{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:34:02Z","timestamp":1776918842651,"version":"3.51.2"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Amyloidosis is a term describing the extracellular deposit of fibrils composed of subunits of several different normal serum proteins in various tissues. Amyloid light chain (AL) amyloidosis contains fibrils that are composed of fragments of monoclonal light chains. Many different disorders and conditions can lead to spontaneous splenic rupture, including AL amyloidosis. We present a case of a 64-year-old woman with spontaneous splenic rupture and hemorrhage. A final diagnosis of systemic amyloidosis secondary to plasma cell myeloma was made with infiltrative cardiomyopathy and possible diastolic congestive heart failure exacerbation. We also provide a narrative review of all documented cases of splenic rupture associated with amyloidosis from the year 2000 until January 2023, along with the main clinical findings and management strategies.<\/jats:p>","DOI":"10.3390\/hematolrep15020038","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:28:45Z","timestamp":1686104925000},"page":"370-383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-2595","authenticated-orcid":false,"given":"Hisham F.","family":"Bahmad","sequence":"first","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-9648","authenticated-orcid":false,"given":"Samantha","family":"Gogola","sequence":"additional","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mount Sinai Medical Center, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferial","family":"Alloush","sequence":"additional","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Cusnir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Howard","sequence":"additional","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"},{"name":"Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vathany","family":"Sriganeshan","sequence":"additional","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"},{"name":"Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/07853890701206887","article-title":"The workings of the amyloid diseases","volume":"39","author":"Bellotti","year":"2007","journal-title":"Ann. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1039\/C9CS00199A","article-title":"Half a century of amyloids: Past, present and future","volume":"49","author":"Ke","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2018022","DOI":"10.4084\/mjhid.2018.022","article-title":"Light Chain Amyloidosis","volume":"10","author":"Milani","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_4","first-page":"6676407","article-title":"Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis","volume":"2021","author":"Bruserud","year":"2021","journal-title":"Case Rep. Crit. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s42155-019-0055-3","article-title":"Review of proximal splenic artery embolization in blunt abdominal trauma","volume":"2","author":"Quencer","year":"2019","journal-title":"CVIR Endovasc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.transci.2015.09.001","article-title":"Spontaneous splenic rupture following stem cell mobilization with G-CSF and plerixafor in AL amyloidosis","volume":"54","author":"Lessi","year":"2016","journal-title":"Transfus. Apher. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"rjz021","DOI":"10.1093\/jscr\/rjz021","article-title":"Splenic rupture secondary to amyloid light-chain (AL) amyloidosis associated with multiple myeloma","volume":"2019","author":"Buzalewski","year":"2019","journal-title":"J. Surg. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ajh.10389","article-title":"Spontaneous rupture of the spleen in AL amyloidosis","volume":"74","author":"Oran","year":"2003","journal-title":"Am. J. Hematol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3904\/kjim.2016.142","article-title":"Unexpected amyloidosis, mimicking a splenic cyst","volume":"33","author":"Chang","year":"2018","journal-title":"Korean J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2169\/internalmedicine.9018-17","article-title":"Atraumatic Splenic Rupture Due to Ectopic Extramedullary Hematopoiesis after Autologous Stem Cell Transplantation in a Patient with AL Amyloidosis","volume":"57","author":"Sato","year":"2018","journal-title":"Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1177\/0300060518814337","article-title":"Multiorgan involvement by amyloid light chain amyloidosis","volume":"47","author":"Li","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.jvir.2015.04.028","article-title":"Nonoperative Management of Spontaneous Splenic Rupture in a Patient with Light-Chain Amyloidosis: A Case Report","volume":"26","author":"Bosch","year":"2015","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/13506120802193357","article-title":"Spontaneous atraumatic rupture of a normal-sized spleen due to AL amyloid angiopathy","volume":"15","author":"Chau","year":"2008","journal-title":"Amyloid"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2141.2008.07347.x","article-title":"Spontaneous splenic rupture due to isolated splenic peliosis in a case of multiple myeloma","volume":"144","author":"Choudhuri","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1016\/j.clml.2013.05.010","article-title":"Fatal splenic rupture in a previously undiagnosed multiple myeloma: Morphological, immunophenotypical and molecular cytogenetic analyses","volume":"13","author":"Magnoli","year":"2013","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4081\/cp.2019.1146","article-title":"Non-traumatic splenic rupture in amyloidosis as a rare evolution of multiple myeloma","volume":"9","author":"Perrone","year":"2019","journal-title":"Clin. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5045\/br.2015.50.1.5","article-title":"Splenic rupture in primary amyloidosis with chronic neutrophilic leukemia","volume":"50","author":"Roh","year":"2015","journal-title":"Blood Res."},{"key":"ref_19","first-page":"427","article-title":"Spontaneous rupture of the spleen secondary to amyloidosis","volume":"23","author":"Shobeiri","year":"2013","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_20","first-page":"533","article-title":"Spontaneous rupture of the spleen secondary to amyloidosis","volume":"78","year":"2010","journal-title":"Cir. Cir."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1600-0609.2007.01005.x","article-title":"Spontaneous rupture of the spleen as immediate complication in autologous transplantation for primary systemic amyloidosis","volume":"80","author":"Cibeira","year":"2008","journal-title":"Eur. J. Haematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1055\/s-2008-1027628","article-title":"Splenic rupture in systemic amyloidosis - case presentation and review of the literature","volume":"47","author":"Skok","year":"2009","journal-title":"Z. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1093\/ndt\/16.12.2446","article-title":"Delayed splenic rupture as a cause of haemoperitoneum in a CAPD patient with amyloidosis","volume":"16","author":"Dedi","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/PAS.0000000000001948","article-title":"Proteomic Identification and Clinicopathologic Characterization of Splenic Amyloidosis","volume":"47","author":"Chiu","year":"2023","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00508-005-0505-x","article-title":"Autologous stem-cell transplantation in progressing amyloidosis is associated with severe transplant-related toxicity","volume":"118","author":"Worel","year":"2006","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/13506120802676922","article-title":"Atraumatic splenic rupture in amyloidosis","volume":"16","author":"Renzulli","year":"2009","journal-title":"Amyloid"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/MEJ.0b013e32833ddeb5","article-title":"Atraumatic splenic rupture: A 6-year case series","volume":"18","author":"Elvy","year":"2011","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1046\/j.1537-2995.2001.41020184.x","article-title":"Spleen enlargement in healthy donors during G\u2013CSF mobilization of PBPCs","volume":"41","author":"Platzbecker","year":"2001","journal-title":"Transfusion"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e232411","DOI":"10.1136\/bcr-2019-232411","article-title":"Atraumatic idiopathic splenic rupture induced by granulocyte-colony stimulating factor (G-CSF) for the treatment of pancytopenia, managed successfully by laparoscopic splenectomy","volume":"13","author":"Chinaka","year":"2020","journal-title":"BMJ Case Rep."}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/15\/2\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:49:15Z","timestamp":1760125755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/15\/2\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["hematolrep15020038"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep15020038","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]}}}