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\u201cUna manera de hacer Europa\u201d","award":["R01HL1528322"],"award-info":[{"award-number":["R01HL1528322"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["CP17\/00114"],"award-info":[{"award-number":["CP17\/00114"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["CPII22\/00006"],"award-info":[{"award-number":["CPII22\/00006"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["SEPAR2019"],"award-info":[{"award-number":["SEPAR2019"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["SOCAP2019"],"award-info":[{"award-number":["SOCAP2019"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["PI21\/01212"],"award-info":[{"award-number":["PI21\/01212"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["2024 FI-3 00065"],"award-info":[{"award-number":["2024 FI-3 00065"]}]},{"name":"predoctoral program AGAUR-FI ajuts","award":["R01HL1528322"],"award-info":[{"award-number":["R01HL1528322"]}]},{"name":"NIH Funding","award":["CP17\/00114"],"award-info":[{"award-number":["CP17\/00114"]}]},{"name":"NIH Funding","award":["CPII22\/00006"],"award-info":[{"award-number":["CPII22\/00006"]}]},{"name":"NIH Funding","award":["SEPAR2019"],"award-info":[{"award-number":["SEPAR2019"]}]},{"name":"NIH Funding","award":["SOCAP2019"],"award-info":[{"award-number":["SOCAP2019"]}]},{"name":"NIH Funding","award":["PI21\/01212"],"award-info":[{"award-number":["PI21\/01212"]}]},{"name":"NIH Funding","award":["2024 FI-3 00065"],"award-info":[{"award-number":["2024 FI-3 00065"]}]},{"name":"NIH Funding","award":["R01HL1528322"],"award-info":[{"award-number":["R01HL1528322"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background\/ Objectives: Long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC) are symptoms that manifest despite passing the acute infection phase. These manifestations encompass a wide range of symptoms, the most common being fatigue, shortness of breath, and cognitive dysfunction. Genetic predisposition is clearly involved in the susceptibility of individuals to developing these persistent symptoms and the variation in the severity and forms. This review summarizes the role of genetic factors and gene polymorphisms in the development of major pulmonary vascular disorders associated with long COVID. Methods: A comprehensive review of current literature was conducted to examine the genetic contributions to pulmonary complications following SARS-CoV-2 infection. Studies investigating genetic polymorphisms linked to pulmonary hypertension, pulmonary thromboembolism, and pulmonary vascular endothelialitis were reviewed and summarized. Results: Findings show that specific genetic variants contribute to increased susceptibility to pulmonary vascular complications in long COVID patients. Variants associated with endothelial dysfunction, coagulation pathways, and inflammatory responses have been implicated in the development of pulmonary hypertension and thromboembolic events. Genetic predispositions influencing vascular integrity and immune responses appear to influence disease severity and progression. Conclusions: Understanding these mechanisms and genetic predispositions could pave the way for targeted therapeutic interventions to alleviate the burden on patients experiencing long COVID.<\/jats:p>","DOI":"10.3390\/idr17010015","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:03:35Z","timestamp":1739419415000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetics of Long COVID: Exploring the Molecular Drivers of Persistent Pulmonary Vascular Disease Symptoms"],"prefix":"10.3390","volume":"17","author":[{"given":"Sana","family":"Ayyoub","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Faculty of Medicine, University of Girona, 17004 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet Kaur","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Mail Stop 3007, 3901 Rainbow Blvd, Kansas City, KS 66160, USA"},{"name":"Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-9790","authenticated-orcid":false,"given":"Olga","family":"Tura-Ceide","sequence":"additional","affiliation":[{"name":"Translational Research Group on Cardiovascular Respiratory Diseases (CAREs), Girona Biomedical Research Institute (IDIBGI-CERCA), Mart\u00ed i Juli\u00e0, Hospital Park Building M2, 17190 Salt, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2112","DOI":"10.1002\/rmv.2112","article-title":"Comparison of confirmed COVID-19 with SARS and MERS cases-Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis","volume":"30","author":"Pormohammad","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s13054-020-03062-7","article-title":"The vascular endothelium: The cornerstone of organ dysfunction in severe SARS-CoV-2 infection","volume":"24","author":"Pons","year":"2020","journal-title":"Crit. Care"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rabaan, A.A., Smajlovi\u0107, S., Tombuloglu, H., \u0106ordi\u0107, S., Hajdarevi\u0107, A., Kudi\u0107, N., Al Mutai, A., Turkistani, S.A., Al-Ahmed, S.H., and Al-Zaki, N.A. (2023). SARS-CoV-2 infection and multi-organ system damage: A review. Biomol. Biomed., 23.","DOI":"10.17305\/bjbms.2022.7762"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Paidas, M.J., Sampath, N., Schindler, E.A., Cosio, D.S., Ndubizu, C.O., Shamaladevi, N., Kwal, J., Rodriguez, S., Ahmad, A., and Kenyon, N.S. (2022). Mechanism of multi-organ injury in experimental COVID-19 and its inhibition by a small molecule peptide. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.864798"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101019","DOI":"10.1016\/j.eclinm.2021.101019","article-title":"Characterizing long COVID in an international cohort: 7 months of symptoms and their impact","volume":"38","author":"Davis","year":"2021","journal-title":"eClinicalMedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"866","DOI":"10.15585\/mmwr.mm7232a3","article-title":"Long COVID and significant activity limitation among adults, by age\u2014United States, June 1\u201313, 2022, to June 7\u201319, 2023","volume":"72","author":"Ford","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11547-020-01295-8","article-title":"The lingering manifestations of COVID-19 during and after convalescence: Update on long-term pulmonary consequences of coronavirus disease 2019 (COVID-19)","volume":"126","author":"Shaw","year":"2021","journal-title":"La Radiol. Medica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pulmoe.2020.10.013","article-title":"Respiratory function in patients post-infection by COVID-19: A systematic review and meta-analysis","volume":"27","author":"Burgos","year":"2021","journal-title":"Pulmonology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14799731211002240","DOI":"10.1177\/14799731211002240","article-title":"Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis","volume":"18","author":"Torralba","year":"2021","journal-title":"Chronic Respir. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"L277","DOI":"10.1152\/ajplung.00195.2020","article-title":"Novel insights on the pulmonary vascular consequences of COVID-19","volume":"319","author":"Potus","year":"2020","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hou, Y., Zhao, J., Martin, W., Kallianpur, A., Chung, M.K., Jehi, L., Sharifi, N., Erzurum, S., Eng, C., and Cheng, F. (2020). New insights into genetic susceptibility of COVID-19: An ACE2 and TMPRSS2 polymorphism analysis. BMC Med., 18.","DOI":"10.1186\/s12916-020-01673-z"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12985-024-02298-x","article-title":"Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt","volume":"21","author":"Elnagdy","year":"2024","journal-title":"Virol. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40001-022-00647-6","article-title":"Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: A systematic review","volume":"27","author":"Li","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e29404","DOI":"10.1002\/jmv.29404","article-title":"Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis","volume":"96","author":"Degano","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-De-Las-Pe\u00f1as, C., Arendt-Nielsen, L., D\u00edaz-Gil, G., G\u00f3mez-Esquer, F., Gil-Crujera, A., G\u00f3mez-S\u00e1nchez, S.M., Ambite-Quesada, S., Palomar-Gallego, M.A., Pellicer-Valero, O.J., and Giordano, R. (2022). Genetic association between ACE2 (rs2285666 and rs2074192) and TMPRSS2 (rs12329760 and rs2070788) polymorphisms with post-COVID symptoms in previously hospitalized COVID-19 survivors. Genes, 13.","DOI":"10.3390\/genes13111935"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Varillas-Delgado, D., Jimenez-Antona, C., Lizcano-Alvarez, A., Cano-de-la-Cuerda, R., Molero-Sanchez, A., and Laguarta-Val, S. (2023). Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316717"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2239952","DOI":"10.1080\/22221751.2023.2239952","article-title":"Host genetic polymorphisms involved in long-term symptoms of COVID-19","volume":"12","author":"Udomsinprasert","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-Las-Pe\u00f1as, C., Giordano, R., D\u00edaz-Gil, G., G\u00f3mez-Esquer, F., Ambite-Quesada, S., Palomar-Gallego, M.A., and Arendt-Nielsen, L. (2022). Post-COVID pain is not associated with inflammatory polymorphisms in people who had been hospitalized by COVID-19. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195645"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-Las-Pe\u00f1as, C., Arendt-Nielsen, L., D\u00edaz-Gil, G., G\u00f3mez-Esquer, F., Gil-Crujera, A., G\u00f3mez-S\u00e1nchez, S.M., Ambite-Quesada, S., Palomar-Gallego, M.A., Pellicer-Valero, O.J., and Giordano, R. (2023). Apolipoprotein E (ApoE) \u03b54 Genotype (ApoE rs429358\u2014ApoE rs7412 Polymorphisms) Is Not Associated with Long COVID Symptoms in Previously Hospitalized COVID-19 Survivors. Genes, 14.","DOI":"10.3390\/genes14071420"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Queiroz, M.A.F., Santiago, A.M., Brito, W.R.d.S., Pereira, K.A.S., de Brito, W.B., Torres, M.K.d.S., Lopes, J.d.C., da Costa, F.P., de Sarges, K.M.L., and Cantanhede, M.H.D. (2023). Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-\u03b1 in severe COVID-19. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1151058"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Danielle, R.C.S., D\u00e9bora, D.M., Alessandra, N.L.P., Alexia, S.S.Z., D\u00e9bora, M.C.R., Elizabel, N.V., Felipe, A.M., Giulia, M.G., Henrique, P.R., and Karen, R.M.B. (2024). Correlating COVID-19 severity with biomarker profiles and patient prognosis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-71951-w"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.jinf.2022.12.026","article-title":"ACE1 rs1799752 polymorphism is not associated with long-COVID symptomatology in previously hospitalized COVID-19 survivors","volume":"86","author":"Giordano","year":"2023","journal-title":"J. Infect."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zamani Rarani, F., Zamani Rarani, M., Hamblin, M.R., Rashidi, B., Hashemian, S.M.R., and Mirzaei, H. (2022). Comprehensive overview of COVID-19-related respiratory failure: Focus on cellular interactions. Cell. Mol. Biol. Lett., 27.","DOI":"10.1186\/s11658-022-00363-3"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2020.11.017","article-title":"Pulmonary embolism in COVID-19 patients: Prevalence, predictors and clinical outcome","volume":"198","author":"Scudiero","year":"2021","journal-title":"Thromb. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ortega-Paz, L., Talasaz, A.H., Sadeghipour, P., Potpara, T.S., Aronow, H.D., Jara-Palomares, L., Sholzberg, M., Angiolillo, D.J., Lip, G.Y.P., and Bikdeli, B. (2022). COVID-19-associated pulmonary embolism: Review of the pathophysiology, epidemiology, prevention, diagnosis, and treatment. Seminars in Thrombosis and Hemostasis, Thieme Medical Publishers, Inc.","DOI":"10.1055\/s-0042-1757634"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11239-020-02134-3","article-title":"COVID-19 update: COVID-19-associated coagulopathy","volume":"50","author":"Becker","year":"2020","journal-title":"J. Thromb. Thrombol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tse, J., Gongolli, J., and Prahlow, J.A. (2024). Hereditary thrombophilia as a possible risk factor for severe disease in COVID-19: A case series. Forensic Sci. Med. Pathol., 1\u20137.","DOI":"10.1007\/s12024-024-00879-4"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Calabrese, C., Annunziata, A., Coppola, A., Pafundi, P.C., Guarino, S., Di Spirito, V., Maddaloni, V., Pepe, N., and Fiorentino, G. (2021). ACE gene I\/D polymorphism and acute pulmonary embolism in COVID19 pneumonia: A potential predisposing role. Front. Med., 7.","DOI":"10.3389\/fmed.2020.631148"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Moness, H., Mousa, S.O., Mousa, S.O., Adel, N.M., Ibrahim, R.A., Hassan, E.E., Meshref, D.A., and Abdullah, N.M. (2024). Thrombophilia genetic mutations and their relation to disease severity among patients with COVID-19. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0296668"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tudoran, C., Tudoran, M., Lazureanu, V.E., Marinescu, A.R., Pop, G.N., Pescariu, A.S., Enache, A., and Cut, T.G. (2021). Evidence of pulmonary hypertension after SARS-CoV-2 infection in subjects without previous significant cardiovascular pathology. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020199"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s43168-023-00201-w","article-title":"Study of pulmonary hypertension in post-COVID-19 patients by transthoracic echocardiography","volume":"17","author":"Taha","year":"2023","journal-title":"Egypt. J. Bronchol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"101187","DOI":"10.1016\/j.cpcardiol.2022.101187","article-title":"Chronic thromboembolic pulmonary hypertension (CTEPH): A review of another sequel of severe post-COVID-19 pneumonia","volume":"48","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_38","first-page":"1169","article-title":"Right ventricular dysfunction and pulmonary hypertension in COVID-19: A meta-analysis of prevalence and its association with clinical outcome","volume":"18","author":"Oktaviono","year":"2022","journal-title":"Arch. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Eroume \u00c0 Egom, E., Shiwani, H.A., and Nouthe, B. (2022). From acute SARS-CoV-2 infection to pulmonary hypertension. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.1023758"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41569-021-00640-2","article-title":"Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: A global perspective","volume":"19","author":"Halawa","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e12191","DOI":"10.1002\/pul2.12191","article-title":"Uncovering common pathobiological processes between COVID-19 and pulmonary arterial hypertension by integrating Omics data","volume":"13","author":"Wang","year":"2023","journal-title":"Pulm. Circ."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Hou, Q., Jiang, J., Na, K., Zhang, X., Liu, D., Jing, Q., Yan, C., and Han, Y. (2024). Potential therapeutic targets for COVID-19 complicated with pulmonary hypertension: A bioinformatics and early validation study. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-60113-7"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Oh, J.H., Tannenbaum, A., and Deasy, J.O. (2020). Identification of biological correlates associated with respiratory failure in COVID-19. BMC Med. Genom., 13.","DOI":"10.1186\/s12920-020-00839-1"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2301742","DOI":"10.1183\/13993003.01742-2023","article-title":"Chronic thromboembolic pulmonary hypertension is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies","volume":"64","author":"Reddy","year":"2024","journal-title":"Eur. Respir. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2000774","DOI":"10.1183\/13993003.00774-2020","article-title":"The Factor V Leiden variant and risk of chronic thromboembolic pulmonary hypertension","volume":"56","author":"Dodson","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1164\/rccm.202402-0471ED","article-title":"Genetically Identifying the \u201cThrombo-embolic\u201d in CTEPH","volume":"209","author":"Eichstaedt","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.31083\/j.rcm.2020.03.126","article-title":"Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy","volume":"21","author":"Zhang","year":"2020","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/00015385.2020.1846921","article-title":"Endothelialitis plays a central role in the pathophysiology of severe COVID-19 and its cardiovascular complications","volume":"76","author":"Vrints","year":"2021","journal-title":"Acta Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yatsenko, T., Rios, R., Nogueira, T., Salama, Y., Takahashi, S., Adachi, E., Tabe, Y., Hattori, N., Osada, T., and Naito, T. (2024). The influence of 4G\/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1445294"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"RECOVERY Collaborative Group (2020). Dexamethasone in Hospitalized Patients with Covid-19. N. Engl. J. Med., 384, 693\u2013704.","DOI":"10.1056\/NEJMoa2021436"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105954","DOI":"10.1016\/j.ijantimicag.2020.105954","article-title":"Cytokine release syndrome in severe COVID-19: Interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality","volume":"55","author":"Zhang","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/s41375-023-01979-w","article-title":"The JAK1\/2 inhibitor ruxolitinib in patients with COVID-19 triggered hyperinflammation: The RuxCoFlam trial","volume":"37","author":"Hammersen","year":"2023","journal-title":"Leukemia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12933-023-02097-8","article-title":"Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: A link with diabetes mellitus","volume":"23","author":"Valencia","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s10753-023-01848-9","article-title":"Protective Role of Endothelial SIRT1 in Deep Vein Thrombosis and Hypoxia-induced Endothelial Dysfunction Mediated by NF-\u03baB Deacetylation","volume":"46","author":"Tang","year":"2023","journal-title":"Inflammation"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1160\/TH15-01-0031","article-title":"Plasminogen activator inhibitor-1 4G\/5G polymorphism, factor V Leiden, prothrombin mutations and the risk of VTE recurrence","volume":"114","author":"Sundquist","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J. Clin. Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/iji.12598","article-title":"Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID-19 severity in Iranian population","volume":"49","author":"Khalilzadeh","year":"2022","journal-title":"Int. J. Immunogenet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11084-024-09648-3","article-title":"Association of ACE2 and TMPRSS2 towards COVID-19 susceptibility","volume":"54","author":"Alam","year":"2024","journal-title":"Discov. Life"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Posadas-S\u00e1nchez, R., Fragoso, J.M., S\u00e1nchez-Mu\u00f1oz, F., Rojas-Velasco, G., Ram\u00edrez-Bello, J., L\u00f3pez-Reyes, A., Mart\u00ednez-G\u00f3mez, L.E., Sierra-Fern\u00e1ndez, C., Rodr\u00edguez-Reyna, T., and Regino-Zamarripa, N.E. (2022). Association of the transmembrane serine protease-2 (TMPRSS2) polymorphisms with COVID-19. Viruses, 14.","DOI":"10.3390\/v14091976"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1007\/s12010-022-03885-w","article-title":"Association of TMPRSS2 gene polymorphisms with COVID-19 severity and mortality: A case-control study with computational analyses","volume":"194","author":"Rokni","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/08820139.2020.1851709","article-title":"Association of TNF-\u03b1 G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients","volume":"51","author":"Saleh","year":"2022","journal-title":"Immunol. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/iji.12605","article-title":"Genetic polymorphisms of IL6 gene\u2013174G> C and\u2013597G> A are associated with the risk of COVID-19 severity","volume":"50","author":"Verma","year":"2023","journal-title":"Int. J. Immunogenet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2141.2010.08529.x","article-title":"Risk of cardiovascular disease in double heterozygous carriers and homozygous carriers of F5 R506Q (factor V Leiden) and F2 (prothrombin) G20210A: A retrospective family cohort study","volume":"153","author":"Roach","year":"2011","journal-title":"Br. J. Haematol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12985-024-02597-3","article-title":"The role of inflammatory gene polymorphisms in severe COVID-19: A review","volume":"21","author":"Yip","year":"2024","journal-title":"Virol. J."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"AbdelAziz, R.A., Abd-Allah, S.T., Moness, H.M., Anwar, A.M., and Mohamed, Z.H. (2024). Role of interleukin 6 polymorphism and inflammatory markers in outcome of pediatric Covid-19 patients. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-05071-9"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1710-1492-10-8","article-title":"Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors","volume":"10","author":"Marson","year":"2014","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.humimm.2021.07.004","article-title":"HLA-DRB1* 04 may predict the severity of disease in a group of Iranian COVID-19 patients","volume":"82","author":"Ebrahimi","year":"2021","journal-title":"Hum. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Baranova, A., Cao, H., Chen, J., and Zhang, F. (2022). Causal association and shared genetics between asthma and COVID-19. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.705379"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sharma, P., Pandey, A.K., and Bhattacharyya, D.K. (2021). Determining crucial genes associated with COVID-19 based on COPD Findings. Comput. Biol. Med., 128.","DOI":"10.1016\/j.compbiomed.2020.104126"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zheng, W., Wang, T., Wu, P., Yan, Q., Liu, C., Wu, H., Zhan, S., Liu, X., Jiang, Y., and Zhuang, H. (2021). Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.718874"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e09","DOI":"10.15420\/ecr.2022.41","article-title":"Noise, air, and heavy metal pollution as risk factors for endothelial dysfunction","volume":"18","author":"Jimenez","year":"2023","journal-title":"Eur. Cardiol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8671713","DOI":"10.1155\/2021\/8671713","article-title":"Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID-19\u2014Mechanisms and Therapeutic Targets","volume":"2021","author":"Fodor","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1007\/s11695-021-05271-7","article-title":"Roux-en-Y gastric bypass downregulates angiotensin-converting enzyme 2 (ACE2) gene expression in subcutaneous white adipose tissue: A putative protective mechanism against severe COVID-19","volume":"31","author":"Kristem","year":"2021","journal-title":"Obes. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Jang, S., Hong, W., and Moon, Y. (2024). Obesity-compromised immunity in post-COVID-19 condition: A critical control point of chronicity. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1433531"}],"container-title":["Infectious Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7449\/17\/1\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:32:44Z","timestamp":1760027564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7449\/17\/1\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["idr17010015"],"URL":"https:\/\/doi.org\/10.3390\/idr17010015","relation":{},"ISSN":["2036-7449"],"issn-type":[{"value":"2036-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}