{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:43:19Z","timestamp":1787636599077,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>De Quervain\u2019s thyroiditis, sometimes referred to as subacute thyroiditis (SAT), is the most common granulomatous disease of the thyroid, typically found after a viral infection in middle-aged women. The mRNA encoding for the angiotensin-converting enzyme-2 (ACE-2) receptor is expressed in follicular thyroid cells, making them a potential target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides infection, SARS-CoV-2 vaccines have also been implicated in SAT pathogenesis. We present a case of a woman developing SAT following vaccination with Comirnaty by Pfizer Inc. (New-York, USA). We performed a systematic review of similar cases available in the literature to provide a better understanding of the topic. We searched the databases PubMed and Embase and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Patient records were then sorted according to the type of administered vaccine and a statistical analysis of the extracted data was performed. No statistically significant difference between mRNA vaccines and other vaccines in inducing SAT was found, nor was any found in terms of patient demographics, symptoms at presentation, initial, or follow-up blood tests. In our case report, we described the possible association between SARS-CoV-2 mRNA-based vaccine Comirnaty and SAT.<\/jats:p>","DOI":"10.3390\/idr14010018","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:47:45Z","timestamp":1645476465000},"page":"142-154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vaccine-Induced Subacute Thyroiditis (De Quervain\u2019s) after mRNA Vaccine against SARS-CoV-2: A Case Report and Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-4877","authenticated-orcid":false,"given":"Giuseppe","family":"Pipitone","sequence":"first","affiliation":[{"name":"Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases \u201cL. Spallanzani\u201d, Via Portuense 292, 00147 Rome, Italy"},{"name":"Department of Medicine, Infectious Disease Unit, ARNAS Civico Di Cristina Hospital, Piazza Leotta Nicola 4, 00128 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-7965","authenticated-orcid":false,"given":"Lorenzo Vittorio","family":"Rindi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Infectious Disease Clinic, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-7567","authenticated-orcid":false,"given":"Nicola","family":"Petrosillo","sequence":"additional","affiliation":[{"name":"Infection Prevention & Control and Infectious Disease Unit, University Hospital \u201cCampus Bio-Medico\u201d, Via \u00c1lvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio Adalberto Maria","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Infectious Disease Clinic, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-0466","authenticated-orcid":false,"given":"Grazia","family":"Caci","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Piazza Pugliatti 1, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Iaria","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Unit, ARNAS Civico Di Cristina Hospital, Piazza Leotta Nicola 4, 00128 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-5798","authenticated-orcid":false,"given":"Davide Roberto","family":"Donno","sequence":"additional","affiliation":[{"name":"Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases \u201cL. Spallanzani\u201d, Via Portuense 292, 00147 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelo","family":"Boumis","sequence":"additional","affiliation":[{"name":"Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases \u201cL. Spallanzani\u201d, Via Portuense 292, 00147 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Paviglianiti","sequence":"additional","affiliation":[{"name":"Unit of Paediatric Radiology, ARNAS Civico-Di Cristina Hospital, Piazza Leotta 5, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Taglietti","sequence":"additional","affiliation":[{"name":"Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases \u201cL. 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