{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:55:14Z","timestamp":1760057714889,"version":"build-2065373602"},"reference-count":9,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background: Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate. Case description: A 61-year-old male presented with upper GI bleeding and a prolonged prothrombin time. Investigations demonstrated an acquired FX deficiency (determined to be secondary to AL amyloidosis). Results: Treatment with FX concentrate to maintain trough FX levels &gt;20% resulted in successful cessation of bleeding symptoms, and levels &gt;50% facilitated urgent invasive procedures. Conclusions: This case report adds valuable insight into the management of this rare condition, and how best to utilize FX concentrates in acquired FX deficiency.<\/jats:p>","DOI":"10.3390\/hematolrep17020010","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:39:07Z","timestamp":1740119947000},"page":"10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factor X Concentrate Treatment Schedule and Dosing in Acquired FX Deficiency"],"prefix":"10.3390","volume":"17","author":[{"given":"Andrew","family":"Ross","sequence":"first","affiliation":[{"name":"Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK"},{"name":"Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, Leahurst Campus, University of Liverpool, Liverpool CH64 7TEK, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Garth","sequence":"additional","affiliation":[{"name":"Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Farrelly","sequence":"additional","affiliation":[{"name":"Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0029-1225763","article-title":"Factor X deficiency","volume":"35","author":"Menegatti","year":"2009","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjh.13058","article-title":"Guideline for the diagnosis and management of the rare coagulation disorders: A United Kingdom Haemophilia Centre Doctors\u2019 Organization guideline on behalf of the British Committee for Standards in Haematology","volume":"167","author":"Mumford","year":"2014","journal-title":"Br. J. Haematol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100833","DOI":"10.1016\/j.blre.2021.100833","article-title":"Diagnosis, therapeutic advances, and key recommendations for the management of factor X deficiency","volume":"50","author":"Peyvandi","year":"2021","journal-title":"Blood Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ehf2.13701","article-title":"Thromboembolism and bleeding in systemic amyloidosis: A review","volume":"9","author":"Nicol","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_5","first-page":"2363","article-title":"Acquired Factor X Deficiency in Light Chain (AL) Amyloidosis Is Rare and Associated with Advanced Disease","volume":"130","author":"Patel","year":"2017","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2324709619832332","DOI":"10.1177\/2324709619832332","article-title":"Acquired Factor X Deficiency in Patients With Primary Light Chain Amyloidosis","volume":"7","author":"Dejhansathit","year":"2019","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1182\/blood-2014-02-556514","article-title":"Utility of factor X concentrate for the treatment of acquired factor X deficiency in systemic light-chain amyloidosis","volume":"123","author":"Mahmood","year":"2014","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1055\/s-0037-1614403","article-title":"Poor recovery and short survival of infused factor X in a case of acquired factor X deficiency and amyloidosis","volume":"82","author":"Duncan","year":"1999","journal-title":"Thromb. Haemost."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2016-06-724351","article-title":"Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions","volume":"129","author":"Muczynski","year":"2017","journal-title":"Blood"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/17\/2\/10\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:39:41Z","timestamp":1760027981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/17\/2\/10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["hematolrep17020010"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep17020010","relation":{},"ISSN":["2038-8330"],"issn-type":[{"type":"electronic","value":"2038-8330"}],"subject":[],"published":{"date-parts":[[2025,2,21]]}}}