{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:57:41Z","timestamp":1760057861922,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background\/Objectives: Although a \u201cforgotten\u201d disease in developed countries, typhoid fever remains a significant global health problem, especially in regions with inadequate sanitation and overcrowding. Despite medical advances, this systemic bacterial infection, caused by Salmonella Typhi, continues to affect millions worldwide. Accurate diagnosis and timely treatment are crucial to prevent severe complications and mortality. Even though antibiotic therapy is effective, the emergence of drug-resistant strains is a growing challenge. Methods: We present a series of cases encountered in a tertiary infectious disease hospital in Romania over 15 years. Results: The hospitalised patients were mainly from Sub-Saharan Africa and the Indian subcontinent; the median time between the onset of the first symptoms and hospital admission was 15 days. The symptoms encountered along with fever were headache, chills, cough, diarrhoea and tachycardia, an unusual feature in the clinical picture of this disease. Aneosinophilia (the absence of peripheral eosinophilic granulocytes) was the most frequently encountered laboratory finding, followed by increased serum transaminases and inflammatory syndrome. Conclusions: S. Typhi was generally identified from blood culture, demonstrating, except in one case, resistance to ciprofloxacin and, in several cases, multi-drug resistance (MDR). In this series of cases, all strains were sensitive to ceftriaxone.<\/jats:p>","DOI":"10.3390\/idr17020016","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:55:48Z","timestamp":1740480948000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imported Typhoid Fever in Romania Between 2010 and 2024"],"prefix":"10.3390","volume":"17","author":[{"given":"Dragos Stefan","family":"Lazar","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-5020","authenticated-orcid":false,"given":"George Sebastian","family":"Gherlan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-3386","authenticated-orcid":false,"given":"Simin Aysel","family":"Florescu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-0333","authenticated-orcid":false,"given":"Corneliu Petru","family":"Popescu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"},{"name":"Virology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Nica","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania"},{"name":"Microbiology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","unstructured":"(2024, November 01). 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