{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:44:49Z","timestamp":1787028289633,"version":"build-2736575974"},"reference-count":94,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes for Health Research (CIHR)","award":["162200"],"award-info":[{"award-number":["162200"]}]},{"name":"Canadian Institutes for Health Research (CIHR)","award":["RGPIN-2018-06281"],"award-info":[{"award-number":["RGPIN-2018-06281"]}]},{"name":"National Science and Engineering Council of Canada (NSERC) Discovery","award":["162200"],"award-info":[{"award-number":["162200"]}]},{"name":"National Science and Engineering Council of Canada (NSERC) Discovery","award":["RGPIN-2018-06281"],"award-info":[{"award-number":["RGPIN-2018-06281"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum.<\/jats:p>","DOI":"10.3390\/idr16040041","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T06:51:53Z","timestamp":1719557513000},"page":"543-560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria"],"prefix":"10.3390","volume":"16","author":[{"given":"Alexandra","family":"Bourgeois","sequence":"first","affiliation":[{"name":"Centre de Recherche en Infectiologie, CRCHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC G1V 4G2, Canada"},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Aline Souza","family":"Lemos","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie, CRCHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Roucheray","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie, CRCHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC G1V 4G2, Canada"},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Sergerie","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie, CRCHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC G1V 4G2, Canada"},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Richard","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie, CRCHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC G1V 4G2, Canada"},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.3390\/molecules171112771","article-title":"Medicinal plants: A source of anti-parasitic secondary metabolites","volume":"17","author":"Wink","year":"2012","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dziduch, K., Greniuk, D., and Wujec, M. 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