{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:47Z","timestamp":1790607407077,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>This study aimed to estimate the diagnostic performance of patient symptoms and to describe the clinical course of RT-PCR-positive compared with RT-PCR-negative patients in primary care. Symptomatic COVID-19 suspects were assessed clinically at the initial consultation in primary care between March and May 2020, followed by phone consultations over a span of at least 28 days. Sensitivity and specificity were estimated for each symptom using the initial RT-PCR result as a reference standard. The proportions of symptomatic patients according to the RT-PCR test results were compared over time, and time to recovery was estimated. Out of 883 patients, 13.9% had a positive RT-PCR test, and 17.4% were not tested. Most sensitive symptoms were cough, myalgia, and a history of fever, while most specific symptoms were fever for \u22654 days, hypo\/anosmia, and hypo\/ageusia. At the final follow up (median time 55 days, range 28\u2013105 days), 44.7% of patients still reported symptoms in the RT-PCR-positive group, compared with 18.3% in the negative group (p &lt; 0.001), mostly with hypo\/anosmia (16.3%), dyspnea (12.2%), and fatigue (10.6%). The discriminative value of individual symptoms for diagnosing COVID-19 was limited. Almost half of the SARS-CoV-2-positive patients still reported symptoms at least 28 days after the initial consultation.<\/jats:p>","DOI":"10.3390\/idr15010012","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:51:06Z","timestamp":1676008266000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Performance of Individual Symptoms to Predict SARS-CoV-2 RT-PCR Positivity and Symptom Persistence among Suspects Presenting in Primary Care during the First Wave of COVID-19"],"prefix":"10.3390","volume":"15","author":[{"given":"Mona","family":"Savoy","sequence":"first","affiliation":[{"name":"Department of Ambulatory Care, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Kopp","sequence":"additional","affiliation":[{"name":"Department of Ambulatory Care, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-0465","authenticated-orcid":false,"given":"Aziz","family":"Chaouch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cohidon","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Ambulatory Care, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-026X","authenticated-orcid":false,"given":"Patrick","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Cabinet M\u00e9dical du Chauderon, 1071 Chexbres, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-212X","authenticated-orcid":false,"given":"Muriel","family":"Maeder","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Payot","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Perdrix","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-3249","authenticated-orcid":false,"given":"Nicolas","family":"Senn","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-4538","authenticated-orcid":false,"given":"Yolanda","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Center for Primary Care and Public Health (Unisant\u00e9), University of Lausanne, 1004 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","unstructured":"OFSP (2023, January 17). 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