{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:49:04Z","timestamp":1783118944610,"version":"3.54.6"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Typhoid fever (Typhoid or enteric fever) is still the most common bacterial bloodstream infection worldwide, caused by Salmonella typhi. The transmission route is indirect through passive vehicles such as contaminated water or food. Main clinical findings are a fever lasting more than three days, abdominal symptoms, leukocytosis, and anemia. Typhoid can cause a wide range of multi-organ complications. We report a particularly severe form of this infection complicated by superior mesenteric vein and splenic vein thrombosis, an extremely uncommon manifestation.<\/jats:p>","DOI":"10.3390\/idr15040038","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T01:02:50Z","timestamp":1688950970000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Severe Typhoid Fever Complicated by Superior Mesenteric and Splenic Vein Thrombosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-9716","authenticated-orcid":false,"given":"Piero","family":"Veronese","sequence":"first","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Maffini","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Rubini","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Giacometti","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatrice","family":"Ruozi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Cella","sequence":"additional","affiliation":[{"name":"Pediatric Radiology, Institute of Radiology, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Icilio","family":"Dodi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Children\u2019s Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1093\/ofid\/ofad021","article-title":"Seroepidemiology for Enteric Fever: Emerging Approaches and Opportunities","volume":"10","author":"Aiemjoy","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/ijn.ijn_497_21","article-title":"Typhoid Fever Complicated by Rhabdomyolysis with Acute Hepatitis, Splenic Infarct, Pancreatitis, and Acute Kidney Injury","volume":"33","author":"Gupta","year":"2023","journal-title":"Indian J. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 328 Diseases and Injuries for 195 Countries, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Vos","year":"2017","journal-title":"Lancet"},{"key":"ref_4","unstructured":"(2023, June 20). World Health Organization Typhoid. Available online: http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/typhoid."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1473-3099(18)30685-6","article-title":"The Global Burden of Typhoid and Paratyphoid Fevers: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"19","author":"Stanaway","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4269\/ajtmh.2010.10-0007","article-title":"Imported Enteric Fever: Case Series from the Hospital for Tropical Diseases, London, United Kingdom","volume":"82","author":"Patel","year":"2010","journal-title":"Am. Soc. Trop. Med. Hyg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid Fever","volume":"347","author":"Parry","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12941-016-0147-z","article-title":"What Proportion of Salmonella Typhi Cases Are Detected by Blood Culture? A Systematic Literature Review","volume":"15","author":"Mogasale","year":"2016","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.diagmicrobio.2006.06.024","article-title":"Evaluation of New-Generation Serologic Tests for the Diagnosis of Typhoid Fever: Data from a Community-Based Surveillance in Calcutta, India","volume":"56","author":"Dutta","year":"2006","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_10","first-page":"108","article-title":"Rapid Diagnostic Tests for Typhoid and Paratyphoid (Enteric) Fever","volume":"5","author":"Wijedoru","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1128\/CMR.00002-15","article-title":"Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections","volume":"28","author":"Crump","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11239-019-01949-z","article-title":"The Role of Anticoagulation in Pylephlebitis: A Retrospective Examination of Characteristics and Outcomes","volume":"49","author":"Naymagon","year":"2020","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jevtic, D., Gavrancic, T., Pantic, I., Nordin, T., Nordstrom, C.W., Antic, M., Pantic, N., Kaljevic, M., Joksimovic, B., and Jovanovic, M. (2022). Suppurative Thrombosis of the Portal Vein (Pylephlebits): A Systematic Review of Literature. J. Clin. Med., 11.","DOI":"10.3390\/jcm11174992"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00004728-200009000-00017","article-title":"Septic Thrombophlebitis of the Mesenteric and Portal Veins: CT Imaging","volume":"24","author":"Balthazar","year":"2000","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1001\/jama.1907.25220500025002d","article-title":"The Work Of A Chronic Typhoid Germ Distributor","volume":"48","author":"Soper","year":"1907","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pitzer, V.E., Bowles, C.C., Baker, S., Kang, G., Balaji, V., Farrar, J.J., and Grenfell, B.T. (2014). Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002642"},{"key":"ref_17","unstructured":"European Centre for Disease Prevention and Control (2020). Typhoid and Paratyphoid Fevers, European Centre for Disease Prevention and Control."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e570","DOI":"10.1016\/S2214-109X(14)70301-8","article-title":"Burden of Typhoid Fever in Low-Income and Middle-Income Countries: A Systematic, Literature-Based Update with Risk-Factor Adjustment","volume":"2","author":"Mogasale","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0950268897008558","article-title":"Risk Factors for Typhoid Fever in an Endemic Setting, Karachi, Pakistan","volume":"120","author":"LUBY","year":"1998","journal-title":"Epidemiol. Infect."},{"key":"ref_20","unstructured":"(2023, June 20). Center for Disease Control and Prevention Information for Healthcare Professionals, Available online: https:\/\/www.cdc.gov\/typhoid-fever\/health-professional.html."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0140-6736(05)67181-4","article-title":"Typhoid and Paratyphoid Fever","volume":"366","author":"Bhan","year":"2005","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Parry, C.M., Thompson, C., Vinh, H., Chinh, N.T., Phuong, L.T., Ho, V.A., Hien, T.T., Wain, J., Farrar, J.J., and Baker, S. (2014). Risk Factors for the Development of Severe Typhoid Fever in Vietnam. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-73"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/ciu078","article-title":"An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution","volume":"58","author":"Waddington","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/archinte.1978.03630270047018","article-title":"Typhoid Fever: Studies of Blood Coagulation, Bacteremia, and Endotoxemia","volume":"138","author":"Butler","year":"1978","journal-title":"Arch. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/NRL.0b013e31825cf3e1","article-title":"Cerebral Venous Sinus Thrombosis Secondary to Typhoid Fever: A Case Report and Brief Summary of the Literature","volume":"18","author":"Pineda","year":"2012","journal-title":"Neurologist"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.eimc.2013.09.002","article-title":"Pylephlebitis: Incidence and Prognosis in a Tertiary Hospital","volume":"32","year":"2014","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e933","DOI":"10.1097\/MJT.0000000000000084","article-title":"Gastrointestinal Variant of Lemierre Syndrome: Fusobacterium Nucleatum: Bacteremia\u2013Associated Hepatic Vein Thrombosis: A Case Report and Literature Review","volume":"23","author":"Zheng","year":"2016","journal-title":"Am. J. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.idcr.2017.06.013","article-title":"A Case of Liver Abscess and Fusobacterium Septicemia","volume":"9","author":"Rahmati","year":"2017","journal-title":"IDCases"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s11605-015-2875-3","article-title":"Pylephlebitis: A Review of 95 Cases","volume":"20","author":"Choudhry","year":"2016","journal-title":"J. Gastrointest. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/archinte.1946.00220060002001","article-title":"TYPHOID: Clinical Analysis of Three Hundred and Sixty Cases","volume":"78","author":"Stuart","year":"1946","journal-title":"Arch. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/jcm.31.6.1439-1443.1993","article-title":"Detection of Salmonella Typhi in the Blood of Patients with Typhoid Fever by Polymerase Chain Reaction","volume":"31","author":"Song","year":"1993","journal-title":"J. Clin. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/pmj.76.892.80","article-title":"Widal Agglutination Test \u2212 100 Years Later: Still Plagued by Controversy","volume":"76","author":"Olopoenia","year":"2000","journal-title":"Postgrad. Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4269\/ajtmh.1978.27.795","article-title":"Diagnostic Value of the Widal Test in Areas Endemic for Typhoid Fever","volume":"27","author":"Levine","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"k5322","DOI":"10.1136\/bmj.k5322","article-title":"Multidrug Resistant Enteric Fever in South Asia: Unmet Medical Needs and Opportunities","volume":"364","author":"Parry","year":"2019","journal-title":"BMJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/317450","article-title":"Azithromycin versus Ceftriaxone for the Treatment of Uncomplicated Typhoid Fever in Children","volume":"31","author":"Frenck","year":"2000","journal-title":"Clin. Infect. Dis."}],"container-title":["Infectious Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7449\/15\/4\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:09:14Z","timestamp":1760126954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7449\/15\/4\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,8]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["idr15040038"],"URL":"https:\/\/doi.org\/10.3390\/idr15040038","relation":{},"ISSN":["2036-7449"],"issn-type":[{"value":"2036-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,8]]}}}