{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:25:34Z","timestamp":1785875134038,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background: In 2019, a new coronavirus disease emerged in Wuhan, China, known as SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, and caused an ongoing pandemic. Symptomatology of the syndrome is variable, with complications extending to hematopoiesis and hemostasis. Approximately a year after onset of the virus, four vaccination formulas became available to the public, based on a viral vector or mRNA technology. These vaccine formulas have been hampered with hematological complications, like vaccine-induced immune thrombotic thrombocytopenia (VITT) and vaccine-related ITP (immune thrombocytopenic purpura). ITP is a disease with autoimmune pathogenesis characterized by antibody production against platelets and an increased hemorrhagic risk. A decent number of cases have been referred to as possible adverse effects of COVID-19 vaccinations. Case presentation: in this case report, we present two cases of newly diagnosed ITP after vaccination with ChAdOx1-S (AstraZeneca), with a good response to treatment with thrombopoietin-receptor agonists (TPO-RAs). Discussion: we observed an absence of response after corticosteroids and IVIG therapy and a positive therapeutic outcome on TPO-RA. Conclusions: in the ongoing pandemic, there is an urgent need to create therapeutic guidelines for vaccination-related clinical entities and to clarify indications for the vaccination of patients with pre-existing hematological diseases.<\/jats:p>","DOI":"10.3390\/hematolrep16040057","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T11:19:33Z","timestamp":1727435973000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Two Cases of Immune Thrombocytopenia (ITP) Related to Viral Vector Vaccination ChAdOx1-S (AstraZeneca) and a Good Response after Thrombopoietin Receptor Agonist (TPO-RA) Therapy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6141-339X","authenticated-orcid":false,"given":"Konstantina","family":"Salveridou","sequence":"first","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"},{"name":"Department of Oncology, Hematology and Palliative Care, Bethesda Hospital Moenchengladbach, 41061 Moenchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Tzamalis","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maika","family":"Klaiber-Hakimi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Gr\u00f6pper","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-4109","authenticated-orcid":false,"given":"Aristoteles","family":"Giagounidis","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology and Palliative Care, Marien Hospital Duesseldorf, 40479 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref_1","unstructured":"COVID-19 Dashboard (2022, January 30). 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