{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:28:25Z","timestamp":1766406505681,"version":"3.48.0"},"reference-count":7,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background and clinical significance: Primary cardiac diffuse large B-cell lymphoma (DLBCL) arising in bioprosthetic valves is exceedingly rare. Most patients present with localized disease often masquerading as suspected thrombi or vegetations. Imaging studies are inconclusive and due to the rarity of the disease, treatment and follow-up data are very limited. Case presentation: We present one such case developing 9 years after aortic valve replacement in an otherwise immunocompetent patient, who presented with minor symptoms despite significant disease burden. This tumor contained Epstein\u2013Barr virus (EBV), was confined to the site of origin, and has behaved non-aggressively after excision with a follow-up of 59 months. Conclusions: This unique disease is classified as Fibrin-associated large B-cell lymphoma (FA-LBCL) in view of its distinct clinical-pathological features. This report also addresses the unique features of this type of lymphoma.<\/jats:p>","DOI":"10.3390\/hematolrep18010001","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:43:31Z","timestamp":1766403811000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibrin-Associated Large B-Cell Lymphoma of Prosthetic Aortic Valve and Aortic Root Graft"],"prefix":"10.3390","volume":"18","author":[{"given":"Ashish","family":"Rajput","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-1427","authenticated-orcid":false,"given":"Abdulrahim","family":"Alabdulsalam","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claribeth","family":"Ruano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabin J.","family":"Bozso","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-339X","authenticated-orcid":false,"given":"Anthea","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Hematology, University of Alberta, Edmonton, AB T6G 2B7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1C9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","unstructured":"McAllister, H.A., and Fenoglio, J.J. (1978). Tumors of the cardiovascular system. Atlas of Tumor Pathology, Armed Forces Institute of Pathology. 2nd Series."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/cncr.25444","article-title":"Primary cardiac lymphoma: An analysis of presentation, treatment, and outcome patterns","volume":"117","author":"Petrich","year":"2011","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/PAS.0b013e3181ce9128","article-title":"Epstein-Barr virus-associated diffuse large B-cell lymphoma arising on cardiac prostheses","volume":"34","author":"Miller","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.14503\/THIJ-13-3567","article-title":"Recurrent primary cardiac lymphoma on aortic valve allograft: Implications for therapy","volume":"41","author":"Farah","year":"2014","journal-title":"Tex. Heart Inst. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of Mature Lymphoid Neoplasms: A report from the Clinical Advisory Committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/PAS.0000000000000775","article-title":"Fibrin-associated EBV-positive large B-cell lymphoma: An indolent neoplasm with features distinct from diffuse large B-cell lymphoma associated with chronic inflammation","volume":"41","author":"Boyer","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1182\/blood.2023020349","article-title":"Fibrin-associated large B-cell lymphoma shows frequent mutations related to immune surveillance and PTEN","volume":"142","author":"Boyer","year":"2023","journal-title":"Blood"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/18\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:23:45Z","timestamp":1766406225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/18\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["hematolrep18010001"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep18010001","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}