: A cohort study","volume":"11","author":"Jiang","year":"2021","journal-title":"BMJ Open"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hsueh, C.-Y., Yang, C.-F., Gau, J.-P., Kuan, E.C., Ho, C.-Y., Chiou, T.-J., Hsiao, L.-T., Lin, T.-A., and Lan, M.-Y. (2019). Nasopharyngeal Lymphoma: A 22-Year Review of 35 Cases. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101604"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Toda, H., Sato, Y., Takata, K., Orita, Y., Asano, N., and Yoshino, T. (2013). Clinicopathologic Analysis of Localized Nasal\/Paranasal Diffuse Large B-Cell Lymphoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057677"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/14\/4\/44\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:49:07Z","timestamp":1760143747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/14\/4\/44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["hematolrep14040044"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep14040044","relation":{},"ISSN":["2038-8330"],"issn-type":[{"type":"electronic","value":"2038-8330"}],"subject":[],"published":{"date-parts":[[2022,10,10]]}}}