{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:12:28Z","timestamp":1790284348881,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["Funding program \u201cOpen Access Publication Funding\u201d"],"award-info":[{"award-number":["Funding program \u201cOpen Access Publication Funding\u201d"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Introduction: Necrotizing fasciitis (NF) is a critical disease with high morbidity and mortality rates that poses significant challenges in diagnosis and treatment. Prognostic factors for the clinical course of NF remain unclear and are currently under research. This study aims to identify such factors in a large cohort of patients which represents a major comprehensive investigation of prognostic factors for NF. Methods: Retrospective analysis was conducted on necrotizing fasciitis cases from 2003 to 2023 at two German hospitals. Data included demographics, comorbidities, laboratory findings, infection site, causative microorganisms and outcomes. Statistical analysis involved t-tests, chi-square tests, and ROC analysis. Results: A total of 209 patients were included, with a mortality rate of 18%. Patients were categorized into survivors (n = 171) and non-survivors (n = 38). Non-survivors were significantly older (68.9 \u00b1 13.9 years vs. 55.9 \u00b1 14.3 years; p &lt; 0.01) and exhibited a higher prevalence of peripheral vascular diseases, cancer, and heart, liver, or renal insufficiency. Laboratory findings and scoring results also varied significantly between the two groups. The ROC curve analysis identified age as a predictor of mortality, with an optimal cut-off value of 68.5 years (sensitivity: 60.5%, specificity: 81.9%). Higher age was associated with increased mortality risk. Conclusions: The patient\u2019s age stands out as the primary predictive element for mortality in necrotizing fasciitis. Additionally, we advocate for employing the Laboratory and Anamnestic Risk Indicator for Necrotizing Fasciitis (LARINF\u2014score), which holds substantial prognostic significance and is straightforward to calculate. Considering our findings, crafting a clinical algorithm or scoring mechanism to forecast mortality in NF would be a promising target for future research.<\/jats:p>","DOI":"10.3390\/idr16030035","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T09:30:03Z","timestamp":1715851803000},"page":"472-480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Factors in Necrotizing Fasciitis: Insights from a Two-Decade, Two-Center Study Involving 209 Cases"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-8002","authenticated-orcid":false,"given":"Ioannis-Fivos","family":"Megas","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"},{"name":"Department of Orthopaedic and Trauma Surgery, Center of Plastic Surgery, Hand Surgery and Microsurgery, Evangelisches Waldkrankenhaus Spandau, 13589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina","family":"Delavari","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"},{"name":"Department of General and Visceral Surgery, Hospital Martha-Maria, 90491 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Marti Edo","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Habild","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, Center of Plastic Surgery, Hand Surgery and Microsurgery, Evangelisches Waldkrankenhaus Spandau, 13589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Billner","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Breidung","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Klinikum N\u00fcrnberg, Paracelsus Medical University, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S1473-3099(22)00583-7","article-title":"Necrotising soft-tissue infections","volume":"23","author":"Hua","year":"2023","journal-title":"Lancet Infect. 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