{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:33:06Z","timestamp":1778621586959,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taif University, Saudi Arabia","award":["TU-DSPP-2024-250"],"award-info":[{"award-number":["TU-DSPP-2024-250"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background\/Objectives: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. Methods: This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals. Results: Serum vitamin D levels were significantly lower in hemophilia A patients than in controls (p &lt; 0.001). The level of serum vitamin D was deficient in 38 (84.4%), insufficient in 4 (8.8%) and sufficient in 3 (6.6%) in the study group while deficient in 8 (17.7%), insufficient in 16 (35.5%) and sufficient in 21 (46.6%) in the control group. Total hemophilia joint health score (HJHS) had a significant negative correlation with serum total calcium (R = \u22120.31, p = 0.038) and serum vitamin D level (R = \u22120.974, p &lt; 0.001) while also positively correlated with alkaline phosphatase (R = 0.834, p &lt; 0.001). A quality-of-life index that is specific to total hemophilia (Haemo-Qol\/Haem-A-QoL) had a significant positive correlation with total hemophilia joint health score (HJHS) (R = 0.934, p &lt; 0.001) and negatively correlated with serum vitamin D level (R = \u22120.924, p-value lower than 0.001), alkaline phosphatase (R = 0.842, p &lt; 0.001), and severity of hemophilia (R = 0.67, p &lt; 0.001). Conclusions: patients with hemophilia A had lower vitamin D levels than healthy controls. The severity of vitamin D deficiency is related positively to (HJHS) hemophilia and quality of life hemophilia cases according to Haemo-QoL.<\/jats:p>","DOI":"10.3390\/hematolrep16040071","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T05:06:53Z","timestamp":1732597613000},"page":"742-751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-9389","authenticated-orcid":false,"given":"Aida M. S.","family":"Salem","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takwa Mohamed","family":"AbdEltwwab","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, General Authority for Health Insurance, Beni-Suef 62511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Hosni","family":"Moawad","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-0552","authenticated-orcid":false,"given":"Marwa O.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef 62764, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3392-6154","authenticated-orcid":false,"given":"Reham S.","family":"Al-Fakharany","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7917-975X","authenticated-orcid":false,"given":"Ahmed","family":"Khames","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Hussein","family":"Meabed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.jtha.2023.06.016","article-title":"Hemophilia gene therapy: First, do no harm","volume":"21","author":"Valentino","year":"2023","journal-title":"J. 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