{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:39:57Z","timestamp":1774330797481,"version":"3.50.1"},"reference-count":13,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient\u2019s condition improved during his 21-day hospital stay and was followed up every 2 weeks for 3 months. The patient\u2019s factor X level recovered after two weeks of discharge with no other hemorrhagic episodes.<\/jats:p>","DOI":"10.3390\/hematolrep15020032","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:56:57Z","timestamp":1684119417000},"page":"312-316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"15","author":[{"given":"Sasmith R.","family":"Menakuru","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine, Muncie, IN 47304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaypal S.","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine, Muncie, IN 47304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Salih","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine, Muncie, IN 47304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-8826","authenticated-orcid":false,"given":"Amir F.","family":"Beirat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine, Muncie, IN 47304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1365-2516.2008.01856.x","article-title":"Diagnosis and treatment of inherited factor X deficiency","volume":"14","author":"Brown","year":"2008","journal-title":"Haemophilia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ajh.21603","article-title":"Systemic AL amyloidosis with acquired factor X deficiency: A study of perioperative bleeding risk and treatment outcomes in 60 patients","volume":"85","author":"Thompson","year":"2009","journal-title":"Am. 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