{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:20:17Z","timestamp":1783837217697,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background: Azacitidine (AZA) is the standard treatment for patients with high-risk myelodysplastic syndromes (MDS). The impact of skeletal muscle depletion (SMD), which is associated with outcomes of hematological malignancies, on the clinical course of MDS patients treated with AZA was investigated. Methods: This retrospective, observational study included 50 MDS patients treated with AZA. Muscle mass was evaluated using the skeletal muscle index (SMI), which is the area of muscle mass at the third lumbar vertebra on CT images divided by the square of the height. Results: Of the enrolled patients, 39 were males, and their median age was 69.5 years. Twenty-seven (20 male and 7 female) patients showed SMD. The median survival was 13.4 months in the SMD group and 15.2 months in the non-SMD group, with no significant difference and no significant association between the response rate or severe non-hematological toxicities and the presence of SMD. By contrast, grade 3\u20134 anemia and thrombocytopenia were significantly more frequent in the SMD group than in the non-SMD group. SMD was associated with severe anemia and thrombocytopenia in MDS patients treated with AZA. Conclusion: Reduced skeletal muscle mass may predict severe hematological toxicity in MDS patients treated with AZA.<\/jats:p>","DOI":"10.3390\/hematolrep16010012","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:56:02Z","timestamp":1709106962000},"page":"114-124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine"],"prefix":"10.3390","volume":"16","author":[{"given":"Eri","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Hematology, Gifu-Seino Medical Center, Ibi Kosei Hospital, Gifu 501-0619, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-7777","authenticated-orcid":false,"given":"Nobuhiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fukuno","sequence":"additional","affiliation":[{"name":"Department of Hematology, Takayama Red Cross Hospital, Gifu 506-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology, Matsunami General Hospital, Gifu 501-6062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Matsunami General Hospital, Gifu 501-6062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Matsunami General Hospital, Gifu 501-6062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Gifu Municipal Hospital, Gifu 500-8513, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-9918","authenticated-orcid":false,"given":"Nobuhiro","family":"Kanemura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senji","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Gifu Municipal Hospital, Gifu 500-8513, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Matsunami General Hospital, Gifu 501-6062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"},{"name":"Department of Hematology, Matsunami General Hospital, Gifu 501-6062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu 501-1194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1056\/NEJMoa1106968","article-title":"Clonal Architecture of Secondary Acute Myeloid Leukemia","volume":"366","author":"Walter","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1200\/JCO.2006.07.5598","article-title":"Myelodysplastic Syndromes in Patients Younger than Age 50","volume":"24","author":"Kuendgen","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/cncr.22570","article-title":"Myelodysplastic Syndromes: Incidence and Survival in the United States","volume":"109","author":"Ma","year":"2007","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2165\/11209430-000000000-00000","article-title":"Azacitidine: A Review of Its Use in the Management of Myelodysplastic Syndromes\/Acute Myeloid Leukaemia","volume":"72","author":"Keating","year":"2012","journal-title":"Drugs"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.clml.2022.04.016","article-title":"Impact of Hypomethylating Agent Use on Hospital and Emergency Room Visits, and Predictors of Early Discontinuation in Patients With Higher-Risk Myelodysplastic Syndromes","volume":"22","author":"Zeidan","year":"2022","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","article-title":"International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes","volume":"89","author":"Greenberg","year":"1997","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised International Prognostic Scoring System for Myelodysplastic Syndromes","volume":"120","author":"Greenberg","year":"2012","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s40520-019-01170-1","article-title":"Malnutrition and Sarcopenia","volume":"31","author":"Sieber","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11912-019-0829-8","article-title":"Malnutrition in Older Adults with Cancer","volume":"21","author":"Zhang","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.clnu.2020.07.023","article-title":"Sarcopenia Predicts Overall Survival in Patients with Malignant Hematological Diseases: A Meta-Analysis","volume":"40","author":"Surov","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00277-015-2499-4","article-title":"Sarcopenia Is an Independent Prognostic Factor in Male Patients with Diffuse Large B-Cell Lymphoma","volume":"94","author":"Nakamura","year":"2015","journal-title":"Ann. Hematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00277-018-3508-1","article-title":"Prognostic Impact of Skeletal Muscle Assessed by Computed Tomography in Patients with Acute Myeloid Leukemia","volume":"98","author":"Nakamura","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000513542","article-title":"Relationship between Low Pretreatment Geriatric Nutritional Risk Index and Poor Tolerability of Azacitidine in Patients with Myelodysplastic Syndromes","volume":"76","author":"Kanehira","year":"2020","journal-title":"Ann. Nutr. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(09)70003-8","article-title":"Efficacy of Azacitidine Compared with That of Conventional Care Regimens in the Treatment of Higher-Risk Myelodysplastic Syndromes: A Randomised, Open-Label, Phase III Study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e11860","DOI":"10.1097\/MD.0000000000011860","article-title":"Incidence and Risk of Hematologic Toxicities with Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukopenia: A Systematic Review and Meta-Analysis","volume":"97","author":"Gao","year":"2018","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 Revision to the World Health Organization Classification of Myeloid Neoplasms and Acute Leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the Classification of the Myelodysplastic Syndromes","volume":"51","author":"Bennett","year":"1982","journal-title":"Br. J. Haematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric Nutritional Risk Index: A New Index for Evaluating at-Risk Elderly Medical Patients","volume":"82","author":"Bouillanne","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1200\/JCO.2013.51.1345","article-title":"Performance of Two Geriatric Screening Tools in Older Patients with Cancer","volume":"32","author":"Kenis","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A New Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/hepr.12774","article-title":"Japan Society of Hepatology Guidelines for Sarcopenia in Liver Disease (1st Edition): Recommendation from the Working Group for Creation of Sarcopenia Assessment Criteria","volume":"46","author":"Nishikawa","year":"2016","journal-title":"Hepatol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood-2005-10-4149","article-title":"Clinical Application and Proposal for Modification of the International Working Group (IWG) Response Criteria in Myelodysplasia","volume":"108","author":"Cheson","year":"2006","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the Freely Available Easy-to-Use Software \u201cEZR\u201d for Medical Statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"ref_24","first-page":"160","article-title":"A Review of Anemia as a Cardiovascular Risk Factor in Patients with Myelodysplastic Syndromes","volume":"1","author":"Oliva","year":"2011","journal-title":"Am. J. Blood Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2018046","DOI":"10.4084\/mjhid.2018.046","article-title":"Thrombocytopenia in Patients with Myelodysplastic Syndromes: Still an Unsolved Problem","volume":"10","author":"Basood","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/gerona\/59.3.M249","article-title":"Hemoglobin Levels and Skeletal Muscle: Results from the InCHIANTI Study","volume":"59","author":"Cesari","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Takata, T., Mae, Y., Yamada, K., Taniguchi, S., Hamada, S., Yamamoto, M., Iyama, T., and Isomoto, H. (2021). Skeletal Muscle Mass Is Associated with Erythropoietin Response in Hemodialysis Patients. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02346-6"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00277-020-04243-8","article-title":"Ruxolitinib Treatment Improves Muscle Mass in Patients with Myelofibrosis","volume":"100","author":"Lucijanic","year":"2021","journal-title":"Ann. Hematol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"79441","DOI":"10.18632\/oncotarget.18345","article-title":"Skeletal Muscle Depletion Predicts Survival of Patients with Advanced Biliary Tract Cancer Undergoing Palliative Chemotherapy","volume":"8","author":"Cho","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3389\/fonc.2019.01075","article-title":"Skeletal Muscle Depletion Predicts the Prognosis of Patients With Hepatocellular Carcinoma Treated With Radiotherapy","volume":"9","author":"Lee","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4048\/jbc.2020.23.e8","article-title":"Prognostic Value of Skeletal Muscle Depletion Measured on Computed Tomography for Overall Survival in Patients with Non-Metastatic Breast Cancer","volume":"23","author":"Huh","year":"2020","journal-title":"J. Breast Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jnci\/djy231","article-title":"Impact of Sarcopenia on Adverse Outcomes After Allogeneic Hematopoietic Cell Transplantation","volume":"111","author":"Armenian","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MCO.0000000000000736","article-title":"Oral Nutritional Supplements, Physical Activity, and Sarcopenia in Cancer","volume":"24","author":"Wang","year":"2021","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_34","first-page":"CD009075","article-title":"Aerobic Physical Exercise for Adult Patients with Haematological Malignancies","volume":"1","author":"Knips","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00520-019-04952-5","article-title":"The Effect of Malnutrition on Mortality in Hospitalized Patients with Hematologic Malignancy","volume":"28","author":"Yilmaz","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/jcsm.12806","article-title":"A Randomized, Feasibility Trial of an Exercise and Nutrition-Based Rehabilitation Programme (ENeRgy) in People with Cancer","volume":"12","author":"Hall","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"203826","DOI":"10.1016\/j.cdev.2023.203826","article-title":"5-Azacytidine Incorporated Skeletal Muscle-Derived Hydrogel Promotes Rat Skeletal Muscle Regeneration","volume":"173","author":"Ahmadi","year":"2023","journal-title":"Cells Dev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1111\/j.1349-7006.2011.01993.x","article-title":"Phase I and II Study of Azacitidine in Japanese Patients with Myelodysplastic Syndromes","volume":"102","author":"Uchida","year":"2011","journal-title":"Cancer Sci."}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/16\/1\/12\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:06:20Z","timestamp":1760105180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/16\/1\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["hematolrep16010012"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep16010012","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]}}}