{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:17:02Z","timestamp":1765808222486,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Hospital rechts der Isar, Department of Medicine II"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Sexually transmitted infections (STIs) are increasing among men who have sex with men (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its diagnostic reliability compared to testing by healthcare professionals (HCPs) requires further investigation. In this prospective, multicenter cohort study in a high-income country, asymptomatic MSM with a sexual risk profile for STIs were included. Sequential swabs for STI nucleic acid-based diagnosis of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) were performed after randomization, either through self-sampling or HCP-performed sampling. Baseline demographic information, sexual risk behavior, and acceptance and feedback on self-sampling were recorded using an electronic questionnaire. Out of 236 asymptomatic MSM, 47 individuals (19.9%) tested positive for CT and\/or NG through self- or HCP-performed sampling. For CT, the sensitivity was 93.3% for both sampling methods, while for NG, it was 90.0% for self-sampling and 95.0% for HCP-performed sampling. Our study demonstrates that self-sampling for asymptomatic STIs has a comparable diagnostic outcome to HCP-performed sampling, with high acceptance in high-risk MSM.<\/jats:p>","DOI":"10.3390\/idr15050047","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:57:35Z","timestamp":1693205855000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Self-Collected Versus Health Care Professional (HCP)-Performed Sampling and the Potential Impact on the Diagnostic Results of Asymptomatic Sexually Transmitted Infections (STIs) in High-Risk Individuals"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7193-2778","authenticated-orcid":false,"given":"Simon","family":"Weidlich","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1117-7836","authenticated-orcid":false,"given":"Sven","family":"Schellberg","sequence":"additional","affiliation":[{"name":"Novopraxis Berlin, Mohrenstr 6, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-8745","authenticated-orcid":false,"given":"Stefan","family":"Scholten","sequence":"additional","affiliation":[{"name":"Praxis Hohenstaufenring K\u00f6ln, Richard-Wagner-Str 9-11, 50674 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Rothe","sequence":"additional","affiliation":[{"name":"Institute for Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Trogerstr. 30, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Wantia","sequence":"additional","affiliation":[{"name":"Institute for Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Trogerstr. 30, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-5367","authenticated-orcid":false,"given":"Christoph D.","family":"Spinner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Noe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany"},{"name":"MVZ M\u00fcnchen am Goetheplatz, Waltherstr. 32, 80807 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"ref_1","unstructured":"(2023, July 13). Global Progress Report on HIV, Viral Hepatitis and Sexually Transmitted Infections. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240027077."},{"key":"ref_2","unstructured":"CDC (2023, July 13). STD Diagnoses among Key US Populations, 5-Year Trends, Available online: https:\/\/www.cdc.gov\/nchhstp\/newsroom\/docs\/2018\/table-data-2018-STD-Prevention-Conference.pdf."},{"key":"ref_3","unstructured":"(2023, July 13). Preventing HIV and STI among Men Who Have Sex with Men\u2014An ECDC Guidance. Available online: https:\/\/www.ecdc.europa.eu\/en\/news-events\/preventing-hiv-and-sti-among-men-who-have-sex-men-ecdc-guidance."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/OLQ.0000000000000384","article-title":"Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex with Men Reporting a History of Receptive Anal Intercourse","volume":"43","author":"Danby","year":"2016","journal-title":"Sex. Transm. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/sextrans-2012-050929","article-title":"Prevalence of pharyngeal and rectal Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in Germany","volume":"90","author":"Haar","year":"2014","journal-title":"Sex. Transm. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1071\/SH12092","article-title":"Anatomic distribution of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium infections in men who have sex with men","volume":"10","author":"Reinton","year":"2013","journal-title":"Sex. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2100591","DOI":"10.2807\/1560-7917.ES.2022.27.14.2100591","article-title":"HIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019","volume":"27","author":"Streeck","year":"2022","journal-title":"Eurosurveillance"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/OLQ.0000000000000754","article-title":"Prevalence of Rectal Chlamydial and Gonococcal Infections: A Systematic Review","volume":"45","author":"Dewart","year":"2018","journal-title":"Sex. Transm. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s15010-018-1124-6","article-title":"Prevalence of asymptomatic sexually transmitted infections in HIV-positive men who have sex with men in Germany: Results of a multicentre cross-sectional study","volume":"46","author":"Spinner","year":"2018","journal-title":"Infection"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jansen, K., Steffen, G., Potthoff, A., Schuppe, A.K., Beer, D., Jessen, H., Scholten, S., Spornraft-Ragaller, P., Bremer, V., and Tiemann, C. (2020). STI in times of PrEP: High prevalence of chlamydia, gonorrhea, and mycoplasma at different anatomic sites in men who have sex with men in Germany. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-4831-4"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/OLQ.0000000000001486","article-title":"Community-Based Prevalence Estimates of Chlamydia trachomatis and Neisseria gonorrhoeae Infections among Gay, Bisexual, and Other Men Who Have Sex with Men in Montr\u00e9al, Canada","volume":"48","author":"Apelian","year":"2021","journal-title":"Sex. Transm. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kularadhan, V., Gan, J., Chow, E.P.F., Fairley, C.K., and Ong, J.J. (2022). HIV and STI Testing Preferences for Men Who Have Sex with Men in High-Income Countries: A Scoping Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19053002"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/hiv.13268","article-title":"Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021","volume":"23","author":"Ryom","year":"2022","journal-title":"HIV Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/hiv.12724","article-title":"Summary of German-Austrian HIV PrEP guideline","volume":"20","author":"Spinner","year":"2019","journal-title":"HIV Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/sextrans-2022-055557","article-title":"Self-sampling strategies (with\/without digital innovations) in populations at risk of Chlamydia trachomatis and Neisseria gonorrhoeae: A systematic review and meta-analyses","volume":"99","author":"Vialard","year":"2023","journal-title":"Sex. Transm. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e3172","DOI":"10.1093\/cid\/ciaa1266","article-title":"Swab-yourself Trial With Economic Monitoring and Testing for Infections Collectively (SYSTEMATIC): Part 1. A Diagnostic Accuracy and Cost-effectiveness Study Comparing Clinician-taken vs Self-taken Rectal and Pharyngeal Samples for the Diagnosis of Gonorrhea and Chlamydia","volume":"73","author":"Wilson","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/0956462412472834","article-title":"Use of the UriSwab collection device for testing of Chlamydia trachomatis and Neisseria gonorrhoeae: Implications for a postal testing service","volume":"24","author":"McNicol","year":"2013","journal-title":"Int. J. STD AIDS"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1071\/SH16117","article-title":"UriSwab: An effective transport medium for nucleic acid detection of Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae","volume":"14","author":"Costa","year":"2017","journal-title":"Sex. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/OLQ.0b013e318227713e","article-title":"Evaluation of self-collected versus clinician-collected swabs for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae pharyngeal infection among men who have sex with men","volume":"38","author":"Freeman","year":"2011","journal-title":"Sex. Transm. 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