{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:55:41Z","timestamp":1773766541334,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Background and Clinical Significance: Diffuse Large B-Cell Lymphoma (DLBCL) is a morphologically and molecularly heterogeneous lymphoproliferative disorder that originates from a clonal B-cell ancestor. Patients usually present with rapidly enlarging lymph nodes or mass(es) at single or multiple sites. Generally, 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography with computed tomography (PET-CT) is performed post-treatment to evaluate remission status, especially in radiologically residual tumors. Myofibroblastoma (MFB) is a benign mesenchymal tumor of the mammary stroma composed of fibroblasts and myofibroblasts. These entities do not often present concurrently. Case presentation: The patient was an 80-year-old man with a history of stage IV-BS Diffuse Large B-Cell Lymphoma (DLBCL) with a high-risk International Prognostic Index (IPI). The patient underwent treatment with a six-cycle R-CHOP regimen. Immediately after the last cycle, an 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography with computed tomography (PET-CT) scan revealed a nodular solid lesion with a faintly increased metabolic standardized uptake value (SUVmax) of 3 in the upper outer quadrant of his left breast. A biopsy of the breast lesion was performed, and it revealed a benign mesenchymal tumor, specifically a Myofibroblastoma. The patient has not presented any symptoms or complications since surgery (12 months) and remains in complete remission (CR). Conclusions: Given the potential diagnostic pitfalls and therapeutic implications of residual tumors in the context of DLBCL, a conscientious evaluation by a multidisciplinary team (MDT) is highly recommended.<\/jats:p>","DOI":"10.3390\/hematolrep18020023","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:03:27Z","timestamp":1773756207000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multidisciplinary Approach to the Diagnosis and Management of a Mammary Myofibroblastoma in a Male with a History of Diffuse Large B-Cell Lymphoma: A Case Report"],"prefix":"10.3390","volume":"18","author":[{"given":"Carmen Montes","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Hematology, Virgen de la Concha Hospital, 49022 Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma C.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Salamanca, 37007 Salamanca, Spain"},{"name":"Molecular Cytogenetics Unit of Salamanca, Cancer Research Center (CIC), University Hospital of Salamanca, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-4882","authenticated-orcid":false,"given":"Elena","family":"Alejo Alonso","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Salamanca, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9030-5556","authenticated-orcid":false,"given":"Susana","family":"Gallego Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Virgen de la Concha Hospital, 49022 Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Gonzaga","family":"D\u00edaz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Nuclear Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Revilla Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virgen de la Concha Hospital, 49022 Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8597-1176","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Hern\u00e1ndez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Salamanca, 37007 Salamanca, Spain"},{"name":"Molecular Cytogenetics Unit of Salamanca, Cancer Research Center (CIC), University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-4725","authenticated-orcid":false,"given":"Idalia","family":"Gonz\u00e1lez Morais","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Cruz S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-3500","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Sayagu\u00e9s","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Pathology, University Hospital of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-3509","authenticated-orcid":false,"given":"Luis Miguel","family":"Chinchilla-T\u00e1bora","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Pathology, Virgen de la Concha Hospital, 49022 Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Mammary myofibroblastoma: An update with emphasis on the most diagnostically challenging variants","volume":"31","author":"Magro","year":"2016","journal-title":"Histol. 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