{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:55:07Z","timestamp":1778172907840,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background: Coronavirus disease 2019 (COVID-19) involves a complex interplay of dysregulated immune responses, a pro-inflammatory cytokine storm, endothelial injury, and thrombotic complications. This study aimed to evaluate the impact of kidney function on clinical, laboratory, and outcome parameters in patients hospitalized with COVID-19. Methods: We conducted a retrospective analysis of 359 patients admitted during the first wave of COVID-19, stratified by estimated glomerular filtration rate (eGFR &lt; 60 vs. \u226560 mL\/min\/1.73 m2). Data on demographics, vital signs, laboratory values, and clinical outcomes\u2014including mortality, hemodialysis requirement, intensive care unit (ICU) admission, and mechanical ventilation (MV)\u2014were collected. Univariate and multivariate linear regression, as well as area under the receiver operating characteristic curve (AUC-ROC) analyses, were performed. A p-value &lt; 0.05 was considered statistically significant. Results: Patients with an eGFR &lt; 60 were older and more likely to have systemic hypertension, chronic kidney disease, a history of solid organ transplantation, and immunosuppressive therapy. This group showed higher rates of mortality (41.6% vs. 19.2%), hemodialysis requirement (32.3% vs. 9.6%), ICU admission (50.9% vs. 37.9%), and MV (39.8% vs. 21.2%). Laboratory results revealed acidosis, anemia, lymphopenia, elevated inflammatory markers, and hyperkalemia. Conclusions: An admission eGFR &lt; 60 mL\/min\/1.73 m2 is associated with worse clinical outcomes in COVID-19 and may serve as a simple, early marker for risk stratification.<\/jats:p>","DOI":"10.3390\/idr17040079","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:19:27Z","timestamp":1751887167000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Kidney Function in Predicting COVID-19 Severity and Clinical Outcomes: A Retrospective Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-818X","authenticated-orcid":false,"given":"Victor Muniz","family":"de Freitas","sequence":"first","affiliation":[{"name":"Department of Medicine, Nephrology Division, Federal University of S\u00e3o Paulo, Borges Lagoa Street, 783, 6th Floor, Vila Clementino, S\u00e3o Paulo 04038-031, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-2484","authenticated-orcid":false,"given":"\u00c9rika Bevilaqua","family":"Rangel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nephrology Division, Federal University of S\u00e3o Paulo, Borges Lagoa Street, 783, 6th Floor, Vila Clementino, S\u00e3o Paulo 04038-031, SP, Brazil"},{"name":"Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, S\u00e3o Paulo 05652-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref_1","unstructured":"(2022). 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