{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:16:50Z","timestamp":1768285010799,"version":"3.49.0"},"reference-count":182,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>The coronavirus disease 2019 (COVID-19), instigated by the zoonotic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), rapidly transformed from an outbreak in Wuhan, China, into a widespread global pandemic. A significant post-infection condition, known as \u2018long- COVID-19\u2032 (or simply \u2018long- COVID\u2019), emerges in a substantial subset of patients, manifesting with a constellation of over 200 reported symptoms that span multiple organ systems. This condition, also known as \u2018post-acute sequelae of SARS-CoV-2 infection\u2019 (PASC), presents a perplexing clinical picture with far-reaching implications, often persisting long after the acute phase. While initial research focused on the immediate pulmonary impact of the virus, the recognition of COVID-19 as a multiorgan disruptor has unveiled a gamut of protracted and severe health issues. This review summarizes the primary effects of long COVID on the respiratory, cardiovascular, and nervous systems. It also delves into the mechanisms underlying these impacts and underscores the critical need for a comprehensive understanding of long COVID\u2019s pathogenesis.<\/jats:p>","DOI":"10.3390\/idr15060072","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T12:57:56Z","timestamp":1702904276000},"page":"806-830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Persisting Shadows: Unraveling the Impact of Long COVID-19 on Respiratory, Cardiovascular, and Nervous Systems"],"prefix":"10.3390","volume":"15","author":[{"given":"Christina-Michailia","family":"Sideratou","sequence":"first","affiliation":[{"name":"Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, 2417 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-8839","authenticated-orcid":false,"given":"Christos","family":"Papaneophytou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, 2417 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41584-021-00608-z","article-title":"Systemic and organ-specific immune-related manifestations of COVID-19","volume":"17","author":"Mariette","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1016\/S2468-2667(22)00223-7","article-title":"COVID-19 mortality and deprivation: Pandemic, syndemic, and endemic health inequalities","volume":"7","author":"McGowan","year":"2022","journal-title":"The Lancet Public Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.3906\/sag-2107-13","article-title":"From asymptomatic to critical illness: Decoding various clinical stages of COVID-19","volume":"51","year":"2021","journal-title":"Turk. J. Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630778","DOI":"10.3389\/fphys.2021.630778","article-title":"Do cellular entry mechanisms of SARS-Cov-2 affect myocardial cells and contribute to cardiac injury in COVID-19 patients?","volume":"12","author":"Balse","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41579-023-00878-2","article-title":"The evolution of SARS-CoV-2","volume":"21","author":"Markov","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abulsoud, A.I., El-Husseiny, H.M., El-Husseiny, A.A., El-Mahdy, H.A., Ismail, A., Elkhawaga, S.Y., Khidr, E.G., Fathi, D., Mady, E.A., and Najda, A. (2023). Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions. Biomed. Pharmacother., 157.","DOI":"10.1016\/j.biopha.2022.113977"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1007\/s12031-020-01767-6","article-title":"Evidence of coronavirus (CoV) pathogenesis and emerging pathogen SARS-CoV-2 in the nervous system: A review on neurological impairments and manifestations","volume":"71","author":"Jha","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"ref_8","first-page":"37","article-title":"SARS-CoV-2 infection and multi-organ system damage: A review","volume":"23","author":"Rabaan","year":"2023","journal-title":"Biomol. Biomed."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12985-020-01363-5","article-title":"The newly emerged COVID-19 disease: A systemic review","volume":"17","author":"Abebe","year":"2020","journal-title":"Virol. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s10096-020-03899-4","article-title":"The genetic sequence, origin, and diagnosis of SARS-CoV-2","volume":"39","author":"Wang","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1007\/s00705-021-05156-1","article-title":"Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses","volume":"166","author":"Walker","year":"2021","journal-title":"Arch. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gitman, M.R., Shaban, M.V., Paniz-Mondolfi, A.E., and Sordillo, E.M. (2021). Laboratory diagnosis of SARS-CoV-2 pneumonia. Diagnostics, 11.","DOI":"10.3390\/diagnostics11071270"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41579-021-00630-8","article-title":"Structural biology of SARS-CoV-2 and implications for therapeutic development","volume":"19","author":"Yang","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"M\u00fcller, M., Volzke, J., Subin, B., Schmidt, C.J., Geerdes-Fenge, H., Reisinger, E.C., and M\u00fcller-Hilke, B. (2022). Distinguishing incubation and acute disease stages of mild-to-moderate COVID-19. Viruses, 14.","DOI":"10.3390\/v14020203"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Silva Andrade, B., Siqueira, S., de Assis Soares, W.R., de Souza Rangel, F., Santos, N.O., dos Santos Freitas, A., Ribeiro da Silveira, P., Tiwari, S., Alzahrani, K.J., and G\u00f3es-Neto, A. (2021). Long-COVID and post-COVID health complications: An up-to-date review on clinical conditions and their possible molecular mechanisms. Viruses, 13.","DOI":"10.3390\/v13040700"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s10194-022-01450-8","article-title":"Long COVID headache","volume":"23","author":"Tana","year":"2022","journal-title":"J. Headache Pain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(21)00031-X","article-title":"NICE guideline on long COVID","volume":"9","author":"Venkatesan","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/23744235.2021.1924397","article-title":"Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments","volume":"53","author":"Yong","year":"2021","journal-title":"Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.NPR.0000722312.25644.b9","article-title":"COVID-19: Epidemiology and clinical practice implications","volume":"45","author":"Rogge","year":"2020","journal-title":"Nurse Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bpa.2021.02.003","article-title":"Impact of COVID-19 infection on the cardiovascular system: An evidence-based analysis of risk factors and outcomes","volume":"35","author":"Kaye","year":"2021","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10238-020-00648-x","article-title":"Organ-specific manifestations of COVID-19 infection","volume":"20","author":"Gavriatopoulou","year":"2020","journal-title":"Clin. Exp. Med."},{"key":"ref_22","first-page":"e14726","article-title":"SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation","volume":"9","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103556","DOI":"10.1016\/j.pdpdt.2023.103556","article-title":"Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: A meta-analysis","volume":"42","author":"Kazantzis","year":"2023","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ilias, I., Vassiliou, A.G., Keskinidou, C., Vrettou, C.S., Orfanos, S., Kotanidou, A., and Dimopoulou, I. (2023). Changes in cortisol secretion and corticosteroid receptors in COVID-19 and non COVID-19 Critically Ill patients with sepsis\/septic shock and scope for treatment. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071801"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101019","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact","volume":"38","author":"Davis","year":"2021","journal-title":"eClinicalMedicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jchf.2021.10.002","article-title":"Use of cardiopulmonary stress testing for patients with unexplained dyspnea post-coronavirus disease","volume":"9","author":"Mancini","year":"2021","journal-title":"JACC Heart Fail."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1012668","DOI":"10.3389\/fneur.2022.1012668","article-title":"Characterization of autonomic symptom burden in long COVID: A global survey of 2314 adults","volume":"13","author":"Larsen","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/occmed\/kqi013","article-title":"A systematic review describing the prognosis of chronic fatigue syndrome","volume":"55","author":"Cairns","year":"2005","journal-title":"Occup. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/jim-2021-002051","article-title":"Long COVID following mild SARS-CoV-2 infection: Characteristic T cell alterations and response to antihistamines","volume":"70","author":"Glynne","year":"2022","journal-title":"J. Investig. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cell.2022.01.014","article-title":"Multiple early factors anticipate post-acute COVID-19 sequelae","volume":"185","author":"Su","year":"2022","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/infdis\/jiab490","article-title":"Markers of immune activation and inflammation in individuals with postacute sequelae of severe acute respiratory syndrome Coronavirus 2 infection","volume":"224","author":"Peluso","year":"2021","journal-title":"J. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s41591-022-01840-0","article-title":"Long COVID after breakthrough SARS-CoV-2 infection","volume":"28","author":"Bowe","year":"2022","journal-title":"Nat. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"00479","DOI":"10.1183\/23120541.00479-2021","article-title":"Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome","volume":"8","author":"Jutant","year":"2022","journal-title":"ERJ Open Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S2213-2600(21)00174-0","article-title":"3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: A prospective study","volume":"9","author":"Wu","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"ref_36","first-page":"2120","article-title":"Delayed symptoms in patients recovered from COVID-19","volume":"49","author":"Moradian","year":"2020","journal-title":"Iran. J. Public Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e418","DOI":"10.3346\/jkms.2020.35.e418","article-title":"Three-month follow-up study of survivors of coronavirus disease 2019 after discharge","volume":"35","author":"Liang","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_38","first-page":"00655","article-title":"Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia","volume":"7","author":"Waller","year":"2021","journal-title":"ERJ Open Res."},{"key":"ref_39","first-page":"36298","article-title":"Follow-up study of the chest CT characteristics of COVID-19 survivors seven months after recovery","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Med."},{"key":"ref_40","first-page":"383","article-title":"Analysis of thin-section CT in patients with coronavirus disease (COVID-19) after hospital discharge","volume":"28","author":"Wei","year":"2020","journal-title":"J. X-ray Sci. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/jclinpath-2020-206879","article-title":"Fatal pulmonary fibrosis: A post-COVID-19 autopsy case","volume":"74","author":"Schwensen","year":"2021","journal-title":"J. Clin. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1038\/s41598-022-07918-6","article-title":"ACE2 protein expression in lung tissues of severe COVID-19 infection","volume":"12","author":"Gheware","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.4103\/lungindia.lungindia_818_20","article-title":"Post-COVID lung fibrosis: The tsunami that will follow the earthquake","volume":"38","author":"Udwadia","year":"2021","journal-title":"Lung India"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: A hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41392-022-01070-3","article-title":"Targeting fibrosis: Mechanisms and clinical trials","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Giacomelli, C., Piccarducci, R., Marchetti, L., Romei, C., and Martini, C. (2021). Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: Lessons from post-COVID-19 patients. Biochem. Pharmacol., 193.","DOI":"10.1016\/j.bcp.2021.114812"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijcard.2022.12.019","article-title":"Acute pericarditis as a major clinical manifestation of long COVID-19 syndrome","volume":"374","author":"Dini","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-021-00679-0","article-title":"The signal pathways and treatment of cytokine storm in COVID-19","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/covid2050040","article-title":"The cytokine storm in COVID-19: The strongest link to morbidity and mortality in the current epidemic","volume":"2","author":"Basheer","year":"2022","journal-title":"COVID"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"118054","DOI":"10.1016\/j.lfs.2020.118054","article-title":"Tackling the cytokine storm in COVID-19, challenges and hopes","volume":"257","author":"Abdin","year":"2020","journal-title":"Life Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1152\/physiol.00033.2021","article-title":"Mechanisms of lung injury induced by SARS-CoV-2 infection","volume":"37","author":"Upadhya","year":"2022","journal-title":"Physiology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pccm.2022.12.002","article-title":"Pulmonary fibrosis: A short- or long-term sequelae of severe COVID-19?","volume":"1","author":"Zheng","year":"2023","journal-title":"Chin. Med. J. Pulm. Crit. Care Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Pandolfi, L., Fossali, T., Frangipane, V., Bozzini, S., Morosini, M., D\u2019Amato, M., Lettieri, S., Urtis, M., Di Toro, A., and Saracino, L. (2020). Broncho-alveolar inflammation in COVID-19 patients: A correlation with clinical outcome. BMC Pulm. Med., 20.","DOI":"10.1186\/s12890-020-01343-z"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Barilli, A., Visigalli, R., Ferrari, F., Bianchi, M.G., Dall\u2019Asta, V., and Rotoli, B.M. (2022). Immune-mediated inflammatory responses of alveolar epithelial cells: Implications for COVID-19 lung pathology. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030618"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lazar, M., Barbu, E.C., Chitu, C.E., Tiliscan, C., Stratan, L., Arama, S.S., Arama, V., and Ion, D.A. (2022). Interstitial lung fibrosis following COVID-19 pneumonia. Diagnostics, 12.","DOI":"10.3390\/diagnostics12082028"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1515\/cclm-2021-1021","article-title":"The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors","volume":"60","author":"Vianello","year":"2022","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S2213-2600(20)30222-8","article-title":"Pulmonary fibrosis secondary to COVID-19: A call to arms?","volume":"8","author":"Spagnolo","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0140-6736(20)31189-2","article-title":"Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: A prospective cohort study","volume":"395","author":"Cummings","year":"2020","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0140-6736(21)00799-6","article-title":"Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO clinical characterisation protocol UK: A prospective, multicentre cohort study","volume":"398","author":"Drake","year":"2021","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11883-022-01032-8","article-title":"Long-term cardiovascular effects of COVID-19: Emerging data relevant to the cardiovascular clinician","volume":"24","author":"Tobler","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_62","first-page":"e31933","article-title":"A review of long COVID with a special focus on its cardiovascular manifestations","volume":"14","author":"Yousif","year":"2022","journal-title":"Cureus"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41392-022-00907-1","article-title":"The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication","volume":"7","author":"Ning","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_64","first-page":"100025","article-title":"Post-acute COVID-19 syndrome and the cardiovascular system: What is known?","volume":"5","author":"Dixit","year":"2021","journal-title":"Am. Heart J. Plus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jamacardio.2020.3557","article-title":"Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from Coronavirus Disease 2019 (COVID-19)","volume":"5","author":"Puntmann","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.jcmg.2020.05.004","article-title":"Cardiac involvement in patients recovered from COVID-2019 identified using magnetic resonance imaging","volume":"13","author":"Huang","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/thoraxjnl-2020-215818","article-title":"\u2018Long-COVID\u2019: A cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19","volume":"76","author":"Mandal","year":"2021","journal-title":"Thorax"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/eurheartj\/ehab075","article-title":"Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance","volume":"42","author":"Kotecha","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/s41591-022-02000-0","article-title":"Long-term cardiac pathology in individuals with mild initial COVID-19 illness","volume":"28","author":"Puntmann","year":"2022","journal-title":"Nat. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ar\u00e9valos, V., Ortega-Paz, L., Rodr\u00edguez-Arias, J.J., Calvo L\u00f3pez, M., Castrillo-Golvano, L., Salazar-Rodr\u00edguez, A., Sabat\u00e9-Tormos, M., Spione, F., Sabat\u00e9, M., and Brugaletta, S. (2021). Acute and chronic effects of COVID-19 on the cardiovascular system. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8100128"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.120.15291","article-title":"ACE2 (Angiotensin-Converting Enzyme 2), COVID-19, and ACE inhibitor and Ang II (Angiotensin II) receptor blocker use during the pandemic","volume":"76","author":"South","year":"2020","journal-title":"Hypertension"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41440-020-0455-8","article-title":"Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19","volume":"43","author":"Kai","year":"2020","journal-title":"Hypertens. Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Visco, V., Vitale, C., Rispoli, A., Izzo, C., Virtuoso, N., Ferruzzi, G.J., Santopietro, M., Melfi, A., Rusciano, M.R., and Maglio, A. (2022). Post-COVID-19 syndrome: Involvement and interactions between respiratory, cardiovascular and nervous Systems. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030524"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13244-021-00973-z","article-title":"Role of advanced imaging in COVID-19 cardiovascular complications","volume":"12","author":"Catapano","year":"2021","journal-title":"Insights Imaging"},{"key":"ref_75","first-page":"e25559","article-title":"New perspectives on Llong COVID syndrome: The development of unusually delayed and recurring pericarditis after a primary SARS-CoV-2 infection","volume":"14","author":"Khasnavis","year":"2022","journal-title":"Cureus"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"102168","DOI":"10.1016\/j.scr.2021.102168","article-title":"The effects of novel coronavirus (SARS-CoV-2) infection on cardiovascular diseases and cardiopulmonary injuries","volume":"51","author":"Li","year":"2021","journal-title":"Stem Cell Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/CIRCRESAHA.120.317055","article-title":"COVID-19 and the heart","volume":"126","author":"Akhmerov","year":"2020","journal-title":"Circ. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.3389\/fimmu.2020.01648","article-title":"Cytokine storm in COVID-19-Immunopathological mechanisms, clinical considerations, and therapeutic approaches: The REPROGRAM consortium position paper","volume":"11","author":"Bhaskar","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3892\/etm.2022.11290","article-title":"Long COVID and neuropsychiatric manifestations","volume":"23","author":"Efstathiou","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"110525","DOI":"10.1016\/j.jpsychores.2021.110525","article-title":"Physical and mental health complications post-COVID-19: Scoping review","volume":"147","author":"Shanbehzadeh","year":"2021","journal-title":"J. Psychosom. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"20406223221076890","DOI":"10.1177\/20406223221076890","article-title":"Neurological manifestations of long-COVID syndrome: A narrative review","volume":"13","author":"Stefanou","year":"2022","journal-title":"Ther. Adv. Chronic. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(21)01755-4","article-title":"1-year outcomes in hospital survivors with COVID-19: A longitudinal cohort study","volume":"398","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Rudroff, T., Fietsam, A.C., Deters, J.R., Bryant, A.D., and Kamholz, J. (2020). Post-COVID-19 fatigue: Potential contributing factors. Brain Sci., 10.","DOI":"10.3390\/brainsci10121012"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.jinf.2020.08.029","article-title":"Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19","volume":"81","author":"Garrigues","year":"2020","journal-title":"J. Infect."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1126\/science.abm2052","article-title":"Nervous system consequences of COVID-19","volume":"375","author":"Spudich","year":"2022","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mahmud, R., Rahman, M.M., Rassel, M.A., Monayem, F.B., Sayeed, S.K.J.B., Islam, M.S., and Islam, M.M. (2021). Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249644"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1513\/AnnalsATS.202009-1175OC","article-title":"Persistent poor health after COVID-19 is not associated with respiratory complications or initial disease severity","volume":"18","author":"Townsend","year":"2021","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1007\/s11469-020-00294-0","article-title":"Adaptation of the fear of COVID-19 scale: Its association with psychological distress and life satisfaction in Turkey","volume":"19","author":"Satici","year":"2021","journal-title":"Int. J. Ment. Health Addict."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e2127403","DOI":"10.1001\/jamanetworkopen.2021.27403","article-title":"Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China","volume":"4","author":"Zhang","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1007\/s10072-021-05586-4","article-title":"Long-term neurological manifestations of COVID-19: Prevalence and predictive factors","volume":"42","author":"Pilotto","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jmv.26368","article-title":"Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation","volume":"93","author":"Halpin","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2215-0366(21)00084-5","article-title":"6-month neurological and psychiatric outcomes in 236\u2009379 survivors of COVID-19: A retrospective cohort study using electronic health records","volume":"8","author":"Taquet","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"El-Arif, G., Farhat, A., Khazaal, S., Annweiler, C., Kovacic, H., Wu, Y., Cao, Z., Fajloun, Z., Khattar, Z.A., and Sabatier, J.M. (2021). The renin-angiotensin system: A key role in SARS-CoV-2-induced COVID-19. Molecules, 26.","DOI":"10.3390\/molecules26226945"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Khazaal, S., Harb, J., Rima, M., Annweiler, C., Wu, Y., Cao, Z., Abi Khattar, Z., Legros, C., Kovacic, H., and Fajloun, Z. (2022). The pathophysiology of long COVID throughout the renin-angiotensin system. Molecules, 27.","DOI":"10.3390\/molecules27092903"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00259-021-05215-4","article-title":"18F-FDG brain PET hypometabolism in patients with long COVID","volume":"48","author":"Guedj","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"n1648","DOI":"10.1136\/bmj.n1648","article-title":"Long covid-mechanisms, risk factors, and management","volume":"374","author":"Crook","year":"2021","journal-title":"BMJ"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s10072-020-04575-3","article-title":"Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients","volume":"41","author":"Yachou","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Nuzzo, D., Vasto, S., Scalisi, L., Cottone, S., Cambula, G., Rizzo, M., Giacomazza, D., and Picone, P. (2021). Post-acute COVID-19 neurological syndrome: A new medical challenge. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091947"},{"key":"ref_99","first-page":"100102","article-title":"Blood-brain barrier pathology in patients with severe mental disorders: A systematic review and meta-analysis of biomarkers in case-control studies","volume":"6","author":"Futtrup","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"592214","DOI":"10.3389\/fncel.2020.592214","article-title":"Neuropathobiology of COVID-19: The role for glia","volume":"14","author":"Tremblay","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jpsychires.2020.06.022","article-title":"The landscape of cognitive function in recovered COVID-19 patients","volume":"129","author":"Zhou","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ana.25807","article-title":"COVID-19: A global threat to the nervous system","volume":"88","author":"Koralnik","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s40478-020-01024-2","article-title":"Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage","volume":"8","author":"Thakur","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbi.2021.02.021","article-title":"Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-up","volume":"94","author":"Mazza","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jns.12482","article-title":"COVID-19 and the peripheral nervous system. A 2-year review from the pandemic to the vaccine era","volume":"27","author":"Taga","year":"2022","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/ceo.14221","article-title":"An eye to the future: Acute and long-term neuro-ophthalmological and neurological complications of COVID-19","volume":"51","author":"Wesselingh","year":"2023","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11910-021-01102-5","article-title":"Peripheral nervous system manifestations associated with COVID-19","volume":"21","author":"Andalib","year":"2021","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_108","first-page":"e21246","article-title":"Post-COVID-19 Guillain-Barr\u00e9 syndrome: A case report with literature review","volume":"14","author":"Kaeley","year":"2022","journal-title":"Cureus"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/jnnp-2020-324837","article-title":"Guillain-Barr\u00e9 syndrome and COVID-19: An observational multicentre study from two Italian hotspot regions","volume":"92","author":"Filosto","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/ana.25987","article-title":"Incidence, clinical, risk factors and outcomes of Guillain-Barr\u00e9 in Covid-19","volume":"89","author":"Fragiel","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e849","DOI":"10.1212\/WNL.0000000000012344","article-title":"Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19","volume":"97","author":"Suh","year":"2021","journal-title":"Neurology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"116969","DOI":"10.1016\/j.jns.2020.116969","article-title":"Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline","volume":"415","author":"Pinna","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/jmv.26289","article-title":"Clinical neurophysiology and cerebrospinal liquor analysis to detect Guillain-Barr\u00e9 syndrome and polyneuritis cranialis in COVID-19 patients: A case series","volume":"93","author":"Manganotti","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_114","first-page":"e11452","article-title":"Peripheral neuropathy as a complication of SARS-CoV-2","volume":"12","author":"Bureau","year":"2020","journal-title":"Cureus"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e1146","DOI":"10.1212\/NXI.0000000000001146","article-title":"Peripheral neuropathy evaluations of patients with prolonged long COVID","volume":"9","author":"Oaklander","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41440-020-0476-3","article-title":"Downregulation of ACE2 induces overstimulation of the renin\u2013angiotensin system in COVID-19: Should we block the renin\u2013angiotensin system?","volume":"43","author":"Silhol","year":"2020","journal-title":"Hypertens. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/hmbci-2020-0052","article-title":"COVID-19 and cardiovascular disease: A review of current knowledge","volume":"42","author":"Pal","year":"2021","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_119","first-page":"737","article-title":"A probable relationship between physical exercise and COVID-19 mediated by the Renin-Angiotensin-Aldosterone System","volume":"34","author":"Souza","year":"2021","journal-title":"Int. J. Cardiovasc. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/all.14238","article-title":"Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China","volume":"75","author":"Zhang","year":"2020","journal-title":"Allergy"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/joim.13144","article-title":"Cytokine storm syndrome in coronavirus disease 2019: A narrative review","volume":"289","author":"Gao","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1033674","DOI":"10.3389\/fphar.2022.1033674","article-title":"The role of IL-6 in coronavirus, especially in COVID-19","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jmii.2022.09.001","article-title":"Impact of SARS-CoV-2 infection on the profiles and responses of innate immune cells after recovery","volume":"55","author":"Ruenjaiman","year":"2022","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1003103","DOI":"10.3389\/fmed.2022.1003103","article-title":"Case report: Treatment of long COVID with a SARS-CoV-2 antiviral and IL-6 blockade in a patient with rheumatoid arthritis and SARS-CoV-2 antigen persistence","volume":"9","author":"Visvabharathy","year":"2022","journal-title":"Front. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/jocs.14596","article-title":"At the heart of COVID-19","volume":"35","author":"Khan","year":"2020","journal-title":"J. Card. Surg."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1080\/07853890.2022.2076901","article-title":"Pathophysiology and mechanism of long COVID: A comprehensive review","volume":"54","author":"Chalon","year":"2022","journal-title":"Ann. Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Romero-Duarte, \u00c1., Rivera-Izquierdo, M., Guerrero-Fern\u00e1ndez de Alba, I., P\u00e9rez-Contreras, M., Fern\u00e1ndez-Mart\u00ednez, N.F., Ruiz-Montero, R., Serrano-Ortiz, \u00c1., Gonz\u00e1lez-Serna, R.O., Salcedo-Leal, I., and Jim\u00e9nez-Mej\u00edas, E. (2021). Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: The ANCOHVID multicentre 6-month follow-up study. BMC Med., 19.","DOI":"10.1186\/s12916-021-02003-7"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1111\/jocn.15290","article-title":"Life in the pandemic: Social isolation and mental health","volume":"29","author":"Usher","year":"2020","journal-title":"J. Clin. Nurs."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1017\/S1041610220004135","article-title":"Loneliness, physical activity, and mental health during COVID-19: A longitudinal analysis of depression and anxiety in adults over the age of 50 between 2015 and 2020","volume":"33","author":"Creese","year":"2021","journal-title":"Int. Psychogeriatr."},{"key":"ref_131","first-page":"621735","article-title":"Infection mechanism of SARS-COV-2 and its implication on the nervous system","volume":"11","author":"Minjarez","year":"2020","journal-title":"Front Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41392-021-00818-7","article-title":"Neurological complications and infection mechanism of SARS-CoV-2","volume":"6","author":"Wan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s40495-023-00312-4","article-title":"CD4\u2009+\u2009Count: A Variable to Be Considered to Prioritize COVID-19 Vaccination in PLHIV","volume":"9","author":"Mounika","year":"2023","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41577-020-0304-7","article-title":"Fighting COVID-19 exhausts T cells","volume":"20","author":"Moon","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.cell.2023.09.013","article-title":"Serotonin reduction in post-acute sequelae of viral infection","volume":"186","author":"Wong","year":"2023","journal-title":"Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e09544","DOI":"10.1016\/j.heliyon.2022.e09544","article-title":"The relationship between the serotonergic system and COVID-19 disease: A review","volume":"8","author":"Najafi","year":"2022","journal-title":"Heliyon"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1152\/physrev.00039.2016","article-title":"Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa","volume":"98","author":"Dantzer","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.7861\/clinmed.2021-0462","article-title":"Hyperbaric oxygen therapy for the treatment of long COVID: Early evaluation of a highly promising intervention","volume":"21","author":"Robbins","year":"2021","journal-title":"Clin. Med."},{"key":"ref_140","first-page":"176","article-title":"Essentials of hyperbaric oxygen therapy: 2019 Review","volume":"116","author":"Kirby","year":"2019","journal-title":"MOMed."},{"key":"ref_141","first-page":"197","article-title":"The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome","volume":"40","author":"Akarsu","year":"2013","journal-title":"Undersea Hyperb. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/02601060221139628","article-title":"Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review","volume":"29","author":"Mehta","year":"2023","journal-title":"Nutr. Health"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3934\/microbiol.2022010","article-title":"Role of vitamin C in preventing of COVID-19 infection, progression and severity","volume":"8","author":"Shahbaz","year":"2022","journal-title":"AIMS Microbiol."},{"key":"ref_144","first-page":"e048391","article-title":"Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study","volume":"11","author":"Dennis","year":"2021","journal-title":"BMJ"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"766","DOI":"10.14309\/ajg.0000000000000620","article-title":"Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional, multicenter study","volume":"115","author":"Pan","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_146","first-page":"e1089","article-title":"Comprehensive health assessment 3 months after recovery from acute Coronavirus Disease 2019 (COVID-19)","volume":"73","author":"Peters","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1036556","DOI":"10.3389\/fmed.2022.1036556","article-title":"Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients","volume":"9","author":"Chudzik","year":"2022","journal-title":"Front. Med."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., Rumyantsev, M., Gamirova, A., Bairashevskaia, A., and Petrova, P. (2022). Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12\u2009months after hospital discharge: A prospective, cohort study in Moscow (StopCOVID). BMC Med., 20.","DOI":"10.2139\/ssrn.4020142"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41440-022-01145-2","article-title":"Long COVID and hypertension-related disorders: A report from the Japanese Society of Hypertension Project Team on COVID-19","volume":"46","author":"Matsumoto","year":"2023","journal-title":"Hypertens. Res."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-Las-Pe\u00f1as, C., Mart\u00edn-Guerrero, J.D., Pellicer-Valero, \u00d3.J., Navarro-Pardo, E., G\u00f3mez-Mayordomo, V., Cuadrado, M.L., Arias-Naval\u00f3n, J.A., Cigar\u00e1n-M\u00e9ndez, M., Hern\u00e1ndez-Barrera, V., and Arendt-Nielsen, L. (2022). Female sex is a risk factor associated with long-term post-COVID related-symptoms but not with COVID-19 Symptoms: The LONG-COVID-EXP-CM multicenter study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020413"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e619","DOI":"10.1016\/j.cmi.2021.11.002","article-title":"Female gender is associated with long COVID syndrome: A prospective cohort study","volume":"28","author":"Bai","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/ijpvm.ijpvm_508_21","article-title":"Post-COVID-19 syndrome mechanisms, prevention and management","volume":"14","author":"Najafi","year":"2023","journal-title":"Int. J. Prev. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"732913","DOI":"10.3389\/fimmu.2021.732913","article-title":"Immunometabolic dysregulation at the intersection of obesity and COVID-19","volume":"12","author":"Khwatenge","year":"2021","journal-title":"Front Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Debski, M., Tsampasian, V., Haney, S., Blakely, K., Weston, S., Ntatsaki, E., Lim, M., Madden, S., Perperoglou, A., and Vassiliou, V.S. (2022). Post-COVID-19 syndrome risk factors and further use of health services in East England. PLOS Global Public Health, 2.","DOI":"10.1371\/journal.pgph.0001188"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s40615-021-01170-w","article-title":"Disproportionate impact of COVID-19 on racial and ethnic minority groups in the United States: A 2021 update","volume":"9","author":"Tai","year":"2022","journal-title":"J. Racial Ethn. Health Dispar."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1038\/s41467-022-30836-0","article-title":"Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records","volume":"13","author":"Thompson","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e1152","DOI":"10.1002\/cti2.1152","article-title":"Regeneration and repair in the healing lung","volume":"9","author":"Lucas","year":"2020","journal-title":"Clin Transl. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2613.2006.00515.x","article-title":"Inflammation-associated remodelling and fibrosis in the lung\u2014A process and an end point","volume":"88","author":"Wallace","year":"2007","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat. Med."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Hua-Huy, T., G\u00fcnther, S., Lorut, C., Subileau, M., Aubourg, F., Morbieu, C., Marey, J., Texereau, J., Fajac, I., and Mouthon, L. (2022). Distal lung inflammation assessed by alveolar concentration of nitric oxide is an individualised biomarker of severe COVID-19 pneumonia. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101631"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"173897","DOI":"10.1016\/j.ejphar.2021.173897","article-title":"Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2","volume":"896","author":"Ge","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijid.2020.10.101","article-title":"CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14","volume":"103","author":"Patterson","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Cardinali, D.P., Brown, G.M., and Pandi-Perumal, S.R. (2022). Possible application of melatonin in long COVID. Biomolecules, 12.","DOI":"10.3390\/biom12111646"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Lorente-Ros, M., Das, S., Elias, J., Frishman, W.H., and Aronow, W.S. (2023). Cardiovascular manifestations of the long COVID syndrome. Cardiol. Rev.","DOI":"10.1097\/CRD.0000000000000552"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"866113","DOI":"10.3389\/fcvm.2022.866113","article-title":"Sulodexide significantly improves endothelial dysfunction and alleviates chest pain and palpitations in patients with long-COVID-19: Insights from TUN-EndCOV study","volume":"9","author":"Charfeddine","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2055102919840614","DOI":"10.1177\/2055102919840614","article-title":"Cognitive behavioural therapy for myalgic encephalomyelitis\/chronic fatigue syndrome is not effective. Re-analysis of a Cochrane review","volume":"6","author":"Vink","year":"2019","journal-title":"Health Psychol. Open"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Vollbracht, C., and Kraft, K. (2021). Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue. Nutrients, 13.","DOI":"10.3390\/nu13041154"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Orend\u00e1\u010dov\u00e1, M., Kva\u0161\u0148\u00e1k, E., and Vr\u00e1nov\u00e1, J. (2022). Effect of neurofeedback therapy on neurological post-COVID-19 complications (A pilot study). PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0271350"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1007\/s10072-021-05444-3","article-title":"New daily persistent headache after SARS-CoV-2 infection: A report of two cases","volume":"42","author":"Dono","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s13760-021-01790-3","article-title":"Indomethacin for refractory COVID or post-COVID headache: A retrospective study","volume":"122","author":"Krymchantowski","year":"2022","journal-title":"Acta Neurol. Belg."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/head.14197","article-title":"Toward a better understanding of persistent headache after mild COVID-19: Three migraine-like yet distinct scenarios","volume":"61","author":"Caronna","year":"2021","journal-title":"Headache"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e815","DOI":"10.3399\/BJGP.2021.0265","article-title":"Recommendations for the recognition, diagnosis, and management of long COVID: A Delphi study","volume":"71","author":"Nurek","year":"2021","journal-title":"Br. J. Gen. Pract."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1148\/radiol.220069","article-title":"Lung abnormalities detected with hyperpolarized 129Xe MRI in patients with long COVID","volume":"305","author":"Grist","year":"2022","journal-title":"Radiology"},{"key":"ref_175","first-page":"14","article-title":"Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis\/chronic fatigue syndrome: A possible approach to SARS-CoV-2 \u2018long-haulers\u2019?","volume":"7","author":"Wood","year":"2021","journal-title":"Chronic Dis. Transl. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/covid2040031","article-title":"A randomised, double-blind, placebo-controlled trial evaluating concentrated phytochemical-rich nutritional capsule in addition to a probiotic capsule on clinical outcomes among individuals with COVID-19-The UK Phyto-V study","volume":"2","author":"Thomas","year":"2022","journal-title":"COVID"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e000385","DOI":"10.1136\/bmjmed-2022-000385","article-title":"Effect of covid-19 vaccination on long covid: Systematic review","volume":"2","author":"Byambasuren","year":"2023","journal-title":"BMJ Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e000229","DOI":"10.1136\/bmjmed-2022-000229","article-title":"Efficacy of first dose of covid-19 vaccine versus no vaccination on symptoms of patients with long covid: Target trial emulation based on ComPaRe e-cohort","volume":"2","author":"Tran","year":"2023","journal-title":"BMJ Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1002\/jmv.27689","article-title":"Relationship between changes in symptoms and antibody titers after a single vaccination in patients with Long COVID","volume":"94","author":"Tsuchida","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijid.2023.09.006","article-title":"Vaccination after developing long COVID: Impact on clinical presentation, viral persistence, and immune responses","volume":"136","author":"Nayyerabadi","year":"2023","journal-title":"Int. J. Infect. Dis."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.vaccine.2023.02.008","article-title":"Protective effect of COVID-19 vaccination against long COVID syndrome: A systematic review and meta-analysis","volume":"41","author":"Watanabe","year":"2023","journal-title":"Vaccine"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"101624","DOI":"10.1016\/j.eclinm.2022.101624","article-title":"Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms: A systematic review","volume":"53","author":"Notarte","year":"2022","journal-title":"eClinicalMedicine"}],"container-title":["Infectious Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7449\/15\/6\/72\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:39:43Z","timestamp":1760132383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7449\/15\/6\/72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":182,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["idr15060072"],"URL":"https:\/\/doi.org\/10.3390\/idr15060072","relation":{},"ISSN":["2036-7449"],"issn-type":[{"value":"2036-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]}}}