{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:13:11Z","timestamp":1788246791463,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematol. Rep.","Hematology Reports"],"abstract":"<jats:p>Background\/Objectives: Systemic inflammation-derived indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), have been proposed as convenient and cost-effective predictive markers of mortality and complications in patients with pulmonary embolism (PE). We aimed to evaluate the prognostic performance of hematological inflammatory indices for in-hospital adverse outcomes among Mongolian patients diagnosed with PE. Methods: This multicenter retrospective study enrolled patients admitted to three tertiary-level hospitals in Ulaanbaatar, Mongolia, with a confirmed diagnosis of PE between September 2019 and January 2025. Data were collected retrospectively from electronic medical records. We calculated the NLR, PLR, and SII using standard formulas. All patients were stratified according to the sPESI. Moreover, we determined the prognostic performance of hematological indices for in-hospital adverse events. Results: We analyzed information on 232 patients with a confirmed diagnosis of PE. According to sPESI scoring, 69.8% (162) were in the high-risk group, with significant differences in comorbidity and age over 60 years (p &lt; 0.001). The most common symptoms were dyspnea, chest pain, cough, leg pain, and hemoptysis. The median NLR was 2.48 (1.66\u20135.08) in the low-risk group and 4.21 (2.04\u201311.35) in the high-risk group (p = 0.001). The median SII level was significantly higher in the high-risk group than in the low-risk group (p = 0.037). However, there was no significant difference in PLR level between the two study groups. ROC analysis of hematological indices for predicting in-hospital adverse outcomes was limited, with poor and non-significant discriminatory performance. Conclusions: In cases of acute pulmonary embolism, elevated inflammatory indices, NLR and SII, were associated with higher sPESI risk stratification. However, their probability to predict in-hospital adverse events was limited by ROC analysis.<\/jats:p>","DOI":"10.3390\/hematolrep18050063","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical and Hematological Markers of Pulmonary Embolism: Multicenter Retrospective Study in Mongolia"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6671-6620","authenticated-orcid":false,"given":"Javzan-Orlom","family":"Dorjjugder","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Allergy, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia"},{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Munkh-Erdene","family":"Dashzeveg","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Zolzaya","family":"Batbold","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Amgalandari","family":"Byambabaatar","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6431-8789","authenticated-orcid":false,"given":"Altankhuyag","family":"Nergui","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Enkh-Amgalan","family":"Tserendorj","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Yerkyejan","family":"Dungyen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Badamsed","family":"Tserendorj","sequence":"additional","affiliation":[{"name":"Department of Radiology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Tumur-Ochir","family":"Tsedev-Ochir","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Third State Central Hospital, Ulaanbaatar 18061, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-2166","authenticated-orcid":false,"given":"Batbold","family":"Batsaikhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Medical Sciences, Ministry of Economy and Development, Ulaanbaatar 13270, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-6031","authenticated-orcid":false,"given":"Solongo","family":"Bandi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Allergy, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global Burden of Thrombosis: Epidemiologic Aspects","volume":"118","author":"Wendelboe","year":"2016","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(04)16004-2","article-title":"Pulmonary embolism","volume":"363","author":"Goldhaber","year":"2004","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1538-7836.2010.04108.x","article-title":"Incidence of venous thromboembolism in Korea: From the Health Insurance Review and Assessment Service database","volume":"9","author":"Jang","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1160\/TH17-02-0134","article-title":"Incidence of Venous Thromboembolism in Asian Populations: A Systematic Review","volume":"117","author":"Lee","year":"2017","journal-title":"Thromb. Haemost."},{"key":"ref_6","unstructured":"Serjmyadag, S., Jarkhyn, T., and Gankhuyag, Z. (2023). Mongolian Statistical Yearbook 2022, National Statistics Office of Mongolia."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jacc.2015.10.060","article-title":"Trends in the Management and Outcomes of Acute Pulmonary Embolism Analysis from the RIETE Registry","volume":"67","author":"Guijarro","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e949964","DOI":"10.12659\/MSM.949964","article-title":"Changes in Hemogram-Derived Ratios in Patients with Sepsis Undergoing Cytokine-Filtered Continuous Renal Replacement Therapy in the Intensive Care Unit: A Retrospective Single-Center Study","volume":"31","author":"Bayram","year":"2025","journal-title":"Med. Sci. Monit."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rugambwa, T.K., Abdihamid, O., Zhang, X., Peng, Y., Cai, C., Shen, H., Zeng, S., and Qiu, W. (2023). Neutrophil\u2013lymphocyte ratio and platelet\u2013lymphocyte ratio as potential predictive markers of treatment response in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1181248"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Negrut, R.L., Cote, A., Feder, B., Bodog, F.D., and Maghiar, A.M. (2025). Comparative Prognostic Role of PLR and NLR in Colon Cancer: A Retrospective Analysis of Preoperative Inflammatory Markers. Medicina, 61.","DOI":"10.3390\/medicina61091580"},{"key":"ref_11","first-page":"248","article-title":"Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism","volume":"20","author":"Altun","year":"2020","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/14017431.2020.1846774","article-title":"A novel marker for predicting severity of acute pulmonary embolism: Systemic immune-inflammation index","volume":"55","author":"Gok","year":"2021","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ma, Y., Mao, Y., He, X., Sun, Y., Huang, S., and Qiu, J. (2016). The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism. BMC Cardiovasc. Disord., 16.","DOI":"10.1186\/s12872-016-0304-5"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/crj.12565","article-title":"Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism","volume":"12","author":"Ertem","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10760296211052292","DOI":"10.1177\/10760296211052292","article-title":"Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism","volume":"27","author":"Slajus","year":"2021","journal-title":"Clin. Appl. Thromb.\/Hemost."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1001\/archinternmed.2010.199","article-title":"Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism","volume":"170","author":"Aujesky","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1111\/j.1538-7836.2011.04469.x","article-title":"The Simplified Pulmonary Embolism Severity Index (PESI): Validation of a clinical prognostic model for pulmonary embolism","volume":"9","author":"Righini","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.30574\/wjbphs.2025.22.1.0447","article-title":"Common clinical presentations of acute pulmonary embolism: A statistical review","volume":"22","author":"Alazzam","year":"2025","journal-title":"World J. Biol. Pharm. Health Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Miniati, M., Cenci, C., Monti, S., and Poli, D. (2012). Clinical presentation of acute pulmonary embolism: Survey of 800 cases. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030891"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1055\/s-0044-1786878","article-title":"Clinical Presentation and Risk Stratification of Pulmonary Embolism","volume":"33","author":"Mohammed","year":"2024","journal-title":"Int. J. Angiol."},{"key":"ref_21","unstructured":"Vrinda Vyas, A.G. (2022). Acute Pulmonary Embolism, StatPearls Publishing."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1183\/13993003.00024-2016","article-title":"Acute pulmonary embolism: Mortality prediction by the 2014 European Society of Cardiology risk stratification model","volume":"48","author":"Becattini","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_23","first-page":"101258","article-title":"Epidemiology of pulmonary embolism in China, 2021: A nationwide hospital-based study","volume":"54","author":"Zhen","year":"2024","journal-title":"Lancet Reg. Health\u2013West. Pac."},{"key":"ref_24","first-page":"111","article-title":"Etiologies and treatment of acute pulmonary embolism at Srinagarind Hospital","volume":"6","author":"Reechaipichitkul","year":"2012","journal-title":"Asian Biomed."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mitroi, D.M., Balteanu, M.A., Cioboata, R., Vlasceanu, S.G., Zlatian, O.M., Catana, O.M., Mirea, A.A., Mogos, G.F.R., Rotaru, I., and Biciusca, V. (2025). Hypercoagulability in Tuberculosis: Pathophysiological Mechanisms, Associated Risks, and Advances in Management\u2014A Narrative Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14030762"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.ATV.7.5.456","article-title":"Deficiency of plasma protein S, protein C, or antithrombin III and arterial thrombosis","volume":"7","author":"Coller","year":"1987","journal-title":"Arteriosclerosis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15321819.2021.2001002","article-title":"Effect of pulmonary tuberculosis on natural anticoagulant activity in therapy-na\u00efve Ghanaian adults; a case-control study","volume":"43","author":"Owusu","year":"2022","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mitroi, D.M., Vlasceanu, S.G., Zlatian, O.M., Olteanu, M., Catan\u0103, O.M., Mititelu, R.R., Riza, A.L., Camen, G., Biciu\u0219c\u0103, V., and Cioboat\u0103, R. (2026). Hypercoagulability in Pulmonary Tuberculosis: Reduced Protein C and Free Protein S Predict Pulmonary Embolism\u2014Evidence from a Prospective Romanian Cohort. J. Clin. Med., 15.","DOI":"10.3390\/jcm15051903"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00005373-198410000-00001","article-title":"Depression of cellular immunity after multiple trauma in the absence of sepsis","volume":"24","author":"Palder","year":"1984","journal-title":"J. Trauma-Inj. Infect. Crit. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/tjem.tjem_198_23","article-title":"Unraveling the clinical significance and prognostic value of the neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, systemic immune inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review","volume":"24","author":"Islam","year":"2024","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4149\/BLL_2021_078","article-title":"Neutrophil-to-lymphocyte ratio, past, present and future perspectives","volume":"122","author":"Zahorec","year":"2021","journal-title":"Bratisl. Med. J."},{"key":"ref_32","first-page":"195","article-title":"Immunodeficiency in different histotypes of radically operable gastrointestinal cancers","volume":"23","author":"Romano","year":"2004","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00262-005-0047-0","article-title":"Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: Implications for survival","volume":"55","author":"Bellone","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.12669\/pjms.40.6.8802","article-title":"Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of mortality in acute pulmonary embolism: A systematic review and meta-analysis","volume":"40","author":"Tang","year":"2024","journal-title":"Pak. J. Med. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Wang, R.H., Wen, W.X., Jiang, Z.P., Du, Z.P., Ma, Z.H., Lu, A.L., Li, H.P., Yuan, F., Wu, S.B., and Guo, J.W. (2023). The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1115031"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2612820","DOI":"10.1080\/07853890.2026.2612820","article-title":"Comparison of the predictive performance of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio for three-month poor functional outcome in ischemic stroke: A systematic review and meta-analysis","volume":"58","author":"Ma","year":"2026","journal-title":"Ann. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ihj.2023.10.008","article-title":"Comparison of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) as marker of adverse prognosis in patients with infective endocarditis","volume":"75","author":"Thottuvelil","year":"2023","journal-title":"Indian. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejim.2024.01.037","article-title":"Performance of the Simplified Pulmonary Embolism Severity Index in predicting 30-day mortality after acute pulmonary embolism: Validation from a large-scale cohort","volume":"124","author":"Zhang","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/2277-9175.187372","article-title":"Comparing three clinical prediction rules for primarily predicting the 30-day mortality of patients with pulmonary embolism: The \u201cSimplified Revised Geneva Score,\u201d the \u201cOriginal PESI,\u201d and the \u201cSimplified PESI\u201d","volume":"5","author":"Tamizifar","year":"2016","journal-title":"Adv. Biomed. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.repc.2023.04.011","article-title":"PrOgnosis in Pulmonary Embolism (PoPE): 30-Day mortality risk score based on five admission parameters","volume":"43","author":"Gerardo","year":"2024","journal-title":"Rev. Port. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1002\/ajh.27379","article-title":"The prognostic value of blood cellular indices in pulmonary embolism","volume":"99","author":"Siddiqui","year":"2024","journal-title":"Am. J. Hematol."}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/18\/5\/63\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:16:37Z","timestamp":1788243397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/18\/5\/63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["hematolrep18050063"],"URL":"https:\/\/doi.org\/10.3390\/hematolrep18050063","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}